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王连永

 性    别:男
 职    称:研究员
 所属部门:生物化学和分子生物学系
 招生专业:高分子化学与物理,生物化学
 研究方向:生物材料与组织工程
::教师简介::
1989-1993:河北师范大学化学系,本科
1993-1996:中科院长春应用化学研究所,高分子化学与物理专业,硕士
1996-1999:河北承德石油高等专科学校,教师(讲师)
1999-2002:南开大学,博士
2002-2004:中科院化学所(北京),博士后
2004-今:南开大学生科院,副研究员,研究员
2009.4-2010.4:哈佛-MIT健康医学中心(HST), 生物医学工程,访问学者
主要研究方向:
1.血管组织工程
2.骨、软骨组织工程
3.生物医用水凝胶:抗菌、止血和促进创伤修复材料
4.纳米医用材料

讲授课程: 生物医用材料(本科), 生物医用微纳米材料的设计及应用(硕士)


科研项目:
1.基于柠檬酸的小口径血管材料的合成及其功能化表面构建 国家自然科学基金  2012-01-01  2015-12-31  王连永 
2.原子转移自由基聚合法制备LDL吸附剂 南开大学  2005-01-01  2006-12-01  王连永 
3.原子转移自由基聚合法制备LDL吸附剂及吸附性能研究 国家自然科学基金  2006-01-01  2008-12-01  王连永
4.具有程序性释药功能的聚合物胶束性能研究,天津市自然科学基金,2013.6-2016.6,主持 
5.重要生命器官构建的工程化技术研究,国家重点研究计划,2016-2020,参与
6.人工小口径血管的原位再生及炎症反应的作用,国家自然科学基金,2017-2020,主持,王连永


近期发表的主要论文 

Differential regulation of skin fibroblasts for their TGF-β1-dependent wound healing activities by biomimetic nanofibers1.Journal of Materials Chemistry B, 2016, 4:5246-5255

1.Wang K, Zheng WT, Pan YW, Zhu Y,* Wang LY,* Kong DL, Three-layered PCL grafts promoted vascular regeneration in arabbit carotid artery model, Macromol. Biosci.. 16(4):608-618, 2016 
2.Zhu MF, Wang ZH, Zhang JM, Wang LN, Yang X, Chen J, Kong DL,* Wang LY.*. Circumferentially aligned fibers guided functional neoartery regeneration in vivo. Biomaterials, 61, 85-94. 2015, 
3.Xu BS., Du LL., Zhang JM., Zhu MF., Ji SL., Zhang Y. Qiang Y.,* Wang LY.*. Circumferentially oriented microfiber scaffold prepared by wet-spinning for tissue engineering of annulus fibrosus, RSC Advances, 5, 42705-42713,2015 
4.Ding XM, Zhu MF, Xu BS, Wang LY*, Ma XL, Yang Q*,Integrated trilayered silk fibroin scaffold for osteochondral differentiation of adipose-derived stem cells,ACS Appl. Mater. Interfaces 6, 16696?16705,2014 
5.Zhang JM, Wang LN, Zhu MF, Wang LY* , Xiao NN, Kong DL,Wet-spun poly(ε-caprolactone) microfiber scaffolds for oriented growth and infiltration of smooth muscle cells,Materials Letters,132,59-62, 2014 
6.Zhu MF, Wang K, Mei JJ, Li C, Zhang JM, Zheng WT, An D, Xiao NN, Zhao Q, Kong DL*, Wang LY*, Fabrication of highly interconnected porous silk fibroin scaffolds for potential use as vascular grafts, Acta Biomaterialia,10,2014–2023,2014 
7.Wang K, Zhu MF, Li T, Zheng WT, Li L, Xu M, Zhao Q, Kong DL*, Wang LY*, Improvement of cell infiltration in electrospun polycaprolactone scaffolds for the construction of vascular grafts, Journal of Biomedical Nanotechnology, 10, 1588–1598, 2014 
8.Du LL, Zhu MF, Yang Q, Zhang JM, Ma XL, Kong DL, Li XL, Xu BS*, Wang LY*. A novel 3D biphasic silk composite scaffold for intervertebral disc tissue engineering. Materials Letters, 117, 237-240, 2014 
9.Zeng C, Yang Q, Zhu MF, Zhang JM, Ma XL, Kong DL, Li XL, Xu BS*, Wang LY*,Silk fibroin porous scaffolds for nucleus pulposus tissue engineering, Materials Science and Engineering C, 37, 232–240, 2014 
10.Mei JJ, Zhang XL, Zhu MF, Wang JN, Wang L*, Wang LY*. Barium-triggered β-sheet formation and hydrogelation of a short peptide derivative. RSC Advances, 4, 1193-1196, 2014
11.Wang K, Xu M, Zhu MF, Su H, Wang HJ*, Kong DL, Wang LY*, Creation of macropores in electrospun silk fibroin scaffolds using sacrificial PEO-microparticles to enhance cellular infiltration, J Biomed Mater Res Part A, 101(12), 3474-3481, 2013 
12.Yang CB, Li DX, Feng Zhao QQ, Wang LY*, Wang L*, Yang ZM. Disulfide bond reduction-triggered molecular hydrogels of folic acid–taxol conjugates. Organic & biomolecular chemistry, 11(40), 6946-6951, 2013 
13.Wei J, Wang HM, Zhu MF, Ding D, Li DX, Yin ZN, Wang LY*, Yang ZM*,Janus nanogels of PEGylated Taxol and PLGA–PEG–PLGA copolymer for cancer therapy, Nanoscale, 5, 9902–990, 2013 
14.Li Q, Wang ZH, Zhang S, Zheng WT, Zhao Q*, Zhang J,Wang LY*, Wang SF, Kong DL, Functionalization of the surface of electrospun poly(epsilon-caprolactone) mats using zwitterionic poly(carboxybetaine methacrylate) and cell-specific peptide for endothelial progenitor cells capture,Materials Science and Engineering C, Volume 33, 1646–1653, 2013 
15.Zheng, WT, Guan, D,Wang, ZH, Zhang, S,Wang LY*,Kong DY,Zhang J*, Functionalization of PCL fibrous membrane with RGD peptide by a naturally occurring condensation reaction ,Chinese Science Bulletin, 59(22), 2776-2784, 2014 
16.Wang WC, Xie H, Sun LS, Ou LL, Wang LY*, Yu YT, Kong DL*, Macroporous poly(vinyl alcohol) microspheres bearing phosphate groups as a new adsorbent for low-density lipoprotein, Biomedical materials, 4(6), 65-70, 2009 
17.Xiao WQ, He JK, Nichol Jason W, Wang LY, Hutson Ché B, Wang B, Du YA, Fan HS, Khademhosseini A*. Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating polymer network hydrogels, Acta Biomaterialia, 7(6), 2384-2393 
18.Zhang J, Duan YJ, Wei D, Wang LY, Wang HJ, Gu ZW, Kong DL, Co-electrospun fibrous scaffold–adsorbed DNA for substrate-mediated gene delivery, J Biomed Mater Res Part A, 96A(1), 212–220, 2011 
19.Qi H , Du YA, Wang LY, Kaji H,Bae HJ, Khademhosseini A*,Patterned Differentiation of individual embryoid bodies in spatially organized 3D hybrid microgels,Adv. Mater. 22(46), 5276–5281, 2010 
20.Zhang ZF, Yang CH, Duan YJ, Wang YM, Liu JF, Wang LY, Kong DL*, Poly(ethylene glycol) analogs grafted with low molecular weight poly(ethylene imine) as non-viral gene vectors, Acta Biomaterialia, 6(7), 2650–2657, 2010 
21.Wang YM, Kong WL, Song Y, Duan YJ, Wang LY, Steinhoff G, Kong DL*, Yu YT, Polyamidoamine dendrimers with a modified pentaerythritol core having high efficiency and low cytotoxicity as gene carriers,Biomacromolecules, 10(3), 617–622, 2009

电子邮箱:wly@nankai.edu.cn
 
::主要学术论文::
::主要科研项目::