Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Shian Wu

 Department: Genetics and Cell Biology
 Address: New Biology Building A301, 94 Weijin Road, Tianjin 300071
 Phone: 86-22-23498210
::Professional Education::

1995--2000    Ph.D. in Plant Biology, Peking University, Beijing, China

1988--1992    B.S. in Biology, Hunan Normal University, Changsha, China


2008--           Nankai University, Professor

2004--2008    Johns Hopkins University School of Medicine, Postdoctoral Fellow

2001--2004    UT Southwestern Medical Center, Postdoctoral Fellow

1992--1995    Jishou University, Assistant professor

::Research Area::
Molecular mechanism of the Hippo pathway in organ size control.
Identification of novel regulators in growth control and homeostasis
::Honors and Awards::
::Representative Publications::

1.   Li C, Kan L, Chen Y, Zheng X, Li W, Zhang W, Cao L, Lin X, Ji S, Huang S, Zhang G, Liu X, Tao Y, Wu S*, and Chen D*, 2015. Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation. Cell Research 25(10): 1152-70.

2.   Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, Gao R, Zhou C, Cao L, Liu J, Zhu Y*, Chen Q*, and Wu S*, 2015. Hypoxia regulates Hippo signaling through the SIAH2 ubiquitin E3 ligase. Nature Cell Biology 17(1):  95–103

3.   Cao L, Wang P, Gao Y, Lin X, Wang F, and Wu S*, 2014. Ubiquitin E3 ligase dSmurf is essential for Wts protein turnover and Hippo signaling. Biochem Biophys Res Commun 454: 167-171

4.   Chen Y, Wang Z, Wang P, Li D, Zhou J*, and Wu S*, 2014. CYLD negatively regulates Hippo signaling by limiting Hpo phosphorylation in Drosophila. Biochem Biophys Res Commun 452: 808-812

5.   Ling C, Zheng Y, Yin F, Yu J, Huang J, Hong Y, Wu S*, and Pan D*, 2010. The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.  Proc Natl Acad Sci U S A. 107 (23): 10532-10537

6.  Wu S, Liu Y, Zheng Y, Dong J and Pan D*, 2008. The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.  Developmental Cell, 14(3): 388-398

7.   Dong J, Feldman G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A, and Pan D*, 2007. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell, 130: 1120-1133.

8.   Huang J, Wu S, Barrera J, Matthews K, and Pan D*, 2005. The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP. Cell, 122: 421-434.

9.  Wu S, Huang J, Dong J, and Pan D*, 2003. Hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts. Cell, 114: 445-456


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