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李明春

 性    别:女
 职    称:教授
 所属部门:微生物学系
 招生专业:微生物学
 研究方向:1)真菌多不饱和脂肪酸脱氢酶基因的表达和调控;2)白念珠菌信号转导途径中重要因子的功能研究
::教师简介::
   教授,博士生导师,中共党员,九三学社社员。现任中国菌物学会理事,中国微生物学会真菌学专业委员会副主任委员,中国微生物学会普及和教育工作委员会副主任委员,中国菌物学会医学真菌专业委员会委员,天津市微生物学会理事。微生物学通报编委,中国真菌学杂志编委。1990年本科毕业于南开大学生物系微生物学专业,1994年在该专业硕博联读并留校任教。2003年3月-2004年l2月赴明尼苏达大学做博士后工作。现任教于南开大学生命科学学院,主要从事微生物学及真菌学教学和科研工作。
    做为项目负责人先后主持国家自然科学基金7项,教育部博士点基金1项,教育部高等学校骨干教师资助计划项目1项,天津市支撑项目和重点基金6项,作为主要负责人参加多项国家级和省部级项目。研究方向一是白念珠菌信号转导途径中重要因子的功能研究:挖掘和鉴定铁代谢途径和钙信号途径参与白念珠菌对环境压力的相关基因应答,研究这些关键基因在白念珠菌形态发育、致病性及耐药性中的作用及其分子机制;研究方向二是真菌多不饱和脂肪酸脱氢酶基因的表达和调控研究:主要对毕赤酵母模式菌株和产油高山被孢霉模式菌株的脂肪酸代谢和调控机制进行研究。
    在教学方面,目前是《微生物学》国家精品课、国家级精品资源共享课负责人,南开大学教学名师,获宝钢优秀教师奖,获“南开大学优秀博士学位论文指导教师”称号。先后主讲过普通真菌学、现代真菌学、分子真菌学与技术、微生物学、微生物细胞结构与功能、分子微生物学进展、分子微生物学大实验、综合微生物学实验、真菌学实验等博士、硕士研究生和本科生课程。2013年获天津市教学成果二等奖,2012年、2008年两次获南开大学教学成果一等奖。指导的研究生先后9人获国家奖学金,1名博士生获南开大学优秀博士学位论文,4名硕士生获南开大学优秀硕士学位论文、4名研究生获南开大学优秀毕业生称号,1名研究生获学术科研先锋称号,1人获获南开大学“知行南开”课外学术作品竞赛二等奖。指导的本科生先后有三个团队获得国家大学生创新性实验计划立项及南开大学百项工程立项,并多次获南开大学本科生创新科研一等奖、二等奖。
    已在Eukaryotic Cell、Molecular Microbiology、Free Radical Biology & Medicine、Fungal Genet Biol、BBA-Molecular Cell Research、Journal of hazardous materials、Int J Med Microbiol、Int J Antimicrobial Agents、RSC Advances、Microbiology -SGM、FEMS Yeast Research、FEBS Letters、微生物学报、微生物学通报、生物工程学报等国内外核心刊物发表论文150余篇、出版论著9部,译著6部,已授权国家专利12项。2006年获天津市技术发明二等奖。

通讯地址:天津市南开大学生命科学学院微生物学系( 邮政编码 300071) 
    电话:(022)23508506
    电子邮件:lmchun68@163.com 或limchun@nankai.edu.cn 

Selected Publications:
1. Chang Jia, Mingchun Li*. Tfp1 is required for ion homeostasis, fluconazole resistance and N-Acetylglucosamine utilization in Candida albicans. Biochimica et Biophysica    Acta- Molecular Cell Research, 2015, 1853: 2731–2744
2. Yijie Dong, Mingchun Li*. The Ccz1 mediates the autophagic clearance of damaged mitochondria in response to oxidative stress in Candida albicans. The International Journal of Biochemistry & Cell Biology, 2015, 69:41–51
3.Qilin Yu, Mingchun Li*. Novel mechanisms of surfactants against Candida albicans growth and morphogenesis. Chemico-Biological Interactions, 2015, 227:1-6 
4.Qilin Yu, Mingchun Li*. Candida albicans autophagy, no longer a bystander: its role in tolerance to ER stress-related antifungal drugs.Fungal Genetics and Biology, 2015,81:238-249
5. Ning Xu, Mingchun Li*. Convergent regulation of Candida albicans Aft2 and Czf1 in invasive and opaque filamentation. Journal of Cellular Biochemistry, 2015, 116:1908–1918
6. Qilin Yu, Mingchun Li*. TiO2 nanoparticles promotes production of unsaturated fatty acids (UFAs) fighting against oxidative stress in Pichia pastoris. RSC Advances,2015, 5,41033 – 41040, 
7.Bing Zhang, Mingchun Li*. The actin-related protein Sac1 is required for morphogenesis and cell wall integrity in Candida albicans. Fungal Genetics and Biology, 2015, 81:261-270
8. Chengdong Zhang*, Mingchun Li*. Edible fungus degrade bisphenol A with no hurmful effect on its fatty acids composition. Ecotoxicology and Environmental Safety, 2015, 118:126–132,
9. Meng Zhang,Mingchun Li*.Deletion of genes encoding fatty acid desaturases leads to alterations in stress sensitivity in Pichia pastoris. FEMS Yeast Research, 10.1093/femsyr/fov020,4-28,2015
10. Qilin Yu, Mingchun Li*. Interaction between the Vacuole, the Mitochondria and Oxidative Stress Response Is Governed by the Transient Receptor Potential Channel in Candida albicans. Free Radical Biology & Medicine, 2014, 77:152-167
11.Ning Xu, Mingchun Li*. Cellular iron homeostasis mediated by the Mrs4-Ccc1-Smf3 pathway is essential for mitochondrial function, morphogenesis and virulence in Candida albicans. Biochim et Biophys Acta-Molecular Cell Research, 2014, 1843(3):629-639   
12.Qilin  Yu, Mingchun  Li*. A Novel Role of the vacuolar calcium channel Yvc1 in stress response, morphogenesis and pathogenicity of Candida albicans.  International Journal of Medical Microbiology, 2014, 304(3):339-350   
13.Meiqing Sun, Mingchun Li*. Lead sulfide nanoparticles increase cell wall chitin content and induce apoptosis in Saccharomyces cerevisiae. Journal of hazardous materials, 2014, 273(30): 7–16
14.Chang Jia, Mingchun Li*. Role of TFP1 in vacuolar acidification, oxidative stress and filamentous development in Candida albicans. Fungal Genetics and Biology, 2014,71: 58–67
15.Qilin Yu, Mingchun Li*. The calcium channel blocker verapamil inhibits oxidative stress response in Candida albicans. Mycopathologia, 2014, 177( 3): 167-177  
16.Ning Xu, Mingchun Li*. Novel role of Candida albicans ferric reductase gene CFL1 in iron acquisition, oxidative stress tolerance, morphogenesis and virulence. Research in Microbiology, 2014, 165:252-261
17.Qilin Yu, Mingchun Li*. Inhibitory effect of verapamil on Candida albicans hyphal development, adhesion and gastrointestinal colonization. FEMS Yeast Research, 2014,14(4) : 633–641
18.Xiao h Ding, Ming C Li*. The type II Ca2+/calmodulin-dependent protein kinases are involved in the regulation of cell wall integrity and oxidative stress response in Candida albicans. Biochemical and Biophysical Research Communications, 2014, 46:1073-1078 
19. Qilin Yu, Mingchun Li*.A novel role of the ferric reductase Cfl1 in cell wall integrity, adhesion and invasion to host cells in Canida albicans. FEMS Yeast Research, 2014, 14(7): 1037-1047
20. Qilin Yu, Mingchun Li*. Interaction between lead sulfide nano-dendrites and Saccharomyce cerevisiae is involved in nanotoxicity. RSC Advances, 2014, 4 (39): 20371-20378 
21. Meiqing Sun, Mingchun Li*. A novel toxicity mechanism of CdSe nanoparticles to Saccharomyces cerevisiae: Enhancement of vacuolar membrane permeabilization (VMP). Chemico-Biological Interactions, 2014, 220:208-213  
22. Qilin Yu, Mingchun Li*. The P-type ATPase Spf1 is required for endoplasmic reticulum functions and cell wall integrity in Candida albicans. Int J Med Microbiol, 2013, 303:257-266.  
23. Qilin Yu, Mingchun Li*. In vitro activity of verapamil alone and in combination with fluconazole or tunicamycin against Candida albicans biofilms. Int J Antimicrob Agents, 2013, 41 (2):179-182. 
24. Ning Xu, Mingchun Li*. Aft2, a novel transcription regulator, is required for iron metabolism, surface adhesion and hyphal development in Candida albicans. PLoS ONE, 2013 , 8(4): e62367.
25. Xiaohui Ding, Mingchun Li*. Ecm7, a regulator of HACS, functions in calcium homeostasis maintenance, oxidative stress response and hyphal development in Candida albicans. Fungal Genet Biol, 2013, 57:23-32. 
26.Xinxin Cheng, Mingchun Li*. Novel insight into the expression and function of the multicopper oxidases in Candida albicans. Microbiology-SGM, 2013, 159(6), 1044-1055. 
27.Tonglei Shi,Mingchun Li*. Identification and characterization of a novel C20-elongase gene from the marine microalgae Pavlova   viridis and its use for the reconstitution of two pathways of long-chain polyunsatured fatty acids biosynthesis in Saccharomyces cerevisiae. Biotechnology Letters,2013, 35: 1194-1205
28.Qilin Yu, Mingchun Li*. Spf1 highly influences Candida albicans calcium homeostasis, hyphal development, biofilm formation and virulence. Microbiology-SGM, 2012, 158(9): 2272-2282
29.Yufan Wang, Mingchun Li*. Effects of the N- terminal and C-terminal domains of Meiothermus ruber CBS-01 trehalose synthase on thermostability and activity. Extremophiles. 2012,16(3):377-385   
30. Ming Li, Mingchun Li*.Cloning and identification of a noval Δ9-specific polyunsaturated fatty acid elongase variant from DHA-producing Isochrysis galbana H29. Biotechnology and Bioprocess Engineering. 2012, 17:22-32
31. Ai-Qun Yu, Ming-Chun Li*. Transcriptional Regulation of Desaturase Genes in Pichia pastoris GS115. Lipids, 2012, 47(11):1099-1108 
32. Tonglei Shi,Mingchun Li*. Identification of a novel C22-Δ4 specific polyunsaturated fatty acid desaturase gene from DHA-producing Isochrysis galbana H29 and its expression in Saccharomyces cerevisiae. Biotechnology Letters. 2012, 34(12) : 2265-2274 
33. Qilin Yu, Mingchun Li*. Roles of Cch1 and Mid1 in morphogenesis, oxidative stress response and virulence in Candida albicans. Mycopathologia, 2012, 174:359–369 
34. Ai-Qun Yu,Ming-Chun Li*. Knockout of fatty acid desaturase genes in Pichia pastoris GS115 and its effect on the fatty acid biosynthesis and physiological consequences. Archives of Microbiology,2012, 194:1023–1032
35. Ning Xu, Mingchun Li*. Identification and functional characterization of mitochondrial carrier Mrs4 in Candida albicans. FEMS Yeast Research,2012,12:844-858
36. Hui Wang,Ming-Chun Li*. Alkaline Stress triggers an immediate calcium fluctuation in Candida albicans mediated by Rim101p and Crz1p transcription factors.  FEMS Yeast Research,2011,11(5):430-9
37. Ming Li,Mingchun Li*. Isolation of a novel C18-Δ9 polyunsaturated fatty acid specific elongase gene from DHA-producing Isochrysis galbana H29 and its use for the reconstitution of the alternative Δ8 pathway in Saccharomyces cerevisiae. Biotechnology Letters. 2011,33:1823–1830
38. Yu Ai-Qun,Li Ming-Chun*. Effects of different carbon sources on the growth, fatty acids production and expression of three desaturase genes of Mortierella alpina ATCC 16266. Current Microbiology, 2011, 62 (5):1617-1622.
39. Yong Liang,Mingchun Li* . Role of Candida albicans Aft2p transcription factor in ferric reductase activity, morphogenesis and virulence. Microbiology -SGM,2010 156: 2912-2919
40. Yueming Zhu,Mingchun Li*. Overexpression and characterization of a thermostable trehalose synthase from Meiothermus rubber. Extremophiles.2010, 14:1–8
41. Dongsheng Wei,Mingchun Li*. Agrobacterium rhizogenes-mediated transformation of a high oil-producing filamentous fungus Umbelopsis isabellina. Journal of Applied Genetics. 2010, 51(2): 225-232
42.主编《真菌生物学实验》,普通高等教育“十二五”国家级规划教材,微生物学实验教程系列,科学出版社,2014.7
43. 主编《真菌细胞生物学》,科学出版社,2013.6
44. 主编《微生物学》,普通高等教育“十一五”国家级规划教材,高等教育出版社,2010.11
45. 主编《普通真菌学》(第二版),普通高等教育“十一五”国家级规划教材,高等教育出版社,2010.6
46. 主译精要速览系列《微生物学》(第三版),中译版,科学出版社,2010.6
47. 主译《BROCK微生物生物学》(11版),科学出版社,2009.1

::主要学术论文::
::主要科研项目::