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王淑芳

 性    别:女
 职    称:教授
 所属部门:生物化学和分子生物学系
 招生专业:高分子化学与物理、生物化学
 研究方向:生物材料与组织工程
::教师简介::
王淑芳, 1963年出生,理学博士,教授,博士生导师;毕业于南开大学化学学院高分子化学与物理专业;现就职于南开大学生命科学学院生物活性材料教育部重点实验室,从事生物材料的结构与功能关系及其应用研究。主持或参加国家级、省部级科研项目二十余项。获得了国家科技进步三等奖、中国专利优秀奖、天津市专利优秀奖、天津市自然科学二等奖、天津市技术发明二等奖(两项)和天津市科技进步二等奖,还获得南开大学优秀教育工作者和优秀硕士论文指导教师等称号。是中国复合材料学会理事、天津生物医学工程学会口腔生物医学工程专业委员会副主任委员、中国生物材料学会会员、中国化学会会员。
承担的项目主要有:
主持国家自然科学基金项目(81671842)原位催化生成NO的人工血管材料炎症反应调控及其对血管再生行为的影响,2017.1-2020.12;
主持天津市自然科学基金重点项目(16JCZDJC37600)小口径人工血管的炎症反应与血管再生功能调控研究,2016.4-2019.3;
主持国家重点实验室(药物化学生物学)开放基金项目:控制释放基质金属蛋白酶的人工血管构建及其功能评价(201603007),2016.1.1-2016.12.31;
主持国家自然科学基金项目——自催化NO原位控释的人工血管植入材料结构设计及其生物功能评价(51073081,2011.1-2013.12);
主持天津市应用基础及前沿技术研究计划项目——负载SOD的γ-PGA水凝胶在皮肤创伤修复中作用机制研究(13JCYBJC24900,2013.4-2016.3);
主持天津市基础研究重点项目——用于组织工程的中长链聚羟基脂肪酸酯PHAMCL的研究(09JCZDJC18400,2009.1-2011.12);
参加国家重点研发计划“生物医用材料研发与组织器官修复替代”重点专项——新型响应性智能水凝胶的设计、制备及工程化技术(2017YFC1103504),2017.7-2020.12;任课题组长;
参加国家重点基础研究发展计划(973计划)子课题(2012CB725204 ):用合成生物学方法构建生物基材料的合成新途径,2012.1-2016.12;
参加天津市科技支撑重点项目——微生物法合成聚谷氨酸的产业化中试及其应用研究(09ZCKFSH00800,2009.1-2011.12);
参加国家自然科学基金重点项目——小口径血管材料结构设计与组织再生(50830104,2009-2012);
参加国家自然科学基金项目——门多萨假单胞菌NK-01合成褐藻寡糖和中长链聚羟基脂肪酸酯的代谢途经改造(31070039,2011.1-2013.12)等。
此外,还主持和参加了多项服务企业的横向科研项目;是南开大学“心血管组织工程教育部创新团队”骨干成员。
在Biomacromolecules,Journal of Materials Chemistry B, Materials Science and Engineering C, Journal of Bioactive and Compatible Polymers, Polymer Degradation and Stability,Polymers for Advanced Technologies, Journal of Molecular Structure, Polymer Testing, Journal of Molecular Catalysis B: Enzymatic等国内外学术期刊发表学术论文五十余篇,多篇被SCI或EI收录;申请中国发明专利四十余项,其中多项授予专利权。
目前的主要研究方向为:生物功能高分子材料的结构与性能关系及其应用研究(包括血管组织工程支架材料构建,新型生物降解高分子材料的药物控释及载药新技术研究)。
招生专业:生物化学与分子生物学;高分子化学与物理 
通讯地址:南开大学生命科学学院分子生物学研究所 ( 邮政编码 300071) 
电话: 022-23503753
传真: 022-23503753
电子邮件: wangshufang@nankai.edu.cn

近期发表的论文包括:
1.Jingchen Gao, Yaping Wang, Siyuan Chen, Di Tang, Li Jiang, Deling Kong and Shufang Wang*. Electrospun poly-3-caprolactone scaffold modified with catalytic nitric oxide generation and heparin for small-diameter vascular graft. RSC Advances, 2017, 7,18775-18784.
2.Yuanyuan Wang, Siyuan Chen, Yiwa Pan, Jingchen Gao, Di Tang, Deling Kong, Shufang Wang*. Rapid in situ endothelialization of small diameter vascular graft with catalytic nitric oxide generation and promoted endothelial cell adhesion. Journal of Materials Chemistry B. 2015.3.9212-9222
3.Jun An, Kai Wang, Siyuan Chen, Meimei Kong, Yuxin Teng, Lianyong Wang, Cunjiang Song, Deling Kong and Shufang Wang*. Biodegradability, cellular compatibility and cell infiltration of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in comparison with poly(e-caprolactone) and poly(lactide-co-glycolide). Journal of Bioactive and Compatible Polymers. 2015.30(2): 209-221. 
4.Jun An, Siyuan Chen, Jingchen Gao, Xu Zhang, Yuanyuan Wang, Yandong Li, Sergey Mikhalovsky, Deling Kong, Shufang Wang. Construction and evaluation of nitric oxide generating vascular graft material loaded with organoselenium catalyst via layer-by-layer self-assembly. Science China, Life Sciences.2015,58(8):765-772.
5.Huahong Zhuang, Yanhang Hong, Jingchen Gao, Siyuan Chen, Yina Ma, Shufang Wang* . A Poly (g-Glutamic Acid)-Based Hydrogel Loaded with Superoxide Dismutase for Wound Healing. Journal of Applied Polymer Science. 2015.132(23): DOI: 10.1002/app.42033
6.Jun Feng, Yanyan Gu, Yufen Quan, Wei Zhang, Mingfeng Cao, Weixia Gao, Cunjiang Song, Chao Yang & Shufang Wang. Recruiting a new strategy to improve levan production in Bacillus amyloliquefaciens. Scientific Reports 2015. | 5:13814 | DOi: 10.1038/srep13814.
7.Siyuan Chen , Jun An , Lei Weng , Yandong Li , Han Xu , Yaping Wang , Dan Ding , Deling Kong , Shufang Wang*. Construction and biofunctional evaluation of electrospun vascular grafts loaded with selenocystamine for in situ catalytic generation of nitric oxide. Materials Science and Engineering C, 2014, 45:491-496. 
8.Jun Feng, Weixia Gao, Yanyan Gu, Wei Zhang, Mingfeng Cao, Cunjiang Song*, Peng Zhang, Min Sun, Chao Yang, Shufang Wang*. Functions of poly-gamma-glutamic acid (g-PGA) degradation genes in g-PGA synthesis and cell morphology maintenance. Appl Microbiol Biotechnol. 2014.98: 6397-6407
9.Wenbin Guo, Jingjing Duan, Weitao Geng, Jun Feng, Shufang Wang*, Cunjiang Song*. Comparison of medium-chain-length polyhydroxyalkanoates synthases from Pseudomonas mendocina NK-01 with the same substrate speci?city. Microbiological Research, 2013, 168(4), 231-237. 
10.Jun Feng, Yanyan Gu, Jingqiang Wang, Cunjiang Song*, Chao Yang, Hui Xie, Wei Zhang, Shufang Wang*. Curing the Plasmid pMC1 from the Poly (g-glutamic Acid) Producing Bacillus amyloliquefaciens LL3 Strain Using Plasmid Incompatibility. Appl Biochem Biotechnol. 2013, 171:532-542. (IF 1.893)
11.Qing Ji, Suai Zhang, Jimin Zhang, Zhihong Wang, Jianing Wang, Yun Cui, Liyun Pang, Shufang Wang, Deling Kong, and Qiang Zhao*, Dual Functionalization of Poly(e-caprolactone) Film Surface through Supramolecular Assembly with the Aim of Promoting In Situ Endothelial Progenitor Cell Attachment on Vascular Grafts. Biomacromolecules, 2013, 14 (11), pp 4099-4107. 
12. Qian Li, Zhihong Wang, Suai Zhang, Wenting Zheng, Qiang Zhao *, Jun Zhang, Lianyong Wang *, Shufang Wang, Deling Kong.  Functionalization of the surface of electrospun poly(epsilon-caprolactone) mats using zwitterionic poly(carboxybetaine methacrylate) and cell-specific peptide for endothelial progenitor cells capture. Mater Sci Eng C-Mater Biol Appl 2013, 33, 1646-1653. 
13.Wenbin Guo, Jian Tao, Chao Yang, Cunjiang Song*, Weitao Geng, Qiang Li, Yuanyuan Wang, Meimei Kong, Shufang Wang*. Introduction of Environmentally Degradable Parameters to Evaluate the Biodegradability of Biodegradable Polymers. PLoS ONE, 2012, 7(5), e38341. 
14.Wenbin Guo, Jun Feng, Weitao Geng, Cunjiang Song*, Yuanyuan Wang, Ning Chen, Shufang Wang*. Augmented production of alginate oligosaccharides by the Pseudomonas mendocina NK-01 mutant. Carbohydrate Research, 2012, 352,109-116. 
15.Qiang Zhao, Shufang Wang*, Meimei Kong, Weitao Geng, Robert K. Y. Li, Cunjiang Song*, Deling Kong. Phase morphology, physical properties, and biodegradation behavior of novel PLA/PHBHHx blends. Journal of Biomedical Materials Research B: Applied Biomaterials. 2012, 100B (1): 23-31. 
16.Wenbin Guo, Cunjiang Song, Meimei Kong, Weitao Geng, Yuanyuan Wang, Shufang Wang*. Simultaneous production and characterization of medium-chain-length polyhydroxyalkanoates and alginate oligosaccharides by Pseudomonas mendocina NK-01. Applied Microbiology and Biotechnology. 2011, 92, 791-801. 
17.Wenbin Guo, Yuanyuan Wang, Cunjiang Song, Chao Yang, Qiang Li, Baobin Li, Wenping Su, Xiumei Sun, Dongfang Song, Xiaojuan Yang, and Shufang Wang*. Complete Genome of Pseudomonas mendocina NK-01, Which Synthesizes Medium-Chain-Length Polyhydroxyalkanoates and Alginate Oligosaccharides. Journal of Bacteriology, 2011, 193(13):3413-3414. 
18.Li Q, Wang ZH, Zhao Q*, Wang LY, Wang SF, Kong DL*. Tissue engineering scaffold electrospun from poly(e-caprolactone)-b-poly(sulfobetaine methacrylate). E-Polymers. 2012, 050: 1-12. 
19.Congxin Li, Tianying Guo, Dezhong Zhou, Yuling Hu, Hao Zhou, Shufang Wang, Jiatong Chen, Zhengpu Zhang. A novel glutathione modified chitosan conjugate for efficient gene delivery. Journal of Controlled Release 2011, 154, 177-188. 
20.Qiang Zhao, Shufang Wang, Xinjian Cheng, Richard CM. Yam, Deling Kong*, Robert KY Li, Surface Modification of Cellulose Fiber via Supramolecular Assembly of Biodegradable Polyesters by the aid of Host-Guest Inclusion Complexation. Biomacromolecules, 2010, 11(5), 1364-1369. 
21.Wenbin Guo, Jian Tao, Chao Yang, Qiang Zhao, Cunjiang Song, Shufang Wang*, The rapid evaluation of material biodegradability using an improved ISO 14852 method with a microbial community, Polymer Testing, 2010, 29, 832-839. 
22.Mingfeng Cao , Cunjiang Song, Yinghong Jin, Li Liu , Jing Liu, Hui Xie, Wenbin Guo, Shufang Wang* Synthesis of Poly (g-glutamic acid) and Heterologous Expression of pgsBCA Genes, Journal of Molecular Catalysis B: Enzymatic, 2010, 67, 111-116. 
23.Mingfeng Cao, Weitao Geng, Li Liu, Congjiang Song, Hui Xie, Wenbin Guo, Yinghong Jin, Shufang Wang*. Glutamic acid independent production of poly(g-glutamic acid) by Bacillus amyloliquefaciens LL3 and cloning of pgsBCA genes. Bioresource technology, 2011, 102(5), 4251-4257.
24.Lei Zhang, Kai Wang, Qiang Zhao, Wenting Zheng, Zhihong Wang, Shufang Wang*, Deling Kong*. Core-shell fibrous vascular graft with nitric oxide releasing property, Science in China Series B: Chemistry, 2010, 53(3): 528-534.
25.Wenting Zheng, Zhihong Wang, Lijie Song, Qiang Zhao, JunZhang, Dong Li, Shufang Wang, Jihong Han, Xi-Long Zheng, Zhimou Yang, Deling Kong,* Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model. Biomaterials. 2012, 33(10): 2880-2891. 
26.Min Zhang, Zhexiang Wang, Zefang Wang, Shuren Feng, Haijin Xu, Qiang Zhao, Shufang Wang, Jianxin Fang,  Mingqiang  Qiao*,  Deling  Kong*.  Immobilization  of  anti-CD31  antibody  on  electrospun poly(e-caprolactone)  scaffolds  through  hydrophobins  for  specific  adhesion  of  endothelial  cells. Colloids Surf B Biointerfaces. 2011, 85 (1): 32-39. 
27.Zhihong Wang, Huaimin Wang, Wenting Zheng, Jun Zhang, Qiang Zhao , Shufang Wang , ZhimouYang , Deling Kong. Highly stable surface modifications of poly(e-caprolactone) (PCL) films by molecular self-assembly to promote cells adhesion and proliferation. Chem Commun 2011, 47: 8901-8903. 
28.Ding, L.; Wang, S. F.; Wu, W. J.; Hu, Y. H.; Yang, C. H.; Tan, M.; Kong, D. L. and Yang, Z. M.*. A Supramolecular Hydrogel Inspired by Elastin. Chin. J. Chem. 2011, 29(10): 2182-2186. 
29.Qian Li, Zhihong Wang, Qiang Zhao, Lianyong Wang, Shufang Wang , Deling Kong. Synthesis and characterization of a zwitterionic copolymer poly(e-caprolactone)-b-poly(carboxybetaine methacrylate) with good cell affinity. Chinese J Biomed Eng 2011, 20: 47-54.
30.Jian Tao; Cunjiang Song; Cao Mingfeng; Dan Hu; Li Liu; Na Liu; Shufang Wang*. Thermal Properties and Degradability of Poly (propylene carbonate) / Poly (b-hydroxybutyrate-co-b-hydroxyvalerate) (PPC / PHBV) Blends. Polymer Degradation and Stability, 2009, 94(4):573-583.
::主要学术论文::
::主要科研项目::