Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Quan Chen

 Department: Genetics and Cell Biology
 Address: College of Life Science,Nankai University, No.94 Weijin Rd., Tianjin 30071, China
 Phone: 86-22-2350-1201
::Professional Education::

1987-1993   Ph.D. in Cell Biology, Department of Cell Biology & State Key Laboratory of Membrane Biology and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

1981-1985   B.Sc. in Biology, Department of Biology, Hubei University, Wuhan, China

::Research Area::

The role of mitochondria in apoptosis
Molecular regulation of mitochondrial dynamics
Mitochondria as target for drug screening
Cancer stem cells

::Honors and Awards::

2003: National outstanding young investigator award
1999: American Association for Cancer Research (AACR)- AFLAC Scholar in Cancer Research Award.

::Representative Publications::

1. Zhao, L., Zhu, Y*., Wang, D., Chen, M., Gao, P., Xiao, W., Rao, G., Wang, X., Jin, H., Xu, L.,Chen Q*. (2010). Morphine induces Beclin 1- and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus. Autophagy 6 (*corresponding author).

2. Shang YL, Liu Y, Du L, Wang YL, Cheng X, Xiao WM, Wang XH, Jin HJ, Yang X, Liu SS and Chen Q. 2009 Targeted Expression of Uncoupling Protein 2 to Mouse Liver Increases the Susceptibility to LPS/GalN-Induced Acute Liver Injury Hepatology, in press

3. Huang F, Nie C; Yang Y, Yue W, Ren Y, Shang YL, Wang X, Jin J, Xu C*, Chen Q.* (2009) Selenite induces redox dependent Bax activation and apoptosis in colorectal cancer cells. Free Radical Biology & Medicine 46:1186-1196

4. .Wang H, Liu B, Zhang C, Peng G, Liu M, Li D, Gu F, Chen Q, Dong JT, Fu L, Zhou J. Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule-dependent mechanism. J Pathol. 2009 Jan 6

5. Zhang QY, Mao JH, Liu P, Huang QH, Lu J, Xie YY, Weng L, Zhang Y, Chen Q, Chen SJ, Chen Z.A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Feb 10

6. Zhao X, Liu Y, Ma Q, Wang X, Jin H, Mehrpour M, Chen Q. (2009) Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells Biochem Biophys Res Commun. 378 21-26

7. Du L, Wang H, He L, Zhang J, Ni B, Wang X, Jin H, Cahuzac N, Mehrpour M, Lu Y*, Chen Q* (2008) CD44 is of functional importance for colorectal cancer stem cell. Clinic Cancer research, 14, 6751-6760

8. Nie C, Tian C, Zhao L, Petit P, Mehrpour M and Chen Q (2008) Cysteine 62 of Bax is critical for its conformational activation and its pro-apoptotic activity in response to H2O2 -induced apoptosis. Journal of Biological Chemistry, 283(22):15359-15369

9. Tian,C., Gao,P., Zheng,Y., Yue,W., Wang,X., Jin,H., and Chen,Q. (2008). Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG(2)) to arsenic trioxide-induced cell death. Cell Res, 18(4):458-71

10. Du L, Yu Y, Chen J, Liu Y, Xia Y, Chen Q, Liu X. 2007 Arsenic induces caspase- and mitochondria-mediated apoptosis in Saccharomyces cerevisiae. FEMS Yeast Res. 7(6):860-5

11. Zhang K, Shang Y, Liao S, Zhang W, Nian H, Liu Y, Chen Q, Han C. 2007 Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis. Biochem Biophys Res Commun. 360 (2):327-32.

12. Liao XD, Liu,JM Du L, Tang AH, Wang SQ, Chen LY*, Chen Q* (2006) Nitric Oxide Signaling in Stretch-induced Apoptosis of Neonatal Rat Cardiomyocytes ( FASEB J, 20: 1883-1885)

13. Lei XB, Chen YY, DuGH, Yu WY, Wang XH, Qu H, Xia B, He HP, Mao JH, Zong WX, Mehrpour M, Hao XJ and Chen Q* 2006 Bak/Bax activation and mPTP opening independent cytochrome c release and apoptosis induced by gossypol which triggers Bcl-2 conformational change ( FASEB J, 20: 2147-2149)

14. Huang M, Wang Y, Sun D, Zhu H, Yin Y, Zhang W, Yang S, Quan L, Bai J, Wang S, Chen Q, Li S, Xu N. Identification of genes regulated by Wnt/beta-catenin pathway and involved in apoptosis via microarray analysis. BMC Cancer. 2006 Sep 7;6(1):221

15. Zheng YH., Tian CH, Wang HG, Chen Q. (2005) arsenic trioxide induces apoptosis through activation of Bax in hematopoietic cells (Oncogene, 24:3339-3347)

16. Wang ZX, Jiang CS, Liu L, Wang XH, Jin HJ, Wu Q, Chen Q, (2005) The role of Akt on Arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation Cell Research 14(1):16-26

17. Liao XD, Wang XH, Gu Y, Chen Q, Chen LY (2005) Involvement of death receptor signaling in mechanical stretch-induced cardiomyocyte apoptosis Life Sciences 77 160 -174

18. Sun YX, Zhou J, Liao XD, Yaxin Lu YX, Deng CX, Huang PT, Chen Q, Xiao Yang (2005) Disruption of Smad5 gene induces mitochondria-dependent apoptosis in cardiomyocytes Experimental Cell Research 306(1):85-93

19. Zheng JT, Rix U, Zhao LX, Mattingly C, Adams V, Chen Q, Rohr J, Yang KQ (2005) Cytotoxic Activities of New Jadomycin Derivatives J. Antibiot. 58(6): 405 -408

20. Zheng YH., Shi R., Jiang CH., Tang H., Chen Q. (Corresponding author) (2004) The mitochondrial Voltage-Dependent Anion Channel (VDAC) plays an essential rolein Arsenic Trioxide-Induced cytochrome c release and apoptosis in multiple myeloma cells Oncogene 23:1239-1247

21. Liao XD., Tang AH, Chen Q., Jin HJ, Wu CH, Chen LY, Wang SQ (2003) Role of Ca2+signaling in initiation of stretch-induced apoptosis in neonatal heart cells BBRC 310: 405-411

22. Chen Q.(Corresponding author), Crosby M., and Almasan A., (2003) Redox Regulation of programmed cell death before and after Cytochrome C release ( Korea Journal of Biological Sciences, 7:1-9; invited review)

23. Shi R, Jiang CS., Chen Q., Tang H., (2003) One step On column affinity purification and functional analysis of recombinant human VDAC1 BBRC 303:475-482

24. Shi R.,Chen JJ., Weng CJ., Chen R.,Zheng YH.,Chen Q.,and Tang H., (2003) Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins BBRC 305 989-996

25. Chen Q., Ray S., Hussein M., Srkalovic G., Almasan A. (2002) Role of Apo2L/TRAIL and Bcl-2 family proteins in apoptosis in Multiple Myeloma Leukemia and Lymphoma 44(7):1209-1214 (invited review

26. Chen Q. Chai Y-Ch, Mazumder S., Jiang C., Macklis RM., Chisolm GM., Almasan A. (2003) The late increase of intracellular free radical species during apoptosis is associated with cytochrome c release, Caspase activation and mitochondrial dysfunction Cell Death and Differentiation, 10(3):323-334

27. Xia T., Jiang CS., Li LJ., Wu CH., Liu SS., Chen Q., (2002) A study on permeability transition pore opening and cytochrome c release from mitochondria induced by Caspase -3 in vitro FEBS Letters 510( 1-2) pp. 62-66

28. Zhou JJ., Jin Y, Hu GX, Huang YM., Chen Q., Wu CH., Feng MF(2002) Genomic-scale analysis of gene expression in tumor necrosis factor-alpha induced human umbilical vein endothelial cells Inflammation Research (Impact Factor 1.49, 51:332-241)

29. Mazumder, S., Gong B., Chen., Q., Drazba, JA., Buchsbaum, JC, Almasan A. (2002) Cyclin E cleavage is associated with the ionizing radiation induced apoptosis and cell cycle deregulation ( Molecular and Cellular Biology, 22( 7): 2398-2409)

30. Zhou JJ, Gao R., Wang HF., Chen Q., Wu CH., Feng MF (2001) TNF-alpha induces cell senescence of human vascular endothelial cells Chinese Science Bulletin 46(19):1626-1640

31. Xia T., Jiang CS., Li LJ., Zhang Y., Wu CH., Liu SS., Chen Q (2002) Bid BH3 peptide, but its mutant form G94E, induces permeability transition pore opening and cytochrome c release in vitro Chinese Science Bulletin 47(7): 553-557

32. Chen Q., Gong B., Zhou A., Hussein M., and Almasan A., (2001) TRAIL/Apo2L Induction and Modulation of Bcl-2-related Proteins Regulates Interferon - induced Apoptosis in Multiple Myeloma Blood, Vol. 98, No. 7, pp. 2183-2192

33. Chen Q., Gong B., Almasan A.: (2000) Distinct stages of cytochrome C release: evidence of the feedback of the amplification of cytochrome C release from mitochondria by Caspases linking to the dysfunction of mitochondria Cell Death and Differentiation 7(2):227-233*

34. Gong B., Chen Q., Endlich B., Mazumder S., Almasan A., (1999) Ionizing radiation-induced, Bax -mediated cell death is dependent on activation of Cysteine and Serine proteases Cell Growth and Differentiation 10: 491-502

35. Chen Q., Li X., Liu S.: (1999) The activation of Na+/H+ exchange on rat preadipocyte plasma membrane and its role in cell proliferation and differentiation Science in China (C) * (both in Chinese and English), 42(2): 240-248

36. Chen Q., Takeyama N., Brady G., Watson A. & Dive C.: (1998) Blood cells with reduced mitochondria membrane potential and cytosolic cytochrome can survive and maintain clonogenicity given appropriate signals to suppress apoptosis Blood, 92(12): 4545-4553

37. Gong B., Chen Q., Almasan A.: (1998) Ionizing radiation induces mitochondria gene expression and stimulates mitochondria activities in a glioblastoma cell line Radiation Research 150: 505-512.

38. Chen Q., Turner J., Watson A., Dive C.: (1997) V-Abelson protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with up-regulation of Bcl-x/L. Oncogene 15: 2249-2254

39. Chen Q., Benson R., Brant S., Donowitz M., Dive C., Watson A.: (1997) The role of acid/base homeostasis in the suppression of apoptosis in IL-3 dependent haemopoietic cells by Abelson protein tyrosine kinase J. Cell. Sci., 110:379-387

40. Wang R., He W., Chen Q., Shi L.: (1993) Studies on the mitotic chromosomes and meiotic synaptonemal complex of the Physignathus cocincinus ACTA Genetica Sinica (both in Chinese and English) 20 (3): 211-215.

41. Chen Q., Liu R., Shi L.: (1991) Studies on the mitotic chromosomes and synaptonemal complexes in Chinese Pangolin. Zoological Research (in Chinese) 12 (3): 299-304.



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