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陈凌懿

 性    别:男
 职    称:教授
 所属部门:遗传学和细胞生物学系
 招生专业:细胞生物学
 研究方向:■ 小鼠胚胎早期发育中转录编程的调控机制;■ 胚胎干细胞的发育多能性的分子机制;■ 建立诱导
::教师简介::
1999        北京大学  学士
2004        美国西北大学  博士
2005--2008  美国哈佛大学  博士后
2008--      南开大学生命科学学院  教授、博导
2016        优秀青年科学基金
1999    B.S.   Peking University
2004    Ph.D.  Northwestern University, USA	
2005--2008     Harvard Medical School, Postdoctoral Fellow
2008--         Nankai University, Professor


Selected Publications 

1. Yu Y, Liu C, Zhang J, Zhang M, Wen W, Ruan X, Li D, Zhang S, Gao M*, and Chen L.* (2017) Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function. Sci Rep. 7:43396.
2. Liu C, Yu Y, Yin G, Zhang J, Wen W, Ruan X, Li D, Zhang S, Cai W, Gao M*, and Chen L.* (2017) C14orf93 (RTFC) is identified as a novel susceptibility gene for familial nonmedullary thyroid cancer. Biochem Biophys Res Commun.  482:590-596.
3. Ma X, Chen H, and Chen L.* (2016) A dual role of Erk signaling in embryonic stem cells. Exp Hematol,  44:151-156.
4. Zhang W, Ni P, Mou C, Zhang, Y, Guo H, Zhao T, Loh YH*, and Chen L.* (2016) Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription. Sci Rep, 6:26804.
5. Liu C, Chen H, Liu L*, and Chen L.* (2015) RNA sequencing analysis to demonstrate Erk dependent and independent functions of Mek. Genom Data, 7:73-75.
6. Chen H, Guo R, Zhang Q, Guo H, Yang M, Wu Z, Gao S, Liu L*, and Chen L.* (2015) Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A, 112(44): E5936-5943.
7. Yang BX, El Farran CA, Guo HC, Yu T, Fang HT, Wang HF, Schlesinger S, Seah YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L, Gunaratne J, Collins JJ, Goff SP, Daley GQ, Li H, Bard FA, and Loh YH. (2015) Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. Cell, 163(1):  230-245.
8. Zhao T, Liu C, and Chen L.* (2015) Roles of Klf5 Acetylation in the Self-Renewal and the Differentiation of Mouse Embryonic Stem Cells. PLoS One, 10(9): e0138168.
9. Wang D, Meng Q, Huo L, Yang M, Wang L, Chen X, Wang J, Li Z, Ye X, Liu N, Li Q, Dai Z, Ouyang H, Li N, Zhou J*, Chen L*, and Liu L.* (2015) Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice. Protein Cell, 6: 152-156
10. Mou C, Zhang Y, Zhang W, Ding Y, and Chen L.* (2014) Lysine residues 639 and 673 of mouse Ncoa3 are ubiquitination sites for the regulation of its stability. Acta Biochim Biophys Sin (Shanghai), 46: 1066-1071
11. Zhao T, Wu Z, Wang S, and Chen L.*  (2014) Expression and function of natural antisense transcripts in mouse embryonic stem cells. Sci China Life Sci, 57: 1183-1190
12. Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe D L, Gagos S, Xiao A, and Liu L.  (2014) Rif1 Maintains Telomere Length Homeostasis of ESCs by Mediating Heterochromatin Silencing. Dev Cell, 29: 7-19
13. Ni P, Zhang Q, Chen H, Chen L*. (2014 ) Inactivation of an integrated antibiotic resistance gene in mammalian cells to re-enable antibiotic selection. BioTechniques. 56(4):198-201.
14. Liu F, You X, Wang Y, Liu Q, Liu Y, Zhang S, Chen L*, Zhang X*, Ye L.* (2014) “The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF.” Carcinogenesis. 35:1144-1153.
15. Liu H, Wu Z, Shi X, Li W, Liu C, Wang D, Ye X, Liu L, Na J*, Cheng H*, Chen L*. (2013). Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryo compaction. Dev Biol. 375(1):13-22.
16. Chen L*and Zhang L. (2012). A Balanced Network: Transcriptional Regulation in Pluripotent Stem Cells. J Stem Cell Res Ther. 0004.
17. Wu Z, Yang M, Liu H, Guo H, Wang Y, Cheng H, Chen L*. (2012). Role of Nuclear Receptor Coactivator 3 (Ncoa3) in Pluripotency Maintenance. Journal of Biological Chemistry. 287 (45) 38295-38304.
18. Liu H, Hu Y, Wang H, Wang J, Kong D, Wang L, Chen L* and Yang Z.* (2011). A Thixotropic Molecular Hydrogel Selectively Enhances Flk1 Expression in Differentiated Murine Embryonic Stem Cells. Soft Matter. 7:5430-5436.
19. Chen L*, Wang D, Wu Z, Ma L, and Daley G.Q.* (2010). Molecular basis of the first cell fate determination in mouse embryogenesis. Cell Res. 20:982-993.
20. Lee K. H, Li M, Michalowski A. M, Zhang X, Liao H, Chen L, Xu Y, Wu X and Huang J. (2010). A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. Proc Natl Acad Sci U S A 107: 69-74.
21. Chen L* and Liu L. (2009). Current progress and prospects of induced pluripotent stem cells. Sci China C Life Sci 52: 622-636.
22. Chen L, Yabuuchi A, Eminli S, Takeuchi A, Lu C. W, Hochedlinger K and Daley G. Q. (2009). Cross-regulation of the Nanog and Cdx2 promoters. Cell Res 19: 1052-1061.
23. Chen L and Daley G. Q. (2008). Molecular basis of pluripotency. Hum Mol Genet 17: R23-27.
24. Chen L and Widom J. (2005). Mechanism of transcriptional silencing in yeast. Cell 120: 37-48.

联系方式/contact                                                                               
电话/Tel: 86-22-23505821     传真/ Fax: 86-22-23505821       E-mail: lingyichen@nankai.edu.cn
实验室主页: chenly-lab.org
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