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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Yajun Duan

 Department: Biochemistry and Molecular Biology
 Address: A309, Biological Station,Nankai University,Tianjin 300071,China
 Phone: 86-22-23501776
 E-mail: yajunduan@nankai.edu.cn
 website:
::Professional Education::

9/2000 -- 6/2004:   BS in Biological Sciences, Nankai University, Tianjin, China

9/2004 -- 12/2009: PhD in Biochemistry and Molecular Biology, Nankai University, Tianjin, China

9/2008 -- 7/2009:   Visiting Student, Duke University, NC, US

7/2009 -- 7/2012:   Assistant Professor, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China

7/2012 -- present:  Associate Professor, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China

::Research Area::
Dr. Duan joined the lab of Dr. Han in 2009 after she finished PhD program. She has been associated with Dr. Han, and worked on the role of lipids in cancer and the combination therapy on atherosclerosis, pharmacology of Chinese Medicines. So far, she has published about 25 papers in the top quality journals, and she is either first or corresponding author in most of these papers. She is the P. I. for several grants issued by the Ministry of Science and Technology of China, National Science Foundation of China (NSFC) and Tianjin Municipal Science and Technology Commission.  She is very active in presentation of her works and other academic issues, such as collaborations.
::Honors and Awards::

2007-2008: Outstanding Graduate Student Scholarship of Nankai University

2000-2004: Outstanding Undergraduate Student Scholarship of Nankai University

::Representative Publications::

*: corresponding author; #: 1st author

1.    Yang X, Sun L, Li Y, Ma C, Yang J, Zhang W, Zhao B, Jia L, Duan Y, Han J, Li X, Chen Y. NaoXinTong inhibits the advanced atherosclerosis and enhances the plaque stability in apoE deficient mice. Journal of Cardiovascular Pharmacology 2015, accepted.

2.    Yang X, Yao H, Chen Y, Sun L, Ma X, Duan S, Li X, Xiang R, Han J*, Duan Y*. Inhibition of glutathione production induces macrophage CD36 expression and foam cell formation. The Journal of Biological Chemistry 2015;290:21788-99.

3.    Zhang W, Wang X, Hu W, Liu L, Li X, Han J, Chen Y*, Duan Y*. Co-treatment of pitavastatin and dexamethasone exacerbates the high fat diet-induced atherosclerosis in apoE-/- mice. Journal of Cardiovascular Pharmacology 2015;66:189-95.

4.    Ma X, Liu Y, Wang Q, Chen Y, Liu M, Li X, Xiang R, Wei Y, Duan Y*, Han J*. Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. BBA-Molecular Basis of Diseases. 2015;1852:1038-1048.

5.    Chen Y#, Duan Y#, Yang X, Sun L, Liu M, Wang Q, Ma X, Zhang W, Li X, Hu W, Miao QR, Xiang R, Hajjar DP, Han J*. Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in apoE deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology 2015;35:948-959.

6.    Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Han J, Li X*, Duan Y*. NaoXinTong inhibits the development of diabetic retinopathy in db/db mice. Evidence-Based Complementary and Alternative Medicine. Volume 2015; Article ID 242517, 8 pages, http://dx.doi.org/10.1155/2015/242517.

7.    Ma X, Wang Q, Chen Y, Zhang L, Jiang M, Liu Y, Li X, Xiang R, Miao RQ, Duan Y*, Han J*. Inhibition of tumor growth by ERK1/2 inhibitors is associated with induction of interferon-g production. International Journal of Cancer 2015;136:771-83 (Journal front cover).

8.    Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Mia R, Hajjar DP, Duan Y*, Han J*.  Identification of interferon-g as a new molecular target of liver X receptor. Biochemical Journal 2014;459:345-354 (Commentary: Biochemical Journal 2014;459:e1-e3).

9.    Chen Y, Liu M, Z Tao, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li G, Li X, Han J, Duan Y*. Danhong Injection inhibits high fat diet-induced atherosclerosis in both Apoe-/- and Ldlr-/- mice. Journal of Cardiovascular Pharmacology 2014;63:441-452.

10.  Liu M, Chen Y, Yang X, Zhang L, Zhao T, Zhao B, Jia L, Zhu Y, Gao X, Zhang B, Li X, Han J, Duan Y*.  Danhong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice. Chinese Science Bulletin 2014;59:1366-1373.

11.  Jiang M, Zhang L, Ma X, Hu W, Chen Y, Wang Q, Li X, Yin Z, Zhu Y, Gao X, Hajjar DP, Duan Y*, Han J*. Tamoxifen inhibits macrophage FABP4 expression by a GR and PPARg combinational pathway. Biochemical Journal 2013;454:467-477.

12.  Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y*, Han J*.  DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux---an LXR-dependent mechanism. BBA-Molecular and Cell Biology of Lipids 2013;1831:1134-45.

13.  Chen Y, Duan Y*, Kang Y, Yang X, Jiang M, Zhang L, Li G, Yin Z, Hu W, Dong P, Li X, Hajjar DP, Han J*. Activation of liver X receptor induces macrophage interleukin-5 expression. The Journal of Biological Chemistry 2012;287:43340-50.

14.  Duan Y#, Chen Y#, Hu W, Li X, Zhou X, Yin Z, Kong D, Hajjar DP, Liu L, Liu Q, Han J. Peroxisome Proliferator-activated receptor g activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. The Journal of Biological Chemistry 2012;287:23667-77.

15.  Hu W, Zhou X, Jiang M, Duan Y*, Chen Y, Li X, Yin Z, He GW, Yao Z, Zhu Y, Hajjar DP, Han J*. Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. Atherosclerosis 2012;222:434-43.

16.  Zhang J#, Duan Y#, Wei D, Wang L, Wang H, Gu Z, Kong D. Co-electrospun fibrous scaffold-adsorbed DNA for substrate-mediated gene delivery. Journal of Biomedical Material Research A. 2011;96:212-20.

17.    Dong P, Xie T, Zhou X, Hu W, Chen Y, Duan Y, Li X, Han J. Induction of macrophage scavenger receptor type BI expression by tamoxifen and 4-hydroxytamoxifen. Atherosclerosis 2011;218:435-42.

18.  Duan Y#, Yang C#, Zhang Z, Liu J, Zheng J, Kong D. Poly(ethylene glycol) -graft-polyethylenimine modified with G250 monoclonal antibody for tumor targeted gene delivery. Human Gene Therapy 2010;21:191-8.

19.  Zhang Z, Yang C, Duan Y, Wang Y, Liu J, Wang L, Kong D. Poly (ethylene glycol) analogs grafted with low molecular weight poly(ethylenimine) as nonviral gene vectors. Acta Biomaterialia 2010;6:2650-7.

20.  Zhao F, Veldhuis JJ, Duan Y, Yang Y, Christoforou C, Ma T, Leong KW. Low oxygen tension and synthetic nanogratings improve the uniformity and stemness of human mesenchymal stem cell layer. Molecular Therapy. 2010;18:1010-8.

21.  Liu J, Liu J, Chu L, Wang Y, Duan Y, Feng L, Yang C, Wang L, Kong D. Novel peptide-dendrimer conjugates as drug carriers for targeting nonsmall cell lung cancer. International Journal of Nanomedicine.  2010;6:59-69.

22.  Duan Y, Yang C, Zhang Z, Liu J, Zheng J, Xu Y, Kong D, Yu Y. Non-viral gene carrier mediated short hairpin RNA interference for inhibition of tumor cells growth. Chinese Science Bulletin 2009;54:2947-52.

23.  Wang Y, Kong W, Song Y, Duan Y, Wang L, Steinhoff G, Kong D, Yu Y. Polyamidoamine dendrimers with a modified pentaerythritol core having high efficiency and low cytotoxicity as gene carriers. Biomacromolecules 2009;10:617-22.

24.  Duan Y, Zheng J, Han S, Wu Y, Wang Y, Li D, Kong D, Yu Y. A tumor targeted gene vector modified with G250 monoclonal antibody for gene therapy. Journal of Controlled Release 2008;127:173-9.

25.  Zhang J, Zhang Y, Duan Y, Ou L, Yu Y, Kong D. Study of bone marrow derived stem cells and gene therapy for engineering of cardiovascular grafts. Key Engineering Materials 2005;288-289:31-4

 


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