陈凌懿

陈凌懿，南开大学生命科学学院教授、博导，副院长，国家优秀青年科学基金获得者。1999 北京大学 学士；2004 美国西北大学 博士；2005--2008 美国哈佛大学 博士后；2008-至今 南开大学生命科学学院 教授、博导。已在包括Cell、Nature、PNAS、Cell Research等杂志上发表论文30余篇。他的研究目标是阐明胚胎干细胞多能性维持的分子机制，以及小鼠早期胚胎发育中细胞命运决定的分子调控机制。例如，胚胎干细胞是如何在不断自我更新的同时维持它的分化潜能？而单个受精卵细胞又是如何分化形成各种类型的细胞？特别是在囊胚形成过程中，内细胞团细胞和滋养层细胞的命运是如何决定的？

1999 北京大学 学士2004 美国西北大学 博士

2005--2008 美国哈佛大学 博士后2008-- 南开大学生命科学学院 教授、博导

（1）胚胎干细胞多能性维持的分子机制；

（2）小鼠早期胚胎发育的分子调控机制；

（3）肿瘤的致病基因及其作用机制。

1. Qin Y, Ni P, Zhang Q, Wang X, Du X, Yin Z, Wang L, Ye L* and Chen L*. (2022). Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1. Development, 149:dev200527

2. Chen H, Li P, DuX, Zhao Y, Wang L, TianY, SongX, Shuai L*, Bai X*, Chen L*. (2022) Homozygous loss of Septin12, but not its haploinsufficiency, leads to male infertility and fertilization failure. Front Cell Dev Biol, 10:850052.

3. Ha N, Ding N, Hong R, Liu R, Roca X, Luo Y, Duan X, Wang X, Ni P, Wu H, Zhang LF*, Chen L*. (2021) The lupus autoantigen La/Ssb is an Xist-binding protein involved in Xist folding and cloud formation. Nucleic Acids Research, 49:11596-11613.

4. Zhao T, Cai M, Liu M, Su G, An D, Moon B, Lyu G, Si Y, Chen L*, Lu W*.(2020) lncRNA 5430416N02Rik promotes the proliferation of mouse embryonic stem cells by activating Mid1 expression through 3D chromatin architecture. Stem Cell Reports, 14:493-505.

5. Li P, Gao L, Cui T, Zhang W, Zhao Z, and Chen L*. (2020) Cops5 safeguards genomic stability of embryonic stem cells through regulating cellular metabolism and DNA repair. Proc Natl Acad Sci U S A, 117:2519-2525.

6. Cheng Z, Nai S, Song S, Chen L*, and Yu Z*. (2020) Photoinduced directional domain sliding motion in peptide hydrogels promotes ectodermal differentiation of embryonic stem cells. SCIENCE CHINA Materials, 63:467-478.

7. Ruan X, Shi X, Dong Q, Yu Y, Hou X, Song X, Wei X, Chen L*, Gao M.* (2019) Antitumor effects of anlotinib in thyroid cancer. Endocr Relat Cancer, 26:153-164.

8. Ha N, Lai LT, Chelliah R, Zhen Y, Yi Vanessa SP, Lai SK, Li HY, Ludwig A, Sandin S, Chen L*, Zhang  LF.* (2018) Live-Cell Imaging and Functional Dissection of Xist RNA  Reveal Mechanisms of X Chromosome Inactivation and Reactivation.  iScience, 8:1-14.

9. Li P, Ding N, Zhang W, Chen L.* (2018) COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells. Stem Cell Reports, 11:317-324.

10. Li W, Hong R, Lai LT, Dong Q, Ni P, Chelliah R, Huq M, Ismail SNB, Chandola U, Ang Z, Lin B, Chen X, Chen L*, Zhang LF*. (2018) Genome-Wide RNAi Screen Identify Melanoma-Associated Antigen Mageb3 Involved in X Chromosome Inactivation. J Mol Biol, 430:2734-2746.

11.   Shi X, Yin Z, Ling B, Wang L, Liu C, Ruan X, Zhang W, and Chen L.* (2017) Rho differentially regulates the Hippo pathway by modulating the interaction between Amot and Nf2 in the blastocyst. Development, 144:3957-3967.

12.   Yin Z, and Chen L.* (2017). Simple Meets Single: The Application of CRISPR/Cas9 in Haploid Embryonic Stem Cells. Stem Cells Int, 2017:2601746.

13.   Yu Y, Liu C, Zhang J, Zhang M, Wen W, Ruan X, Li D, Zhang S, Gao M*, and Chen L.* (2017) Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function. Sci Rep, 7:43396.

14.  Liu C, Yu Y, Yin G, Zhang J, Wen W, Ruan X, Li D, Zhang S, Cai W, Gao M*, and Chen L.* (2017) C14orf93 (RTFC) is identified as a novel susceptibility gene for familial nonmedullary thyroid cancer.Biochem Biophys Res Commun, 482:590-596.

15.  Ma X, Chen H, and Chen L.* (2016) A dual role of Erk signaling in embryonic stem cells. Exp Hematol, 44:151-156.

16.  Zhang W, Ni P, Mou C, Zhang, Y, Guo H, Zhao T, Loh YH*, and Chen L.* (2016) Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription. Sci Rep, 6:26804.

17.  Chen H, Guo R, Zhang Q, Guo H, Yang M, Wu Z, Gao S, Liu L*, and Chen L.* (2015) Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A, 112:E5936-5943.

18.  Yang BX, El Farran CA, Guo HC, Yu T, Fang HT, Wang HF, Schlesinger S, Seah YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L, Gunaratne J, Collins JJ, Goff SP, Daley GQ, Li H, Bard FA, and Loh YH.* (2015) Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. Cell, 163: 230-245.

19.  Liu F, You X, Wang Y, Liu Q, Liu Y, Zhang S, Chen L*, Zhang X*, Ye L.* (2014) The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF. Carcinogenesis, 35:1144-1153.

20.  Liu H, Wu Z, Shi X, Li W, Liu C, Wang D, Ye X, Liu L, Na J*, Cheng H*, Chen L*. (2013) Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryo compaction. Dev Biol, 375:13-22.

21.  Wu Z, Yang M, Liu H, Guo H, Wang Y, Cheng H, Chen L*. (2012) Role of Nuclear Receptor Coactivator 3 (Ncoa3) in Pluripotency Maintenance. Journal of Biological Chemistry, 287:38295-38304.

22.  Chen L*, Wang D, Wu Z, Ma L, and Daley G.Q.* (2010) Molecular basis of the first cell fate determination in mouse embryogenesis.Cell Res, 20:982-993.

23.  Chen L, Yabuuchi A, Eminli S, Takeuchi A, Lu C. W, Hochedlinger K and Daley G. Q. (2009) Cross-regulation of the Nanog and Cdx2 promoters. Cell Res, 19:1052-1061.

24.  Chen L and Daley G. Q. (2008) Molecular basis of pluripotency. Hum Mol Genet, 17: R23-27.

25.  Chen L and Widom J. (2005) Mechanism of transcriptional silencing in yeast. Cell, 120:37-48.

天津市细胞生物学学会  理事

天津市医师协会生殖医学专业委员会  常委

Scientific Reports  编委

本科生课程： 细胞生物学   2010-至今。

研究生课程： 干细胞与发育生物学  2013-至今。

国家优秀青年科学基金获得者

教育部新世纪优秀人才

天津市杰出青年科学基金获得者