Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Weihui Wu

 Department: Microbiology
 Address: Rm 216, Department of Microbiology, College of Life Sciences, Nankai University
 Phone: 86-22-23508874
::Professional Education::

Professional Education:

1994-1998    B.S. in Microbiology  Nankai University, Tianjin, China

1998-2001    M.S. in Microbiology Nankai University, Tianjin, China

2001-2006    Ph.D. in Immunology and Microbiology, University of Florida,  Gainesville, FL, USA


05/2006-10/2006,  Postdoctoral Fellow, Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.

10/2006-6/2009,    Postdoctoral Fellow, Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

7/2009-8/2011,      Postdoctoral Fellow, Channing Lab, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

2011-,                  Professor, College of Life Sciences, Nankai University

::Research Area::

1.  Regulation and function of pathogenic bacterial virulence factors

2.  Mechanisms of antibiotic resistance in pathogenic bacteria

4.  Host immune responses during infection

4.  Vaccine development

I have been studying bacteria caused infectious diseases since 2001, including bacteria gene regulation, host immune responses and vaccine development. In my research, I have elucidated multiple regulatory pathways of bacterial virulence factors and antibiotic resistant genes. As in host immune response, I focused on the mechanism of reactive oxygen species generated by neutrophils and macrophages, which is critical in bacteria killing and cell signaling. Besides, I have identified bacterial proteins that can elicit host Th17 response and constructed protective vaccines. In September 2011, I joined the Department of Microbiology in the College of Life Sciences, Nankai University. In 2012, I was selected in the Tianjin 1,000 Yong Talents Plan. Currently, the bacteria under investigation in my laboratory is Pseudomonas aeruginosa, which is an opportunistic pathogen causing a variety of infections. We are mainly working on mechanisms whereby the bacteria cause disease and antibiotic resistance, as well as host pathogen interaction and vaccine development.

::Honors and Awards::

1995-1998      Scholarship for Outstanding Undergraduate Students       Nankai University

1998-2001      Guanghua Scholarship for Outstanding Graduate Students  Nankai University 

2005               Student Travel Grant Award                American Society for Microbiology 

2006               Outstanding International Student Award                   University of Florida

2008               Research Award      Society of Chinese Bioscientists in America Texas Chapter

2009               AMGEN Award, Basic Science Research             M.D. Anderson Cancer Center

2012               Tianjin Youth Experts Program

::Representative Publications::

1.    Shi J, Jin Y, Bian T, Li K, Sun Z, Cheng Z, Jin S, Wu W.SuhB is a Novel Ribosome Associated Protein that Regulates Expression of MexXY by Modulating Ribosome Stalling in Pseudomonas aeruginosa. Molecular Microbiology. Jul 14. doi: 10.1111/mmi.13126 (2015).

2.    Jia J, Bai F, Jin Y, Santostefano KE, Ha UH, Wu D, Wu W, Terada N, Jin S. Efficient Gene Editing in Pluripotent Stem Cells by Bacterial Injection of Transcription Activator-Like Effector Nuclease Proteins. Stem Cells Translational Medicine. Jun 10. pii: sctm.2015-0030 (2015) .

3.    Sun Z, Shi J, Liu C, Jin Y, Li K, Chen R, Jin S, Wu W. PrtR Homeostasis Contributes to Pseudomonas aeruginosa Pathogenesis and Resistance against Ciprofloxacin. Infection and Immunity. 82(4):1638-47 (2014).

4.    Li K, Xu C, Jin Y, Sun Z, Liu C, Shi J, Chen G, Chen R, Jin S, Wu W. SuhB Is a Regulator of Multiple Virulence Genes and Essential for Pathogenesis of Pseudomonas aeruginosa. MBio. Oct 29;4(6). doi:pii: e00419-13. 10.1128/mBio.00419-13 (2013).

5.    Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP. Collaboration between macrophages and vaccine-induced CD4 T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia. J Infect Dis. Oct 24. (2012).

6.    Wu W, Huang J, Duan B, Traficante DC, Hong H, Risech M, Lory S, Priebe GP. Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia.  Am. J. Respir. Crit. Care Med. Sep 1;186(5) (2012). 

7.    Wu, W., YM. Hsu, L. Bi, Z. Songyang, X. Lin. CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol. 10(11):1208-14 (2009).

8.    Ha, U., J-H. Lim, W. Wu, S. Jin and J-D. Li. MKP1 regulates the induction of MUC5AC Mucin by S. pneumoniae Pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 283(45):30624-31 (2008).

9.    Wu, W., Y. Song, S. Jin and S. Chen. An Interactive Map of Regulatory Networks of Pseudomonas aeruginosa Genome. Systems Biology and Regulatory Genomics of Lecture Notes in Computer Science. 4023: 1-10 (2006).  

10.  Jyot, J., A. Sonawane, W. Wu and R. Ramphal. Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus. Mol Microbiol. 63(4):1026-38 (2007).

11.  Wu, W. and S. Jin. PtrB of Pseudomonas aeruginosa Suppresses Type III Secretion System Under the Stress of DNA Damage. J Bacteriol. 187(17):6058-68 (2005).

12.  Wu, W., H. Badrane, S. Arora, H. Baker and S. Jin. MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa. J Bacteriol. 186(22):7575-85 (2004).


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