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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Jiafu Long

 Department: Department of Biochemistry and Molecular Biology
 Address: Rm C206, Biological Building, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin
 Phone: 86-22-23507159 (office); 86-22-23503552 (lab)
 E-mail: jflong@nankai.edu.cn; long.lab@icloud.com
 website: https://www.researchgate.net/profile/Jiafu_Long
::Professional Education::

1995-1999    B.S. in Biochemistry and Molecular Biology, Nankai University, Tianjin, China

1999-2004    Ph.D. in Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China

 2004-2006, Postdoctoral Fellow, Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong

2007- present, Professor, College of Life Sciences and State Key Laboratory of Medicinal Chemical Biology, Nankai University

::Research Area::

1.  Epigenetic gene regulation

2.  Mechanisms of protein complex assembly via scaffold proteins

3.  Mechanisms of disease-related proteins in human disease and structure-based small molecule drug design and screening

4.  Structure-based protein engineering and application

::Honors and Awards::

- New Century Talent of the Ministry of Education of China                                  2007

- First Prize of the Tianjin Natural Science Award (Ranked Fifth)                          2014

::Representative Publications::
1.    Xu H, Lin Z, Li F, Diao W, Dong C, Zhou H, Xie X, Wang Z, Shen Y*, Long J*,. Dimerization of elongator protein 1 is essential for Elongator assembly. Proc Natl Acad Sci USA. 112(34): 10697-10702 (2015). 
2.    Li Y, Zhou H, Li F, Chan S, Lin Z, Wei Z, Yang Z, Guo F, Lim C, Xing W, Shen Y, Hong W, Long J*, Zhang M*. Angiomotin binding-induced activation of Merlin/NF2 in the hippo signaling pathway. Cell Res. 25(7): 801-817 (2015). 
3.    Dong C, Lin Z, Diao W, Li D, Chu X, Wang Z, Zhou H, Xie Z, Shen Y*, Long J*. The Elp2 subunit is essential for Elongator assembly and functional regulation. Structure. 23(6): 1078-1086 (2015). 
4.    Chu X, Qin X, Xu H, Li L, Wang Z, Li F, Xie X, Zhou H, Shen Y*, Long J*. Structural insights into Paf1 complex assembly and histone binding. Nucleic Acids Res. 41(22): 10619-10629 (2013). 
5.    Lin Z, Zhao W, Diao W, Xie X, Wang Z, Zhang J, Shen Y*, Long J*. Crystal structure of Elongator subcomplex Elp4-6. J Biol Chem. 287(25): 21501-21508 (2012). 
6.    Zhang X, Chu X, Wang L, Wang H, Liang G, Zhang J, Long J*, Yang Z*. Rational design of a tetrameric Protein to enhance interactions between self-assembled fibers confers molecular hydrogels. Angew Chem Int Ed. 51(18): 4388-4392 (2012). 
7.    Wang Z, Yang X, Chu X, Zhang J, Zhou H, Shen Y*, Long J*. The structural basis for the oligomerization of the N-terminal domain of SATB1. Nucleic Acids Res. 40(9): 4193-4202 (2012). 
8.    Long J&, Feng W&, Wang R, Chan L-N, Fanny Ip, Xia J, Nanc, Ip, Zhang M. Autoinhibition of X11/Mint Scaffold Proteins Revealed by the Closed Conformation of the PDZ Tandem. Nat Struct Mol Biol. 12(8): 722-728 (2005). 
9.    Feng W&, Long J&, Zhang, M. A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins. Proc Natl Acad Sci USA. 102(19): 6861-6866 (2005). 
10.   Feng W&, Long J&, Fan J-S, Suetake T, Zhang M. The tetrameric L27 domain complex as an organization platform for supramolecular assemblies. Nat Struct Mol Biol. 11(5): 475-480 (2004).

 For more information about the published papers, please click the website in:

http://www.researcherid.com/rid/B-7420-2012

 


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