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张伟英

 性    别:女
 职    称:副教授
 所属部门:生物化学和分子生物学系
 招生专业:生物化学与分子生物学
 研究方向:1.肿瘤发病分子机制研究; 2. 肿瘤新靶点研究;3.抗肿瘤药物筛选
::教师简介::
   2001年本科毕业于内蒙古大学生物系,2009年博士毕业于南开大学生物化学系,博士期间从事乙肝病毒导致的肝癌发生发展分子机制研究。2007年以交流访问学者赴香港科技大学生物化学系合作交流。2009年博士毕业留在南开大学生命科学学院,任讲师。 2013年赴美国乔治敦大学医学中心进行博士后训练,从事胰腺癌发病机制和抗肿瘤药物筛选研究。先后主持国家自然基金1项、863项目子课题1项,主持校级课题1项;参加973项目5项(课题骨干1项,参加4项),参加国家自然基金9项,参加天津市自然科学基金2项。在美国Nova科学出版社出版专著2部。获得中国抗癌协会2013年度科技奖二等奖1项,获得第六届中国侨界贡献(创新团队)奖 1 项,获得南开大学2014-2016年实验教学技术成果奖二等奖 1 项。任现职以来共发表SCI论文27篇,核心期刊论文1篇。其中以第一作者或通讯作者发表SCI论文12篇(其中IF>5的5篇),核心期刊论文1篇。

研究领域
?肿瘤发病分子机制研究;
?肿瘤新靶点研究;
?抗肿瘤药物筛选及开发。

发表SCI文章:
1.	Cai X, Cao C, Li J, Chen F, Zhang S, Liu B, Zhang WY* (co-corresponding author), Zhang X*, Ye L*. Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1. Oncotarget. 2017 Apr 6. doi: 10.18632/oncotarget.16873. [Epub ahead of print] (IF=5.008, 一区)
2.	Feng G, Li J, Zheng M, Yang Z, Liu Y, Zhang S, Ye L, Zhang WY* (co-corresponding author), Zhang X*. Hepatitis B virus X protein up-regulates C4b-binding protein α through activating transcription factor Sp1 in protection of hepatoma cells from complement attack. Oncotarget. 2016 May 10;7(19):28013-26. doi: 10.18632/oncotarget.8472. (IF=5.008, 一区)
3.	Liu F#, Zhang WY# (co-first author), You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X, Ye L. The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer. Oncotarget. 2015;6(29):27199-213. (IF=6.359, 一区)
4.	Zhang WY, Nandakumar N, Shi Y, Manzano M, Smith A, Graham G, Gupta S, Vietsch EE, Laughlin SZ, Wadhwa M, Chetram M, Joshi M, Wang F, Kallakury B, Toretsky J, Wellstein A, Yi C. Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Sci Signal. 2014;7(324):ra42. (IF=6.337, 二区) 
5.	Zhang WY, Lu Z,Kong G, Gao Y, Wang T, Wang Q, Cai N, Wang H, Liu F, Ye L and Zhang X. Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP. Mol Cancer.  2014, 13:128, (IF=5.397, 二区) 
6.	Zhang WY, Kong G, Zhang J, Wang T, Ye LH, Zhang XD. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7(2): e31450. (IF=4.092, 二区) 
7.	Zhang WY, Lu Z, Gao Y, Ye L, Song T, Zhang X. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA. Biochem Biophys Res Commun. 2015; 460(3):793-8. (IF=2.297, 三区) 
8.	Feng G, Shi H, Li J, Yang Z, Fang R, Ye L, Zhang WY* (co-corresponding author), Zhang X*. MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA. Biochem Biophys Res Commun. 2016;472(3):516-22.  (IF=2.297, 三区)
9.	Lu Z, Zhang WY# (co-first author), Gao S, Jiang Q, Xiao Z, Ye L, Zhang X. MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA. Biochem Biophys Res Commun. 2015;468(1-2):8-13 (IF=2.297, 三区)  
10.	You J, Yang J, Fang R, Hu N, Zhang X, Zhang WY* (co-corresponding author), Ye L*. Analysis of Phosphatidylcholines (PCs) and Lysophosphatidylcholines (LysoPCs) in Metastasis of Breast Cancer Cells.  Progress in Biochemistry and Biophysics. 2015;42(6): 563-573. (IF=0.324, 四区) 
11.	Zhang WY, Cai N, Ye LH, Zhang XD. Transformation of human liver L-O2 cells mediated by stable HBx transfection. Acta Pharmacol Sin. 2009; 30(8):1153-61. (IF=2.912) 
12.	Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH, Zhang XD. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacol Sin. 2009; 30(4):424-434 (IF=2.9)
13.	Gao Y, Feng J, Yang G, Zhang S, Liu Y, Bu Y, Sun M, Zhao M, Chen F, Zhang WY, Ye L, Zhang X. HBx-elevated MSL2 Modulates HBV cccDNA through Inducing Degradation of APOBEC3B to Enhance Hepatocarcinogenesis. Hepatology. 2017 Jun 13. doi: 10.1002/hep.29316. [Epub ahead of print] (IF=13.246)
14.	Murakami S#, Shahbazian D#, Surana R#, Zhang WY, Chen H, Graham GT, White SM, Weiner LM, Yi C. Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene. 2017 Mar 2;36(9):1232-1244. (IF=8.5)
15.	Wang Y#, Fang R#, Cui M, Zhang WY, Bai X, Wang H, Liu B, Zhang X, Ye L. The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer. Cancer Lett. 2017 Jan 28;385:234-242. (IF=5.99)
16.	Wang Y, Chen F, Yang Z, Zhao M, Zhang S, Gao Y, Feng J, Yang G, Zhang WY, Ye L, Zhang X. The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2. Sci Rep. 2017 May 18;7(1):2070. (IF=4.259)
17.	Wang Y, Cai X, Zhang S, Cui M, Liu F, Sun B, Zhang WY, Zhang X, Ye L*. HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer. Biochem Biophys Res Commun. 2017 Mar 11;484(3):565-571. 
18.	Shi H, Fang R, Li Y, Li L, Zhang WY, Wang H, Chen F, Zhang S, Zhang X, Ye L. The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells. Cancer Lett. 2016 Nov 28;382(2):147-156. (IF=5.99)
19.	Zhao Y, Li H, Zhang Y, Li L, Fang R, Li Y, Liu Q, Zhang WY, Qiu L, Liu F, Zhang X, Ye L. Oncoprotein HBXIP modulates abnormal lipid metabolism and growth of breast cancer cells by activating theLXRs/SREBP-1c/FAS signaling cascade. Cancer Res.  2016 Aug 15;76(16):4696-707 (IF=8.56)
20.	Li L, Fang R, Liu B, Shi H, Wang Y, Zhang WY, Zhang X, Ye L. Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth. Oncogene.  2016 Aug 4;35(31):4048-57. (IF=8.5)
21.	Yue L, Li LL, Liu FF, Hu N, Zhang WY, Bai X, Li YH, Fu L, Zhang XD, Ye LH. Oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells. Carcinogenesis. 2013;34(4):927-35. (IF=5.3)
22.	Zhang X, You XN, Li N, Zhang WY, Gagos S, Wang Q, Banos A, Cai N, Zhang H, Zhang H, Zhang XZ, Shan CL, Qiu LY, Zhang S, Lv N, Chen MS, Du YM, Xia JC, Ye LH, Zhang XD. Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/Alu core sequence/subtelomeric DNA. FEBS Lett. 2012;586(19): 3215-21 (IF=3.2)
23.	Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang WY, Zhang XD, Ye LH. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells from complement attack. FEBS Lett. 2012;586(6):766-71 (IF=3.2)
24.	Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, Bai X, Zhang Z, Zhang WY, Zhang XD*, Ye LH*. miR-520b regulates migration of breast cancer cells through targeting hepatitis B X-interacting protein and interleukin-8. J Biol Chem. 2011;286(15):13714-22. (IF=4.6)
25.	Cui WJ, Zhang YW, Hu N, Shan CL, Zhang S, Zhang WY, Zhang XD, Ye LH. MiRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 3′UTR of CD46. Cancer Biol Ther. 2010;10(3):232-241. (IF=3.1)
26.	Wang Q, Zhang WY, Ye LH, Zhang XD. A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin. 2010 ; 31(3): 367-374 (IF=2.9)
27.	Wang Q, Zhang WY, Liu Q, Zhang X, Lv N, Ye LH, Zhang XD. A Mutant of Hepatitis B Virus X Protein (HBxDelta127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase. Neoplasia. 2010;12(2):103-15. (IF=4.3)


出版著作:
1.参编:《Progress in Hepatitis B Research》 (ISBN: 1-60021-687-0) Editors: Dorothy V. Denyer. Nova publishers of America. Published in Dec. 2007. 
Xiaodong Zhang, Weiying Zhang and Lihong Ye wrote the Chapter V - Hepatitis B Virus Research Focus; pp. 113-201
2.主编:《Hepatitis B Virus Research Focus》(ISBN: 978-1-60456-299-6) Nova publishers of America. Published in Nov 2008.
Writers: Xiaodong Zhang, Weiying Zhang, Lihong Ye. 
::主要学术论文::
::主要科研项目::