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张涛

 性    别:男
 职    称:教授
 所属部门:动物生物学和发育生物学系
 招生专业:生物信息学/神经信息学
 研究方向:神经生理与计算神经生物学
::教师简介::
    张涛,男,1982和88年获浙江大学学士(固体力学)、硕士(计算力学),1997年获英国伯明翰大学博士(生理学)。现为南开大学教授,博士生导师 (动物与发育生物学系主任)。曾在英国曼彻斯特大学、日本理化学研究院脑研究所和英国伦敦SBU大学从事博士后、研究员和高级研究员工作。
  回国以来已经完成多项国家级基金和省部级科学基金,目前主持两项国家级基金和一项天津市基础研究重点项目。在国内外学术刊物上发表论文壹佰余篇。组建了以硕士和博士生为主体的研究队伍。
硕士生、博士生招生专业:计算神经生物学,神经生理学
电话:+22 23500237
电子邮件:zhangtao@nankai.edu.cn

在研项目信息:
项目名称:神经信息流与突触传递可塑性
经费来源:国家自然科学基金面上项目
起止年月:2012.01.01-2015.12.31
负责内容:项目负责人
经费:    66万


项目名称:关于知觉认知与知觉决策的神经动力学研究与实验分析
经费来源:国家自然科学基金重点项目
起止年月:2013.01 - 2017.12
负责内容:项目负责人(南开大学)
经费:    103万

项目名称:神经振荡与突触可塑性及其对认知功能损伤检测的意义
经费来源:天津市科委重点项目
起止年月:2012.01.01-2014.12.31
负责内容:项目负责人
经费:    20万


                              近期发表主要论文(* 通讯作者):
Xueliang Shang, Bo Xu, Qun Li, Baohui Zhai, Xiaxia Xu, Tao Zhang. Neural oscillations as a Bridge between Glutamatergic System and Emotional Behaviors in Simulated Microgravity-Induced Mice. Behaviors Brain Research, 2017. 317:286-291. DOI:10.1016/j.bbr.2016.09.063

Ning Cheng, Qun Li, Xiaxia Xu and Tao Zhang. A precise annotation of phase-amplitude coupling intensity. Plos One, 2016. 11(10):e0163940. DOI:10.1371/journal.pone.0163940

Yingchun Shang, Xin Wang, Xueliang Shang1, Hui Zhang, Zhipeng Liu, Tao Yin, Tao Zhang. Repetitive transcranial magnetic stimulation effectively improves spatial cognition and synaptic plasticity via enhancing BDNF- dependent presynaptic protein in Wistar rats. Neurobiology of Learning and Memory. 2016. 134:369-378. DOI:10.1016/j.nlm.2016.08.016

Xiaochen Zhang; Hongqiang Yin; Zhigui Li; Tao Zhang; Zhuo Yang. Nano-TiO2 induces autophagy to protect against cell death through antioxidative mechanism in podocytes. Cell Biology and Toxicology. 2016, DOI:10.1007/s10565-016-9352-y.

Shan Gao, Yipeng Ren, Yu Sun, Zhenfeng Wu, Jishou Ruan, Bingjun He, Tao Zhang, xin Yu, Xiaoxuan Tian, Wenjun Bu. PacBio Full-length transcriptome profiling of insect mitochondrial gene expression. RNA Biology. 2016, 13(9): 820-825. DOI:10.1080/15476286.2016.1197481.

Xueliang Shang, Yingchun Shang, Jingxuan Fu, Tao Zhang. Nicotine significantly improves chronic stress-induced impairments of cognition and synaptic plasticity in C57BL/6 mice. Molecular Neurobiology. 2016, DOI: 10.1007/s12035-016-0012-2

Jiajia Yang, Chunxiao Yang, Chunhua Liu, Tao Zhang, Zhuo Yang. Paradoxical effects of VEGF on synaptic activity partially involved in Notch1 signaling in the mouse hippocampus. Hippocampus. 2016. 26: 589-600

Xiaxia Xu, Chenguang Zheng, Lei An, Rubin Wang, Tao Zhang. Effects of dopamine and serotonin systems on modulating neural oscillations in hippocampus-prefrontal cortex pathway in rats. Brain topography. 2016, 29(4): 539-551.  DOI: 10.1007/s10548-016-0485-3.

Jingxuan Fu, Hui Wang, Jing Gao, Mei Yu, Rubin Wang, Zhuo Yang, Tao Zhang. Rapamycin effectively impedes melamine-induced impairments of cognition and synaptic plasticity in Wistar rats. Molecular Neurobiology. 2016. D OI:10.1007/s12035-016-9687-7.

Qun Li, Chen-guang Zheng, Ning Cheng, Yi-yi Wang, Tao Yin, Tao Zhang. Two generalized algorithms measuring phase-amplitude cross-frequency coupling in neuronal oscillations network. Cognitive Neurodynamics. 2016. 10(3): 235-243. DOI: 10.1007/s11571-015-9369-6

Lei An, Tao Zhang. Comparison impairments of spatial cognition and hippocampal synaptic plasticity between prenatal and postnatal melamine exposure in male adult rats. Neurotoxicity Research. 2016. 29(2): 218-229DOI: 10.1007/s12640-015-9578-0

Hui Zhang, Hui Wang, Xi Xiao, Tao Zhang. Melamine altered glutamatergic synaptic transmission of CA3-CA1 synapses presynapticly via increasing autophagy in the rat hippocampal slice. Neurotoxicity Research. 2016. 29(1):135-142. DOI: 10.1007/s12640-015-9570-8

Chunhua Liu, Xiaxia Xu, Jing Gao, Tao Zhang, Zhuo Yang*. Hydrogen sulfide prevents synaptic plasticity from VD-induced damage via Akt/GSK-3? pathway and Notch signaling pathway in rats. Molecular Neurobiology. 2016. 53(6):4159-4172

Mei Yu, Yuan Zhang, Xiaoyu Chen, Tao Zhang*. Antidepressant-like effects and possible mechanisms of amantadine on cognitive and synaptic deficits in a depressive rat model. Stress. 2016. 19(1): 104-113.DOI:10.3109/10253890.2015.1108302

Hui Wang, Na Gao, Zhigui Li, Zhuo Yang, Tao Zhang*. Autophagy alleviates melamine-induced cell death in PC12 cells via decreasing ROS level. Molecular Neurobiology. 2016. 53(3): 1718-1729.  DOI: 10.1007/s12035-014-9073-2

Zhaowei Liu, Jiajia Yang, Xiaocheng Zhang, Pengjun Xu, Tao Zhang, Zhuo Yang. Developmental changes in the expression and function of TRPC6 channels related to the F-action organization during differentiation in podocytes. Cell Calcium. 2015, 58(6): 541-548. DOI:10.1016/j.ceca.2015.09.001

Xiaxia Xu, Chunhua Liu, Zhanyong Li, Tao Zhang*. Effects of hydrogen sulfide on modulation of theta-gamma coupling in hippocampus in vascular dementia rats. Brain topography. 2015. DOI: 10.1007/s10548-015-0430-x.

Chenguang Zheng, Tao Zhang*. Synaptic plasticity related neural oscillations on hippocampus-prefrontal cortex pathway in depression. Neuroscience. 2015. 292:170-180. 

Hui Wang, Na Gao, Zhigui Li, Zhuo Yang, Tao Zhang*. Autophagy alleviates melamine-induced cell death in PC12 cells via decreasing ROS level. Molecular Neurobiology. 2015. DOI: 10.1007/s12035-014-9073-2.

Lei An, Tao Zhang*. Reversible effects of vitamins C and E combination on cognitive deficits and oxidative stress in the hippocampus of melamine-exposed rats. Pharmacology, Biochemistry and Behavior. 2015. DOI:10.1016/j.pbb.2015.03.009 

Lei An, Tao Zhang*. Prenatal melamine exposure induces impairments of spatial cognition and hippocampal synaptic plasticity in male adolescent rats. Reproductive Toxicology. 2014. 49:78-85

Ting Chen, Jiajia Yang, Hui Zhang, Guogang Ren, Zhuo Yang, Tao Zhang*. Multi-walled carbon nanotube inhibits CA1 glutamatergic synaptic transmission in rat’s hippocampal slices. Toxicology Letter, 2014, 229: 423-429. 

Lei An, Tao Zhang*. Vitamins C and E reverse melamine-induced deficits in spatial cognition and hippocampal synaptic plasticity in rats. Neurotoxicology, 2014, 44:132-139.

Xichao Mi, Ning Cheng, Tao Zhang*. Performance comparison of both gPDC and PCMI algorithms for measuring directionality of neural information flow. Journal of Neuroscience Method. 2014, 227: 57-64

Jiajia Yang, Yang Yao, Ting Chen, Tao Zhang*. VEGF ameliorates cognitive impairment in in vivo and in vitro ischemia via improving neuronal viability and function. NeuroMolecular Medicine. 2014, 16:376-388.

Xiaxia Xu, Lei An, Xichao Mi, Tao Zhang*. Impairment of cognitive function and synaptic plasticity associated with alteration of information flow in theta and gamma oscillations in melamine-treated rats. Plos One. 2013, 8(10):e77796

Xiaxia Xu, Chenguang Zheng, Tao Zhang*. Reduction in LFP cross-frequency coupling between theta and gamma rhythms associated with impaired STP and LTP in a rat model of brain ischemia. Frontiers in Computational Neuroscience. 2013, Volume 7: Article 27

Chenguang Zheng, Tao Zhang*. Alteration of phase-phase coupling between theta and gamma rhythms in a depression-model of rats. Cognitive Neurodynamics. 2013, 7(2):167-172.

Jiajia Yang, Zhaowei Liu, Yongling Xie, Zhuo Yang, Tao Zhang*. Peroxynitrite alters GABAergic synaptic transmission in immature rat hippocampal slices: a possible involvement of presynaptic VGCCs. Neuroscience Research. 2013, 75:210-217

Ting Chen, Jiajia Yang, Guogang Ren, Zhuo Yang, Tao Zhang*. Multi-walled carbon nanotube increases the excitability of hippocampal CA1 neurons through inhibition of potassium channels in rat’s brain slices. Toxicology Letter. 2013, 217(3):212-128

Lei An, Zhuo Yang, Tao Zhang*. Imbalanced synaptic plasticity induced spatial cognition impairment in male offspring rats treated with chronic prenatal ethanol exposure. Alcoholism: Clinical and Experimental Research. 2013. 37(5): 763-770

Lei An, Zhuo Yang, Tao Zhang*. Melamine Induced Impairments of Spatial Cognition and Long-term Depression Associated With Alteration of Cholinergic System in Wistar Rats. Neurobiology of Learning and Memory. 2013, 100:18-24

Chenguang Zheng, Meina Quan, Tao Zhang*. Decreased thalamo-cortical connectivity by alteration of neural information flow in theta oscillation in depression-model rats. Journal o f Computational Neuroscience. 2012, 33(3):547-558.

Xiaxia Xu, Zhanyong Li, Zhuo Yang, Tao Zhang*. Decrease of Synaptic Plasticity Associated with Alteration of Information Flow in a Rat Model of Vascular Dementia. Neuroscience. 2012, 206: 136-143

Lei An, Shichang Liu, Zhuo Yang, Tao Zhang*. Cognitive impairment in rats induced by nano-CuO and its possible mechanisms. Toxicology Letter. 2012, 213(2): 220-227

Ning Zhang, Yuanming Feng, Shan Gao, Jishou Ruan and Tao Zhang*. New insights regarding protein folding as learned from beta-sheets. EXCLI Journal. 2012, 11:543-555

Tian Yutao, Lei Ting, Yang Zhuo, Zhang Tao*. Urethane decreases hippocampal CA1 neuron excitability via alter presynaptic of glutamate release and potassium channels. Brain Research Bulletin. 2012, 87: 420-426

Lei An, Zhanyong Li, Zhuo Yang, Tao Zhang*. Melamine induced cognitive impairment associated with oxidative damage in rat's hippocampus. Pharmacology, Biochemistry and Behavior. 2012,102(2):196-202

Chenguang Zheng, Meina Quan, Zhuo Yang, Tao Zhang*. Directionality index of neural information flow as a measure of synaptic plasticity in chronic unpredictable stress rats. Neuroscience Letter. 2011, 490:52-56

Mei Zhang, Chenguang Zheng, Meina Quan, Lei An, Zhuo Yang, Tao Zhang*. Directional indicator on neural oscillations as a measure of synaptic plasticity in chronic unpredictable stress rats. NeuroSignals. 2011, 19:189-197

Yi-yi Wang, Shi-chang Liu, Zhuo Yang, Tao Zhang*. Impaired hippocampal synaptic plasticity in C6 glioma-bearing rats. J Neuro-Oncology. 2011, 103(3):469–477.

Zhanyong Li, Yiyi Wang, Yongling Xie, Zhuo Yang, Tao Zhang*. Protective Effects of Exogenous Hydrogen Sulfide on Neurons of Hippocampus in a Rat Model of Brain Ischemia. Neurochemistry Research. 2011, 36(10):1840–1849

Lei Zhang, Ning Zhang, Ji-Shou Ruan, Tao Zhang*. Studies on the Rules of β-Strand Alignment in a Protein β-Sheet Structure. Journal of Theoretical Biology. 2011, 285(1):69-76

Yi-Yi Wang, Ning Li,Jie Huang,Zhuo Yang, Tao Zhang*. Effects of ionic products from silicon-substituted hydroxyapatite on the rat brain activity: Morris water maze studies and long term potentiation in hippocampal CA1. Materials Science & Engineering: C (Materials for Biological Applications). 2011, 31: 1558–1566

Jiajia Yang, Lei An, Yang Yao, Zhuo Yang, Tao Zhang*. Melamine impairs spatial cognition and hippocampal synaptic plasticity by presynaptic inhibition of glutamatergic transmission in infant rats. Toxicology. 2011, 289: 167-174

Lei An, Zhanyong Li, Zhuo Yang, Tao Zhang*. Cognitive Deficits Induced by Melamine in Rats. Toxicology Letter. 2011, 206: 276-280

发表论文详细情况(含全文下载):
http://www.nkbiox.com/Chinese/pubs.asp?cn=zhangtao&classID=1
::主要学术论文::
::主要科研项目::