Kongdeling

Dr.Kong Deling was born in 1966,currently a Professor at College of Life Sciences, Nankai University,the director of the Scientific Research Department of Nankai University.(For more information, refer to Honor title) He has presided 1 project of national Key research and development Plan, 4 key projects of National Natural Science Foundation of China. For publication He has published more than 300 SCI papers, cited more than 14,000 times with H Index 59.More than 20 invention patents have been authorized. As the first accomplisher, he won 1 first prize and 1 second prize of Natural science in Tianjin, also be the participant won the second prize of National Science and Technology Progress, the first prize of Tianjin Natural Science, the second prize of Tianjin Science and Technology Progress, etc. Besides, One patented artificial blood vessel technology has been transformed and Lingbo Biotechnology (Hangzhou) Co.(For more information, refer to social appointment)

1985.9-1989.7: Undergraduate study(bachelor), Department of Chemistry, Nankai University; 1989.9-1992.7: Graduate study (master), Polymer Chemistry & Physics,Nankai University; 1994.9-1997.7: Graduate study (PhD), Polymer Chemistry & Physics,Nankai University.

1992.8-1994.8: Research associate, Institute of Molecular Biology, Nankai University; 1998.9-2000.9: Postdoc, Center of Bioengineering, Rostock, Germany; 2000.9-2003.8: Postdoc, Brigham & women’s Hospital, Harvard Medical School; 3003.9-present: Professor, College of Life Science, Nankai University; 2004.12-2017.6: Director, the Key Laboratory of Bioactive Materials, Ministry of education; 2017.6-2018.11: Dean, the College of Life Science; 2018.11-present: Director, the Department of Science & Technology of Nankai University.

Research interests: Cardiovascular biomaterials and tissue engineering  

(1) Small-diameter artificial blood vessel materials: focusing on the construction of multi-functional active vessel scaffold materials. Biodegradable micro-nano vascular materials were prepared by electrostatic spinning and melt spinning, and the pore structure, fiber orientation, mechanical properties and degradation behavior of vascular materials were designed and optimized. The vascular materials were modified by activity and functionalization to fix growth factors, anticoagulant molecules, endothelial cells to capture molecules and vasoactive substances. Rapid cytalization, endothelialization, medium and outer membrane regeneration were realized. With the complete degradation of the material, the blood vessels are completely regenerated, with the same structure and function as natural blood vessels, maintaining long-term patency.  

(2) Stem cell therapy for ischemic diseases: Stem cell therapy is carried out for common myocardial ischemia, lower limb ischemia, renal ischemia and other diseases, mainly mesenchymal stem cells and induced pluripotent stem cells (iPS); The preparation of stem cell transplantation vector materials, mainly various active hydrogels, regulates the proliferation, differentiation and secretion of stem cells and improves the survival rate of transplanted stem cells. To develop novel molecular probes to trace the behavior, function and fate of transplanted stem cells in vivo. The stem cells were treated with materials and engineering methods to regulate the functions of stem cells, including exosome secretion and exosome function regulation. The functional culture of stem cells was carried out to improve the proliferation ability and anti-apoptosis ability of stem cells. 

(3) Other biological materials, including drug-controlled release, nano-drugs, nano-vaccines, including nerve, skin, cartilage and other tissue repair and regeneration materials.

Scientific research projects:

(1) National Natural Science Foundation of China, Innovative Research Group Project, Tissue and Organ Injury Repair and Regeneration, 81921004, 2020.01-2024.12, 10.5 million RMB. PI: Kong Deling;

(2) Key project of The National Natural Science Foundation of China, bioactive carrier material regulating stem cells and tissue microenvironment for the treatment of acute kidney injury, 81830060, 2019.01.01 -- 2023.12.31, direct expenditure: 2.94 million RMB.  PI: Kong Deling;

(3) National Key RESEARCH and development program project, design, preparation and engineering technology of new responsive intelligent hydrogel, 13.96 million Yuan, 2017YFC1103500, 2017.07-2020.12, direct expenditure: 13.96 million RMB.  PI: Kong Deling;

(4) The key project of the National Natural Science Foundation of China, the construction of bioactive small-caliber artificial blood vessels and the mechanism of inducing angiogenesis. Project Approval No. 81530059, 2016.01-2020.12, Expenditure: 3.26 million RMB.  PI: Kong Deling;

(5) General project of the National Natural Science Foundation of China, study on the enhancement of immunotherapeutic effect of mesenchymal stem cells by engineering culture, 31771066,018.01-2021.12, direct expenditure: 630,000 RMB,  PI: Kong Deling;

(6) Tianjin Key project of science and Technology support, development of new products to enhance vascularized bone repair materials, 16YFZCSY01020, 2016.04-2019.03. Funds 300,000 RMB,  PI: Kong Deling;

(7) National Natural Science Foundation of China international (regional) Cooperation and exchange project, major cooperative research project, molecular imaging tracer stem cell transplantation for myocardial infarction, 81220108015, 2013.01-2017.12. Funds 3 million RMB,  PI: Kong Deling;

(8) Biological and pathological Evaluation of endothelial stem cell capture in small-caliber artificial blood vessel Research, national Natural Science Foundation of China, 81171478, January 2012 -- December 2015. Funds 600,000 YUAN, RMB， PI: Kong Deling;

(9) Key project of National Natural Science Foundation of China, Structure Design and tissue regeneration of Small-caliber blood vessel Materials, Project Approval No. : 50830104, 2009.01-2012.12. Funds 2 million RMB, PI: Kong Deling;

Selected Publication (Recently):

（1）Midgley AC*, Wei Y, Zhu D, Gao F, Yan H, Khalique A, Luo W, Jiang H, Liu X, Guo J, Zhang C, Feng G, Wang K, Bai X, Ning W, Yang C, Zhao Q, Kong D*. Multifunctional Natural Polymer Nanoparticles as Antifibrotic Gene Carriers for CKD Therapy. J Am Soc Nephrol. 2020 Aug 7:ASN.2019111160. 

（2）Ran Zhang, Wenya Luo, Yue Zhang, Dashuai Zhu, Adam C. Midgley, Hao Song, Anila Khalique, Haoqi Zhang, Jie Zhuang, Deling Kong*, Xinglu Huang*. Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases. Science Advances 2020 May 6: eaaz8011.

（3）Hongyu Yan, Xingyan Mi, Adam C. Midgley, Xinchen Du, Ziqi Huang, Tingting Wei, Ruihua Liu, Tengzhi Ma, Dengke Zhi, Dashuai Zhu, Ting Wang, Guowei Feng, Ying Zhao, Weiye Zhang, Ju He, Meifeng Zhu*, Deling Kong*, Kai Wang*. Targeted Repair of Vascular Injury by Adipose‐Derived Stem Cells Modified with P‐Selectin Binding Peptide. Advanced Science, 2020 April 22;1903516, DOI: 10.1002/advs.201903516.

（4）Wu P, Wang L, Li W, Zhang Y, Wu Y, Zhi D, Wang H, Wang L, Kong D*, Zhu M*. Construction of vascular graft with circumferentially oriented microchannels for improving artery regeneration. Biomaterials. 2020 Mar 4;242:119922.

（5）Mao D, Zhang C, Kenry, Liu J, Wang X, Li B, Yan H, Hu F, Kong D*, Wang Z*, Liu B*. Bio-orthogonal click reaction-enabled highly specific in situ cellularization of tissue engineering scaffolds. Biomaterials. 2020 Feb;230:119615.

（6）Gao F, Wu J, Gao H, Hu X, Liu L, Midgley AC, Liu Q, Sun Z, Liu Y, Ding D, Wang Y, Kong D*, Huang X*. Hypoxia-tropic nanozymes as oxygen generators for tumor-favoring theranostics. Biomaterials. 2020 Feb;230:119635.

（7）Zhu M, Li W, Xianhao Dong , Xingyu Yuan , Adam C Midgley, Hong Chang, Yuhao Wang, Haoyu Wang, Kai Wang*, Peter X Ma, Hongjun Wang*,Deling Kong*. In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration. Nature Communications. 2019 Oct 11;10(1):4620. 

（8）Li W, Midgley AC, Bai Y, Zhu M*, Chang H, Zhu W, Wang L, Wang Y, Wang H, Kong D*. Subcutaneously engineered autologous extracellular matrix scaffolds with aligned microchannels for enhanced tendon regeneration: Aligned microchannel scaffolds for tendon repair. Biomaterials. 2019 Dec;224:119488.

（9）Dong X, Yuan X, Wang L, Liu J, Midgley AC, Wang Z, Wang K, Liu J, Zhu M*,Kong D*. Construction of a bilayered vascular graft with smooth internal surface for improved hemocompatibility and endothelial cell monolayer formation. Biomaterials. 2018 Oct;181:1-14.

（10）Zhu M, Wu Y, Li W, Dong X, Chang H, Wang K, Wu P, Zhang J, Fan G, Wang L, Liu J, Wang H*, Kong D*. Biodegradable and elastomeric vascular grafts enable vascular remodeling. Biomaterials. 2018 Nov;183:306-318.

（11）Yang P, Song H, Qin Y, Huang P, Zhang C, Kong D*, Wang W*. Engineering Dendritic-Cell-Based Vaccines and PD-1 Blockade in Self-Assembled Peptide Nanofibrous Hydrogel to Amplify Antitumor T-Cell Immunity. Nano Lett. 2018 Jul 11;18(7):4377-4385. 

（12）Duo Mao, Fang Hu, Kenry, Shenglu Ji, Wenbo Wu, Dan Ding, Deling Kong*, Bin Liu*. Metal-organic framework-assisted in vivo bacterial metabolic labeling and precise antibacterial therapy. Advanced Materials.2018 May;30(18):e1706831.

（13）Huijuan Song, Pingsheng Huang, Jinfeng Niu, Gaona Shi, Chuangnian Zhang, Deling Kong*, Weiwei Wang*. Injectable polypeptide hydrogel for dual-delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma. Biomaterials 2018 Jan 3;159:119-129.

（14）Mao D, Liu J, Ji S, Wang T, Hu Y, Zheng D*, Yang R, Kong D*, Ding D*. Amplification of near-infrared fluorescence in semiconducting polymer nanoprobe for grasping the behaviors of systemically administered endothelial cells in ischemia treatment. Biomaterials. 2017 Oct;143:109-119.

Scientific Research Awards:

• In 2009, The second prize of National Science and Technology Progress Award, "Creation of high-performance blood Purification medical adsorption resin" (The fourth accomplisher)
  

• 2010 Tianjin Natural Science Second Prize, "Cardiovascular Tissue Engineering Research combining Stem cells and Gene Therapy" (The first accomplisher)
  

• 2014 Tianjin Natural Science First Prize, "Preparation and Biomedical Application of Supramolecular Hydrogel" (The fourth accomplisher)
  

• The second Prize of Tianjin Science and Technology Progress award in 2016, "Basic and Applied Research of New Therapy for Diabetes complicated with Cardiovascular Disease" (The 5th accomplisher)
  

• The Second Prize of Tianjin Natural Science in 2018, "Research on the Molecular Mechanism of Hydrophobic Protein Self-Assembly in Fungi and the Function of Material Surface Modification" (The sixth accomplisher)
  

• The second Prize of Tianjin Science and Technology Progress Award in 2018, "Construction and Application of Nano and hydrogel Carriers for Delivery of Bioactive Substances" (The third accomplisher)
  

• The first Prize of Tianjin Natural Science In 2019, "The Pro-angiogenesis effect of Bioactive Materials in the Treatment of ischemic diseases" (The first accomplisher)
  

• In 2019, the project of Shensuo -- the world's first innovative first-generation neural catheter guiding doctoral students won the gold medal in the fifth China Internet + Innovation and Entrepreneurship Competition for College Students
  

• In 2019, the Cardiovascular biomaterials and Tissue Engineering Team was awarded the Model Group in Tianjin
  

• Executive Director, Chinese Society of Biomedical Engineering
  

• China Biomaterials Society, executive Director

• Vice Chairman, Cardiovascular biomaterials Branch, Chinese Society of Biomaterials

• Standing member, Medical Device Management Professional Committee, China Medical Education Association

• Regional Offices, International Society for Blood Purification

• Vice President of Tianjin Biomedical Engineering Society

• Member of academic Committee, State Key Laboratory of Experimental Hematology
  

• Member of academic Committee, Key Laboratory of Biomechanics and Force Biology, Ministry of Education, Beihang University
  

Elective course for Doctoral and Postgraduate students, Organizational Engineering, 32 hours, second semester.

Teachers: Professor Kong Deling, Associate Professor Wang Kai

Prof.Kong also supervised the doctoral student's project of Shensuo -- the world's First innovative first-generation neural catheter, which won the gold medal in the 5th China Internet+ Innovation and Entrepreneurship Competition for College Students

• In 2007, he won the National Outstanding Youth Science Foundation project

• In 2009, he was selected as the national candidate of the New Century Talent Project
  

• In 2013, he received special government allowance from the State Council
  

• In 2013, he was selected into the innovation team of Cardiovascular Tissue Engineering of the Ministry of Education
  

• In 2016, he was selected as Fellow of The International Union of Biomaterials Science and Engineering
  

• In 2018, he won the honorary title of Advanced Organization of the All-China Overseas Chinese Federation System
  

• In 2019, the National Natural Science Foundation of China launched an innovative research group