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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Xinqi Liu

 Department: Biochemistry and Molecular Biology
 Address: Rm A204, Biology Station, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 30007
 Phone: Tel: 86-22-23505130 ; Fax : 86-22-23505130
 E-mail: liu2008@nankai.edu.cn
 website: http://sky.nankai.edu.cn/teacher.asp?id=liuxq
::Professional Education::

Education:

1990-1994    B.S. in Microbiology, China Agricultural University, Beijing, China

1994-1999    Ph.D. in Molecular Biology, Institute of Biophysics, Chinese   Academy of Sciences, Beijing, Chain.

Positions:

10/1999-06/2004, Postdoctoral Fellow, National Jewish Health/ Howard Hughes Medical Institute, Colorado, USA.

07/2004-10/2007, Research Scientist, Department of Biology, Purdue University, Indiana, USA

05/2008-,            Professor, College of Life Sciences, Nankai University

::Research Area::

Research Interests:

1.   Structure of HIV envelope and receptors.

2.   Mechanisms of anti-viral proteins in host.

3.   Structure of proteins in apoptosis and autophagy.

Profile:

My laboratory works on the structural and functional studies of the molecules involved in immune responses following the infection of pathogenic microbes, such as Toll-like receptors and Nod-like receptors in innate immunity. My interest also includes the Bcl-2 family proteins and other related apoptotic molecules playing important roles in tumorigenesis and neural degeneration. Currently three specific focuses are ongoing and seeking chances for collaboration: (1) Structural studies of HIV (serotype CRF07 B/C epidemic in China) envelope protein gp120 and its CD4 receptor complex. (2) Molecules in antiviral innate immune response, such as RIG-I, MAVS and MITA. (3) Bcl-2 mutants that form pro-apoptotic complex.

::Honors and Awards::
::Representative Publications::

1.    Qian L, Han X, Liu X. Structural insight into equine lentivirus receptor 1. Protein Sci. 2015 Jan 5. doi: 10.1002/pro.2634.

2.    Qian L, Liu X. Purification, characterization and structure of nucleoside diphosphate kinase from Drosophila melanogaster. Protein Expression and Purification. 2014, 103, 48-55.

3.    Du J, Wang X, Ma J, Wang J, Qin Y, Zhu C, Liu F, Shao Y, Zhou J, Qiao W, Liu X. Structural and biochemical insights into the V/I505T mutation found in the EIAV gp45 vaccine strain. Retrovirology. 2014 Mar 21;11:26. doi: 10.1186/1742-4690-11-26.

4.    Han X, Xiong X, Jiang D, Chen S, Huang E, Zhang W, Liu X. Crystal structure of L-sorbose dehydrogenase, a pyrroloquinoline quinone-dependent enzyme with homodimeric assembly, from Ketogulonicigenium vulgare. Biotechnol Lett. 2014 May;36(5):1001-8. doi: 10.1007/s10529-013-1446-5. Epub 2014 Feb 21.

5.    Han X, Xiong X, Hu X, Li M, Zhang W, Liu X. Crystallization and structural analysis of 2-hydroxyacid dehydrogenase from Ketogulonicigenium vulgare. Biotechnol Lett. 2014 Feb;36(2):295-300. doi: 10.1007/s10529-013-1354-8. Epub 2013 Sep 26.

6.    Du J, Xue H, Ma J, Liu F, Zhou J, Shao Y, Qiao W, Liu X. The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat. Virology. November 2013, 446, 86-94.

7.    Feng Y, Yu W, Li X, Lin S, Zhou Y, Hu J, Liu X. Structural insight into Golgi membrane stacking by GRASP65 and GRASP55. J Biol Chem. 2013, 288(39):28418-27.

8.    Wang J, Xu M, Zhu K, Li L*, Liu X*. The N-terminus of FILIA Forms an Atypical KH Domain with a Unique Extension Involved in Interaction with RNA. PLoS ONE, 2012, 7(1): e30209. doi:10.1371/journal.pone.0030209.

9.    Chen Y, Su C, Ke M, Jin X, Xu L, Zhang Z, Wu A, Sun Y, Yang Z, Tien P, Ahola T, Liang Y, Liu X*, Guo D*. Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2'-O-Methylation by nsp16/nsp10 Protein Complex. PLoS Pathogens, 2011, 7(10): e1002294. doi:10.1371/journal.ppat.1002294.

10.  Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X*, Rapoport TA*, and Hu J*. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proceedings of the National Academy of Sciences. U S A. 2011, 108 (10), 3976-3981.

 


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