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吴卫辉

 性    别:男
 职    称:教授
 所属部门:微生物学系
 招生专业:微生物学
 研究方向:微生物学
::教师简介::
个人简历
1998        南开大学 学士
2001        南开大学 硕士
2006        美国佛罗里达大学 博士
2006--2009  美国德克萨斯大学M.D.安德森癌症研究中心 博士后
2009--2011  美国哈佛大学医学院布雷根及妇女医院     博士后
2011--      南开大学生命科学学院  教授
1998        B.S. Nankai University
2001        M.S. Nankai University
2006        Ph.D. University of Florida, USA
2006--2009  University of Texas M.D. Anderson Cancer Center, Postdoctoral Fellow 
2009--2011  Harvard Medical School Brigham and Women’s Hospital, Postdoctoral Fellow
2011--      Nankai University College of Life Sciences, Professor

研究方向
■ 致病菌毒性基因的表达调控及作用机制;
■ 致病菌耐药机理研究;
■ 宿主在感染过程中的免疫反应
Research Fields
■ Regulation and function of pathogenic bacterial virulence factors 
■ Mechanisms of antibiotics resistance in pathogenic bacteria 
■ Host immune responses during infection

Selected Publications
1. Tan H, Zhang L, Weng Y, Chen R, Zhu F, Jin Y, Cheng Z, Jin S, Wu W. PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa. (2016) Front Microbiol.7:317.
2. Chen R, Weng Y, Zhu F, Jin Y, Liu C, Pan X, Xia B, Cheng Z, Jin S, Wu W. Polynucleotide Phosphorylase Regulates Multiple Virulence Factors and the Stabilities of Small RNAs RsmY/Z in Pseudomonas aeruginosa. (2016) Front Microbiol. 2;7:247.
3. Guo Q, Wei Y, Xia B, Jin Y, Liu C, Pan X, Shi J, Zhu F, Li J, Qian L, Liu X, Cheng Z, Jin S, Lin J, Wu W. Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa. (2016) Sci Rep. 6:19141.
4. Jin Y, Jin S, Wu W. Regulation of bacterial gene expression by ribosome stalling and rescuing.(2015) Curr Genet. Nov 26
5. Shi J, Jin Y, Bian T, Li K, Sun Z, Cheng Z, Jin S, Wu W. SuhB is a novel ribosome associated protein that regulates expression of MexXY by modulating ribosome stalling in Pseudomonas aeruginosa. (2015) Mol Microbiol. 98(2):370-83.
6. Bai F, Ho Lim C, Jia J, Santostefano K, Simmons C, Kasahara H, Wu W, Terada N, Jin S. Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors. (2015) Sci Rep.5:15014. 
7. Jia J, Bai F, Jin Y, Santostefano KE, Ha UH, Wu D, Wu W, Terada N, Jin S. Efficient Gene Editing in Pluripotent Stem Cells by Bacterial Injection of Transcription Activator-Like Effector Nuclease Proteins. (2015) Stem Cells Transl Med.;4(8):913-26. 
8. Neeld D, Jin Y, Bichsel C, Jia J, Guo J, Bai F, Wu W, Ha UH, Terada N, Jin S. Pseudomonas aeruginosa injects NDK into host cells through a type III secretion system. (2014) Microbiology. 160(Pt 7):1417-26.
9. Jia J, Jin Y, Bian T, Wu D, Yang L, Terada N, Wu W, Jin S. (2014) Bacterial delivery of TALEN proteins for human genome editing.PLoS One. 11;9(3):e91547.
10. Sun Z, Shi J, Liu C, Jin Y, Li K, Chen R, Jin S, Wu W. PrtR homeostasis contributes to Pseudomonas aeruginosa pathogenesis and resistance against ciprofloxacin. (2014) Infect Immun. 82(4):1638-47.
11. Li K, Xu C, Jin Y, Sun Z, Liu C, Shi J, Chen G, Chen R, Jin S, Wu W. SuhB is a regulator of multiple virulence genes and essential for pathogenesis of Pseudomonas aeruginosa.(2013) MBio. 4(6):e00419-13.
12. Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP. Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia. (2013) J Infect Dis. 207(1):39-49.
13. Wu, W, J Huang, B Duan, DC Traficante, H Hong, M Risech, S Lory, GP Priebe. Th17-stimulating Protein Vaccines Confer Protection against Pseudomonas aeruginosa Pneumonia. (2012) Am J Respir Crit Care Med. 186(5):420-7. 
14. Bi, L., S. Gorjestani, W. Wu, YM. Hsu, J. Zhu, K. Ariizumi, X. Lin. (2010) CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans. J Biol Chem. 20;285(34):25969-77.
15. Wu, W., YM. Hsu, L. Bi, Z. Songyang, X. Lin. (2009) CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol. 10(11):1208-14.
16. Ha, U., J-H. Lim, W. Wu, S. Jin and J-D. Li. (2008) MKP1 regulates the induction of MUC5AC Mucin by S. pneumoniae Pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 283(45):30624-31.
17. Yang, H., Z. Shan, J. Kim, W. Wu, W. Lian, L. Zeng, L. Xing and S. Jin. (2007) Regulatory role of PopN and its interacting partners in type III secretion of Pseudomonas aeruginosa. J Bacteriol. 189(7):2599-609.
18. Jyot, J., A. Sonawane, W. Wu and R. Ramphal. (2007) Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus. Mol Microbiol. 63(4):1026-38.
19. Wu, W. and S. Jin. (2005) PtrB of Pseudomonas aeruginosa Suppresses Type III Secretion System Under the Stress of DNA Damage. J Bacteriol. 187(17):6058-68.
20. Wu, W., Y. Song, S. Jin and S. Chen. (2006) An Interactive Map of Regulatory Networks of Pseudomonas aeruginosa Genome. Systems Biology and Regulatory Genomics of Lecture Notes in Computer Science. 4023: 1-10.
21. Wu, W., H. Badrane, S. Arora, H. Baker and S. Jin. (2004) MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa. J Bacteriol. 186(22):7575-85. 


联系方式: 办公电话 022-23508874         电子邮件 wuweihui@nankai.edu.cn
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