Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Zhenzhou Wu

 Department: Microbiology
 Address: Room A407, New Biological Station, College of Life Science, Nankai University.
 Phone: 18602618077
::Professional Education::

1998-2002    B.S. in Biology   Nankai University, Tianjin, China

2003-2008    Ph.D. in Microbiology Nankai University, Tianjin, China

::Research Area::

Tumor and inflammation immunology

Interaction between gut bacteria and immune system

::Honors and Awards::
::Representative Publications::

1. Zhao N, Hao J, Ni Y, Luo W, Liang R, Cao G, Zhao Y, Wang P, Zhao L, Tian Z, Flavell R, Hong Z, Han J, Yao Z, Wu Z, Yin Z. Vg4 gdT Cell-Derived IL-17A Negatively Regulates NKT Cell Function in Con A-Induced Fulminant Hepatitis. J Immunol. 2011 15;187(10):5007-14.

2. Lin Y, Wen T, Meng X, Wu Z, Zhao L, Wang P, Yin Z. Mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE protein and regulates cell proliferation and apoptosis in melanoma B16-F0 cells. Biochem J. 2012 443(3):779-88.

3. Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Yin Z. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgt and STAT3J Immunol. 2014, 15;192(12):5599-609.

4. Li Z, Zhang LJ, Zhang HR, Tian GF, Tian J, Mao XL, Jia ZH, Meng ZY, Zhao LQ, Yin ZN, Wu ZZ. Tumor-Derived Transforming Growth Factor-b is Critical for Tumor Progression and Evasion from Immune Surveillance. Asian Pac J Cancer Prev. 2014;15(13):5181-6.

5. Hao J, Dong S, Xia S, He W, Jia H, Zhang S, Wei J, O'Brien RL, Born WK, Wu Z, Wang P, Han J, Hong Z, Zhao L, Yin Z. Regulatory Role of Vg1 gdT Cells in Tumor Immunity through IL-4 Production. J Immunol. 2011 Nov 15;187(10):4979-86.  

6. Qian P, Zuo Z, Wu Z, Meng X, Li G, Wu Z, Zhang W, Tan S, Pandey V, Yao Y, Wang P, Zhao L, Wang J, Wu Q, Song E, Lobie PE, Yin Z, Zhu T. Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Res. 2011 15;71(20):6463-74.

7. Tao J, Kamanaka M, Hao J, Hao Z, Jiang X, Craft JE, Flavell RA, Wu Z, Hong Z, Zhao L, Yin Z. IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis. Arthritis Res Ther. 2011;13(6):R212

8. Wen T, Li Y, Wu M, Sun X, Bao X, Lin Y, Hao J, Han L, Cao G, Wang Z, Liu Y, Wu Z, Hong Z, Wang P, Zhao L, Li Z, Wang Q, Yin Z. Therapeutic effects of a novel Tylophorine analog NK-007 on collagen-induced arthritis through suppressing TNF-a production and Th17 differentiation. Arthritis Rheum. 2012 64(9):2896-2906.

9. Wen T, Li Y, Wu M, Chen X, Han L, Bao X, Wang Z, Wang K, Hu Y, Zhou X, Wu Z, Wang P, Hong Z, Zhao L, Wang Q, Yin Z. A novel tylophorine analog NK-007 ameliorates colitis through inhibition of innate immune response. Int Immunopharmacol. 2012 14(4):487-94.

10. Meng X, Zhang Y, Jia Z, Huo X, He X, Tian G, Wu M, Wang Z, Zhou X, Xiong S, Gao X, Wu Z, Han J, Zhao L, Wang P, Hong Z, Wang Q, Yin Z. A novel tylophorine analog W-8 upregulates forkhead FoxP3 expression and ameliorates murine colitis. J Leukoc Biol. 2013 93(1):83-93.

11. Zhang S, Liang R, Luo W, Liu C, Wu X, Gao Y, Hao J, Cao G, Chen X, Wei J, Xia S, Li Z, Wen T, Wu Y, Zhou X, Wang P, Zhao L, Wu Z, Xiong S, Gao X, Gao X, Chen Y, Ge Q, Tian Z, Yin Z. High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-g dysregulation of CD4+ T cells. Hepatology. 2013 57(4):1620-31.

12. Li YG, Wen T, Zhu MZ, Li LX, Wei J, Wu XL, Guo MZ, Liu SP, Zhao HY, Xia SY, Huang WL, Wang PY, Wu ZZ, Zhao LQ, Shui WQ, Li Z and Yin ZN. Glycoproteomic Analysis of Tissues from Patients with Colon Cancer Using Lectin Microarrays and NanoLC-MS/MS. Mol Biosyst. 2013; 9(7):1877-87.

13. Wei J, Xia SY, Sun HY, Zhang S, Wang JY, Gao JX, Zhao HY, Wu XL, Chen X, Hao JL, Zhou XL, Zhu ZM, Gao X, Wang PY, Wu ZZ, Zhao LQ, Yin ZN. Critical role of DC-derived IL-27 in antitumor immunity through regulating the recruitment and function of NK and NKT cells. J Immunol 2013; 191:500-508.

14. Wu X, Zhang JY, Huang A, Li YY, Zhang S, Wei J, Xia S, Wan Y, Chen W, Zhang Z, Li Y, Wen T, Chen Y, Tanaka Y, Cao Y, Wang P, Zhao L, Wu Z, Wang FS, Yin Z. Decreased Vd2 gdT cells associated with liver damage by regulation of Th17 response in patients with chronic hepatitis B. J Infect Dis. 2013 Oct 15;208(8):1294-304.

15. Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech SM, Weaver CT, Flavell RA, Zhao L, Yao Z, Yin Z. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via Cdkn2a-dependent mechanism. J Leukoc Biol. 2013; 94(6):1103-12.

16. Xia S, Wei J, Wang J, Sun H, Zheng W, Li Y, Sun Y, Zhao H, Zhang S, Wen T, Zhou X, Gao JX, Wang P, Wu Z, Zhao L, Yin Z. A requirement of dendritic cells derived interleukin-27 for the tumor infiltration of regulatory T cells. J Leukoc Biol. 2014 doi:10.1189/jlb.0713371.

17. Mao X, Wu Y, Diao H, Hao J, Tian G, Jia Z, Li Z, Xiong S, Wu Z, Wang P, Zhao L, Yin Z. Interleukin-6 promotes systemic lupus erythematosus progression with Treg suppression approach in a murine systemic lupus erythematosus model. Clin Rheumatol. 2014 Jun 15. DOI 10.1007/s10067-014-2717-9.

18. Hao J, Wu X, Xia S, Li Z, Wen T, Zhao N, Wu Z, Wang P, Zhao L, Yin Z. Current progress in gdT-cell biology. Cell Mol Immunol. 2010; 7(6):409-413.

19. Wu zz, Xuanyuan zz, Li RQ, Jiang DZ, Li C, Xu HJ, Bai YL, Zhang XM, Hikka T, Saris PEJ, Savilahti H, Qiao MQ. Mu transposition complex mutagenesis in Lactococcus lactis - identification of genes affecting nisin production. J Appl Microbiol. 2009;106(1):41-48.


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