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韩际宏

 性    别:男
 职    称:教授
 所属部门:生物化学和分子生物学系
 招生专业:生物化学与分子生物学
 研究方向:心血管生物学
::教师简介::
学历 

学位	专业	   授予时间       学校地址
学士	化学        1987          南开大学,中国天津
硕士	化学        1989          南开大学,中国天津
博士	生物化学    1995          康乃尔大学医学院,美国纽约


工作经历

1999-2005: 助理教授 (Assistant Professor of Pathology), 血管生物学中心, 康乃尔大学医学院, 美国纽约(Center of Vascular Biology, Weill Medical College of Cornell University, New York, USA)
2004-2007: 副教授 (Associate Professor of Pathology), 血管生物学中心, 康乃尔大学医学院, 美国纽约
2006-至今: 中国国家自然科学基金药物药理学、临床医学基础学科基金申请评审专家
2007-至今: 天津南开大学生命科学学院特聘教授
2009-至今: 973计划项目首席科学家,长江学者特聘教授


专业协会成员 (Memberships in Professional Societies)

American Association for the Advancement of Science
American Heart Association
American Society for Investigate Pathology
American Society for Biochemistry and Molecular Biology
Federation of American Society for Experimental Biology
科技部国际合作评审战略专家
中国生物化学与分子生物学会脂质与脂蛋白专业委员会常务委员
天津市生化与分子生物学会理事会副理事长
天津市神经科学学会理事会副理事长
国家自然科学基金委会评专家

近五年研究团队指导学生获奖

207年度:美国实验学生物学年会研究生旅行奖1人次,南开大学优秀博士毕业论文1人次
2016年度:博士生国家奖学金1人次,硕士生国家奖学金1人次,周恩来奖学金1人次,博士生一等和二等奖学金各1人次,美国实验学生物学年会研究生旅行奖1人次
2015年度:博士生国家奖学金1人次,博士生二等奖学金1人次,美国实验学生物学年会研究生旅行奖1人次,南开大学优秀博士毕业论文1人次
2014年度:博士生国家奖学金1人次,博士生二等奖学金1人次,美国实验学生物学年会研究生旅行奖1人次
2013年度:博士生国家奖学金2人次,博士生光华奖学金1人次,世界肺癌大会研究生旅行奖1人次
2012年度:博士生国家奖学金1人次,博士生一等奖学金1人次


联系方式

Tel: 022-23500522; 022-23501776
E-mail: jihonghan2008@nankai.edu.cn; jhan@med.cornell.edu


代表性论文
1.Yang X, Orgah J, Wang D, Fan G, Jingyang H, Han J, Qin G, Gao X, Zhu Y.Danhong injection reduces vascular remodeling and up-regulates the Kallikrein-kinin system in spontaneously hypertensive rats.Scientific Reports. 2017;7:4308. 
2.Sun L, Yang X, Li Q, Zeng P, Liu Y, Liu L, Chen Y, Yu M, Ma C, Li X, Li Y, Zhang R, Zhu Y, Miao QR, Han J*, Duan Y*. Activation of adiponectin receptor regulates proprotein convertase subtilisin/kexin type 9 expression and inhibits lesions in apoE deficient mice. Arteriosclerosis Thrombosis and Vascular Biology. 2017;37(7):1290-1300.
3.Hu W, Zhang W, Chen Y, Rana U, Teng R, Duan Y, Liu Z, Zhao B, Foeckler J, Weiler H, Kallinger RE, Thomas MJ, Zhang K, Han J*, Miao QR*. Nogo-B receptor deficiency increases LXRα nuclear translocation and hepatic lipogenesis. Hepatology 2016;64:1559-1576.
4.Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J*, Duan Y*. 2016. Inhibition of macrophage CD36 expression and cellular oxLDL accumulation by tamoxifen--A PPARγ dependent mechanism. The Journal of Biological Chemistry 2016;291:16977-89 (封面论文) 
5.Yang X, Zhang W, Chen Y, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J*, Yajun Duan*. 2016 Activation of PPARγ and CD36 expression--the dual pathophysiological role of progesterone. The Journal of Biological Chemistry 2016;291:15108-18 
6.Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, Li LY, Miao QR, Hajjar DP, Duan Y*, Han J*. 2016. MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport--an anti-atherogenic function of ERK1/2 inhibition. BBA-Molecular and Cell Biology of Lipid 2016;1861:1180-1191
7.Wang Q, Sun L, Yang X, Ma X, Li Q, Chen Y, Liu Y, Zhang D, Li X, Xiang R, Wei Y, Han J*, Duan Y*. 2016. Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene. Scientific Reports 2016;6:27295.
8.Yang M, Orgah J, Zhu J, Fan G, Han J, Wang X, Zhang B, Zhu Y. Danhong Injection attenuates cardiac injury induced by ischemic and reperfused neuronal cells through regulating arginine vasopressin expression and secretion. Brain Research 2016;1642:516-23.
9.Zhang Y, Shen L, Stupack DG, Bai N, Xun J, Ren G, Han J, Li L, Luo Y, Xiang R, Tan X. JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. Oncotarget 2016;7:29387-99. 
10.Li X, Cao X, Zhang X, Kang Y, Zhang W, Yu M, Ma C, Han J, Duan Y, Chen Y. MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes. Biochemical and Biophysical Research Communications 2016;473:939-46. 
11.Liu M, Zhang W, Li X, Han J, Chen Y, Duan Y. Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. Biochemical and Biophysical Research Communications 2016;469;456-462
12.Yang X, Sun L, Li Y, Ma C, Yang J, Zhang W, Zhao B, Jia L, Duan Y, Han J, Li X*, Chen Y*. NaoXinTong inhibits the advanced atherosclerosis and enhances the plaque stability in apoE deficient mice. Journal of Cardiovascular Pharmacology 2016;67:203-11
13.Yang X, Yao H, Chen Y, Sun L, Ma X, Duan S, Li X, Xiang R, Han J*, Duan Y*. Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake. The Journal of Biological Chemistry 2015;290:21788-21799
14.Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J*, Duan Y*. Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy. Scientific Reports 2015;5,11219; doi: 10.1038/srep11219 
15.Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang X, Duan Y, Han J*. Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II. The Journal of Biological Chemistry 2015;290:14418–14429 
16.Zhang W, Wang X, Hu W, Liu L, Li X, Han J, Chen Y*, Duan Y*. Co-treatment of pitavastatin and dexamethasone exacerbates the high fat diet-induced atherosclerosis in apoE-/- mice. Journal of Cardiovascular Pharmacology 2015;66:189-95
17.Ma X, Liu Y, Wang Q, Chen Y, Liu M, Li X, Xiang R, Wei Y, Duan Y*, Han J*. Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. BBA-Molecular Basis of Diseases 2015;1852:1038-1048
18.Chen Y, Duan Y, Yang X, Sun L, Liu M, Wang Q, Ma X, Zhang W, Li X, Hu W, Miao QR, Xiang R, Hajjar DP, Han J*. Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in apoE deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology 2015;35:948-959 
19.Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Han J, Li X*, Duan Y*. NaoXinTong inhibits the development of diabetic retinopathy in db/db mice. Evidence-Based Complementary and Alternative Medicine Volume 2015; Article ID 242517, 8 pages, http://dx.doi.org/10.1155/2015/242517
20.Ma X, Wang Q, Liu Y, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao RQ, Duan Y*, Han J*. Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production. International Journal of Cancer 2015;136:771-783 (封面论文)
21.Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y*, Han J*. Identification of interferon-γ as a new molecular target of liver X receptor. Biochemical Journal 2014;459:345-354 (专评论文: Biochemical Journal. 2014;459:e1-e3) 
22.Chen Y, Liu M, Zhao T, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li G, Li X, Xiang R, Han J, Duan Y*. Danhong Injection inhibits the development of atherosclerosis in both Apoe-/- and Ldlr-/- mice. Journal of Cardiovascular Pharmacology 2014;63:441-452
23.Liu M, Chen Y, Yang X, Zhang L, Zhao T, Zhao B, Jia L, Zhu Y, Gao X, Zhang B, Li X, Han J, Duan Y*. Danhong injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice. Chinese Science Bulletin 2014;59:1366-1373
24.Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells 2013;31:2538-2550 
25.Jiang M, Zhang L, Ma X, Hu W, Chen Y, Yu M, Wang Q, Li X, Yin Z, Zhu Y, Gao X, Hajjar DP, Duan Y*, Han J*. Tamoxifen inhibits macrophage FABP4 expression through the combined effects of GR and PPARγ pathways. Biochemical Journal 2013;454:467-477 
26.Qiao L, Wu Q, Lu X, Zhou Y, Fernández-Alvarez A, Ye L, Zhang X, Han J, Casado M, Liu Q. SREBP-1a activation by HBx and the effect on hepatitis B virus enhancer II/core promoter. Biochemical Biophysical Research Communication 2013;432:643-649 
27.Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y*, Han J*. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux---an LXR-dependent mechanism. BBA-Molecular and Cell Biology of Lipids 2013;1831:1134-1145 
28.Meng X, Zhang Y, Jia Z, Huo X, He X, Tian G, Wu M, Wang Z, Zhou X, Xiong S, Gao X, Wu Z, Han J, Zhao L, Wang P, Hong Z, Wang Q, Yin Z. A novel tylophorine analog W-8 up-regulates forkhead boxP3 expression and ameliorates murine colitis. Journal of Leukocyte Biology  2013;93:83-93
29.Chen Y, Duan Y*, Kang Y, Yang X, Li G, Yin Z, Hu W, Dong P, Li X, Hajjar DP, Han J*. Activation of liver X receptor induces macrophage interleukin-5 expression. The Journal of Biological Chemistry 2012;287:43340-43350
30.Duan Y, Chen Y, Hu W, Li X, Zhou X, Yin Z, Kong D, Hajjar DP, Liu L, Liu Q,  Han J*. PPAR? activation by ligands and dephosphorylation induces PCSK9 and LDLR expression. The Journal of Biological Chemistry 2012;287:23667-23677
31.Hu W, Zhou X, Jiang N, Duan Y, Chen Y, Li X, Yin Z, He G, Yao Z, Zhu Y, Hajjar DP, Han J*. Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. Atherosclerosis 2012;222:434-443
32.Zheng W, Wang Z, Song L, Zhao Q, Zhang J, Li D, Wang S, Han J, Zheng XL, Yang Z, Kong D. Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model. Biomaterials 2012;33:2880-2891 
33.Zhao N, Hao J, Ni Y, Luo W, Liang R, Cao G, Zhao Y, Wang P, Zhao L, Tian Z, Flavell R, Hong Z, Han J, Yao Z, Wu Z, Yin Z. Vg4γδT cell-derived IL-17A negatively regulates NKT cell function in Con A-induced fulminant hepatitis. The Journal of Immunology 2011;187:5007-5014 
34.Hao J, Dong S, Xia S, He W, Jia H, Zhang S, Wei J, O'Brien RL, Born WK, Wu Z, Wang P, Han J, Hong Z, Zhao L, Yin Z. Regulatory role of Vg1gdT cells in tumor immunity through IL-4 production. The Journal of Immunology 2011;187:4979-4986 
35.Dong P, Xie T, Zhou X, Hu W, Chen Y, Duan Y, Li X, Han J*. Induction of macrophage scavenger receptor type BI expression by tamoxifen and 4-hydroxytamoxifen. Atherosclerosis 2011;218:435-442 
36.He W, Hao J, Dong S, Gao Y, Tao J, Chi H, Flavell R, O'Brien RL, Born WK, Craft J, Han J, Wang P, Zhao L, Wu J, Yin Z. Naturally activated Vγ4γδT cells play a protective role in tumor immunity through expression of eomesodermin. The Journal of Immunology 2010;185:126-133 
37.Zhou X, Yin Z, Guo X, Hajjar DP, Han J*. Inhibition of ERK1/2 and activation of LXR synergistically induce macrophage ABCA1 expression and cholesterol efflux. The Journal of Biological Chemistry 2010;285:6316-6326 
38.Nakaya H, Summers BD, Nicholson AC, Gotto AM Jr, Hajjar DP, Han J*. Atherosclerosis in LDLR knockout mice is inhibited, but not reversed by the PPARγ ligand pioglitazone. American Journal of Pathology 2009;174:2007-2014
39.Huang Z, He W, Zhou X, Hajjar DP, Nicholson AC, Gotto AM Jr, Han J*. Activation of PPARα induces hepatic LDL receptor expression. British Journal of Pharmacology 2008:155:596-605 
40.Zhou X, He W, Huang Z, Gotto AM Jr, Hajjar DP, Han J*. Genetic deletion of low density lipoprotein receptor impairs mouse macrophage ABCA1 expression-A SREBP-1 dependent mechanism. The Journal of Biological Chemistry 2008;283:2129-138 
41.Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, Ma X. Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by the homeoprotein pre-B-cell leukemia transcription factor-1. Immunity 2007:27:952-964 
42.Nicholson AC, Zhou X, He W, Gotto AM Jr, Hajjar DP, Han J*.  Anti-adipogenic action of pitavastatin occurs through the coordinate regulation of PPAR? and Pref-1 expression. British Journal of Pharmacology 2007;151:807-815
43.Han J*, Zhou X, Parsons M, Nicholson AC, Gotto AM Jr, Yokoyama T, Hajjar DP. 2005. Regulation of macrophage scavenger receptor expression-New pleiotropic effects of statins. pp265-269. Advances in Heart Disease, International Academy of Cardiology. Asher Kimchi, Ed. International Proceeding
44.Han J*, Parsons M, Zhou X, Nicholson AC, Gotto AM Jr, Hajjar DP. Functional interplay between the macrophage scavenger receptor class B type I (SR-BI) and pitavastatin (NK-104). Circulation 2004;110:3472-3479 
45.Han J, Zhou X, Hajjar DP, Gotto AM Jr, Nicholson AC. Pitavastatin down-regulates expression of the macrophage type B scavenger receptor, CD36. Circulation 2004;109:790-796 
46.Sun L, Nicholson AC, Hajjar DP, Gotto AM Jr, Han J*. Adipogenic differentiating agents regulate expression of fatty acid binding protein (aP2) and CD36 in macrophages. Journal of Lipid Research 2003;44:1877-1886 
47.Han J, Markle RA, Summers BD, Yokoyama T, Hajjar KA, Hajjar DP, Gotto AM Jr, Nicholson AC. Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells. Journal of Cellular Biochemistry 2003;90:23-32 
48.Febbraio M, Gotto AM Jr, Han J, Nicholson AC, Sharma K, Podrez EA, Hoff HF, Hazen SL, Smith JD, Hajjar DP, Silverstein RL. 2002. Regulation of CD36 by PPAR-γ: Pro- or anti-Atherogenic? International Symposium on PPARγ: From Basic Science to Clinical Application. Fruchart JC, Gorro AM Jr, Paoletti R, Staels B, Catapano AL, Eds. Kluwer Academic Publisher 
49.Han J, Hajjar DP, Zhou X, Gotto AM Jr, Nicholson AC. Regulation of peroxisome proliferator-activated receptor-γ-mediated gene expression. A new mechanism of action for high density lipoprotein. The Journal of Biological Chemistry 2002;277:23582-23586
50.Han J, Nicholson AC, Zhou X, Feng J, Gotto AM Jr, Hajjar DP. Oxidized LDL decreases macrophage expression of scavenger receptor B-I (SR-BI). The Journal of Biological Chemistry 2001;276:16567-16572 
51.Nicholson AC, Han J, Febbraio M, Silverstein RL, Hajjar DP. Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis. Annals of New York Academy of Science 2001;947:224-229 
52.Nicholson AC, Han J, Febbraio M, Pearce SFA, Gotto AM Jr, Hajjar DP. 2001. CD36, the Macrophage class B scavenger receptor: Regulation and role in atherosclerosis. pp41-47, Atherosclerosis and Autoimmunity, Y. Shoenfeld, D. Harats and G. Wick, editors, Elsevier Science B.V. 
53.Naruszewicz M, Han J, Nicholson AC, Hajjar, DP. Homocyst(e)ine increase the functional expression of the macrophage receptor CD36. Atherosclerosis 2000;151:60-61
54.Nicholson AC, Febbraio M, Han J, Silversterin RL, Hajjar DP. CD36 in Atherosclerosis. The role of a class B macrophage scavenger receptor.  Annals of New York Academy of Science 2000;902:128-133 
55.Han J, Feng J, Pearce SFA, Silverstein RL, Gotto AM Jr, Hajjar DP, Nicholson AC. Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPARγ. Journal of Lipid Research 2000;40:688-696 
56.Han J, Hajjar DP, Tauras JM, Feng J, Gotto AM Jr, Nicholson AC. Transforming growth factor-β1 (TGF-β1) and TGF-β2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-γ. The Journal of Biological Chemistry 2000;275:1241-1246 
57.Han J, Hajjar DP, Tauras JM, Nicholson AC. Cellular cholesterol regulates the expression of macrophage scavenger type B receptor, CD36. Journal of Lipid Research 1999;40:830-838 
58.Han J, Nicholson AC. Lipoproteins modulate expression of the macrophage scavenger receptor. The American Journal of Pathology 1998;152:1647-1654 
59.Han J, Febbraio M, Hajjar DP, Nicholson AC. Native and modified low density lipoproteins increase the functional expression of macrophage class B scavenger receptor, CD36. The Journal of Biological Chemistry 1997;272:21654-21659 
60.Ito K, Bian H, Molina M, Han J, Magram JS, Bolir DL, Nagy Z. HLA-DR4-IE chimeric class II transgenic, murine class II deficient mice are susceptible to experimental allergic encephalomyelitis. Journal of Experimental Medicine 1996;183:2635-2644 
61.Rusakow LS, Han J, Hayward MA, Griffith OW. Pulmonary oxygen toxicity in mice is characterized by alterations in ascorbate redox status. Journal of Applied Physiology 1995;79:1769-1776 
62.M?rtensson J, Han J, Griffith OW, Meister A. Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs. Proceedings of the National Academy of Sciences, USA 1993;90:317-321 
::主要学术论文::
::主要科研项目::