Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors


Ming Lei

 Department: Biochemistry and Molecular Biology
 Address: 94 Weijin Road, Nankai District Tianjin 300071, P.R.China
::Professional Education::

1994    Tsinghua University, Beijing, China
Department of Physics
B.Sc. in Physics

1996   McGill University, Montreal, Quebec, Canada
Department of Physics
M.Sc. in Physics
Advisor: Dr. Hong Guo

2001   Harvard University, Cambridge, MA
Laboratory of Molecular Medicine at Children’s Hospital Boston
Ph.D. in Biophysics
Advisor: Dr. Stephen C. Harrison

::Research Area::
::Honors and Awards::

2009-2014    Howard Hughes Medical Institute Early Career Award

                    Howard Hughes Medical Institute

2006-2010    American Cancer Society Scholar

                    American Cancer Society

2006-2008    Sidney Kimmel Scholar

                    Sidney Kimmel Foundation

2004             Biological Science Scholar

                    University of Michigan

2001-2004    Paul Sigler / Agouron Institute Fellow

                    Helen Hay Whitney Foundation

::Representative Publications::
1.  Lei, M., Zhu, N.-J. and Guo, H. (1995) Quantum Hall Effect in the Presence of an Antidot Potential. Phys. Rev. B 52(23): 16784-16792.
2.  Lei, M. and Guo, H. (1996) Numerical Confirmation of Universality of Transmission Microsymmetry Relations in a Four-probe quantum Dot. Phys. Rev. B 54(16): 11630-11637.
3.  Zhu, N.-J., Lei, M. and Guo, H. (1996) Magnetoresistance Oscillation in Window-coupled Wire Systems. J. Appl. Phys. 79: (9) 7036-7040.
4.  Quadri, L., Weinreb, P., Lei, M., Nakano, M., Zuber, P. and Walsh, C. (1998) Characterization of Sfp, a Bacillus Subtilis Phosphophantetheinyl Transferase for Peptidyl Carrier Protein Domains in Peptide Synthetases. Biochemistry, 37(6): 1585-1595.
5.  Xu, W., Doshi, A., Lei, M., Eck, M. and Harrison, S.C. (1999) Crystal Structures of c-Src Reveals Features of Its Autoinhibitory Mechanism. Molecular Cell, 3(5):629-638.
6.  Lei, M., Lu, W., Meng, W., Parrini, M.C., Eck, M., Mayer, B.J. and Harrison, S.C. 2000. Structure of PAK1 in an Autoinhibited Conformation Reveals a Multi-stage Activation Switch. Cell, 102(3):387-397.
7.  Lowry, W.E., Huang, J., Lei, M., Rawlings, D. and Huang, X.Y. (2001) Role of the PHTH module in protein substrate recognition by Bruton's agammaglobulinemia tyrosine kinase.  J. Biol. Chem. 276(48):45276-45281.
8.  Parrini, M.C., Lei, M., Harrison, S.C. and Mayer, B.J. 2002. Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Molecular Cell, 9(1):73-83.
9.  Lei, M., Baumann, P. and Cech, T.R. (2002) Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry. 41(49):14560-14568.
10.  Lei, M., Podell, E.R., Baumann, P. and Cech, T.R. (2003) DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature, 426:198-203.
11.  Lei, M., Podell, E.R. and Cech, T.R. (2004) Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat. Struct. Mol. Biol. 11(12):1223-1229.
12.  Lei, M., Zaug, A.J., Podell, E.R. and Cech, T.R. (2005) Switching human telomerase on and off with hPOT1 protein in vitro. J. Biol. Chem. 280(21):20449-56.
13.  Lei, M., Robinson, M.A. and Harrison, S.C. (2005) The active conformation of the PAK1 kinase domain. Structure. 13: 769-778.
14.  Opresko, P.L., Mason, P.A., Podell, E.R., Lei, M., Hickson, I.D., Cech, T.R., and Bohr, V.A. (2006) POT1 stimulates RecQ helicases WRN and BLM to unwind DNA substrates. J. Biol. Chem. 280(37):32069-80.
15.  Chen, Y., Yang, Y., Wang, F., Wan, K., Yamane, K., Zhang, Y., and Lei, M. (2006) Crystal structure of human lysince-specific demethylase 1 (LSD1). PNAS 103(38): 13956-61.
16.  Wang, F., Podell, E.R., Zaug, A.J., Yang, Y., Baciu, P., Cech, T.R., and Lei, M. (2007) The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445: 506-510.
17.  Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., and Lei, M. (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319(5866):1092-6.
18.  Sowd, G., Lei, M., and Opresko, P.L. (2008) Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner Syndrome helicase. Nucleic Acids Research, 36(13):4242-56.
19.  Yu, E.Y., Wang, F., Lei, M., and Lue, N.F. (2008) Analysis of Candida albicans telomerase protein Est3: evidence for an OB-fold structure with a novel protein interaction surface. Nat Struct Mol Biol., 15(9):985-9.
20.  Wang, W., Yang, Y., Gao, Y., Zhu, S., Wang, F., Old, W., Resing, K., Ahn, N., Lei, M.*, and Liu, X.* (2008) Structural and mechanistic insights into Mps1 kinase activation. Journal of Cellular and Molecular Medicine, in print. (*: co-corresponding authors). Published Online: Dec 16, 2008. DOI: 10.1111/j.1582-4934.2008.00605.


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