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丁丹

 性    别:男
 职    称:研究员
 所属部门:生物化学和分子生物学系
 招生专业:
 研究方向:纳米药物与分子影像探针
::教师简介::
丁丹课题组主要从事新型分子影像探针以及纳米药物的设计、制备和生物医疗应用。课题组基于“聚集诱导发光”材料、半导体共轭高分子等新型材料构建生物探针,应用于肿瘤、组织缺血等重要疾病的诊断与治疗。
Lab home page: www.dinglab.net

Dan Ding obtained his Bsc. in Chemistry (2005) and DPhil. (2010) in Polymer Chemistry and Physics from Nanjing University, where his DPhil was supervised by Professor Xiqun Jiang. After a postdoctoral training with Professor Bin Liu in the Department of Chemical & Biomolecular Engineering in National University of Singapore, he joined Nankai University in March 2013, where he is currently an associate professor in the College of Life Sciences and State Key Laboratory of Medicinal Chemical Biology. In 2013, he was selected in the Tianjin 1,000 Young Talents Plan. In 2014, he was selected in the 100 Young Academic Leaders Plan in Nankai University. In 2016, he was obtained the China National Science Fund for Excellent Young Scientists. His current research interest focuses on the design and preparation of nanomedicines and new molecular imaging probes as well as exploration of their biomedical applications. To date, he has published around 36 papers as the corresponding/first author in the journals such as Acc Chem Res, Adv Mater and ACS Nano. His h-Index is 27 (December 2016).

主持科研项目:
1. 国家自然科学基金优秀青年项目“荧光材料与分子探针”。 经费:150万;执行年限:2017.01-2019.12;项目批准号:51622305;
2. 国家自然科学基金面上项目“具有“聚集诱导发光”性质的多功能纳米生物探针的制备及其生物医学应用”。 经费:29.8万;执行年限:2016.01-2017.12;项目批准号:31571011;
3. 国家自然科学基金青年项目“基于共轭高分子的生物探针的制备及其应用于干细胞示踪的研究”。 经费:23万;执行年限:2014.01-2016.12;项目批准号:81301311;
4. 天津市自然科学基金一般项目“纳米结构形成诱导的荧光开启用于生物分子检测的研究”。 经费:10万;执行年限:2015.04-2018.03;项目批准号:15JCYBJC29800。

Publications after joining Nankai University:
1.	Song, Z.; Mao, D.; Sung, S. H. P.; Kwok, R. T. K.; Lam, J. W. Y.; Kong, D.; Ding, D.;* Tang, B. Z.* Activatable Fluorescent Nanoprobe with Aggregation-Induced Emission Characteristics for Selective In Vivo Imaging of Elevated Peroxynitrite Generation, Adv. Mater. 2016, 28, 7249-7256.
2.	Zhu, H.; Fang, Y.; Zhen, X.; Wei, N.; Gao, Y.; Luo, K. Q.; Xu, C.; Duan, H.; Ding, D.;* Chen, P.;* Pu, K.* Multilayered Semiconducting Polymer Nanoparticles with Enhanced NIR Fluorescence for Molecular Imaging in Cells, Zebrafish and Mice. Chem. Sci. 2016, 7, 5118-5125.
3.	Han, A.; Wang, H.; Kwok, R. T. K.; Ji, S.; Li, J.; Kong, D.; Tang, B. Z.; Liu, B.;* Yang, Z.;* Ding, D.* Peptide-Induced AIEgen Self-Assembly: A New Strategy to Realize Highly Sensitive Fluorescent Light-Up Probes, Anal. Chem. 2016, 88, 3872-3878.
4.	Chen, C.; Hua, Y.; Hu, Y.; Fang, Y.; Ji, S.; Yang, Z.; Ou, C.;* Kong, D.;* Ding, D.* Far-Red/Near-Infrared Fluorescence Light-Up Probes for Specific In Vitro and In Vivo Imaging of a Tumour-Related Protein, Sci. Rep. 2016, 6, 23190.
5.	Ding, D.; Kwok, R. T. K.; Yuan, Y.; Feng, G.; Tang, B. Z.;* Liu, B.* A Fluorescent Light-Up Nanoparticle Probe with Aggregation-Induced Emission Characteristics and Tumor-Acidity Responsiveness for Targeted Imaging and Selective Suppression of Cancer Cells, Mater. Horiz. 2015, 2, 100-105.
6.	Jin, G.; Mao, D.; Cai, P.; Liu, R.; Tomczak, N.; Liu, J.; Chen, X.; Kong, D.; Ding, D.;* Liu, B.;* Li, K.* Conjugated Polymer Nanodots as Ultrastable Long-Term Trackers to Understand Mesenchymal Stem Cell Therapy in Skin Regeneration. Adv. Funct. Mater. 2015, 25, 4263-4273.
7.	Chen, G.; Hua, Y.; Ou, C.; Zhang, X.; Mao, D.; Yang, Z.; Ding, D.;* Chen, M.* Nanostructure Formation-Induced Fluorescence Turn-On for Selectively Detecting Protein Thiols in Solutions, Bacteria and Live Cells. Chem. Commun. 2015, 51, 10758-10761.
8.	Xue, Q.; Ren, H.; Xu, C.; Wang, G.; Ren, C.; Hao, J.;* Ding, D.* Nanospheres of Doxorubicin as Cross-Linkers for a Supramolecular Hydrogelation. Sci. Rep. 2015, 5, 8764.
9.	Wang, H.; Mao, D.; Wang, Y.; Wang, K.; Yi, X.; Kong, D.; Yang, Z.; Liu, Q.;* Ding, D.* Biocompatible Fluorescent Supramolecular Nanofibrous Hydrogel for Long-Term Cell Tracking and Tumor Imaging Application. Sci. Rep. 2015, 5, 16680.
10.	Yang, C.; Chu, L.; Zhang, Y.; Shi, Y.; Liu, J.; Liu, Q.; Fan, S.; Yang, Z.; Ding, D.;* Kong, D.;* Liu, J.* Dynamic Biostability, Biodistribution, and Toxicity of L/D-Peptide-Based Supramolecular Nanofibers. ACS Appl. Mater. Interfaces 2015, 7, 2735-2744.
11.	Tian, R.; Wang, H.; Niu, R.;* Ding, D.* Drug Delivery with Nanospherical Supramolecular Cell Penetrating Peptide-Taxol Conjugates Containing a High Drug Loading. J. Colloid. Interface Sci. 2015, 453, 15-20.
12.	Zhang, J.; Wang, G.; Mao, D.; Han, A.; Xiao, N.; Qi, X.;* Ding, D.;* Kong, D. Targeted In Vivo Imaging of Mouse Hindlimb Ischemia Using Fluorescent Gelatin Nanoparticles. J. Nanomater. 2015, 704817.
13.	Ding, D.; Mao, D.; Li, K.; Wang, X.; Qin, W.; Liu, R.; Chiam, D. S.; Tomczak, N.; Yang, Z.; Tang, B. Z.;* Kong, D.;* Liu, B.* Precise and Long-Term Tracking of Adipose-Derived Stem Cells and Their Regenerative Capacity via Superb Bright and Stable Organic Nanodots, ACS Nano 2014, 8, 12620-12631.
14.	Wang, H.; Liu, J.; Han, A.; Xiao, N.; Xue, Z.; Wang, G.; Long, J.; Kong, D.; Liu, B.;* Yang, Z.;* Ding, D.* Self-Assembly-Induced Far-Red/Near-Infrared Fluorescence Light-up for Detecting and Visualizing Specific Protein-Peptide Interactions, ACS Nano 2014, 8, 1475-1484.
15.	Liu, J. F.; Liu, J. J.; Chu, L. P.; Zhang, Y. M.; Xu, H. Y.; Kong, D. L.; Yang, Z. M.; Yang, C. H.;* Ding, D.* Self-Assembling Peptide of D-Amino Acids Boosts Selectivity and Antitumor Efficacy of 10-Hydroxycamptothecin, ACS Appl. Mater. Interfaces 2014, 6, 5558-5565.
16.	Shi, Y.; Zhou, H.; Zhang, X.; Wang, J.; Long, J.; Yang, Z.;* Ding, D.* Self-Assembling Choline Mimicks with Enhanced Binding Affinities to C-LytA Protein, Sci. Rep. 2014, 4: 6621.
17.	Wang, W.; Li, G; Zhang, W.; Gao, J.; Zhang, J.; Li, C.;* Ding, D.* Kong, D., Reduction-Triggered Formation of EFK8 Molecular Hydrogel for 3D Cell Culture, RSC Adv. 2014, 4, 30168-30171.
18.	Zhang, X.; Zhou, H.; Xie, Y.; Ren, C.; Ding, D.;* Long, J.;* Yang Z.* Rational Design of Multifunctional Hetero-Hexameric Proteins for Hydrogel Formation and Controlled Delivery of Bioactive Molecules, Adv. Healthcare Mater. 2014, 3, 1804-1811.
::主要学术论文::
::主要科研项目::