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Lingyi Chen

Gender: male

Department: Genetics and Cell Biology

Tel: 022-23505821

Office Location: New Biolgical Station B301

Career: Professor

Major: Cell Biology

Email: lingyichen@nankai.edu.cn

Address: 94 Weijin Road

Resume

Professor Lingyi Chen, recipient of the National Science Fund for Excellent Young Scholars,has published more than 30 papers in high impact journals, including Cell, Nature, PNAS, Cell Research. The goal of his research is to understand the regulatory mechanisms underlying pluripotency maintenance and establishment, in embryonic stem cells and during early embryogenesis. How do embryonic stem cells maintain their differentiation potential while proliferate unlimited? How does a zygote differentiate into various types of cells? Particularly, how are the cell fates of the inner cell mass and the trophectoderm determined during the development of the blastocyst?

Education

1999 B.S. Peking University2004 Ph.D. Northwestern University, USA

WorkExperience

2005--2008 Harvard Medical School, Postdoctoral Fellow2008-- Nankai University, Professor

Research Fields

(1)Molecular mechanism of pluripotency maintenance in embryonic stem cells.

(2)Molecular basis underlying mouse preimplantation development.

(3)Oncogenes and their functions in tumors.

Achievement

1. Qin Y, Ni P, Zhang Q, Wang X, Du X, Yin Z, Wang L, Ye L* and Chen L*. (2022). Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1. Development, 149:dev200527

2. Chen H, Li P, DuX, Zhao Y, Wang L, TianY, SongX, Shuai L*, Bai X*, Chen L*. (2022) Homozygous loss of Septin12, but not its haploinsufficiency, leads to male infertility and fertilization failure. Front Cell Dev Biol, 10:850052.

3. Ha N, Ding N, Hong R, Liu R, Roca X, Luo Y, Duan X, Wang X, Ni P, Wu H, Zhang LF*, Chen L*. (2021) The lupus autoantigen La/Ssb is an Xist-binding protein involved in Xist folding and cloud formation. Nucleic Acids Research, 49:11596-11613.

4. Zhao T, Cai M, Liu M, Su G, An D, Moon B, Lyu G, Si Y, Chen L*, Lu W*.(2020) lncRNA 5430416N02Rik promotes the proliferation of mouse embryonic stem cells by activating Mid1 expression through 3D chromatin architecture. Stem Cell Reports, 14:493-505.

5. Li P, Gao L, Cui T, Zhang W, Zhao Z, and Chen L*. (2020) Cops5 safeguards genomic stability of embryonic stem cells through regulating cellular metabolism and DNA repair. Proc Natl Acad Sci U S A, 117:2519-2525.

6. Cheng Z, Nai S, Song S, Chen L*, and Yu Z*. (2020)  Photoinduced directional domain sliding motion in peptide hydrogels  promotes ectodermal differentiation of embryonic stem cells. SCIENCE CHINA Materials, 63:467-478.

7. Ruan X, Shi X, Dong Q, Yu Y, Hou X, Song X, Wei X, Chen L*, Gao M.* (2019) Antitumor effects of anlotinib in thyroid cancer. Endocr Relat Cancer, 26:153-164.

8. Ha N, Lai LT, Chelliah R, Zhen Y, Yi Vanessa SP, Lai SK, Li HY, Ludwig A, Sandin S, Chen L*, Zhang   LF.* (2018) Live-Cell Imaging and Functional Dissection of Xist RNA   Reveal Mechanisms of X Chromosome Inactivation and Reactivation.   iScience, 8:1-14.

9. Li P, Ding N, Zhang W, Chen L.* (2018) COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells. Stem Cell Reports, 11:317-324.

10. Li W, Hong R, Lai LT, Dong Q, Ni P, Chelliah R, Huq M, Ismail SNB, Chandola U, Ang Z, Lin B, Chen X, Chen L*, Zhang  LF*. (2018) Genome-Wide RNAi Screen Identify Melanoma-Associated  Antigen Mageb3 Involved in X Chromosome Inactivation. J Mol Biol,  430:2734-2746.

11.   Shi X, Yin Z, Ling B, Wang L, Liu C, Ruan X, Zhang W, and Chen L.* (2017)  Rho differentially regulates the Hippo pathway by modulating the  interaction between Amot and Nf2 in the blastocyst. Development,  144:3957-3967.

12.   Yin Z, and Chen L.* (2017). Simple Meets Single: The Application of CRISPR/Cas9 in Haploid Embryonic Stem Cells. Stem Cells Int, 2017:2601746.

13.   Yu Y, Liu C, Zhang J, Zhang M, Wen W, Ruan X, Li D, Zhang S, Gao M*, and Chen L.* (2017) Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function. Sci Rep, 7:43396.

14.  Liu C, Yu Y, Yin G, Zhang J, Wen W, Ruan X, Li D, Zhang S, Cai W, Gao M*, and Chen L.* (2017)  C14orf93 (RTFC) is identified as a novel susceptibility gene for  familial nonmedullary thyroid cancer.Biochem Biophys Res Commun,  482:590-596.

15.  Ma X, Chen H, and Chen L.* (2016) A dual role of Erk signaling in embryonic stem cells. Exp Hematol, 44:151-156.

16.  Zhang W, Ni P, Mou C, Zhang, Y, Guo H, Zhao T, Loh YH*, and Chen L.* (2016) Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription. Sci Rep, 6:26804.

17.  Chen H, Guo R, Zhang Q, Guo H, Yang M, Wu Z, Gao S, Liu L*, and Chen L.* (2015)  Erk signaling is indispensable for genomic stability and self-renewal  of mouse embryonic stem cells. Proc Natl Acad Sci U S A, 112:E5936-5943.

18.  Yang  BX, El Farran CA, Guo HC, Yu T, Fang HT, Wang HF, Schlesinger S, Seah  YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L,  Gunaratne J, Collins JJ, Goff SP, Daley GQ, Li H, Bard FA, and Loh YH.*  (2015) Systematic Identification of Factors for Provirus Silencing in  Embryonic Stem Cells. Cell, 163: 230-245.

19.  Liu F, You X, Wang Y, Liu Q, Liu Y, Zhang S, Chen L*, Zhang  X*, Ye L.* (2014) The oncoprotein HBXIP enhances angiogenesis and  growth of breast cancer through modulating FGF8 and VEGF.  Carcinogenesis, 35:1144-1153.

20.  Liu H, Wu Z, Shi X, Li W, Liu C, Wang D, Ye X, Liu L, Na J*, Cheng H*, Chen L*. (2013)  Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates  Ezrin during eight-cell embryo compaction. Dev Biol, 375:13-22.

21.  Wu Z, Yang M, Liu H, Guo H, Wang Y, Cheng H, Chen L*. (2012)  Role of Nuclear Receptor Coactivator 3 (Ncoa3) in Pluripotency  Maintenance. Journal of Biological Chemistry, 287:38295-38304.

22.  Chen L*, Wang  D, Wu Z, Ma L, and Daley G.Q.* (2010) Molecular basis of the first cell  fate determination in mouse embryogenesis.Cell Res, 20:982-993.

23.  Chen L, Yabuuchi  A, Eminli S, Takeuchi A, Lu C. W, Hochedlinger K and Daley G. Q. (2009)  Cross-regulation of the Nanog and Cdx2 promoters. Cell Res,  19:1052-1061.

24.  Chen L and Daley G. Q. (2008) Molecular basis of pluripotency. Hum Mol Genet, 17: R23-27.

25.  Chen L and Widom J. (2005) Mechanism of transcriptional silencing in yeast. Cell, 120:37-48.

Social Appointments

Teaching Experience

Undergraduate Course: Cell Biology                                               2010 - till now

Graduate Course:          Stem Cell and Developmental Biology      2013 - till now

Honor Title

Recipient of the National Science Fund for Excellent Young Scholars

Program for New Century Excellent Talents in University

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