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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Zhinan Yin

 Department: Microbiology/Biochemistry
 Address: Room A404, New Biological Station, College of Life Science, Nankai University
 Phone: Tel: 022-23503270 Fax: 022-23503270
 E-mail: yinzn@nankai.edu.cn
 website:
::Professional Education::

1984  B.S.   Hubei Medical University

1988  M.S.   Shanghai Second Medical University

1997  Ph.D.  Free University Berlin, Germany

1997-2007    Yale School of Medicine, Postdoctoral Fellow, Associate Professor

2007-           Nankai University, Dean, Professor, Cheung Kong Scholar, Principal Scientist of the National Basic Research Program

::Research Area::

Research Area:

* gd T cell differentiation and function

* Molecular mechanisms of tumor immunity

* Discovery of small molecules for cancer and inflammatory diseases

* Mechanisms of autoimmune disease

* Function of different subsets of dendritic cells

Funding:

1. "Function research of proteins involved in the interaction process between tumor cell and immune cell" The National Basic Research Program of China.

2. "Research of Immunologic mechanism and Intervention strategy in Rheumatoid arthritis" The National Basic Research Program of China.

3. "Mechanism of autoimmune recognition and response" The National Natural Science Foundation of China.

4. "Differentiation and function in tumor immunity of gd T cells" China National Funds for Distinguished Young Scientists.

5. "Development of breast cancer vaccine" Science and technology support key project plan of Tianjin.

support key project plan of Tianjin.

::Honors and Awards::

1988  Honor Certificate (First Honor) from the Chinese Association of Microbiology, National Science Foundation, P.R. China, for thesis work:  "b-D-galatosidase/anti b-D-galactosidase monoclonal antibody complex (GAG) and its use in ELISA and immunohistochemistry".

1997  Brown-Coxe Fellowship, Yale School of Medicine

      Argall L. and Anna G. Hull Cancer Research           

2000  National Arthritis Foundation Fellowship (2000-03)

2000  Associate Member of Yale Cancer Center

2000  Member of American College of Rheumatology (ACR)

2000  Award, Yale Cancer Center (2000-01)

2002  Member of American Association of Immunologists (AAI)

2002  Member of American Association of Cancer Society (AAC)

2004  American Association of Immunologists (AAI) Junior Faculty Travel Award

2006  Faculty Award for Achievement in Research, Department of Internal Medicine, Yale School of Medicine

::Representative Publications::

1. L. Chen, W. He, S. T. Kim, J. Tao, Y. Gao, H. Chi, A. M. Intlekofer, B. Harvev, S. L. Reiner, Z. Yin*, R.A. Flavell, and J. Craft. Both epigenetic and transcriptional programs contribute to default IFN-g production by gd T cells. J Immunol. 2007;178(5):2730-6

2. J. Tao, Y. Gao, M. O. Li, W. He, L. Chen, B. Harvev, R. J. Davis, R.A. Flavell, and Z. Yin*. JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Euro. J. Immunol. 2007;37(3):818-29

3. Y. Gao, J. Tao, M. O. Li, D. Zhang, H. Chi, O. Henegariu, S. Kaech, R. Davis, R. A. Flavell, and Z. Yin*. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol. 2005;175:5783-5789

4. Y. Gao, W. Yang, M. Pang, E. Scully, M. Girardi, L.H. Augenlicht, J Craft and Z. Yin*. gd T cells provide early source of IFN-g in tumor immunity. J. Exp. Med. 2003;198:433-442

5. X. You, M. Pang, W. Gao, H.S. Shiah, D. Zhang, F. Koumpouras, S. Wang, H. Zhou, J.A. Madri, D.C. Baker, Y.C. Cheng, and Z. Yin*. Effect of a novel tylophorine on inflammatory arthritis through inhibition of innate immune response. Arthritis Rheum. 2006;54:877-886

6. T. Wang, Y. Gao, E. Scully, D. Beasley, J. Anderson, Z. Yin, J. Craft, and E. Fikrig. gd T cells facilitate adaptive immunity against west nile virus infection in mice. J Immunol. 2006;177:1825-1832

7. D. Jiang, J. Liang, J. Hodge, B. Lu, Z. Zhu, S. Yu, J. Fan, Y. Gao, Z. Yin, R. Homer, C. Gerard, and P. W. Noble.  Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J. Clin. Invest. 2004;14:191-199

8. T. Wang, E. Scully, Z. Yin, J. H. Kim, S. Wang, J. Yang, M. Mamula, J. F. Anderson, J. Craft and E. Fikrig. IFN-g producing gd T cells help control murine West Nile virus infection. J Immunol 2003;171:2524-2531

9. Z. Yin, G. Bahtiyar, N. Zhang, L. Liu, M. P. Madaio, and J. Craft. IL-10 regulates murine lupus. J Immunol. 2002;169:2148-2155

10. Z. Yin, C. Chen, S. J. Szabo, L. H. Glimcher, A. Ray, and J.Craft. T-bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-g by gd T cells. J Immunol 2002;168:1566-1571

 


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