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杨志谋

 性    别:男
 职    称:教授
 所属部门:生物化学和分子生物学系
 招生专业:
 研究方向:水凝胶;生物材料;药物释放
::教师简介::
1997.9-2001.7   南京大学高分子系  学士
2001.7-2002.12  南京大学高分子系 科研助手(临时)
2003.2-2006.8   香港科技大学化学系  博士
2006.8-2007.3   香港科技大学化学系  博士后                          
2007.3-2008.12  斯坦福大学微生物与病原体系 博士后
2009.3至今      南开大学, 教授, 博士生导师

杨志谋课题组主要从事小分子水凝胶的制备及其在组织工程、药物释放、癌症治疗等领域的应用。
目前为止主要在下列方向上希望能开展深入工作:
1)基于抗癌药物的小分子水凝胶;
2)短肽小分子水凝胶体内外生物相容性评价;
3)小分子水凝胶对干细胞分化的调控;
4)基于蛋白-多肽特异性结合的水凝胶;
5) 细胞和微生物表面工程。

本课题组从生物化学及分子生物学以及高分子化学两个方向招生,欢迎热衷科研的学生报考。
我们欢迎具有高分子合成、有机合成、以及细胞培养方面经验的博士生加盟(博士后)。

Email: yangzm@nankai.edu.cn
For a brief description of our research, please click the link below:
lab home page: http://yang-lab.org
Research ID: http://www.researcherid.com/rid/F-1798-2010


Refereed publications after joining NKU:

12. Zheng, W. T.~; Gao, J.~; Song, L. J.; Chen, C. Y.; Guan, D.; Wang, Z. H.; Li, Z. B.*; Kong, D. L.*; and Yang, Z. M.* "Surface-induced hydrogelation inhibits platelets aggregation" J. Am. Chem. Soc.,DOI: 10.1021/ja308690y.( ~equal contributions)
11. Wang, H. M.; Shi, Y.; Wang, L.; and Yang, Z. M.*  "Recombinant proteins as cross linkers for hydrogelations" Chem. Soc. Rev. DOI:10.1039/C2CS35358J.
10. Wang, H. M.~; Wei, J.~; Yang, C. B.; Zhao, H. Y.; Li, D. X.; Yin, Z. N.; and Yang, Z. M.*  "The Inhibition of Tumor Growth and Metastasis by Self-assembled Nanofibers of Taxol" Biomaterials, 2012, 33(24), 5848-5853.( ~equal contributions)
9. Zhang, X. L.; Chu, X. L.; Wang, L.; Wang, H. M.; Liang, G. L.; Zhang, J. X.; Long, J. F.*; and Yang, Z. M.* "Rational Design of A Tetrameric Protein to Enhance Interactions Between Self-assembled Fibers Gives Molecular Hydrogels" Angew. Chem. Int. Ed., 2012, 51, 1-6.
8. Wang, H. M. and Yang, Z. M.* "Molecular hydrogels of hydrophobic compounds: a novel self-delivery system for chemotherapy", Soft Matter, 2012, 8, 2344-2347. (Invited Highlight)
7. Mao, L. N,; Wang, H. M.; Tan, M.; Ou, L. L.; Kong, D. L. and Yang, Z. M.* "Conjugation of Two Complementary Anti-Cancer Drugs Confers Molecular Hydrogels as A Co-delivery System", Chem. Commun. 2011, 48(3), 395-397.
6. Wang, Z. H.; Zheng, W. T.; Wang, H. M.; Wang, S. F.; Zhao, Q.; Zhang, J.; Yang, Z. M.* ; Kong, D. L.* "Highly stable surface modification of PCL by molecular self-assembly of a gelator" Chem. Commun., 2011, 47 (31), 8907-8903.
5. Wang, H. M.; Yang, C. H.; Wang, L.; Kong, D. L.; Yang, Z. M.* " Self-assembled Nanospheres as a Novel Delivery System for Taxol: A Molecular Hydrogel with Nanosphere Morphology" Chem. Commun., 2011, 47 (15), 4439-4441.
4. Ren, C. H.; Song, Z. J.; Zheng, W. T.; Wang, L.; Kong, D. L.; Yang, Z. M.* "Disulfide bond as a cleavable linker for molecular self-assembly and hydrogelation" Chem. Commun., 2011, 47, 1619-1621.
3. Wang, H. M.; Wang, Z.; Yi, X. Y.; Long, J. F.; Liu, J. F.; Yang, Z. M.* "Anti-degradation of a recombinant complex protein by incorporation in small molecular hydrogels" Chem. Commun., 2011, 47, 955-957.
2. Wang, J. Y.; Wang, Z. H.; Wang, L.;* Yang, Z. Y.; Kong, D. L.;* and Yang, Z. M.* "Incorporation of Supramolecular Hydrogels into Agarose Hydrogels Affords Novel Materials as Potential Drug Delivery Carriers" J. Mater. Chem., 2009, 19, 7892-7896.
1. Gao, J.; Wang, H. M.; Wang, L.;* Wang, J. Y.; Kong, D. L.;* and Yang, Z. M.* "Enzyme Promotes the Hydrogelation from a Hydrophobic Small Molecule" J. Am. Chem. Soc. 2009, 131, 11286-11287.
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