Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Zhongyin Zhang

 Department: Biochemistry and Molecular Biology
 Address: 94 Weijin Road, Nankai District Tianjin 300071, P.R.China
 Phone: 86-22-23503406
::Professional Education::

1984, B.S. Nankai University

1990, Ph.D. Purdue University, USA

::Research Area::

*  Molecular basis of PTP substrate recognition and regulation

*  Interaction proteomics for rapid isolation and identification of physiological PTP substrates/regulators

*  Chemical genetics approaches to devolope and use PTP-specific small molecule inhibitors as tools to establish functional roles for members of the PTP family

::Honors and Awards::
::Representative Publications::

1.  Zhou, B. and Zhang, Z.-Y. "The Activity of the Extracellular Signal-Regulated Kinase 2 Is Regulated by Differential Phosphorylation in the Activation Loop" J. Biol. Chem. 277, 13889-13899 (2002).
2.  Zhou, B., Wang, Z.-X., Zhao, Y., Brautigan, D. L. and Zhang, Z.-Y. "The Specificity of Extracellular Signal-Regulated Kinase 2 Dephosphorylation by Protein Phosphatases" J. Biol. Chem. 277, 31818-31825 (2002).
3.  Sun, J.-P., Fedorov, A. A., Lee, S.-Y., Guo, X.-L., Shen, K., Lawrence, D. S., Almo, S. C. and Zhang, Z.-Y. "Crystal Structure of PTP1B in Complex with a Potent and Selective Bidentate Inhibitor" J. Biol. Chem. 278, 12406-12414 (2003).
4.  Liang, F., Huang, Z., Lee, S.-Y., Liang, J., Ivanov, M. I., Alonso, A., Bliska, J. B., Lawrence, D. S., Mustelin, T., and Zhang, Z.-Y. "Aurintricarboxylic Acid Blocks in vitro and in vivo Activity of YopH, an Essential Virulent Factor of Yersinia pestis, the Agent of Plague", J. Biol. Chem. 278, 41734-41741 (2003).
5.  Kumar, S., Zhou, B., Liang, F., Wang, W.-Q., Huang, Z., and Zhang, Z.-Y. "Activity-Based Probes for Protein Tyrosine Phosphatases", Proc. Natl. Acad. Sci. USA 101, 7943-7948 (2004).
6.  Liu, S., Sun, J.-P., Zhou, B. and Zhang, Z.-Y. "Structural basis of docking interaction between ERK2 and MAP kinase phosphatase 3", Proc. Natl. Acad. Sci. USA 103, 5326-5331 (2006).
7.  Yu, X., Sun, J.-P., He, Y., Guo, X.-L., Liu, S., Zhou, B., Hudmon, A. and Zhang, Z.-Y. "Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases", Proc. Natl. Acad. Sci. USA 104, 19767-19772 (2007).
8.  Liang, F., Luo, Y., Dong, Y., Walls, C. D., Liang, J., Jiang, H.-Y., Sanford, J. R., Wek, R. C. and Zhang, Z.-Y. "Translational Control of C-terminal Src Kinase (Csk) Expression by PRL3 Phosphatase", J. Biol. Chem. 283, 10339-10346(2008).


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