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Faculty

Academicians | Yangtze River Scholars | Outstanding Young Talent | Professors | Associate Professors

 

Lihong Ye

 Department: Department of Biochemistry
 Address: Institute for Molecular Biology,College of Life Sciences,Nankai University,94 Weijin Road,Tianjin
 Phone: +86-22-23501385
 E-mail: yelihong@nankai.edu.cn
 website:
::Professional Education::

*  Ph.D., Department of Molecular Pharmacology, Gunma University, Japan

*  M.Sc., Department of Pharmacology, Yanbian University School of Medicine, China

*  M.D., Chinese Medical University, China

::Research Area::

*  Molecular mechanisms of breast cancer metastasis.

*  Molecular mechanisms of liver cancer mediated by hepatitis B virus X protein (HBx).
::Honors and Awards::

*  April 1997-Mar 1999, Postdoctoral Fellowship from Japan Society for the Promotion of Science (JSPS), Japan

*  Oct.1992-Mar.1997, Fellowship of Ministry of Culture and Education, Japan

::Representative Publications::

1. Zhang X, Ye LH*, Zhang XD. A mutant of hepatitis B virus X protein (HBx127) enhances cell migration via osteopontin (OPN) involving 5-lipoxygenase. Acta Pharmacol Sin. 2010 Apr 5. [Epub ahead of print] (IF=1.67)

2. Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J Med Virol. 2010; 82: 920-928 (IF=2.7)

3. Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH*, Zhang XD. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res. 2010 Apr 13. [Epub ahead of print] (IF=4.535)

4. Wang Q, Zhang WY, Ye LH*, Zhang XD. A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin. 2010; 31(3): 367-374 (IF=1.67)

5. Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye LH*, Zhang XD. A Mutant of Hepatitis B Virus X Protein (HBxDelta127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase. Neoplasia. 2010;12(2):103-15. (IF=5.1)

6. Zhou XL, Qin XR, Zhang XD, Ye LH*. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling. Acta Pharmacol Sin. 2010;31(2):202-10. (IF=1.6)

7. Zhang H, Wu LY, Zhang S, Qiu LY, Li N, Zhang X, Zhang XZ, Shan SL, Ye LH*, Zhang XD. Anti-hepatitis B Virus (HBV) X protein (HBx) in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBV. J Biomed Biotechnol doi:10.1155/2009/289068 (IF=2.5)

8. Zhang WY, Cai N, Ye LH*, Zhang XD. Transformation of human liver L-O2 cells mediated by stable HBx transfection. Acta Pharmacol Sinica. 2009; 30(8):1153-61. (IF=1.6)

9. Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH*, Zhang XD. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacologica Sinica,2009; 30(4):424-434 (IF=1.6)

10. You J, Mi D, Zhou X, Qiao L, Xu S, Zhang XD, Ye LH*. Positive feedback between activated ERK and COX/LOX contributes to breast cancer cell proliferation and migration. Endocrinology, 2009;150(4):1607-17. (IF=5.0)

11. Zhou X, Liu Y, You J, Zhang XD, Ye LH*. Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. Cancer Letters 2008; 270:312-327. (IF=3.4)

12. Qiao L, Xu ZL, Zhao TJ, Ye LH*, Zhang XD. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters 2008;269(1):67-77. (IF=3.4)

13. Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye LH*, Zhang XD. Depression of tumorigenesis mediated by human mesenchymal stem cells in a model of hepatoma cells. Cell Res 2008;18:500-507 (IF=4.535)

14. Ye LH, Dong N,Wang Q,Xu ZL,Cai N,Wang HH,Zhang XD. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology, 2008;51:50-58  (IF=1.5)

15. Zhang H, Shan C, Li N, Zhang X, Zhang X, Xu F, Zhang S, Qiu L, Ye LH*, Zhang XD. Identification of a natural mutant of HBV X protein truncated 27 amino acids at COOH-terminal and its effect on liver cell proliferation. Acta Pharmacologica Sinica,2008;29(4):473-80 (IF=1.6)

16. Qiao L, Zhao T, Wang F, Shan C, Ye LH*, Zhang XD. NF-kB downregulation maybe involved the depression of proliferation of tumor cells mediated by human mesenchymal stem cells. Acta Pharmacologica Sinica, 2008;29(3):333-340  (IF=1.6)

17. Wang F, Sha L, Ye LH*, Zhang XD. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. Acta Pharmacologica Sinica, 2008; 29(1)-83-89. (IF=1.6)

18. Qin X, Zhang H, Zhou X, Zhang H, Zhang X, Ye LH*. Proliferation and migration mediated by Dkk-1/Wnt/b-catenin cascade in a model of hepatocellular carcinoma (HCC) cells. Translational Res 2007;150(5): 281-294 (IF=2.0)

19. Wang F, Sha L, Zhang W, Wu L, Zhang XD, Ye LH*. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. Acta Pharmacologica Sinica, 2007;28(3) : 431-438  (IF=1.6)

20. Zhang XD, Zhang W, Ye LH*. Pathogenesis of hepatitis B virus infection. Future Virol 2006;1(5):637-647

21. Zhang XD, Zhang H, Ye LH*. Effects of hepatitis B virus X protein on the development of liver cancer. J Lab. Clin. Med. 2006;.147(2):58-66  (IF=2.0)

22. Zhang XD, Dong N, Zhang H, You J, Wang H and Ye LH*. Effects of hepatitis B virus X protein on hTERT expression and activity in hepatoma cells. J Lab. Clin. Med. 2005; 145(2):98-104 (IF=2.0)

23. Zhang XD, Dong N, Yin L, Cai N, Ma H, Zhang H, You J, Wang H, He R and Ye LH*. Hepatitis B virus X protein up-regulates survivin expression in hepatoma tissues. J Med. Virol 2005; 77:374-381 (IF=2.5)

24. Ye LH, Kishi H, Nakamura A, Okagaki T, Tanaka T, Oiwa K,and Kohama K. Myosin light chain kinase of smooth muscle stimulates myosin ATPase activity without phosphorylating  myosin light chain. Proc.Natl.Acad.Sci. 1999;96: 6666-6671 (IF=2.0)

25. Ye LH, Hayakawa K, Kishi H, Imamura M, Nakamura A, Okagaki T, Takagi T, Iwata A , Tanaka T, and Kohama K. The structure and function of the actin-binding domain of myosin light chain kinase of smooth muscle. J. Biol. Chem. 1997;272: 32182-32189

26. Wang HH, Nakamura A, Matsumoto A, Yoshiyama S, Qin X, Ye LH, Xie C, Zhang Y, Gao Y, Ishikawa R, Kohama K. Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine. Am J Physiol Heart Circ Physiol. 2009;296(5):H1683-93.

27. Wang HH, Tanaka H, Qin X, Zhao T, Ye LH, Okagaki T, Katayama T, Nakamura A, Ishikawa R, Thatcher SE, Wright GL, Kohama K. Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction. Am J Physiol Heart Circ Physiol. 2008;294(5):H2060-8.

28. Nakamura A, Xie C, Zhang Y, Gao Y, Wang HH, Ye LH, Kishi H, Okagaki T, Yoshiyama S, Hayakawa K, Ishikawa R, Kohama K. Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi. Biochem Biophys Res Commun. 2008;369(1):135-43

29. Katayama T, Watanabe M, Tanaka H, Hino M, Miyakawa T, Ohki T, Ye LH, Xie C, Yoshiyama S, Nakamura A, Ishikawa R, Tanokura M, Oiwa K, Kohama K.Stimulatory effects of arachidonic acid on myosin ATPase activity and contraction of smooth muscle via myosin motor domain. Am J Physiol Heart Circ Physiol. 2010;298(2):H505-14.

 

Books

1. <Progress in Hepatitis B Research> (ISBN: 1-60021-687-0) Editors: Dorothy V. Denyer. Nova publishers of America. Published in Dec. 2007.

Xiaodong Zhang, Weiying Zhang and Lihong Ye wrote the Chapter V - Hepatitis B Virus Research Focus; pp. 113-201

2. <Hepatitis B Virus Research Focus> (ISBN: 978-1-60456-299-6) Writers: Xiaodong Zhang, Weiying Zhang, Lihong Ye. Nova publishers of America. Published in Nov 2008.

 


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