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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Dengwen Li

 Department: Department of Genetics and Cell Biology
 Address: Room A403, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
 Phone: 022-23494816
 E-mail: dwli@nankai.edu.cn
 website:
::Professional Education::

1993.9-1997.7     B.S. Nankai University

1997.9-2000.7     M.S. Nankai University

2002.9-2005.7     Ph.D. Nankai University

::Research Area::

Post modification and function of proteins

::Honors and Awards::
::Representative Publications::

1.     Cep70 regulates microtubule stability by interacting with HDAC6. Shi X, Yao Y, Wang Y, Zhang Y, Huang Q, Zhou J, Liu M, Li D. FEBS Lett. 2015 Jul 8;589(15):1771-7.

2.     HDAC6 regulates neuroblastoma cell migration and may play a role in the invasion process. Zhang L, Liu N, Xie S, He X, Zhou J, Liu M, Li D. Cancer Biol Ther. 2014;15(11):1561-70.

3.     Modulation of the stability and activities of HIV-1 Tat by its ubiquitination and carboxyl-terminal region. Zhang L, Qin J, Li Y, Wang J, He Q, Zhou J, Liu M, Li D. Cell Biosci. 2014 Oct 7;4(1):61.

4.     End-binding protein 1 stimulates paclitaxel sensitivity in breast cancer by promoting its actions toward microtubule assembly and stability. Luo Y, Li D, Ran J, Yan B, Chen J, Dong X, Liu Z, Liu R, Zhou J, Liu M. Protein Cell. 2014 Jun;5(6):469-79.

5.     Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells. Xie S, Chen M, Yan B, He X, Chen X, Li D. PLoS One. 2014 Apr 9;9(4):e94496.

6.     CYLD coordinates with EB1 to regulate microtubule dynamics and cell migration. Li D, Gao J, Yang Y, Sun L, Suo S, Luo Y, Shui W, Zhou J, Liu M. Cell Cycle. 2014;13(6):974-83. 

7.     Identification of a cytoplasmic linker protein as a potential target for neovascularization. Xie S, Dong B, Sun X, Tala, He X, Zhou J, Liu M, Li D. Atherosclerosis. 2014 Apr;233(2):403-9.

8.     Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells. Li D, Sun X, Zhang L, Yan B, Xie S, Liu R, Liu M, Zhou J. Protein Cell. 2014 Mar;5(3):214-23.

9.     CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Yang Y, Liu M, Li D, Ran J, Gao J, Suo S, Sun SC, Zhou J. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2158-63.

10.  Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells. Zhang C, Sun X, Ren Y, Lou Y, Zhou J, Liu M, Li D. Cancer Biol Ther. 2012 Oct;13(12):1214-20.

11.  Inhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration. Peng G, Ren Y, Sun X, Zhou J, Li D. Biochem Pharmacol. 2012 May 15;83(10):1374-82.

12.  Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity. Sun X, Li D, Yang Y, Ren Y, Li J, Wang Z, Dong B, Liu M, Zhou J. J Pathol. 2012 Mar;226(4):666-73.

13.  Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner. Li D, Xie S, Ren Y, Huo L, Gao J, Cui D, Liu M, Zhou J. Protein Cell. 2011 Feb;2(2):150-60.

14.  Tat acetylation regulates its actions on microtubule dynamics and apoptosis in T lymphocytes. Huo L, Li D, Sun L, Liu M, Shi X, Sun X, Li J, Dong B, Dong X, Zhou J.J Pathol. 2011 Jan;223(1):28-36.

15.  Cep70 promotes microtubule assembly in vitro by increasing microtubule elongation. Shi X, Wang J, Yang Y, Ren Y, Zhou J, Li D. Acta Biochim Biophys Sin (Shanghai). 2012 May;44(5):450-4.

 


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