马克·巴特拉姆（Mark Gerrard Bartlam），男，国籍：英国，1999年毕业于牛津大学（University of Oxford）分子生物物理专业，获博士学位（D.Phil），2000—2003年在清华大学结构生物学实验室做博士后，2003—2007年任清华大学结构生物学实验室副教授、中科院生物物理所大分子国家重点实验室客座副教授，现任南开大学生命科学学院特聘教授、博士生导师。

目前主要研究方向：与病毒相关蛋白质的结构与功能、与肿瘤相关蛋白质的结构与功能、基于结构的药物发现、蛋白质折叠与疾病。
硕士生、博士生招生专业：生物化学
通讯地址：天津市南开大学生命科学学院 ( 邮政编码 300071)
电子邮件：bartlam@xtal.tsinghua.edu.cn

代表性论文：  
1. Huo, X., Su, D., Wang, A., Zhai, Y., Xu, J., Li, X., Bartlam, M.*, Sun, F. & Rao, Z. (2007) Preliminary molecular characterization and crystallization of mitochondrial respiratory complex II from porcine heart. Febs J 274, 1524-1529.
2. Zheng, W., Sun, F., Bartlam, M., Li, X., Li, R. & Rao, Z. (2007). The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis. J Mol Biol 366, 1447-58.
3. Zhao, Q., Qin, L., Jiang, F., Wu, B., Yue, W., Xu, F., Rong, Z., Yuan, H., Xie, X., Gao, Y., Bai, C., Bartlam, M., Pei, X. & Rao, Z. (2007). Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation. J Biol Chem 282, 647-56.
4. Ye, S., Wu, X., Wei, L., Tang, D., Sun, P., Bartlam, M. & Rao, Z. (2007). An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. J Biol Chem 282, 3391-402.
5. Xue, X., Yang, H., Shen, W., Zhao, Q., Li, J., Yang, K., Chen, C., Jin, Y., Bartlam, M. & Rao, Z. (2007). Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction. J Mol Biol 366, 965-75.
6. Wu, B., Liu, Y., Zhao, Q., Liao, S., Zhang, J., Bartlam, M., Chen, W. & Rao, Z. (2007). Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis. J Mol Biol 367, 1405-12.
7. Liao, X., Li, S., Lou, Z., Chen, Z. & Bartlam, M.* (2007). Crystallization and preliminary crystallographic analysis of transgelin. Protein Pept Lett 14, 209-11.
8. Li, J., Shen, W., Liao, M. & Bartlam, M.* (2007). Preliminary crystallographic analysis of avian infectious bronchitis virus main protease. Acta Crystallograph Sect F Struct Biol Cryst Commun 63, 24-6.
9. Yang, H., Bartlam, M. & Rao, Z. (2006). Drug design targeting the main protease, the Achilles' heel of coronaviruses. Curr Pharm Des 12, 4573-90.
10. Xu, X., Zhai, Y., Sun, F., Lou, Z., Su, D., Xu, Y., Zhang, R., Joachimiak, A., Zhang, X. C., Bartlam, M. & Rao, Z. (2006). New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15. J Virol 80, 7909-17.
11. Su, D., Lou, Z., Sun, F., Zhai, Y., Yang, H., Zhang, R., Joachimiak, A., Zhang, X. C., Bartlam, M. & Rao, Z. (2006). Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10. J Virol 80, 7902-8.
12. Ou, X., Ji, C., Han, X., Zhao, X., Li, X., Mao, Y., Wong, L. L., Bartlam, M. & Rao, Z. (2006). Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1). J Mol Biol 357, 858-69.
13. Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M. & Rao, Z. (2006). Crystal structure of human pyrroline-5-carboxylate reductase. J Mol Biol 359, 1364-77.
14. Meng, Z., Lou, Z., Liu, Z., Hui, D., Bartlam, M. & Rao, Z. (2006). Purification, characterization, and crystallization of human pyrroline-5-carboxylate reductase. Protein Expr Purif 49, 83-7.
15. Lou, Z., Xu, Y., Xiang, K., Su, N., Qin, L., Li, X., Gao, G. F., Bartlam, M. & Rao, Z. (2006). Crystal structures of Nipah and Hendra virus fusion core proteins. Febs J 273, 4538-47.
16. Liang, W., Yang, H., Xue, X., Huang, Q., Bartlam, M.* & Chen, S. (2006). Expression, crystallization and preliminary X-ray studies of the immunoglobulin-like domain 3 of human palladin. Acta Crystallograph Sect F Struct Biol Cryst Commun 62, 556-8.
17. Li, X., Liu, X., Sun, F., Gao, J., Zhou, H., Gao, G. F., Bartlam, M. & Rao, Z. (2006). Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor. Biochem Biophys Res Commun 339, 407-14.
18. Li, X., Chen, Y., Liu, Y., Gao, J., Gao, F., Bartlam, M., Wu, J. Y. & Rao, Z. (2006). Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway. J Biol Chem 281, 28430-7.
19. Li, S., Liao, X., Chen, Z. & Bartlam, M.* (2006). Crystallization and preliminary crystallographic analysis of allograft inflammatory factor 1. Protein Pept Lett 13, 855-8.
20. Zhai, Y., Sun, F., Li, X., Pang, H., Xu, X., Bartlam, M. & Rao, Z. (2005). Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer. Nat Struct Mol Biol 12, 980-6.
21. Yang, H., Xie, W., Xue, X., Yang, K., Ma, J., Liang, W., Zhao, Q., Zhou, Z., Pei, D., Ziebuhr, J., Hilgenfeld, R., Yuen, K. Y., Wong, L., Gao, G., Chen, S., Chen, Z., Ma, D., Bartlam, M. & Rao, Z. (2005). Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol 3, e324.
22. Wang, H., Pang, H., Bartlam, M. & Rao, Z. (2005). Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity. J Mol Biol 348, 917-26.
23. Sun, L., Bartlam, M., Liu, Y., Pang, H. & Rao, Z. (2005). Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver. Protein Sci 14, 791-8.
24. Sun, F., Huo, X., Zhai, Y., Wang, A., Xu, J., Su, D., Bartlam, M. & Rao, Z. (2005). Crystal structure of mitochondrial respiratory membrane protein complex II. Cell 121, 1043-57.
25. Dong, Y. J., Bartlam, M.★, Sun, L., Zhou, Y. F., Zhang, Z. P., Zhang, C. G., Rao, Z. & Zhang, X. E. (2005). Crystal structure of methyl parathion hydrolase from Pseudomonas sp. WBC-3. J Mol Biol 353, 655-63.
26. Bartlam, M.★, Yang, H. & Rao, Z. (2005). Structural insights into SARS coronavirus proteins. Curr Opin Struct Biol 15, 664-72.
27. Wu, B., Li, P., Liu, Y., Lou, Z., Ding, Y., Shu, C., Ye, S., Bartlam, M., Shen, B. & Rao, Z. (2004). 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. Proc Natl Acad Sci U S A 101, 8348-53.
28. Shi, N., Ye, S., Bartlam, M., Yang, M., Wu, J., Liu, Y., Sun, F., Han, X., Peng, X., Qiang, B., Yuan, J. & Rao, Z. (2004). Structural basis for the specific recognition of RET by the Dok1 phosphotyrosine binding domain. J Biol Chem 279, 4962-9.
29. Pang, H., Liu, Y., Han, X., Xu, Y., Jiang, F., Wu, D., Kong, X., Bartlam, M. & Rao, Z. (2004). Protective humoral responses to severe acute respiratory syndrome-associated coronavirus: implications for the design of an effective protein-based vaccine. J Gen Virol 85, 3109-13.
30. Pang, H., Bartlam, M.★, Zeng, Q., Miyatake, H., Hisano, T., Miki, K., Wong, L. L., Gao, G. F. & Rao, Z. (2004). Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. J Biol Chem 279, 1491-8.
31. Liu, B., Li, X., Gao, R., Zhou, W., Xie, G., Bartlam, M., Pang, H., Feng, Y. & Rao, Z. (2004). Crystallization and preliminary X-ray analysis of inorganic pyrophosphatase from the hyperthermophilic archaeon Pyrococcus horikoshii OT3. Acta Crystallogr D Biol Crystallogr 60, 577-9.
32. Liu, B., Bartlam, M.★, Gao, R., Zhou, W., Pang, H., Liu, Y., Feng, Y. & Rao, Z. (2004). Crystal structure of the hyperthermophilic inorganic pyrophosphatase from the archaeon Pyrococcus horikoshii. Biophys J 86, 420-7.
33. Han, X., Bartlam, M., Jin, Y. H., Liu, X., He, X., Cai, X., Xie, Q. & Rao, Z. (2004). The expression of SARS-CoV M gene in P. Pastoris and the diagnostic utility of the expression product. J Virol Methods 122, 105-11.
34. Bartlam, M.★, Wang, G., Yang, H., Gao, R., Zhao, X., Xie, G., Cao, S., Feng, Y. & Rao, Z. (2004). Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1. Structure 12, 1481-8.
35. Zhang, X., Roe, S. M., Hou, Y., Bartlam, M., Rao, Z., Pearl, L. H. & Danpure, C. J. (2003). Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1. J Mol Biol 331, 643-52.
36. Zeng, Q., Li, X., Bartlam, M., Wang, G., Pang, H. & Rao, Z. (2003). Purification, crystallization and preliminary X-ray analysis of human pirin. Acta Crystallogr D Biol Crystallogr 59, 1496-8.
37. Yang, H., Yang, M., Ding, Y., Liu, Y., Lou, Z., Zhou, Z., Sun, L., Mo, L., Ye, S., Pang, H., Gao, G. F., Anand, K., Bartlam, M., Hilgenfeld, R. & Rao, Z. (2003). The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A 100, 13190-5.
38. Wang, G., Guo, R., Bartlam, M.★, Yang, H., Xue, H., Liu, Y., Huang, L. & Rao, Z. (2003). Crystal structure of a DNA binding protein from the hyperthermophilic euryarchaeon Methanococcus jannaschii. Protein Sci 12, 2815-22.
39. Sun, F., Li, P., Ding, Y., Wang, L., Bartlam, M., Shu, C., Shen, B., Jiang, H., Li, S. & Rao, Z. (2003). Design and structure-based study of new potential FKBP12 inhibitors. Biophys J 85, 3194-201.
40. He, H., Ding, Y., Bartlam, M.★, Sun, F., Le, Y., Qin, X., Tang, H., Zhang, R., Joachimiak, A., Liu, J., Zhao, N. & Rao, Z. (2003). Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation. J Mol Biol 325, 1019-30.
41. Guo, Q., Zhou, W., Too, H. M., Li, J., Liu, Y., Bartlam, M., Dong, Y., Wong, K. B., Shaw, P. C. & Rao, Z. (2003). Substrate binding and catalysis in trichosanthin occur in different sites as revealed by the complex structures of several E85 mutants. Protein Eng 16, 391-6.
42. Ding, Y., Too, H., Wang, Z., Liu, Y., Bartlam, M., Dong, Y., Wong, K., Shaw, P. & Rao, Z. (2003). The structural basis of Trp192 and the C-terminal region in trichosanthin for activity and conformational stability. Protein Eng 16, 351-6.
43. Zhang, H., Wang, Z., Ding, Y., Wang, G., Wang, X., Bartlam, M., Tang, H., Liu, Y., Jiang, F., Barraclough, R., Rudland, P. S. & Rao, Z. (2002). Crystallization and preliminary crystallographic analysis of a metastasis-inducing protein, human S100A4. Acta Crystallogr D Biol Crystallogr 58, 127-9.
44. Yu, M., Wang, E., Liu, Y., Cao, D., Jin, N., Zhang, C. W., Bartlam, M., Rao, Z., Tien, P. & Gao, G. F. (2002). Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of Newcastle disease virus. J Gen Virol 83, 623-9.
45. Wang, G., Guo, R., Bartlam, M., Xue, H., Yang, H., Liu, Y., Huang, L. & Rao, Z. (2002). Expression, purification, crystallization and preliminary X-ray analysis of a DNA-binding protein from Methanococcus jannaschii. Acta Crystallogr D Biol Crystallogr 58, 1240-2.
46. Shi, N., Zhou, W., Tang, K., Gao, Y., Jin, J., Gao, F., Peng, X., Bartlam, M., Qiang, B., Yuan, J. & Rao, Z. (2002). Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein. Acta Crystallogr D Biol Crystallogr 58, 2170-2.
47. Lin, W., Zhao, Q., Bartlam, M., Ding, Y., Li, D., Chen, Y., Bao, H., Xie, Q. & Rao, Z. (2002). Purification, crystallization and X-ray analysis of swine vesicular disease virus. Acta Crystallogr D Biol Crystallogr 58, 1056-8.
48. Jin, J., Chen, X., Zhou, Y., Bartlam, M., Guo, Q., Liu, Y., Sun, Y., Gao, Y., Ye, S., Li, G., Rao, Z., Qiang, B. & Yuan, J. (2002). Crystal structure of the catalytic domain of a human thioredoxin-like protein. Eur J Biochem 269, 2060-8.
49. Chen, Y., Song, G., Jiang, F., Feng, L., Zhang, X., Ding, Y., Bartlam, M., Yang, A., Ma, X., Ye, S., Liu, Y., Tang, H., Song, H. & Rao, Z. (2002). Crystal structure of a staphylokinase: variant a model for reduced antigenicity. Eur J Biochem 269, 705-11.
50. Chen, Y., Shao, R., Bartlam, M., Li, J., Jin, L., Gao, Y., Liu, Y., Tang, H., Zhen, Y. & Rao, Z. (2002). Crystallization and preliminary X-ray crystallographic studies of a macromolecular antitumour antibiotic, C1027. Acta Crystallogr D Biol Crystallogr 58, 173-5.
51. Wang, Z., Zhang, H., Ding, Y., Wang, G., Wang, X., Ye, S., Bartlam, M., Tang, H., Liu, Y., Jiang, F., Barraclough, R., Rudland, P. S. & Rao, Z. (2001). Preliminary X-ray crystallographic analysis of a Ca2+-binding protein human S100A1. Acta Crystallogr D Biol Crystallogr 57, 882-3.
52. He, H., Ding, Y., Cao, Z., Shao, Y., Bartlam, M., Tang, H., Jiang, F., Liu, Y., Liu, J., Zhao, N. & Rao, Z. (2001). Crystallization and preliminary X-ray crystallographic analysis of native and selenomethionyl recombinant tabtoxin-resistance protein complexed with acetyl-coenzyme A. Acta Crystallogr D Biol Crystallogr 57, 1729-31.
53. Sunde, M., Serpell, L. C., Bartlam, M., Fraser, P. E., Pepys, M. B. & Blake, C. C. (1997). Common core structure of amyloid fibrils by synchrotron X-ray diffraction. J Mol Biol 273, 729-39.
★ denotes first author; * denotes corresponding author.