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尹芝南

 性    别:男
 职    称:教授
 所属部门:微生物学系
 招生专业:生物化学与分子生物学
 研究方向:1.肿瘤免疫的分子机制;2.gammadelta细胞分化;3.癌症和自身免疫疾病的免疫学机制和小分子药物筛选。
::教师简介::
1997年12月毕业于德国柏林自由大学免疫学专业,获博士学位。
1984年7月毕业于湖北医科大学医疗系获学士学位,1988年8月毕业于上海第二医科大学上海市免疫学研究所。获免疫学硕士。曾为意大利国家肿瘤中心访问学者,1997-2006年历任美国耶鲁大学医学院内科系风湿科博士后、助理研究员、助理教授、副教授和访问副教授。 2007年3月应聘为南开大学生命科学学院院长、博导、长江学者特聘教授、国家杰出青年基金获得者、973项目首席科学家、天津市生物医药创业领军人才。
通讯地址:天津市南开大学生命科学学院,邮编:300071
电话:022-23503270
传真:022-23503270
电子邮件:yinzn@nankai.edu.cn
代表性论文:
1.Chen, L., W.He, S.T.Kim, J.Tao, Y. Gao, H.Chi, A.M.Intlekofer, B.Harvev, S.L.Reiner, Z.Yin*, R.A. Flavell, and J. Craft.  Both epigenetic and transcriptional programs contribute to default IFN-g production by gd T cells. J Immunol  2007;178(5):2730-6

2.Tao, J., Y. Gao, M.O.Li, W. He, L. Chen, B.Harvev, R.J.Davis, R.A. Flavell, and Z. Yin*.  JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response.  Eur J Immunol 2007;37:818-829

3. Pandey, V., P. X. Qian, J. Kang, J. K. Perry, M. D. Mitchell, Z. Yin, Z. S. Wu, D. X. Liu, T. Zhu, and P. E. Lobie. Artemin stimulates oncogenicity and invasiveness of human endometrial carcinoma cells. Endocrinology 2010;151:909-920

4.Zhou, X., Z. Yin, X. Guo, D. P. Hajjar, and J. Han. Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux. J Biol Chem 2010;285:6316-6326

5.Tang, J. Z., Z. H. Zuo, X. J. Kong, M. Steiner, Z. Yin, J. K. Perry, T. Zhu, D. X. Liu, and P. E. Lobie. Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior. Endocrinology 2010;151:43-55

6.Shi, Y., X. F. Liu, Y. Zhuang, J. Y. Zhang, T. Liu, Z. Yin, C. Wu, X. H. Mao, K. R. Jia, F. J. Wang, H. Guo, R. A. Flavell, Z. Zhao, K. Y. Liu, B. Xiao, Y. Guo, W. J. Zhang, W. Y. Zhou, G. Guo, and Q. M. Zou. Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice. J. Immunol. 2010;184:5121-5129.

7. He, W., J. Hao, S. Dong, Y. Gao, J. Tao, H. Chi, R. Flavell, R. O’Brien, W. Born, J. Craft , J. Han, P. Wang, L. Zhao, J. Wu, and Z. Yin*. Naturally Activated Vg4 gd T Cells Play a Protective Role in Tumor Immunity Through Expression of Eomesodermin. J. Immunol. 2010;185:126-133 

8.Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science. 2011 Apr 22;332(6028):478-84.

9.Hao, J., X. Wu, S. Xia, Z. Li, , T. Wen, N. Zhao, Z.Wu, P.Wang, L.Zhao, Z. Yin*. Current Progress in gd T-Cell Biology. Cell Mol Immunol 2010. 7: 409-413.

10.Hao, J., S. Dong, W. He, H. Jia, S. Zhang, J. Wei, R. O'Brien, W. Born, Z. Wu, P. Wang, L. Zhao,    Z. Yin*. Regulatory Role of Vg1 gd T Cells in Tumor Immunity through IL-4 Production. J Immunol 2011. In press.

11.Zhao, N., J. Hao, Y. Ni, W. Luo, P. Wang, L. Zhao, Z. Tian, R. Flavell, Z. Yao, Z. Wu, Z. Yin*. Vg4 gd T Cell-Derived IL-17A Negatively Regulates NKT Cell Function in Con A-Induced Fulminant Hepatitis. J Immunol 2011. In press.

12.Qian, P. X., Z. Zuo, Z. S. Wu, X. Meng, G. Li, Z. Wu, W. Zhang, S. Tan, V. Pandey, Y. Yao, P. Wang, L. Zhao, J. Wang, Q. Wu, E. Song, P. Lobie, Z. Yin*, and T. Zhu. 2011. Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Res 2011. In press.


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