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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Jintang Dong

 Department: Genetics and Cell Biology
 Address: College of Life Science,Nankai University,No.94 Weijin Rd.Tianjin 30071,China
 Phone: 86-22-2350-6205
 E-mail: jtdong@nankai.edu.cn
 website:
::Professional Education::

Education

a.  07.1984, B.Sc. in Biology, Nankai University, Tianjin, China. Thesis advisor: Prof. Yuhe Li

b.  10.1989, Ph.D. in Pathophysiology/Cancer Biology, Peking Union Medical College and Chinese Academy of Medical Sciences (two names for the same institution), Beijing, China. Mentor: Dr. Xian-Mao Luo

Postgraduate Training:

c.  Postdoctoral Fellow in Molecular Cancer Biology, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina. Mentor: Dr. J. Carl Barrett. 10.1990-09.1994

d.  Postdoctoral Fellow in prostate cancer biology, the Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Mentor: Dr. John T. Isaacs. 10.1994-09.1996

::Research Area::

We aim to understand the molecular mechanisms underlying the development and progression of human cancer,including of discovering and identifying some cancer genes,and their molecule signal pathway. Currently we focus on human breast cancer.

::Honors and Awards::

a. Ministry of Public Health of China, Second class prize (Participant), "Molybdenum in the development and prevention of esophageal cancer", 1988

b. Ministry of Public Health of China, Third class prize (Participant), "Trace elements and lung cancer in Yunnan Tin miners", 1992

c. US NIH postdoctoral fellowship for advanced training in cellular biology, 1990-1994

d. US NIH Director's award, "KAI1, a metastasis suppressor gene for prostatic cancer", 1996

e. Georgia Cancer Coalition Distinguished Physician and Scientist Award, 2002-2007

f. National Natural Science Foundation of China (NSFC), Outstanding Overseas Young Investigator Award, 2004-2006

g. The Chinese Central Government "Thousand Talents Program", 2009-present

::Representative Publications::

(1) Dong JT, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT, Barrett JC (1995) KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268:884-886.

(2) Dong JT, Suzuki H, Pin SS, Bova GS, Schalken JA, Isaacs WB, Barrett JC, Isaacs JT (1996) Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss. Cancer Res 56:4387-4390.

(3) Dong JT, Sipe TW, Hyytinen ER, Li CL, Heise C, McClintock DE, Grant CD, Chung LW, Frierson HF, Jr. (1998) PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate. Oncogene 17:1979-1982.

(4) Dong JT, Li CL, Sipe TW, Frierson HF, Jr. (2001) Mutation of PTEN/MMAC1 in primary prostate cancers from Chinese patients. Clin Cancer Res 7:304-308.

(5) Dong JT (2001) Chromosomal deletions and tumor suppressor genes in prostate cancer. Cancer Metastasis Rev 20:173-193.

(6) Chen C, Bhalala HV, Qiao H, and Dong JT (2002) A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. Oncogene 21:6567-6572.

(7) Chen C, Hyytinen ER, Sun X, Helin HJ, Koivisto PA, Frierson HF, Vessella RL, and Dong JT (2003) Deletion, mutation, and loss of expression of the KLF6 tumor suppressor gene in a subset of prostate cancer. Am J Pathol 162:1349-1354.

(8) Chen C, Zhou Y, Zhou Z, Sun X, Otto KB, Uht RM, and Dong JT (2004) Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells. Gene 330:133-142.

(9) Chen C, Sun X, Ran Q, Wilkinson KD, Murphy TJ, Simons JW, and Dong JT (2005) Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene 24:3319-3327, 2005.

(10) Sun X, Frierson HF, Chen C, Li C, Ran Q, Otto KB, Cantarel BL, Vessella RL, Gao AC, Petros J, Miura Y, Simons JW, and Dong JT (2005) Frequent somatic mutations of the ATBF1 transcription factor in human prostate cancer. Nat Genet 37: 407-412.

(11) Chen C, Guo P, Sun X, Dong XY, Sethi P, Cheng X, Zhou J, Ling J, Simons JW, Lingrel JB, and Dong JT (2005) KLF5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. J Biol Chem 280:41553-41561.

(12) Chen C, Benjamin MS, Sun X, Otto KB, Guo P, Dong XY, Bao Y, Zhou Z, Cheng X, Simons JW & Dong JT (2006). KLF5 promotes cell proliferation and tumorigenesis through gene regulation in the TSU-Pr1 human bladder cancer cell line. Int J Cancer 118:1346-1355.

(13) Sun X, Chen C, Vessella RL, and Dong JT (2006) Microsatellite instability and mismatch repair target gene mutations in cell lines and xenografts of prostate cancer. Prostate 66:660-666.

(14) Dong XY, Chen C, Sun X, Guo P, Vessella RL, Wang RX, Chung LW, Zhou W, and Dong JT (2006) FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting AR signaling in prostate cancer. Cancer Res 66:6998-7006.

(15) Dong JT (2006) Prevalent mutations in prostate cancer. J Cell Biochem 97:433-447.

(16) Chen C, Sun X, Guo P, Dong XY, Sethi P, Zhou W, Zhou Z, Petros J, Frierson HF, Vessella RL, Atfi A, and Dong JT (2007) Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. Oncogene 26: 2386-2394.

(17) Sun X, Zhou Y, Otto KB, Wang M, Chen C, Zhou W, Subramanian K, Vertino PM, and Dong JT (2007) Infrequent mutation of ATBF1 in human breast cancer. J Cancer Res Clin Oncol 133:103-5.

(18) Dong XY, Rodriguez C, Guo P, Sun X, Talbot JT, Zhou W, Petros J, Li Q, Vessella RL, Kibel AS, Stevens VL, Calle EE, and Dong JT (2008) SnoRNA U50 is a candidate tumor suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer. Hum Mol Genet 17:1031-142.

(19) Chen L, Zhu Z, Sun X, Dong XY, Wei J, Gu F, Sun YL, Zhou J, Dong JT, and Fu L (2008) Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis. Breast Cancer Res Tt 116:471-8

(20) Guo P, Dong XY, Zhang X, Zhao KW, Sun X, Li Q, and Dong JT (2009) Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modification. J Biol Chem 284(10):6071-8..

(21) Guo P, Zhao KW, Dong XY, Sun X, and Dong JT (2009) Acetylation of KLF5 alters the assembly of P15 transcription factors in TGFbeta-mediated induction in epithelial cells. J Biol Chem 284:18184-93.

(22) Guo P, Dong XY, Zhao KW, Sun X, Li Q, and Dong JT (2009) Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells. Int J Cancer 126:81-9.

(23) Dong XY, Guo P, Boyd J, Sun X, Li Q, Zhou W, and Dong JT (2009) Implication of snoRNA U50 in human breast cancer. J Genet Genomics 36:447-54.

(24) Guo P, Dong XY, Zhao KW, Sun X, Li Q, and Dong JT (2009) Opposing effects of KLF5 on the transcription of Myc in epithelial proliferation in the context of TGFbeta. J Biol Chem 284:28243-52.

(25) Dong JT and Chen C (2009) Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cell Mol Life Sci 66:2691-706.

 


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