Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Mark Gerrard Bartlam

 Department: Biochemistry and Molecular Biology
 Address: A201, New Life Sciences Building, College of Life Sciences, Nankai University, Tianjin 300071, China
 Phone: 022-23502351
::Professional Education::

 2000-2003: Post-doctoral fellow, Department of Biological Sciences & Biotechnology, Tsinghua University

 1999-2000: Post-doctoral fellow, Wellcome Trust Centre for Human Genetics, University of Oxford

 1995-1999: D.Phil. in Molecular Biophysics, Laboratory of Molecular Biophysics, University of Oxford

Supervisor: David Stuart, Colin C. F. Blake

 1992-1995: B.Sc. (Hons) in Physics, Imperial College London

::Research Area::

· Structure and function of virus- and tumor-related proteins

· Structure and function of membrane proteins

· Structure-based drug discovery

· Protein folding and disease

· Computational structural biology

::Honors and Awards::


::Representative Publications::

1. Yuan, P., Bartlam, M., Lou, Z., Chen, S., Zhou, J., He, X., Lv, Z., Ge, R., Li, X., Deng, T., Fodor, E., Rao, Z. & Liu, Y. (2009). Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature 458, 909-13 (co-first author)

2. Xu, F., Bell, S. G.*, Peng, Y., Johnson, E. O., Bartlam, M.*, Rao, Z. & Wong, L. L. (2009). Crystal structure of a ferredoxin reductase for the CYP199A2 system from Rhodopseudomonas palustris. Proteins. (in press) (co-corresponding author)

3. Wang, X., Lou, Z., Dong, X., Yang, W., Peng, Y., Yin, B., Gong, Y., Yuan, J., Zhou, W., Bartlam, M.*, Peng, X.* & Rao, Z. (2009). Crystal structure of the C-terminal domain of human DPY-30-like protein: A component of the histone methyltransferase complex. J Mol Biol 390, 530-7. (co-corresponding author)

4. Yang, X., Morita, M., Wang, H., Suzuki, T., Yang, W., Luo, Y., Zhao, C., Yu, Y., Bartlam, M.*, Yamamoto, T.* & Rao, Z. (2008). Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity. Nucleic Acids Res 36, 6872-81. (co-corresponding author)

5. He, X., Zhou, J., Bartlam, M., Zhang, R., Ma, J., Lou, Z., Li, X., Li, J., Joachimiak, A., Zeng, Z., Ge, R., Rao, Z., and Liu, Y. (2008). Crystal structural of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature 454, 1123-1127.

6. Dong, H., Li, X., Lou, Z., Xu, X., Su, D., Zhou, X., Zhou, W., Bartlam, M.*, and Rao, Z. (2008) Crystal structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family. J. Mol. Biol. 383, 455-64. (corresponding author)

7. Li, L., Liu, X., Yang, W., Xu, F., Wang, W., Feng, L., Bartlam, M.*, Wang, L.*, and Rao, Z. (2008). Crystal structure of long-chain alkane monooxygenase (LadA) in complex with coenzyme FMN: unveiling the long-chain alkane hydroxylase. J Mol Biol 376, 453-465. (co-corresponding author)

8. Huo, X., Su, D., Wang, A., Zhai, Y., Xu, J., Li, X., Bartlam, M.*, Sun, F.* & Rao, Z. (2007) Preliminary molecular characterization and crystallization of mitochondrial respiratory complex II from porcine heart. Febs J 274, 1524-1529. (co-corresponding author)

9. Sun, F., Huo, X., Zhai, Y., Wang, A., Xu, J., Su, D., Bartlam, M. & Rao, Z. (2005). Crystal structure of mitochondrial respiratory membrane protein complex II. Cell 121, 1043-57.

10. Zhai, Y., Sun, F., Li, X., Pang, H., Xu, X., Bartlam, M. & Rao, Z. (2005). Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer. Nat Struct Mol Biol 12, 980-6.

11. Yang, H., Xie, W., Xue, X., Yang, K., Ma, J., Liang, W., Zhao, Q., Zhou, Z., Pei, D., Ziebuhr, J., Hilgenfeld, R., Yuen, K. Y., Wong, L., Gao, G., Chen, S., Chen, Z., Ma, D., Bartlam, M. & Rao, Z. (2005). Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol 3, e324.

12. Bartlam, M.†, Yang, H. & Rao, Z. (2005). Structural insights into SARS coronavirus proteins. Curr Opin Struct Biol 15, 664-72. (review; first author)

13. Bartlam, M.†, Wang, G., Yang, H., Gao, R., Zhao, X., Xie, G., Cao, S., Feng, Y. & Rao, Z. (2004). Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1. Structure 12, 1481-8. (first author)


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