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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Xiaodong Zhang

 Department: Department of Cancer Research,Institute for Molecular Biology,College of Life Sciences
 Address: College of Life Sciences,Nankai University,94 Weijin Road,Tianjin,300071,China
 Phone: +86-22-23506830
 E-mail: Zhangxd@nankai.edu.cn
 website:
::Professional Education::

*  Nov 1998 - Nov 2000: Postdoctoral fellow, Institute for Molecular and Cellular Biology, University of Tokyo, Japan, supported by Japan Society for the Promotion of Science (JSPS)

*  Aug 1993 - Jul 1996:  Ph.D., Fourth Military Medical University, China

*  Aug 1987 - Jul 1990:  MSc, Fourth Military Medical University, China

*  Aug 1979 - Jul 1984:  M.D. Fourth Military Medical University, China

::Research Area::

*  Molecular mechanisms of liver cancer mediated by hepatitis B virus X protein (HBx)

*  Molecular mechanisms of breast cancer metastasis

::Honors and Awards::

Fellowship Award

*  Nov.1998-Nov.2000   Postdoctoral Fellowship from Japan Society for the Promotion of Science (JSPS), Japan

*  Feb.1998-Nov.1998    DAAD Fellowship, Germany

*  Jan. 1997-Jan. 1998    Royal Society Fellowship, UK

Scientific Award

*  Second class of National Science and Technology Progress Class Prize in March 1999

*  First Class of Shaanxi Province Science and Technology Progress Prize in March 1998

::Representative Publications::

1. Zhang X, Ye LH, Zhang XD*. A mutant of hepatitis B virus X protein (HBx127) enhances cell migration via osteopontin (OPN) involving 5-lipoxygenase. Acta Pharmacol Sin. 2010 Apr 5. [Epub ahead of print] (IF=1.67)

2. Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD*. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J Med Virol. 2010; 82: 920-928 (IF=2.7)

3. Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH, Zhang XD*. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res. 2010 Apr 13. [Epub ahead of print] (IF=4.535)

4. Wang Q, Zhang WY, Ye LH, Zhang XD*. A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin. 2010; 31(3): 367-374 (IF=1.67)

5. Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye LH, Zhang XD*. A Mutant of Hepatitis B Virus X Protein (HBxDelta127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase. Neoplasia. 2010;12(2):103-15. (IF=5.1)

6. Zhou XL, Qin XR, Zhang XD*, Ye LH. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling. Acta Pharmacol Sin. 2010;31(2):202-10. (IF=1.6)

7. Zhang H, Wu LY, Zhang S, Qiu LY, Li N, Zhang X, Zhang XZ, Shan SL, Ye LH, Zhang XD*. Anti-hepatitis B Virus (HBV) X protein (HBx) in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBV. J Biomed Biotechnol doi:10.1155/2009/289068  (IF=2.5)

8. Zhang WY, Cai N, Ye LH, Zhang XD*. Transformation of human liver L-O2 cells mediated by stable HBx transfection. Acta Pharmacol Sinica. 2009; 30(8):1153-61. (IF=1.6)

9. Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH*, Zhang XD*. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacologica Sinica,2009; 30(4):424-434  (IF=1.6)

10. You J, Mi D, Zhou X, Qiao L, Xu S, Zhang XD*, Ye LH. Positive feedback between activated ERK and COX/LOX contributes to breast cancer cell proliferation and migration. Endocrinology,2009;150(4):1607-17. (IF=5.0)

11. Zhou X, Liu Y, You J, Zhang XD*, Ye LH. Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. Cancer Letters 2008; 270:312-327. (IF=3.4)

12. Qiao L, Xu ZL, Zhao TJ, Ye LH, Zhang XD*. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters 2008;269(1):67-77. (IF=3.4)

13. Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye LH, Zhang XD*. Depression of tumorigenesis mediated by human mesenchymal stem cells in a model of hepatoma cells. Cell Res 2008;18:500-507 (IF=4.535)

14. Ye LH, Dong N,Wang Q,Xu ZL,Cai N,Wang HH,Zhang XD*. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology, 2008;51:50-58 (IF=1.5)

15. Zhang H, Shan C, Li N, Zhang X, Zhang X, Xu F, Zhang S, Qiu L, Ye LH, Zhang XD*. Identification of a natural mutant of HBV X protein truncated 27 amino acids at COOH-terminal and its effect on liver cell proliferation. Acta Pharmacologica Sinica,2008;29(4):473-80 (IF=1.6)

16. Qiao L, Zhao T, Wang F, Shan C, Ye LH, Zhang XD*. NF-κB downregulation maybe involved the depression of proliferation of tumor cells mediated by human mesenchymal stem cells. Acta Pharmacologica Sinica, 2008;29(3):333-340 (IF=1.6)

17. Wang F, Sha L, Ye LH, Zhang XD*. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. Acta Pharmacologica Sinica, 2008; 29(1)-83-89. (IF=1.6)

18. Qin X, Zhang H, Zhou X, Zhang H, Zhang X*, Ye LH. Proliferation and migration mediated by Dkk-1/Wnt/b-catenin cascade in a model of hepatocellular carcinoma (HCC) cells. Translational Res 2007;150(5): 281-294  (IF=2.0)

19. Wang F, Sha L, Zhang W, Wu L, Zhang XD*, Ye LH. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. Acta Pharmacologica Sinica, 2007;28(3) : 431-438  (IF=1.6)

20. Zhang XD*, Zhang W, Ye LH. Pathogenesis of hepatitis B virus infection. Future Virol 2006;1(5):637-647

21. Zhang XD*, Zhang H, Ye LH. Effects of hepatitis B virus X protein on the development of liver cancer. J Lab. Clin. Med. 2006;.147(2):58-66  (IF=2.0)

22. Zhang XD*, Dong N, Zhang H, You J, Wang H and Ye LH. Effects of hepatitis B virus X protein on hTERT expression and activity in hepatoma cells. J Lab. Clin. Med. 2005; 145(2):98-104  (IF=2.0)

23. Zhang XD*, Dong N, Yin L, Cai N, Ma H, Zhang H, You J, Wang H, He R and Ye LH. Hepatitis B virus X protein up-regulates survivin expression in hepatoma tissues. J Med. Virol 2005; 77:374-381 (IF=2.5)

 

Books

1. <Progress in Hepatitis B Research> (ISBN: 1-60021-687-0) Editors: Dorothy V. Denyer. Nova publishers of America. Published in Dec. 2007.

   Xiaodong Zhang, Weiying Zhang and Lihong Ye wrote the Chapter V - Hepatitis B Virus Research Focus; pp. 113-201

2. <Hepatitis B Virus Research Focus> (ISBN: 978-1-60456-299-6) Writers: Xiaodong Zhang, Weiying Zhang, Lihong Ye. Nova publishers of America. Published in Nov 2008.

 


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