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白芳

 性    别:女
 职    称:副教授
 所属部门:微生物学系
 招生专业:
 研究方向:病原微生物,抗菌药物研发,细菌III型分泌系统应用
::教师简介::
教育经历
  2003-2008  南开大学生命科学学院,微生物专业,博士
  1999-2003  吉林大学生命科学学院,生物制药专业,学士
工作经历
  2016-至今  南开大学生命科学学院,副教授
  2013-2015  美国佛罗里达大学医学院,访问学者
  2008-2012  南开大学药学院,讲师

研究兴趣
  抗菌药物研发及抗菌机制研究
  细菌III型蛋白质分泌系统的研究及其应用

通讯地址:南开大学八里台校区生物楼317室 (邮政编码:300071)
E-mail: baifang1122@nankai.edu.cn

代表性论文

通讯或第一作者(*)
1.	F Bai, CH Lim, J Jia, KE Santostefano, C Simmons, H Kasahara, N Terada, S Jin. Directed Differentiation of Embryonic Stem Cells into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors. Scientific Reports, 2015, 5, 15014.
2.	AT Garrison*, F Bai*, Y Abouelhassan, NG Paciaroni, S Jin, RW Huigens III. Bromophenazine derivatives with potent inhibition, dispersion and eradication activities against Staphylococcus aureus biofilms. RSC Advances, 2015, 5 (2), 1120-1124.
3.	J Jia*, F Bai*, Y Jin, KE Santostefano, UH Ha, D Wu, W Wu, N Terada, S Jin. Efficient Gene Editing in Pluripotent Stem Cells by Bacterial Injection of Transcription Activator-Like Effector Nuclease Proteins. Stem cells translational medicine, 2015, 4(8): 913-926.
4.	X Cao, C Zhang, Y Dong, P Geng, F Bai*, G Bai. Modeling of Cooked Starch Digestion Process Using Recombinant Human Pancreatic α-Amylase and Maltase-Glucoamylase for in vitro Evaluation of α-Glucosidase Inhibitors. Carbohydrate Research, 2015, 414, 15-21.
5.	Y Liu, L Ren, L Ge, Q Cui, X Cao, Y Hou, F Bai*, G Bai. A strategy for fusion expression and preparation of functional glucagon-like peptide-1 (GLP-1) analogue by introducing an enterokinase cleavage site. Biotechnology letters, 2014, 36 (8), 1675-1680.
6.	P Meng, C Xie, P Geng, X Qi, F Zheng, F Bai*. Inhibitory Effect of Components from Streptomyces Species on α-Glucosidase and α-Amylase of Different Origin. Applied Biochemistry and Microbiology, 2013, 49(2): 160–168.
7.	L Wang, Y Hou, J Peng, X Qi, F Bai*, G Bai. Bioactivity-Based HPLC Tandem Q/TOF for Alpha-Glucosidase Inhibitors. Screening, Identification, and Quantification from Actinomycetes. Latin American Journal of Pharmacy, 2012, 31 (5): 693-698.
8.	F Bai, H Xu, Q Zhang, X Qi, R Mou, G Bai, M Qiao. Functional characterization of pfm in protein secretion and lung infection of Pseudomonas aeruginosa. Canadian Journal of Microbiology, 2011, 57: 829-837.
9.	P Meng, Y Guo, Q Zhang, J Hou, F Bai*, P Geng, G Bai. A novel amino-oligosaccharide isolated from the culture of Streptomyces strain PW638 is a potent inhibitor of α-amylase. Carbohydrate Research, 2011, 346: 1898-1902.
10.	L Ren, X Cao, P Geng, F Bai*, G Bai. Study of the inhibition of two human maltase-glucoamylases catalytic domains by different α-glucosidase inhibitors. Carbohydrate Research, 2011, 346: 2688-2692.
11.	F Bai, Y Li, H Xu, H Xia, T Yin, H Yao, L Zhang, X Zhang, Y Bai, S Jin, M Qiao. Identification and functional characterization of pfm, a novel gene involved in swimming motility of Pseudomonas aeruginosa. Gene, 2007, 401: 19-27.

合作论文:
1.	AT Garrison, Y Abouelhassan, VM Norwood, D Kallifidas, F Bai, M Nguyen, M Rolfe, GM Burch, S Jin, H Luesch, RW Huigens III. Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines that Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. J. Med. Chem., 2016, 59(8): 3808-3825.
2.	A Basak, Y Abouelhassan, VM Norwood, F Bai, M Nguyen, S Jin, RW Huigens III. Synthetically Tuning the 2-Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways. Chemistry–A European Journal, 2016, 22 (27), 9181-9189.
3.	M Li, Y Long, Y Liu, Y Liu, R Chen, J Shi, L Zhang, Y Jin, L Yang, F Bai, S Jin, Z Cheng, W Wu. HigB of Pseudomonas aeruginosa enhances killing of phagocytes by up-regulating the type III secretion system in ciprofloxacin induced persister cells. Frontiers in Cellular and Infection Microbiology, 2016, 125.
4.	H Tan, L Zhang, Q Zhao, R Chen, C Liu, Y Weng, Q Peng, F Bai, Z Cheng, S Jin, W Wu, Y Jin. DeaD contributes to Pseudomonas aeruginosa virulence in a mouse acute pneumonia model. FEMS Microbiology Letters, 2016, 363.
5.	J Yang, XP Xu, M Li, F Bai, Q Zhang. Construction and Application of Strains that Constitutively Express the Arginase I Gene. Applied Biochemistry and Microbiology 2016, 52 (2), 149-152.
6.	Y Abouelhassan, AT Garrison, F Bai, VM Norwood, M Nguyen, S Jin, RW Huigens III. A Phytochemical-Halogenated Quinoline Combination Therapy Strategy for the Treatment of Pathogenic Bacteria. ChemMedChem, 2015, 10, 1157-1162. 
7.	Y Li, F Bai, H Xia, L Zhuang, H Xu, Y Jin, X Zhang, Y Bai, M Qiao. A novel regulator PA5022 (aefA) is involved in swimming motility, biofilm formation and elastase activity of Pseudomonas aeruginosa. Microbiological Research, 2015, 176, 14-20.
8.	AT Garrison, Y Abouelhassan, D Kallifidas, F Bai, M Ukhanova, V Mai, S Jin, H Luesch, RW Huigens III. Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis. Angew. Chem. 2015, 127, 15032-15036.
9.	D Neeld, Y Jin, C Bichsel, J Jia, J Guo, F Bai, W Wu, UH Ha, N Terada, S Jin. Pseudomonas aeruginosa injects NDK into host cells through a type III secretion system. Microbiology, 2014, 160 (Pt 7), 1417-1426.
10.	NV Borrero, F Bai, C Perez, BQ Duong, JR Rocca, S Jin, RW Huigens III. Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents against Staphylococcus aureus and Staphylococcus epidermidis. Organic & biomolecular chemistry, 2014, 12 (6), 881-886.
11.	L Wang, Q Cui, Y Hou, F Bai, J Sun, X Cao, P Liu, M Jiang, G Bai. An integrated strategy of ultra-high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and virtual screening for the identification of α-glucosidase inhibitors in acarviostatin-containing complex. Journal of Chromatography A, 2013, 1319, 88-96.
12.	P Pan, Q Zhang, J Hou, Z Liu, F Bai, M Cao, T Sun, G Bai. Cell Surface Glycoprotein Profiling of Cancer Cells based on Bioorthogonal Chemistry. Analytical and Bioanalytical Chemistry. 2012; 403(6):1661-70.
13.	X Guo, P Geng, F Bai, G Bai, T Sun, X Li, L Shi, Q Zhong. Draft genome sequence of Streptomyces coelicoflavus ZG0656 reveals the putative biosynthetic gene cluster of acarviostatin family a-amylase inhibitors. Letters in Applied Microbiology. 2012, 55: 162-169.
14.	R Mou, F Bai, Q Duan, X Wang, H Xu, Y Bai, X Zhang, S Jin, M Qiao. Mutation of pfm affects the adherence of Pseudomonas aeruginosa to host cells and the quorum sensing system. FEMS Microbiology Letters, 2011, 324(2):173-80.
15.	X Qin, L Ren, X Yang, F Bai, L Wang, P Geng, G Bai, Y Shen. Structures of human pancreatic a-amylase in complex with acarviostatins: Implications for drug design against type II diabetes. Journal of Structural Biology, 2011, 174: 196-202.
16.	L Ren, X Qin, X Cao, L Wang, F Bai, G Bai, Y Shen. Structural insight into substrate specificity of human intestinal maltase-glucoamylase. Protein & Cell, 2011, 2(10): 827–836.
17.	J Hou, Q Zhang, X Li, Y Tang, M Cao, F Bai, Q Shi, C Yang, D Kong, G Bai. Synthesis of novel folate conjugated fluorescent nanoparticles for tumor imaging. Journal of Biomedical Materials Research A, 2011, 99(4): 684-689.
::主要学术论文::
::主要科研项目::