Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Zihe Rao

 Department: Biochemistry and Molecular Biology
 Address: A201,New Life Sciences Building,College of Life Sciences,Nankai University,Tianjin,300071,P.R.China
 Phone: 022-23502351
::Professional Education::

St. Vincent's Institute of Medical Research and Department of Biochemistry,

Melbourne University, Australia

Ph.D. in Protein Crystallography 1985-1989

Supervisor: Prof. Neil Isaacs, FRSE

University of Science & Technology of China (USTC) and Institute of Biophysics,

Chinese Academy of Sciences

M.Sc. in Protein Crystallography 1979-1982

Supervisor: Prof. Dong-Cai Liang, MCAS

Department of Physics, University of Science & Technology of China (USTC),

Chinese Academy of Sciences

B.Sc. in Biophysics 1973-1977

::Research Area::

The study of the three-dimensional structures of significant proteins related to human disease or with important physiological functions, as well as in innovative drug discovery.

::Honors and Awards::

Melbourne University Postgraduate Scholarship 1985-1989

Qiushi Outstanding Scientist Prize in Life Sciences 1999

Yangtze River Distinghuished Scholar, Ministry of Education, China 1999

He-Liang-He-Li Foundation Science & Technology Prize 2003

Chen Jiageng Science Prize for Life Science 2006

Trieste Science Prize for Medical Science 2006

Life Achievement Prize, Tan Jia-Zhen Awards for Life Sciences 2008

Outstanding Academic Leadership 2009

::Representative Publications::

1. Yuan P, Bartlam M, Lou Z, Chen S, Zhou J, He X, Lv Z, Ge R, Li X, Deng T, Fodor E, Rao Z* & Liu Y*. 2009. Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature, 458(7240):909-13

2. He X, Zhou J, Bartlam M, Zhang R, Ma J, Lou Z, Li X, Li J, Joachimiak A., Zeng Z, Ge R, Rao Z* & Liu YF*. 2008. Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus Nature, 454(7208):1123-6.

3. Rao Z, Belyaev A, Fry E, Jones I, Roy P & Stuart D. 1995. Crystal Structure of SIV Matrix Antigen and its Implications for Virus Assembly. Nature,378(6558): 743-747

4. Sun F, Huo X, Zhai YJ, Wang AJ, Xu JX, Su D, Bartlam M & Rao Z*. 2005. Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex Ⅱ. Cell, 121: 1043-1057

5. Rao Z, Handford P, Mayhew M, Knott V, Brownlee G & Stuart D. 1995. The Structure of a Calcium Binding Epidermal Growth Factor-like Domain - its Role in Protein-Protein Interactions. Cell, 82(1): 131-141

6. Zhang W, Wang L, Liu Y, Xu J, Zhu G, Cang H, Li X, Bartlam M, Hensley K, Li G, Rao Z* & Zhang XC. 2009. Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. Genes Dev. 23(12):1387-92

7. Yang H, Xie WQ, Xue XY, Yang KL, Ma J, Liang WX, Zhao Q, Zhou Z, Pei DQ,  J. Ziebuhr, R. Hilgenfeld, K. Y. Yuen, Wong L., Gao GX, Chen SJ, Chen Z, Ma DW, Bartlam M & Rao Z*. 2005. Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. PLoS Biology, 3(10):e324, 1742-1752

8. Zhai Y, Sun F, Li X, Pang H, Xu X, Bartlam M, & Rao Z*. 2005. Structural insights into coronavirus transcription/replication from the crystal structure of the SARS-CoV hexadecameric nsp7•nsp8 super-complex. Nature Structural & Molecular Biology, 12(11): 980-986

9. Xu F, Bell SG, Lednik J, Insley A, Rao Z* & Wong L*. 2005. The Heme Monooxygenase Cytochrome P450cam Can Be Engineered to Oxidize Ethane to Ethanol. Angew Chem Int Ed Engl., 44(26):4029-4032

10. Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B* & Rao Z*. 2004. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. Proc Natl Acad Sci USA., 101(22): 8348-8353

11.Yang H, Yang M, Ding Y, Liu Y, Lou Z, Sun L, Zhou Z, Ye S, Pang H, Gao G, Anand K, Bartlam M, Hilgenfeld R & Rao Z*. 2003. The Crystal Structures of SARS Virus Main Protease Mpro and Its Complex with an Inhibitor. Proc Natl Acad Sci USA., 100(23): 13190-13195

12.Bell S.G, Chen X, Sowden R.J, Xu F, Williams J.N, Wong L* & Rao Z*. 2003. Molecular Recognition in (+)-alpha-Pinene Oxidation by Cytochrome P450(cam). J Am Chem Soc., 125(3): 705-714



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