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张晓东

 性    别:男
 职    称:教授
 所属部门:生物化学和分子生物学系
 招生专业:生物化学与分子生物学
 研究方向:肿瘤分子生物学,探讨乙肝病毒致癌分子机制和乳腺癌转移分子机制,筛选抗肿瘤药物
::教师简介::
现任南开大学生命科学学院教授,博士生导师,分子生物学研究所肿瘤研究室主任,中组部国家“千人计划”入选者。
地址:天津市卫津路94号南开大学分子生物学研究所303,022-23506830, zhangxd@nankai.edu.cn

受教育情况:
?	1998年11月-2000年11月:日本东京大学分子细胞生物学研究所博士后(日本学术振兴会JSPS博士后奖学金资助)
?	1993年8月-1996年7月:第四军医大学病理学专业博士生,获博士学位(Ph.D.)
?	1987年8月-1990年7月:第四军医大学病理学专业在职硕士生,获硕士学位(MSc)
?	1979年8月-1984年7月:第四军医大学医学专业本科生,获学士学位(M.D.)

工作经历:
?	2000年11月-现在:以“引进人才”任南开大学生命科学学院分子生物学研究所肿瘤研究室主任,教授,博士生导师。
?	1998年11月-2000年11月:日本国东京大学分子细胞生物学研究所博士后(日本学术振兴会JSPS博士后奖学金资助)
?	1998年2月-1998年11月:德国海涅大学(Heinrich Heine University)医学院访问学者(德国DAAD奖学金资助)
?	1997年1月-1998年1月:英国基尔大学(Keele University)生物学系访问学者(英国皇家协会奖学金资助Royal Society Fellowship)
?	1994年7月-1996年12月第四军医大学基础部病理学教研室助教,副教授


研究领域:RNA结构与功能;肿瘤分子生物学,开展乙肝病毒致癌分子机制和乳腺癌转移分子机制研究;筛选抗肿瘤药物

科研成果
2013年度中国抗癌协会科技奖二等奖《乙肝病毒致癌分子机制研究》
第六届中国侨界贡献(创新团队)奖
国家科技进步奖二等奖:《人原发性肝癌发病机制的免疫病理学和分子病理学研究》
陕西省科技进步奖一等奖:《肝炎、肝硬变和肝癌发病关系的免疫病理学和分子病理学研究》

社会兼职
天津滨海抗癌新药创制产业技术创新战略联盟理事长,中国抗癌协会肿瘤标志委员会常委,天津市抗癌协会常务理事,千人计划联谊会生命科学与生物医药专业委员会委员,大连医科大学客座教授,兰州大学第二医院/第二临床医学院客座教授。Cancer Research, Oncogene等杂志审稿人,香港食品健康局基金评审专家,国家自然科学基金项目评审专家。

回国后获得基金和研究生培养情况
2000年11月回国,先后获得并参加973计划项目5项(2项为课题组组长)、主持国家自然科学基金6项,参加国家自然科学基金9项,主持天津市科技发展计划科技攻关项目4项。迄今培养博士生39人(毕业30人),硕士生39人(毕业29人),其中多人现已在高校、科研院所中成为教授、副教授、研究员等。目前,已获得国家发明专利2项。5年内发表SCI论文50余篇,影响因子累计大于260。
发表SCI论文:(*通讯作者)

2017 Publications (*corresponding author)

1.Gao Y, Feng J, Yang G, Zhang S, Liu Y, Bu Y, Sun M, Zhao M, Chen F, Zhang W, Ye L, Zhang X. HBx-elevated MSL2 Modulates HBV cccDNA through Inducing Degradation of APOBEC3B to Enhance Hepatocarcinogenesis. Hepatology. 2017 Jun 13. doi: 10.1002/hep.29316. [Epub ahead of print]
2.Wang Y, Chen F, Yang Z, Zhao M, Zhang S, Gao Y, Feng J, Yang G, Zhang W, Ye L, Zhang X. The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2. Sci Rep. 2017 May 18;7(1):2070. 
3.Zhang SQ, Yang Z, Cai XL, Zhao M, Sun MM, Li J, Feng GX, Feng JY, Ye LH, Niu JQ*, Zhang XD*. miR-511 promotes the proliferation of human hepatoma cells by targeting the 3'UTR of B cell translocation gene 1 (BTG1) mRNA. Acta Pharmacol Sin. 2017 Jun 12. doi: 10.1038/aps.2017.62. [Epub ahead of print]
4.Yang G, Wang Y, Feng J, Liu Y, Wang T, Zhao M, Ye L, Zhang X. Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling. Biochem Biophys Res Commun. 2017 May 6;486(3):827-832.
5.Zhang S, Gao S, Zhao M, Liu Y, Bu Y, Jiang Q, Zhao Q, Ye L, Zhang X. Anti-HBV Drugs Suppress the Growth of HBV-related Hepatoma Cells via Down-regulation of Hepatitis B Virus X Protein. Cancer Lett. 2017 Apr 28;392:94-104.
6.Cai X, Cao C, Li J, Chen F, Zhang S, Liu B, Zhang W*, Zhang X*, Ye L*. Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1. Oncotarget. 2017 Apr 6. doi: 10.18632/oncotarget.16873. [Epub ahead of print]
7.Yang Z, Li J, Feng G, Gao S, Wang Y, Zhang S, Liu Y, Ye L, Li Y, Zhang X. MicroRNA-145 Modulates N6 methyladenosine Levels by Targeting the 3' Untranslated mRNA Region of the N6-methyladenosine binding YTH Domain Family 2 Protein. J Biol Chem. 2017 Jan 19. pii: jbc.M116.749689. doi: 10.1074/jbc.M116.749689. [Epub ahead of print] 
8.Wang Y, Cai X, Zhang S, Cui M, Liu F, Sun B, Zhang W, Zhang X, Ye L. HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer. Biochem Biophys Res Commun. 2017 Mar 11;484(3):565-571.
9.Wang Y, Fang R, Cui M, Zhang W, Bai X, Wang H, Liu B, Zhang X*, Ye L*. The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer. Cancer Lett. 2017 Jan 28;385:234-242. 


2016 Publications (*corresponding author)

1.Wang Y, Chen F, Zhao M, Yang Z, Zhang S, Ye L, Gao H*, Zhang X*. MiR-107 suppresses proliferation of hepatoma cells through targeting HMGA2 mRNA 3'UTR. Biochem Biophys Res Commun. 2016 Nov 18;480(3):455-460. 
2.Shi H, Fang R, Li Y, Li L, Zhang W, Wang H, Chen F, Zhang S, Zhang X*, Ye L*. The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells. Cancer Lett. 2016 Sep 5;382(2):147-156.
3.Zhao Y, Li H, Zhang Y, Li L, Fang R, Li Y, Liu Q, Zhang W, Qiu L, Liu F, Zhang X*, Ye L*. Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activatingthe LXRs/SREBP-1c/FAS Signaling Cascade. Cancer Res.  2016 Aug 15;76(16):4696-707 
4.Feng G, Li J, Zheng M, Yang Z, Liu Y, Zhang S, Ye L, Zhang W*, Zhang X*. Hepatitis B virus X protein up-regulates C4b-binding protein αthrough activating transcription factor Sp1in protection of hepatoma cells from complement attack. Oncotarget. 2016 May 10;7(19):28013-26. 
5.Feng G, Shi H, Li J, Yang Z, Fang R, Ye L, Zhang W*, Zhang X*. MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA. Biochem Biophys Res Commun. 2016 Apr 8;472(3):516-22.
6.Gao YE, Wang Y, Chen FQ, Feng JY, Yang G, Feng GX, Yang Z, Ye LH*, Zhang XD*. Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN byendogenous siRNA cleaved from hairpin within PTEN mRNA 3'UTR in human liver cells. Acta Pharmacol Sin. 2016 Jul;37(7):898-907.
7.Shi H, Li Y, Feng G, Li L, Fang R, Wang Z, Qu J, Ding P, Zhang X, Ye L*. The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells. Biochem Biophys Res Commun. 2016 Feb 26;471(1):89-94. doi: 10.1016/j.bbrc.2016.01.174. Epub 2016 Jan 29. 
8.Lu Z, Xiao Z, Liu F, Cui M, Li W, Yang Z, Li J, Ye L*, Zhang X*. Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1). Oncotarget. 2016 Jan 5;7(1):241-54. doi: 10.18632/oncotarget.6280.
9.Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang X*, Ye L*. HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc. Cancer Res.  2016 Jan 15;76(2):293-304. 
10.Li LL, Fang RP, Liu BW, Shi H, Wang Y, Zhang WY, Zhang XD*, Ye LH*. Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth. Oncogene, 2016 Aug 4;35(31):4048-57. 

2015 Publications

1.Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, Zhang X*, Ye L* Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.Oncogene. 2015 Dec 14. doi: 10.1038/onc.2015.476. [Epub ahead of print]
2.Lu Z, Zhang W, Gao S, Jiang Q, Xiao Z, Ye L*, Zhang X*. MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA. Biochem Biophys Res Commun. 2015 Dec 4;468(1-2):8-13.
3.Lu Z, Xiao Z, Liu F, Cui M, Li W, Yang Z, Li J, Ye L, Zhang X. Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1). Oncotarget. 2016 Jan 5;7(1):241-54. 
4.Liu F, Zhang W, You X Liu Y, Li Y, Wang Z, Wang Y, Zhang X*, Ye L*. The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer. Oncotarget. 2015 Sep 29;6(29):27199-213.
5.Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, Gao Y, Li Y, Zhang X*, Ye L*. The Oncoprotein HBXIP Modulates the Feedback Loop of MDM2/p53 to Enhance the Growth of Breast Cancer. J Biol Chem. 2015; 290(37):22649-61.
6.Lu ZP, Xiao ZL, Yang Z, Li J1, Feng GX, Chen FQ Li YH, Feng JY, Gao YE, Ye LH, Zhang XD. Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2α and sphingosine kinase 1. Acta Pharmacol Sin. 2015;36(10):1228-36.
7. Zhang W, Lu Z, Gao Y, Ye L, Song T, Zhang X. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA. Biochem Biophys Res Commun. 2015; 460(3):793-8.
8.Gao Y, Wang Y, Feng J, Feng G, Zheng M, Yang Z, Xiao Z, Lu Z, Ye LH, Zhang XD. A hairpin within YAP mRNA 3'UTR functions in regulation at post-transcription level. Biochem Biophys Res Commun. 2015; 459(2):306-12
9.Li L, Liu B, Zhang XD, Ye LH. The oncoprotein HBXIP promotes migration of breast cancer cells via GCN5-mediated microtubule acetylation. Biochem Biophys Res Commun. 2015; 458(3):720-5
10.Cui M, Zheng M, Sun B, Wang Y, Ye Lh and Zhang XD. A long non-coding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis. Neoplasia, 2015;17(1):79-88 (IF=5.4)
11.Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L, Zhang XD. Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9–Mediated RXRA Signaling Pathway. Cancer Res, 2015; 75(5): 846-857 (IF=9.2)

2014 Publications

1.Zhang XD, Wang Y, Ye LH. Hepatitis B virus X protein accelerates the development of hepatoma. Cancer Biol Med. 2014;11(3):182-90. 
2.Li Y, Zhang Z, Zhou X, Li L, Liu Q, Wang Z, Bai X, Zhao Y, Shi H, Zhang XD, Ye LH.The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling. Cancer Letters, 2014 Oct 7. pii: S0304-3835(14)00588-6. doi: 10.1016/j.canlet.2014;355:288-296 (IF=5.0)
3.Wang Y, Cui M, Sun BD, Liu FB, Zhang XD, Ye LH*. MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR. Acta Pharmacol Sin. 2014;35(9):1207-14. (IF=2.49)
4.Zhang W, Lu Z,Kong G, Gao Y, Wang T, Wang Q, Cai N, Wang H, Liu F, Ye L and Zhang X*. Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP. Molecular Cancer, 2014, 13:128, (IF=5.39)
5.Wang Y, Cui M, Cai X, Sun B, Liu F, Zhang X, Ye LH*. The oncoprotein HBXIP up-regulates SCG3 via activating E2F1 and suppressing miR-509-3p to promote proliferation of hepatoma cells. Cancer Letters, 2014, 352(2):169-78(IF=5.0)
6.Xu F, Zhu X, Han T, You X, Liu F, Ye L, Zhang X, Wang X, Yao Y. The oncoprotein hepatitis B X-interacting protein promotes the migration of ovarian cancer cells through the upregulation of S-phase kinase-associated protein 2 by Sp1. Int J Oncol. 2014 Jul;45(1):255-63. doi: 10.3892/ijo.2014.2411. Epub 2014 Apr 29.
7.Cui M, Xiao Z, Sun B, Wang Y, Zheng M, Ye L, Zhang XD*. Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4. Biochem Biophys Res Commun., 2014 Feb 24. pii: S0006-291X(14)00330-1. doi: 10.1016/j.bbrc.2014.02.068. [Epub ahead of print] (IF=2.7)
8.Liu FB, You XN, Wang Y, Liu Q, Liu YX, Zhang SQ, Chen LY, Zhang XD, Ye LH*. The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF. Carcinogenesis 2014;35(5):1144-53. (IF=5.26)
89cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA. Biochem Biophys Res Commun., 2014;444: 270-275 (IF=2.7)
10.Liu FB, You XN, Chi YM, Wang T, Ye LH, Niu JQ, Zhang XD*.Hepatitis B virus X protein mutant HBxD127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Biochem Biophys Res Commun., 2014;444: 128-134 (IF=2.7)


2013 Publications

1.Zhang T, Zhang J, Cui M,  Liu F, You X, Du Y, Gao Y, Zhang S, Lu Z, Ye L and Zhang X. Hepatitis B virus X protein inhibits tumor suppressor miR-205 via inducing hypermethylation of miR-205 promoter to enhance carcinogenesis. Neoplasia, 2013;15(11): 1282-1291 (IF=5.4)
2. Zhang YY, Zhao Y, Li H, Li YH, Cai XL, Shen Y, Shi H, Li LL, ian Liu1, Zhang XD*, Ye LH*. The Nuclear import of oncoprotein hepatitis B X-interacting protein depends on interacting with c-Fos and phosphorylation of both proteins in breast cancer cells. J Biol Chem 2013; in press (IF=4.7)
3.Zhang YY, Zhao Y, Li LL, Shen Y, Cai XL, Zhang XD*, Ye LH*. The Oncoprotein HBXIP up-regulates PDGFB via activating transcription factor Sp1 to promote proliferation of breast cancer cells. Biochem Biophys Res Commun.,2013;434: 305-310 (IF=2.7)
4.Qiao L, Wu Q, Lu X, Zhou Y, Fernández-Alvarez A, Ye L, Zhang X, Han J, Casado M, Liu Q*. SREBP-1a activation by HBx and the effect on hepatitis B virus enhancer II/core promoter. Biochem Biophys Res Commun. 2013; 432(4):643-9 (IF=2.7)
5.You XN, Liu FB, Zhang T, Li YH, Ye LH*, Zhang XD*. Hepatitis B virus X protein up-regulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells. Carcinogenesis, 2013 Mar 7. [Epub ahead of print] (IF=5.4)
6.Liu Q, Zhang XD*, Ye LH*. The oncoprotein HBXIP up-regulates Lin28B via activating TFⅡD to promote proliferation of breast cancer cells. Int J Cancer. 2013 Mar 11. doi: 10.1002/ijc.28154. [Epub ahead of print (IF=5.4)
7.Xu FQ, You XN, Liu FB, Shen XH, Yao YQ, Ye LH*, Zhang XD*.The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells. Cancer Letters, 2013; 333(1):124-32 (IF=4.23)
8.Zhang S, Shan CL, Cui WJ, You XN, Du YM, Kong GY, Gao FB, Ye LH*, Zhang XD*. Hepatitis B virus X protein protects hepatoma and hepatic cells from complement-dependentcytotoxicity by up-regulation of CD46. FEBS Letters 2013;587 (6): 645-51. (IF=3.6)
9.You X, Liu F, Zhang T, Lv N, Liu Q, Shan C, Du Y, Kong G, Wang T, Ye LH* and Zhang XD*. Hepatitis B virus X protein up-regulates Lin28A/Lin28B through Sp-1/c-Myc to enhance the proliferation of hepatoma cells. Oncogene, Jan 14. doi: 10.1038/onc.2012.618. [Epub ahead of print] (IF=7.4)
10.Yue L, Li LL, Liu FF, Hu N, Zhang WY, Bai X, Li HY, Fu L, Zhang XD*, Ye LH*. Oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells. Carcinogenesis, 2013;34(4):927-35. (IF=5.4)

2012 publications

1.Zhang X, You XN, Li N, Zhang WY, Gagos S, Wang Q, Banos A, Cai N, Zhang H, Zhang H, Zhang XZ, Shan CL, Qiu LY, Zhang S, Lv N,   Chen MS, Du YM, Xia JC, Ye LH, Zhang XD*. Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/Alu core sequence/subtelomeric DNA. FEBS Letters,2012; 586(19):3215-21 (IF=3.6)
2.Liu SP, Li LL, Zhang YY, Zhang YW, Zhao Y, Lin ZH, Zhang XD*, Ye LH.HBXIP upregulates s100a4 via stat4 and pten to promote growth and migration of breast cancer cells. J Biol Chem 2012;287(36):30228-39. (IF=5.4)
3.Zhang T, Zhang J, You X, Liu Q, Du Y, Gao Y, Shan C, Kong G, Ye LH and Zhang XD*. Hepatitis B Virus X Protein (HBx) Modulates Oncogene YAP via CREB to Promote Growth of Hepatoma Cells. Hepatology, 2012 Jun 18. doi: 10.1002/hep.25899. [Epub ahead of print](IF=11.66)
4.Du Y, Kong G, You X, Zhang S, Zhang T, Ye LH, Zhang XD*.Up-regulated long non-coding RNA HULC by HBx enhances growth of hepatoma cells via down-regulating p18. J Biol Chem. 2012;287(31):26302-11 (IF=5.4)
5. Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, Zhang Z, Zhang S, Shan C, Ye LH, Zhang XD*. Hepatitis B virus X protein promotes cell migration via multiple cross-talk cascade loops involving 5-LOX, NF-κB, OPN and Capn4. PLoS One, 2012;7(2):e31458. (IF=4.3)
6.Zhang W, Kong G, Zhang J, Wang T, Ye LH, Zhang XD*. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7(2): e31450. (IF=4.3)
7.Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang W, Zhang XD*, Ye LH. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells from complement attack. FEBS Letters,2012;586(6):766-71 (IF=3.6)
8.Zhao Y, Wang W, Wang Q, Zhang XD*, Ye LH. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells. Biochem Biophys Res Commun. 2012; 418(4):647-651 (IF=2.7)
9.Zhang S, Shan CL, Kong GY, Du YM, Ye LH, Zhang XD*.MicroRNA-520e Suppresses Growth of Hepatoma Cells by Targeting the NF-κB-inducing Kinase (NIK). Oncogene, 2012;31(31):3607-20.(IF=7.4)
10.Wang Q,Zhang T,Ye LH,Wang WH,Zhang XD*. Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China. Cancer Epidemiol. 2012; 36: 369-374 (IF=1.4)


2011 publications

1.Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH, Zhang XD*. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin. 2011;32:1173-1180 (IF=1.9)
2.Kong G, Zhang J, Zhang S, Shan C, Ye LH, Zhang XD*. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model. PLoS One. 2011;6(5):e19518.(IF=4.3)
3.Shan C, Zhang S, Cui W, You X, Kong G, Du Y, Qiu L, Zhang Z, Ye LH, Zhang XD*. HBx activates CD59 through indirectly binding to the region of the CD59 promoter and down-regulating Let-7i. Carcinogenesis. 2011;32 (8):1190-7 (IF=5.4)
4.Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, Bai X, Zhang Z, Zhang W, Zhang XD*, Ye LH. miR-520b regulates migration of breast cancer cells through targeting hepatitis B X-interacting protein and interleukin-8. J Biol Chem. 2011;286(15):13714-22. (IF=5.4)
5.Hu N, Li Y, Zhao Y, Wang Q, You JC, Zhang XD*, Ye LH.A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. Acta Pharmacol Sin. 2011; 2011;32:921-929  (IF=1.9)

2010 publicatinos

1.Cui WJ, Zhang YW, Hu N, Shan CL, Zhang S, Zhang WY, Zhang XD*, Ye LH. MiRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 3′UTR of CD46. Cancer Biol Ther. 2010;10(3):232-241. (IF=2.7)
2.Cui WJ, Liu Y, Zhou XL, Wang FZ, Zhang XD*, Ye LH.Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway. Acta Pharmacol Sin. 2010;31(6):725-732 (IF=1.9)
3.Zhang X, Ye LH*, Zhang XD*. A mutant of hepatitis B virus X protein (HBx datar 127) enhances cell migration via osteopontin (OPN) involving 5-lipoxygenase. Acta Pharmacol Sin. 
2010; 31(5):593-600 (IF=1.9)
4.Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD*. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J Med Virol. 2010; 82: 920-928 (IF=2.7)
5.Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH, Zhang XD*. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res. 2010; 20(5):563-75 (IF=9.4)
6.Wang Q, Zhang WY, Ye LH, Zhang XD*. A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin. 2010; 31(3): 367-374 (IF=1.9)
7.Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye LH, Zhang XD*. A Mutant of Hepatitis B Virus X P3otein (HBxDelta127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase. Neoplasia. 2010;12(2):103-15. (IF=5.4)
8.Zhou XL, Qin XR, Zhang XD*, Ye LH. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling. Acta Pharmacol Sin. 2010;31(2):202-10. (IF=1.9)

出版著作:
1.《Progress in Hepatitis B Research》 (ISBN: 1-60021-687-0) Editors: Dorothy V. Denyer. Nova publishers of America. Published in Dec. 2007. 
Xiaodong Zhang wrote the Chapter V - Hepatitis B Virus Research Focus; pp. 113-201
2.《Hepatitis B Virus Research Focus》(ISBN: 978-1-60456-299-6) Writers: Xiaodong Zhang, Weiying Zhang, Lihong Ye. Nova Science Publishers of America. Published in Oct 2008.

获得授权专利
1.叶丽虹,张晓东,吴莲英, 朱惠芳.高转移倾向的人乳腺癌细胞系及其建立方法,获得国家发明专利,专利号:ZL.031310264.5 
2.叶丽虹,张晓东,秦宵然, 朱惠芳,王洪辉.人肝癌转移亚克隆细胞系及其建立方法,获得国家发明专利,专利号:ZL 200410019057.2 
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