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刘新奇

 性    别:男
 职    称:教授
 所属部门:生物化学和分子生物学系
 招生专业:生物化学和分子生物学
 研究方向:免疫,病毒感染和细胞凋亡的蛋白质晶体学研究
::教师简介::
刘新奇:教授、博士生导师、教育部新世纪优秀人才
Tel: 022-23505130; Email: liu2008@nankai.edu.cn

经历:
1994年7月毕业于中国农业大学生物学院,1994年至1999年于中国科学院生物物理研究所获蛋白质晶体学博士学位。1999年至2004年在美国霍华德休斯医学院(HHMI)做博士后。2004年至2007年在美国普渡大学做 Research Scientist。2008年起,应聘于南开大学生命科学学院教授。

研究方向:
我的实验室主要是利用X-射线晶体学技术,并结合其它的分子生物学,生物化学,细胞生物学等技术从分子水平上研究蛋白质的结构和功能之间的关系。目前研究的方向主要是病原性细菌和病毒在感染人体后所引起的免疫应答过程中所涉及的分子反应机理,像先天免疫中的TLR(Toll-like receptors)通路和NLR( Nod-like receptors)通路,以及后天免疫中的TCR-MHC通路。这些研究将会为我们如何去预防和控制这些影响人类的重大疾病(如艾滋病)提供线索。对艾滋病病毒(HIV)的致病机制和疫苗研制是我们目前工作的重点之一。另外,细胞凋亡以及相关的癌症机理研究也是我们感兴趣的方向。已知的绝大部分癌症都与细胞凋亡的失调有关,对此类分子的研究将会为药物的开发提供基础。

近期发表论文:

Ma J, Zhang X, Feng Y, Zhang H, Wang X, Zheng Y, Qiao W, Liu X. Structural and Functional Study of Apoptosis-linked Gene-2?Heme-binding Protein 2 Interactions in HIV-1 Production. J Biol Chem. 2016 Dec 23;291(52):26670-26685. doi: 10.1074/jbc.M116.752444.
Liu M, Duan L, Wang M, Zeng H, Liu X, Qiu D. Crystal structure analysis and the identification of distinctive functional regions of the protein elicitor mohrip2. Frontiers in Plant Science. 2016, 7, 1103. doi:10.3389.
Li G, Zhang H, Sun Z, Liu X, Reetz M. Multiparameter optimization in directed evolution: engineering thermostability, enantioselectivity, and activity of an epoxide hydrolase. ACS Catalysis. 2016, 6, 3679-3687.
Duan L, Du J, Wang X, Zhou J, Wang X, Liu X. Structural and functional characterization of EIAV gp45 fusion peptide proximal region and asparagine-rich layer. Virology. 2016, 491, 64-72.
Duan L, Du J, Liu X. Insights into vaccine development for acquired immune deficiency syndrome from crystal structures of human immunodeficiency virus-1 gp41 and equine infectious anemia virus gp45. Protein Sci. 2015 Oct;24(10):1549-59. doi: 10.1002/pro.2750.
Han X, Qian L, Zhang L, Liu X. Structural and biochemical insights into nucleotide-rhamnose synthase/epimerase-reductase from Arabidopsis thaliana. Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1476-86. doi: 10.1016/j.bbapap.2015.06.007.
Qian L, Han X, Liu X. Structural insight into equine lentivirus receptor 1. Protein Sci. 2015 May;24(5):633-42. doi: 10.1002/pro.2634. 
Qian L, Liu X. Purification, characterization and structure of nucleoside diphosphate kinase from Drosophila melanogaster. Protein Expression and Purification. 2014, 103, 48-55.
Du J, Wang X, Ma J, Wang J, Qin Y, Zhu C, Liu F, Shao Y, Zhou J, Qiao W, Liu X. Structural and biochemical insights into the V/I505T mutation found in the EIAV gp45 vaccine strain. Retrovirology. 2014 Mar 21;11:26. doi: 10.1186/1742-4690-11-26.
Han X, Xiong X, Jiang D, Chen S, Huang E, Zhang W, Liu X. Crystal structure of L-sorbose dehydrogenase, a pyrroloquinoline quinone-dependent enzyme with homodimeric assembly, from Ketogulonicigenium vulgare. Biotechnol Lett. 2014 May;36(5):1001-8. doi: 10.1007/s10529-013-1446-5. Epub 2014 Feb 21. 
Han X, Xiong X, Hu X, Li M, Zhang W, Liu X. Crystallization and structural analysis of 2-hydroxyacid dehydrogenase from Ketogulonicigenium vulgare. Biotechnol Lett. Biotechnol Lett. 2014 Feb;36(2):295-300. doi: 10.1007/s10529-013-1354-8. Epub 2013 Sep 26.
Du J, Xue H, Ma J, Liu F, Zhou J, Shao Y, Qiao W, Liu X. The crystal structure of HIV CRF07 B’/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat. Virology. November 2013, 446, 86-94.
Feng Y, Yu W, Li X, Lin S, Zhou Y, Hu J, Liu X. Structural insight into Golgi membrane stacking by GRASP65 and GRASP55. J Biol Chem. 2013,288(39):28418-27.
Li X, Feng Y, Liu X. Crystallization and preliminary crystallographic studies of GRASP65 GRASP domain from Rattus norvegicus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jul; 69(Pt 7):792-5. 
Wang J, Xu M, Zhu K, Li L*, Liu X*. The N-terminus of FILIA Forms an Atypical KH Domain with a Unique Extension Involved in Interaction with RNA. PLoS ONE, 2012, 7(1): e30209. doi:10.1371/journal.pone.0030209.
Chen Y, Su C, Ke M, Jin X, Xu L, Zhang Z, Wu A, Sun Y, Yang Z, Tien P, Ahola T, Liang Y, Liu X*, Guo D*. Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex. PLoS Pathogens, 2011, 7(10): e1002294. doi:10.1371/journal.ppat.1002294.
Sun P, Lv S, Zhou J, Liu X*. Cloning, expression and preliminary crystallographic analysis of the equine infectious anaemia virus (EIAV) gp45 ectodomain. Acta Crystallographica Section F. 2011, 67, 482-485.
Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X*, Rapoport TA*, and Hu J*. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proceedings of the National Academy of Sciences. U S A. 2011, 108 (10), 3976-3981.
Wang J, Zhang T, Liu X*. Preliminary crystallographic analysis of the N-terminal domain of FILIA, a protein essential for embryogenesis. Acta crystallgrophy F. 2010, 66, 1111-1114.
Xinqi Liu, Yanan Zhu, Shaodong Dai, Janice White, Fred Peyerl, John W. Kappler, and Philippa Marrack. Bcl-xl does not have to bind Bax to protect T cells from death. Journal of Experimental Medicine. (2006). 203, 2953-2961.
Yanan Zhu, Xinqi Liu, David Hildeman, Fred W. Peyerl, Janice White, Elenora Kushnir, John Kappler, and Philippa Marrack. Bax does not have to adopt its final form to drive T cell death. (2006). Journal of Experimental Medicine. 203, 1147-1152.
Xinqi Liu, Shaodong Dai, Yanan Zhu, Philippa Marrack, and John W. Kappler. The structure of a Bcl-xL/Bim complex: Implications for Bax/Bak activation. Immunity. (2003). 19, 341-52.
Xinqi Liu, Shaodong Dai, Frances Crawford, Rachel Fruge, Philippa Marrack, and John Kappler. Alternate interactions define the binding of peptides to the MHC molecule IAb. Proceedings of the National Academy of Sciences of the United States of America. (2002), 99, 8820-8825.

::主要学术论文::
::主要科研项目::