Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Youjia Cao

 Department: Biochemistry and Molecular Biology
 Address: 224 Molecular Biology Building, Nank Weijin Rd., Tianjin 30071, China
 Phone: +86-22-23500808
::Professional Education::

1994  Ph.D. in Biochemistry, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indiana, USA

1987  B.S. in Biochemistry, Department of Biology, Nankai University, Tianjin, China

::Research Area::

*  Molecular mechanisms in host immune response against viral infection

*  Cell signaling in T cell activation and apoptosis

::Honors and Awards::

2004  New Century Talents by Ministry of Education, China

1998  American Cancer Research Fellowship, USA

1994-1995 National Research Service Award. NIH, USA

1992    American Diabetes Foundation Summer Research Award. USA

::Representative Publications::

1. Jin H, Ma Y, Prabhakar BS, Feng Z, Valyi-Nagy T, Yan Z, Verpooten D, Zhang C, Cao Y, He B. The gamma 1 34.5 protein of herpes simplex virus 1 is required to interfere with dendritic cell maturation during productive infection. J Virol. 2009 May;83(10):4984-94. Epub 2009 Mar 11.

2. Verpooten D, Feng Z, Valyi-Nagy T, Ma Y, Jin H, Yan Z, Zhang C, Cao Y,* He B. Dephosphorylation of eIF2{alpha} Mediated by the {gamma}134.5 Protein of Herpes Simplex Virus 1 Facilitates Viral Neuroinvasion. J Virol. 2009 Dec. p. 12626–12630

3. Zhang H, Li Y, Bai Y, Niu R, Jia Y, Zhang C, Zhang L, Feng X, and Cao Y.* Metastatic cell detection using a phage peptide modified light addressable potentiometric sensor. Biotechnol. Appl. Biochem. 2009, 53, 185-192.

4. Zhang HK, Li X, Bai Y, Niu R, Jia Y, Zhang C, Zhang L, Feng X, Cao Y.* “Metastatic cell detection using phage-peptide modified light addressable potentiometric sensor.” Biotechnol Appl Biochem.ePub on Sep 4,2008.

5. Li X., Lou ZY., Li XM., Zhou WH., Ma M., Cao Y.*, Geng YQ., Bartlam M., Zhang XJ., and Rao Z. “Structure of Human Cytosolic X-Prolyl Aminopeptidase: A  Double Mn(II) Dependent Dimeric Enzyme with a Novel Three-domain Subunit.”  J. Biol. Chem. (2008) 283(33):22858-22866

6. Zhang CZ, Tang J, Xie J, Zhang HK, Li YP, Zhang J, Verpooten D, He B, and Cao Y. A conserved domain of herpes simplex virus ICP34.5 regulates protein phosphatase complex in mammalian cells. FEBS Lett. (2008) 582:171-176

7. Cao Y.*, Li YP., Zhang YC,. and Zhang CZ. “T Cell Receptor Signaling Pathways: New Targets for Herpes Simplex Virus.” VIROLOGICA SINICA, 2008, 23 (6):429-437 review

8. Zhou Z, Yin J, Dou Z, Tang J, Zhang C, Cao Y.* The Calponin Homology Domain of Vav1 Associates with Calmodulin and Is Prerequisite to T Cell Antigen Receptor-induced Calcium Release in Jurkat T Lymphocytes. J Biol Chem. (2007) 282(32):23737-23744

9. Zhou Z, Dou Z, Zhang C, Yu HQ, Liu YJ, Zhang C, and Cao Y.* “A Strategy to Optimize the Oligo-Probes for Microarray-based Detection of Viruses.” VIROLOGICA SINICA, (2007)  22 (4):326-335

10.Cao, Y., Janssen, E.M., Duncan, A. W., Altman,A., Billadeau,D.D., and Abraham, R.T. "Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line." EMBO J. (2002) 21: 4809-4819.


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