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马克.巴特拉姆

 性    别:男
 职    称:教授
 所属部门:生物化学和分子生物学系
 招生专业:生物化学;分子生物学
 研究方向:与病毒相关的蛋白质结构与功能;与肿瘤相关的蛋白质结构与功能;基于蛋白质结构的新型药物设计
::教师简介::
   Mark Bartlam (马克.巴特兰姆),长江学者特聘教授、博士生导师    

   1995年于英国帝国理工大学取得学士学位,1999年于英国牛津大学取得博士学位。Bartlam教授一直从事与重要人类疾病相关的蛋白质结构与功能,以及新型药物创制的研究。至今已解析110余个蛋白晶体结构,在Nature,Cell,PNAS,PLoS Biology, EMBO Journal,Nature Structural & Molecular Biology等国际顶尖级学术杂志上发表SCI论文110余篇,单篇引用率600余次。

   Bartlam教授为外专局认证的外籍专家,2010年获天津市海河友谊奖、教育部新世纪优秀人才,2011年获得中国国家友谊奖,天津市国际科学技术合作奖。现兼任生物物理学会理事会理事及秘书会委员。担任《Acta Crystallographica Section D》,《Acta Crystallographica Section F》等国际知名期刊编委。主持并参与国家“973”,“863”,重大专项,国家基金委面上项目,天津市重点项目,欧盟第六框架(EU-FP6),中英联合项目(Wellcome Trust,  Royal Society)等多项国内以及国际合作科研项目。

代表性论文(#为第一作者,*为通讯作者)

1.Yang W, Chen WY, Wang H, Ho JW, Huang JD, Woo PC, Lau SK, Yuen KY, Zhang Q, Zhou W, Bartlam M*, Watt RM, Rao Z. 2011. Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis. Nucleic Acids Res., 39(22):9803-19.
2.Wang, H., M. Morita, X. Yang, T. Suzuki, W. Yang, J. Wang, K. Ito, Q. Wang, C. Zhao, M. Bartlam*, T. Yamamoto*, and Z. Rao. 2010. Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity. EMBO J 29: 2566-76.
3.Yang, W., S. G. Bell*, H. Wang, W. Zhou, N. Hoskins, A. Dale, M. Bartlam*, L.L. Wong, and Z. Rao. 2010. Molecular characterization of a class I P450 electron transfer system from Novosphingobium aromaticivorans DSM12. J Biol Chem 285: 27372-84.
4.Yang, W., S. G. Bell*, H. Wang, W. Zhou, M. Bartlam*, L. L. Wong, and Z. Rao. 2010. The structure of CYP101D2 unveils a potential path for substrate entry into the active site. Biochem. J. 433(1):85-93.
5.Yuan, P., Bartlam, M.#, Lou, Z., Chen, S., Zhou, J., He, X., Lv, Z., Ge, R., Li, X., Deng, T., Fodor, E., Rao, Z. & Liu, Y. (2009). Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature 458, 909-13.
6.He, X., Zhou, J., Bartlam, M., Zhang, R., Ma, J., Lou, Z., Li, X., Li, J., Joachimiak, A., Zeng, Z., Ge, R., Rao, Z., and Liu, Y. (2008). Crystal structural of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature 454, 1123-1127.
7.Yang, X., Morita, M., Wang, H., Suzuki, T., Yang, W., Luo, Y., Zhao, C., Yu, Y., Bartlam, M.*, Yamamoto, T.* & Rao, Z. (2008). Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity. Nucleic Acids Res 36, 6872-81. 
8.Dong, H., Li, X., Lou, Z., Xu, X., Su, D., Zhou, X., Zhou, W., Bartlam, M.*, and Rao, Z. (2008) Crystal structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family. J. Mol. Biol. 383, 455-64. 
9.Li, L., Liu, X., Yang, W., Xu, F., Wang, W., Feng, L., Bartlam, M.*, Wang, L.*, and Rao, Z. (2008). Crystal structure of long-chain alkane monooxygenase (LadA) in complex with coenzyme FMN: unveiling the long-chain alkane hydroxylase. J Mol Biol 376, 453-465.
10.Sun, F., Huo, X., Zhai, Y., Wang, A., Xu, J., Su, D., Bartlam, M. & Rao, Z. (2005). Crystal structure of mitochondrial respiratory membrane protein complex II. Cell 121, 1043-57.
::主要学术论文::
::主要科研项目::