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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Liqing Zhao

 Department: Biochemistry and molecular biology
 Address: 94 Weijin Road, Nankai District Tianjin 300071, P.R.China
 Phone: 022-23500767
 E-mail: lqzhao@nankai.edu.cn
 website:
::Professional Education::

1980-1984  B.S. in Biochemistry, Nankai University

1984-1988  M.S. in Biochemistry, Nankai University

1995-1998  Ph.D. in Molecular Genetics, Nankai University

2000-2003  Visiting Postdoctoral Fellow in the University of California, San Francisco.

 

::Research Area::

Research work focuses on the development of the distal lung, the formation of alveoli. Alveoli are key functional units of the lungs where gas exchange takes place, yet the regulation of alveolar morphogenesis is not well understood.  Our hypothesis is that since the formation of alveoli occurs in a defined period, genes that regulate alveolar morphogenesis must be differentially expressed during periods of active and inactive alveolar formation. We used suppression subtractive hybridization to identify genes that may control alveolar generation during periods of pre- and postnatal active alveolar development. P311, a putative neuronal protein, was highly differentially expressed during periods of active distal lung morphogenesis. The role of P311 will then be tested using gain- and loss-of function studies both in vitro and in vivo.

::Honors and Awards::
::Representative Publications::

1. Liqing Zhao, Thiennu Vu, Identification of genes regulating alveolar morphogenesis by supression subtractive hybridization, Journal of Molecular Cell Biology, 2006, 39 (6) : 553-562

2.Liqing Zhao, James K. Leung, Hiroaki Yamamoto, Sangeeta Goswami, FarrahKheradmand, and Thiennu H. Vu,  Identification of P311 as a potential gene regulating alveolar generation, American Journal of Respiratory Cell and Molecular Biology, 2006 Jul;35(1):48-54

3. Liqing Zhao, Ke Wang, Napoleone Ferrara, Thiennu H. Vu, Vascular endothelia growth factor co-ordinates proper development of lung epitheliaum and vasculature, Mechanisms of Development, 2005, 122:877-886

4. Liqing Zhao, Thiennu Vu, Embryonic lung cell allografts under the renal capsule--- a new model for the study of lung development, Acta Biology Experimentalis Sinica, 2004, 37 (4) : 303-309.

5. Liqing Zhao, Thiennu Vu, The Potential Effect of P311 on Alveolar Morphogenesis, Acta Science Naturalium University Nankaiensis, 2004, 37 (2) 34-39.

 

 


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