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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Junjie Hu

 Department: Genetics and Cell Biology
 Address: 94 Weijin Road, New Biology Building Room A-408
 Phone: 86-22-23507017
 E-mail: huj@nankai.edu.cn
 website: http://hu-lab.org
::Professional Education::

2000 Fudan University B.S.

2006 New York University Ph.D.

 

::Research Area::

Biological membranes adopt different shapes, many of which are conserved amongst eukaryotes. The morphological dynamics of the lipid bilayer have been shown to play important roles in many cellular processes, be it organelle biogenesis, endocytosis, or vesicular trafficking, and defects have been linked to many diseases. Endoplasmic reticulum (ER) is an organelle with extensive and continuous membrane network. How morphologically different ER domains are formed is not clear. Our research focuses on the generation of the tubular ER network. A class of membrane proteins, the reticulons and DP1/Yop1p, was identified recently to play an important role in shaping the ER tubules. These proteins are localized mainly to the tubular ER, their overexpression or deletion changes the morphology of the ER, and purified proteins of this class form tubules upon reconstitution with lipids. We use combined approaches to further investigate the mechanism and regulation of the tubular ER network formation. We also study the functional significance of different ER morphologies, and their implication in various human diseases.

::Honors and Awards::

 

::Representative Publications::

1. Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C. A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell. 2009

2. Shibata Y, Hu J, Kozlov MM, Rapoport TA. Mechanisms shaping the membranes of cellular organelles. Annu Rev Cell Dev Biol. 2009

3. Shibata Y, Voss C, Rist JM, Hu J, Rapoport TA, Prinz WA, Voeltz GK. The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem. 2008

4. Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA. Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science. 2008

5. Hu J, Hubbard SR. Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. J Mol Biol. 2006

6. Marciniak SJ, Garcia-Bonilla L, Hu J, Harding HP, Ron D. Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK. J Cell Biol. 2006

7. Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR. Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Mol Cell. 2005

8. Hu J, Hubbard SR. Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins. J Biol Chem. 2005

9. Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR. Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell. 2003

 


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