Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Ju Zhang

 Department: Institute of Molecular Biology, Biochemistry and Molecular Biology
 Address: 94 Weijin Road, Nankai District Tianjin 300071, P.R.China
 Phone: 022-23501548
::Professional Education::

1989/05-1994/01        Biochemistry (Ph.D. degree), Institute of Biochemistry, Innsbruck University, Austria, mentored by Prof. Manfred Schweiger

1982/02-1984/12       Biochemistry (, Department of Chemistry, Nankai University, China, mentored by Prof. He Binglin

1978/02-1982/02       Biochemistry (, Department of Biology, Nankai University, China

::Research Area::

1.     The molecular mechanism of estrogen action in benign prostatic hyperplasia, prostate cancer and cardiovascular disease

2.     Screening and identification of serum biomarkers for prostate cancer

3.     Traditional Chinese medicine with estrogenic activities in the prevention and treatment of estrogen-related disease


::Honors and Awards::

Ø  Awardee of the Ministry of Education Cross-century Talents Foundation

Ø  Special Professor of Nankai University

Ø  Winner of the third prize by Tianjin Natural Science (first honorees)

Ø  The Ministry of Education Cross-century Talents Foundation, 2000

Ø  Special Professor of Nankai University award since 2001


::Representative Publications::

1.    Chao Wang, Fei Luo, Ying Zhou, Xiaoling Du, Jiandang Shi, Xiaoling Zhao, Yong Xu, Yan Zhu, Wei Hong*, Ju Zhang* (2015): The therapeutic effects of docosahexaenoic acid on oestrogen/androgen-induced benign prostatic hyperplasia in rats; Experimental Cell Research. in press, DOI:10.1016/j.yexcr.2015.03.026.

2.    Chao Wang, Xiaoling Du, Rui Yang, Jie Liu, Da Xu, Jiandang Shi*, Linfeng Chen, Rui Shao, Guanwei Fan, Xiumei Gao, Guo Tian, Yan Zhu, Ju Zhang* (2014): The prevention and treatment effects of tanshinone IIA on oestrogen/androgen-induced benign prostatic hyperplasia in rats; The Journal of Steroid Biochemistry and Molecular Biology. 145C:28-37. 

3.    Rui Shao, Jiandang Shi*, Haitao Liu, Xiaoyu Shi, Xiaoling Du, Helmut Klocker, Chung Lee, Yan Zhu, Ju Zhang* (2014): Epithelial-to-mesenchymal transition and estrogen receptor α mediated epithelial dedifferentiation mark the development of benign prostatic hyperplasia; The Prostate. 74(9):970-82.

4.    Zhaochen Ning, Xiaoling Du, Ju Zhang*, Kuo Yang, Lin Miao, Yan Zhu, Hui Yuan, Linlin Wang, Helmut Klocker, Jiandang Shi* (2014): PGE2 modulates the transcriptional activity of ERRa in prostate stromal cells; Endocrine. 47(3):901-912..

5.    Yanfei Peng, Jiandang Shi, Xiaoling Du, Liang Wang, Helmut Klocker, Linjian Mo, Zengnan Mo and Ju Zhang* (2013): Prostaglandin E2 induces Stromal cell-derived factor-1 expression in prostate stromal cells by activating Protein kinase A and transcription factor Sp1; The International Journal of Biochemistry & Cell Biology. 45(3):521-30.

6.    Lin Yu, Jiandang Shi*, Sa Cheng, Yan Zhu, Xiulan Zhao, Kuo Yang, Xiaoling Du,Helmut klocker,Xiaoli Yang,Ju Zhang* (2012): Estrogen Promotes Prostate Cancer Cell Migration via Paracrine Release of ENO1 from Stromal Cells; Molecular Endocrinology. 26(9):1521-1530.

7.    Yu Lin, Wang Chunyu, Shi Jiandang, Miao Lin, Du Xiaoling, Mayer Doris, Ju Zhang*(2011): Estrogens Promote Invasion of Prostate Cancer Cells in a Paracrine Manner through Up-Regulation of Matrix Metalloproteinase 2 in Prostatic Stromal Cells; Endocrinology. 152(3):773-81.      

8.    Rui Yang, Yu-Xia Ma, Lin-Feng Chen, Ying Zhou, Zhan-Po Yang, Yan Zhu, Xiao-Ling Du, Jian-Dang Shi*, Hong-Shun Ma, Ju Zhang*(2010): Antagonism of estrogen-mediated cell proliferation by raloxifene in prevention of ageing-related prostatic hyperplasia; Asian Journal of Andrology. 12(5):735-743.

9.    Lin Miao, Jiandang Shi*, Chun-Yu Wang, Yan Zhu, Xiaoling Du, Hongli Jiao, Zengnan Mo, Helmut Klocker, Chung Lee, Ju Zhang*(2010):Estrogen receptor-related receptor ɑ mediates up-regulation of aromatase expression by prostaglandin E2 in prostate stromal cells; Molecular endocrinology. 24(6):1175-1186.

10. Zhisong Zhang, Liang Wang, Mei Mei, Yan Zhu, Xiaoling Du, Chung Lee,Irwin Park, Ju Zhang*, Jiandang Shi*(2010): Both nongenomic and genomic effects are involved in estradiol's enhancing the phenotype of smooth muscle cells in cultured prostate stromal cells; The Prostate, 70(3):317-332.



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