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冯喜增

 性    别:男
 职    称:教授
 所属部门:生物化学和分子生物学系
 招生专业:生物化学与分子生物学,化学
 研究方向:新材料学、纳米生物学
::教师简介::
学习与工作经历:
    冯喜增,博士、教授、博士研究生导师,1990年至1996年在南开大学化学系,获理学硕士和理学博士学位;1996年至2003年分别在中国科学院化学研究所、美国、英国从事博士后研究;2003年回国,被聘为南开大学特聘教授。

研究方向:
    ① 新材料学—构建新的软物质、非病毒类基因载体、生物活性界面材料等,研究探讨其结构与功能特性间的科学问题。
    ② 纳米生物学—研究核酸、蛋白质-核酸相互作用的结构生物学与功能;生物大分子、细胞的结构与功能;利用微制作等技术探讨蛋白质和细胞在固/液界面的粘附、细胞在表面分化等生物医学等的基本科学问题。

联系方式:
    通信地址: 天津市南开区卫津路94号,南开大学分子生物学研究所126室,邮编300071;
    电话/传真:022-2350-7022(O); 电子邮箱; xzfeng@nankai.edu.cn  

教学任务:
    ① 本科生教学---结构生物学 36学时;
    ② 研究生教学---纳米生物技术研究进展 36学时;

在研科学基金项目:
    1.国自然重点:基于新型感知方法的多维大跨度纳米操控方法研究,2017年-2021年,469.8万元;
    2.国自然联合基金项目-重点:面向药物筛选的单细胞自动化微纳操控与同步检测方法研究,2017年-2020年,354.4万元;
    3.国自然面上:基于斑马鱼模型探讨熄风胶囊治疗癫痫的时-量-效-毒关系,2017年-2020年,80.29万元;
    4.天津市应用基础及前沿-重点项目:仿生界面材料的构筑与应用研究,2010年4月至2013年3月,20万元;
    5.国家自然科学基金—面上项目:微制作技术构建组织工程神经支架的研究,2011年1月至2013年12月,35万元;
    6.国家自然科学基金科学仪器基础研究专项基金项目:面向生命科学的跨尺度快速AFM系统研制,2012年1月-2015年12月,280万元;
2016年发表的主要论文:
1.Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2- hydroxyacetophenone),Jiajia Jiao1,*, Lili Sun2,*, Zaiyu Guo3,*, Sen Hou2, Robert Holyst2, Yun Lu3 & Xizeng Feng,Scientific reports
1DOI: 10.1038/srep38973.(Impact Factor =5.228)
2. Biostable L?DNA-Templated Aptamer-Silver Nanoclusters for Cell-Type-Specific Imaging at Physiological Temperature,Gui-Mei Han,?,?,∥ Zhen-Zhen Jia,?,§,∥ Yan-Jun Zhu,?,?,∥ Jia-Jia Jiao,?,§ De-Ming Kong,*,?,?and Xi-Zeng Feng*,?,§,Analytical chemistry ,2016, 88, 10800?10804.(Impact Factor =5.886)
3.SiO2 nanoparticles cause depression and anxiety-like behavior in adult zebrafish,Xiang Li,1,? Xiaodong Liu,1,? Teng Li,2,? Xu Li,3,? Daofu Feng,4,? Xiangyu Kuang,1, ? Jia Xu3, Xin Zhao,2 Mingzhu Sun,2,* Dongyan Chen 3,*, Zhixiang Zhang,4,6 * and Xizeng Feng1,*,RSC advances.  (Impact Factor =3.289)
4.Evaluating the biological impact of polyhydroxyalkanoates (PHAs) on developmental and exploratory profile of zebrafish larvae,Xiang Li,?a Xu Li,?b Di Chen,?c Jia-Liang Guo,?d Dao-Fu Feng,e Ming-Zhu Sun,c Yun Lu,*d Dong-Yan Chen,*b Xin Zhao*c and Xi-Zeng Feng*a,RSC Advances,2016, 6, 37018.(Impact Factor =3.289)
5.Behavioural effect of low-dose BPA on male zebrafish: Tuning of male mating competition and female mating preference during courtship process,Xiang Li a, 1, Jia-Yu Guo b, 1, Xu Li c, 1, Hai-Jun Zhou d, Shu-Hui Zhang a, Xiao-Dong Liu a,Dong-Yan Chen c, *, Yong-Chun Fang b, *, Xi-Zeng Feng a, *,Chemosphere,169 (2017) 40-52.(Impact Factor =3.698)

2012年发表的主要论文: 
1.Unlabeled multi tumor marker detection system based on bioinitiated light addressable potentiometric sensor, Yun-Fang Jia*,Chun-Ying Gao,Jia He, Dao-Fu Feng,Ke-Li Xing,Ming Wu,Yang Liu,Wen-Sheng Cai, Xi-Zeng Feng*, Analyst, 2012, 137, 3806–3813. (Impact Factor =4.23)

2. Adsorption Behavior of Hydrophobin Proteins on Polydimethylsiloxane Substrates, Yingzhe Liu, Ming Wu, Xizeng Feng, Xueguang Shao, Wensheng Cai*, J. Phys. Chem. B 2012, 116, 12227?12234.(Impact Factor =3.696) 

3. L-3,4-dihydroxyphenylalanine-collagen modi?ed PDMS surface for controlled cell culture?, Chun-Ying Gao,?a Yuan-Yuan Guo,?b Jia He,?c Ming Wu,a Yang Liu,a Zhong-Liang Chen,a Wen-Sheng Cai,c Yan-Lian Yang,*b Chen Wangb and Xi-Zeng Feng*a, J. Mater. Chem., 2012, 22, 10763–10770. (一区,Impact Factor = 5.099)
4. Polyethyleneimine functionalized polymer microsphere: a novel delivery vector for cells?, Chunying Gao,?a Han Zhang,?b Ming Wu,a Yang Liu,a Yipan Wu,a Xinlin Yang*b and Xizeng Feng*a, Polym. Chem., 2012, 3, 1168–1173. (Impact Factor =5.321)
5. A progressive approach on zebrafish toward sensitive evaluation of nanoparticles’   toxicity in vivo , Yang Liu a, Bin Liu b, Daofu Feng c, Chunying Gao a, Ming Wu a, Ningning He c, Xinlin Yang b*, Lei Li c* and Xizeng Fenga*,  Integrative Biology, 2012, 4,285-291. (Impact Factor =4.439) 

2011年发表的主要论文:
1. Optical tracking and biocompatibility assessment of nanoparticles from triblock copolymer encapsulating-dye complexes, Yang Liu, Yipan Wu, Daofu Feng, Qijun Ye, Xi Yang, Xiao Liu, Chunying Gao, Ming Wu, Dongyan Chen, Yanjun Zhang*, Lei Li* and Xizeng Feng*, J. Mater. Chem., 2011, 21, 18704-18710. (一区,Impact Factor = 5.099) 
2. Bio-initiated light addressable potentiometric sensor for unlabeled biodetection and its MEDICI simulation?, Yunfang Jia*a, Chunying Gaob, Daofu Fengc, Ming Wub, Yang Liub, Xinjuan Chenc, Keli Xingd, and Xizeng Feng*b, Analyst, 2011, 136, 4533–4538. (Impact Factor = 3.913);
3. In?uence of block sequences in polymer vectors for gene transfection in vitro and toxicity assessment of zebra?sh embryos in vivo?, Yang Yao,a Dao-Fu Feng,b Yi-Pan Wu,a Qi-Jun Ye,b Lei Liu,c Xin-Xin Li,a Sen Hou,a Yan-Lian Yang,*c Chen Wang,c Lei Li*b and Xi-Zeng Feng*a, J Materials Chem., 2011, 21, 4538-4545. (一区,Impact Factor = 5.099) 
4. Facile synthesis of functional bismuth–amino acid coordination polymer nano-structures, Rui Chen,a Chunying Gao,b Yipan Wu,b Hu Wang,a Huijing Zhou,a Yuping Liu,a Pingchuan Sun,a Xizeng Feng*b and Tiehong Chen*a, Chemical Communications, 2011, 47:8136-8138..  (Impact Factor =5.787);
5. Predicting the coordination geometry for Mg2+ in the p53 DNA-binding domain: insights from computational studies, Teng Wang,a Xueguang Shao,a Wensheng Cai,*a Yonglai Xue,b Shuai Wangb and Xizeng Fengb, Phys. Chem. Chem. Phys., 2011, 13, 1140-1151. (Impact Factor =4.116); 
6. Cell adhesive and growth behavior on electrospun nano?brous scaffolds by designed multifunctional composites, Ding Caoa, Yi-PanWub, Zhi-Feng Fua*, Yuan Tianc, Cong-Ju Lic*, Chun-Ying Gaob, Zhong-Liang Chenb, Xi-Zeng Fengb*, Colloids and Surfaces B: Biointerfaces, 2011, 84, 26–34. (Impact Factor =2.600) ;

::主要学术论文::
::主要科研项目::