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赵立青

 性    别:女
 职    称:教授
 所属部门:生物化学和分子生物学系
 招生专业:生物化学与分子生物学
 研究方向:肺组织远端发育 肿瘤免疫
::教师简介::
    1984年南开大学生物系生物化学专业本科毕业,1988年南开大学生物系生物化学专业硕士毕业,1998年南开大学生命科学院分子遗传专业博士毕业。2000.10---2003.9美国加州大学旧金山分校(UCSF),医学系,肺生物学研究中心博士后。1988.4---2005.4天津中医学院教师,2005.5---今 南开大学生命科学院生物化学系教师。
研究方向:肺组织远端发育;肿瘤免疫
开设课程:生物化学2-2,生物化学实验,生物科学综合实验
在研项目:IL-10+ CD8+调节性T 细胞功能及作用机制研究(自然基金资助项目),DC来源IL-27在肿瘤免疫中作用机制的研究(自然基金资助项目)等
主要研究成果:
1. Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech SM, Weaver CT, Flavell RA, Zhao L*, Yao Z, Yin Z. IL-4 induces a suppressive IL-10+CD8+ T cell population mediated via Cdkn2a. J Leukoc Biol .2013. 94(6):1103-12
2. Jun Wei, Siyuan Xia, Huayan Sun, Song Zhang, Jingya Wang, Huiyuan Zhao, Xiaoli Wu, Xi Chen, Jianlei Hao, Xinglong Zhou, Zhengmao Zhu, Xiang Gao,
Jian-xin Gao, Puyue Wang, Zhenzhou Wu, Liqing Zhao, and Zhinan Yin*. Critical Role of Dendritic Cell–Derived IL-27 in Antitumor Immunity through Regulating the Recruitment and Activation of NK and NKT Cells. The Journal of Immunology.2013. 191:500-508
3. Song Zhang, Ruifang Liang, Wei Luo, Chang Liu, Xiaoli Wu, Yanan Gao, Jianlei Hao, Guangchao Cao,Xi Chen, Jun Wei, Siyuan Xia, Zheng Li, Ti Wen, Yunyun Wu, Xinglong Zhou, Puyue Wang, Liqing Zhao, Zhengzhou Wu, Sidong Xiong, Xiaoming Gao, Xiang Gao, Yongyan Chen, Qing Ge, Zhigang Tian,5 and Zhinan Yin. High Susceptibility to Liver Injury in IL-27 p28Conditional Knockout Mice Involves IntrinsicInterferon-c Dysregulation of CD41 T Cells. HEPATOLOGY, 2013.l. 57(. 4):1620-1631
4. Zhou XH, Liu Y, Hu NY, Wang CY,Zhao LQ. Screening and Identification of P311 Binding Proteins. Progress in Biochemistry and Biophysics. 2010, 37(12): 1303~1312
5. Zhao LQ, Leung JK, Yamamoto H, Goswami S, Ferrara N,, and Vu TH, Identification of P311 as a potential gene regulating alveolar generation, American Journal of Respiratory Cell and Molecular Biology, 2006 Jul;35(1):48-54.
6. Zhao LQ, Wan K g, Ferrara N, Vu TH,Vascular endothelia growth factor co-ordinates proper development of lung epitheliaum and vasculature, Mechanisms of Development, 2005, 122:877-886.

::主要学术论文::
::主要科研项目::