Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Xinqi Liu

 Department: Biochemistry and Molecular Biology
 Address: Rm A204, Biology Station, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 30007
 Phone: Tel: 86-22-23505130 ; Fax : 86-22-23505130
::Professional Education::


1990-1994    B.S. in Microbiology, China Agricultural University, Beijing, China

1994-1999    Ph.D. in Molecular Biology, Institute of Biophysics, Chinese   Academy of Sciences, Beijing, Chain.


10/1999-06/2004, Postdoctoral Fellow, National Jewish Health/ Howard Hughes Medical Institute, Colorado, USA.

07/2004-10/2007, Research Scientist, Department of Biology, Purdue University, Indiana, USA

05/2008-,            Professor, College of Life Sciences, Nankai University

::Research Area::

Research Interests:

1.   Structure of HIV envelope and receptors.

2.   Mechanisms of anti-viral proteins in host.

3.   Structure of proteins in apoptosis and autophagy.


My laboratory works on the structural and functional studies of the molecules involved in immune responses following the infection of pathogenic microbes, such as Toll-like receptors and Nod-like receptors in innate immunity. My interest also includes the Bcl-2 family proteins and other related apoptotic molecules playing important roles in tumorigenesis and neural degeneration. Currently three specific focuses are ongoing and seeking chances for collaboration: (1) Structural studies of HIV (serotype CRF07 B/C epidemic in China) envelope protein gp120 and its CD4 receptor complex. (2) Molecules in antiviral innate immune response, such as RIG-I, MAVS and MITA. (3) Bcl-2 mutants that form pro-apoptotic complex.

::Honors and Awards::
::Representative Publications::

1.    Qian L, Han X, Liu X. Structural insight into equine lentivirus receptor 1. Protein Sci. 2015 Jan 5. doi: 10.1002/pro.2634.

2.    Qian L, Liu X. Purification, characterization and structure of nucleoside diphosphate kinase from Drosophila melanogaster. Protein Expression and Purification. 2014, 103, 48-55.

3.    Du J, Wang X, Ma J, Wang J, Qin Y, Zhu C, Liu F, Shao Y, Zhou J, Qiao W, Liu X. Structural and biochemical insights into the V/I505T mutation found in the EIAV gp45 vaccine strain. Retrovirology. 2014 Mar 21;11:26. doi: 10.1186/1742-4690-11-26.

4.    Han X, Xiong X, Jiang D, Chen S, Huang E, Zhang W, Liu X. Crystal structure of L-sorbose dehydrogenase, a pyrroloquinoline quinone-dependent enzyme with homodimeric assembly, from Ketogulonicigenium vulgare. Biotechnol Lett. 2014 May;36(5):1001-8. doi: 10.1007/s10529-013-1446-5. Epub 2014 Feb 21.

5.    Han X, Xiong X, Hu X, Li M, Zhang W, Liu X. Crystallization and structural analysis of 2-hydroxyacid dehydrogenase from Ketogulonicigenium vulgare. Biotechnol Lett. 2014 Feb;36(2):295-300. doi: 10.1007/s10529-013-1354-8. Epub 2013 Sep 26.

6.    Du J, Xue H, Ma J, Liu F, Zhou J, Shao Y, Qiao W, Liu X. The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat. Virology. November 2013, 446, 86-94.

7.    Feng Y, Yu W, Li X, Lin S, Zhou Y, Hu J, Liu X. Structural insight into Golgi membrane stacking by GRASP65 and GRASP55. J Biol Chem. 2013, 288(39):28418-27.

8.    Wang J, Xu M, Zhu K, Li L*, Liu X*. The N-terminus of FILIA Forms an Atypical KH Domain with a Unique Extension Involved in Interaction with RNA. PLoS ONE, 2012, 7(1): e30209. doi:10.1371/journal.pone.0030209.

9.    Chen Y, Su C, Ke M, Jin X, Xu L, Zhang Z, Wu A, Sun Y, Yang Z, Tien P, Ahola T, Liang Y, Liu X*, Guo D*. Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2'-O-Methylation by nsp16/nsp10 Protein Complex. PLoS Pathogens, 2011, 7(10): e1002294. doi:10.1371/journal.ppat.1002294.

10.  Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X*, Rapoport TA*, and Hu J*. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proceedings of the National Academy of Sciences. U S A. 2011, 108 (10), 3976-3981.


© 2006-2008 College of Life Sciences, Nankai University