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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Wen Ning

 Department: Genetics and Cell Biology
 Address: College of Life Sciences, Nankai Unversity, Tianjin 300071, P.R.China
 Phone: 86-22-23505502
 E-mail: ningwen108@nankai.edu.cn
 website:
::Professional Education::

1988- 1994     B.S., M.S., Ph.D. Nanjing University

1994- 2000     Nanjing University, Associate Professor

2000- 2005     University of Pittsburgh School of Medicine, Postdoctoral Fellow

2005- 2008     Nanjing University, Professor

2008-             Nankai University, Professor

::Research Area::

My research focuses around the lung development and diseases. My interest is in studying the role of Follistatin-like 1 (Fstl1) in lung both in vivo and in vitro. Fstl1 is an extraceullar glycoprpotein that was originally cloned from a mouse osteoblastic cell line as a TGF-b1 inducible gene. It has been shown to exert potent anti-proliferative, anti-apoptosis and pro-inflammatory effects in models of tumor, heart disease and RA. We generate Fstl1 deficient mice which died of respiratory failure shortly after birth, and hypothesize the involvement of Fstl1 in embryonic lung development. My research also checks the role of Fstl1 in Bleomycin-induced lung fibrosis model using Fstl1 heterozygous mice. The data has demonstrated a delay in alveolar maturation reflected by thickened intersaccular interstitium and apparently collapsed alveoli, and haploinsufficient of Fstl1 inhibits Bleo-induced fibrosis development. My current area of focus includes investigation examining the mechanism by which Fstl1 functions. To data, there are a number of gene targets including SP-B/C and BMP4 as well as signaling moleculars that are being explored including Smad and MAP kinases. Increasing our understanding of how Fstl1 functions to exert its effects will lead potentially to a novel therapeutic modality and translate into a treatment for a variety of disorders such as RDS and organ fibrosis.

::Honors and Awards::
::Representative Publications::

1.  Dong Y, Geng Y, Li L, Li X-H, Yan X, Fang Y, Li X-X, Dong S, Liu X, Li X, Yang X, Zheng X, Xie T, Liang J, Dai H, Liu X-Q, Yin Z, Noble P, Jiang D* and Ning W*. Blocking Follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice. J Exp Med, 2015. 212(2): 235-252

2.  Geng Y, Li L, Dong Y, Liu X, Li X-H, Ning W*. Impaired Elastin Deposition in Fstl1-/- Lung Allograft under the Renal Capsule. PLoS ONE, 2013, 8(11): e81368 

3.  Li L, Li X-X, Liu X, Dong Y, Geng Y, Liu X-Q*, Ning W*.  Expression, characterization, and preliminary X-ray crystallographic analysis of recombinant murine Follistatin-like 1 expressed in Drosophila S2 cells. BioScience Trends. 2013; 7(2):93-100.

4.  Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen Y-G*, Jiang D*, and Ning W*. Fstl1 Is a BMP4 Signaling Antagonist in Controlling Mouse Lung Development. Proc Natl Acad Sci U S A.. 2011  108(17):7058-7063 

5.  Shen N, Gong T, Wang J-D, Meng F-L, Qiao L, Yang R-L, Xue B, Pan F-Y,  Zhou X-J, Chen H-Q, Ning W*, Li C*. Cigarette Smoke-Induced Pulmonary Inflammatory Responses Are Mediated by EGR-1/GGPPS/MAPK Signaling. Am. J. Pathol. 2011 178(1): 110-118.               

6.  Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ, Watkins SC, Pilewski JK, Sciurba FC, Peters DG, Hogg JC, Choi AM. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A.  2004 ;101(41):14895-900.)

 

 


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