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朱玉山

 性    别:男
 职    称:教授
 所属部门:遗传学和细胞生物学系
 招生专业:细胞生物学
 研究方向:细胞自噬与细胞凋亡调控
::教师简介::
南开大学,生命科学学院,教授
研究方向:线粒体生物学与肿瘤生物学;着重关注线粒体在细胞凋亡中的关键作用,线粒体质量控制与肿瘤发生相关研究。相关论文发表在Nature Cell Biology,Nature Communications,Molecular Cell, Cell Research, Autophagy, Protein Cell, Clinical Cancer Research, Journal of Biological Chemistry等杂志。
主持或参加科研项目及人才计划项目情况:
(1)国家自然科学基金面上项目:细胞自噬关键膜蛋白ATG9运输的分子调控; 2017.1-2020.12,在研、主持.
(2)国家自然科学基金面上项目:SDHB在线粒体能量代谢和三羧酸循环中的关键作用;2013.1-2016.12;在研;主持。
(3)国家自然科学基金面上项目:FUNDC1与LC3相互作用结构域在线粒体自噬调控中的关键作用;2015.11-2018.12;在研;主持。
(4)973项目:基因组稳定性及细胞周期调控信号通路蛋白质群的作用机制研究;2010.1-2014.8;已结题;课题骨干。
(5)973项目:肿瘤和免疫细胞相互作用过程中蛋白质功能研究;2007.1-2012.8;已结题;课题骨干。
(6)天津市自然基金重点项目;Beclin-1调控细胞自噬和细胞凋亡转换功能研究;2010.4-2013.3;主持;已结题。
研究论文
(1)Zhou C, Ma K, Gao R, Mu C, Chen L, Liu Q, Luo Q, Feng D, Zhu Y*, Chen Q*. (2017) Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy, Cell Research. 2017 Feb;27(2):184-201.  (*通讯作者, IF=15.6067)
(2)Kuang Y, Ma K, Zhou C, Ding P, Zhu Y*, Chen Q*, Xia B*.(2016) Structural Basis for the Phosphorylation of FUNDC1 LIR as a Molecular Switch of Mitophagy. Autophagy: 2016 Dec;12(12):2363-2373 (IF=9.108)
(3)Ma B, Cheng H, Gao R, Mu C, Chen L, Chen Q, Zhu Y*. (2016) Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways. Nature communications, 7, 11123. (*通讯作者, IF=12.124)
(4)Song P, Li S, Wu H, Gao R, Rao G, Wang D, Chen Z, Ma B, Wang H, Sui N, Deng H, Zhang Z, Tang T, Tan Z, Han Z, Lu T, Zhu Y*, Chen Q*. (2016) Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease. Protein Cell 7: 114-29. (*通讯作者, IF=5.374)
(5)Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, Gao R, Zhou C, Cao L, Liu J, Zhu,Y*, Chen Q*, Wu S*. (2015) Hypoxia regulates Hippo signaling through the SIAH2 ubiquitin E3 ligase. Nature Cell Biology, 17(1): 95-103 (*通讯作者, IF=20.058,他引19) 
(6)Li J, Qi W, Chen G, Fenf D, Liu J, Ma B, Zhou C, Mu C, Zhang W, Chen Q*, Zhu Y*. (2015) Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy. Autophay 11: 1216-1229 ( *通讯作者, IF=11.423,他引4) 
(7)Zhu Y, Chen G, Chen L, Zhang W, Liu L, Feng D, Chen Q. (2014) Monitoring Mitophagy in Mammalian Cells, Methods in Enzymology 547: 39-55(IF=2.194) 他引2
(8)Chen G, Han Z, Feng D, Chen Y, Chen L, Zhou C, Cai Y,Fu C, Duan L, Wang X, Liu X, Shen Y, Zhu Y*.Chen Q*. (2014) A regulatory signaling loop comprising?the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy, Molecular Cell,2014, 54(3):362-77 (*通讯作者;IF=15.28,他引38)
(9)Liu J, Mu C, Yue W, Li J, Ma B, Zhao L, Liu L, Chen Q, Yan C, Liu H, Hao X, Zhu Y* (2013) A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis. Free Radical Biology & Medicine 63: 485-494 (*通讯作者 ; IF=5.710 他引4)
(10)Zhu Y, Li M, Wang X, Jin H, Liu S, Xu J, Chen Q (2012) Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release. Cell Research 22: 127-141 (IF=11.981, 他引17)
(11)Ni B, Ma Q, Li B, Zhao L, Liu Y, Zhu Y*, Chen Q* (2012) Phenylarsine oxide induces apoptosis in Bax- and Bak-deficient cells through upregulation of Bim. Clinical Cancer Research 18: 140-151(*通讯作者, IF=7.837,他引6)
(12)Zhao L*, He F*, Liu H*, Zhu Y*, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q (2012) Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. Journal of Biological Chemistry 287: 1054-1065 (*共同第一, IF=4.651,他引22)
(13)Zhao L, Zhu Y*, Wang D, Chen M, Gao P, Xiao W, Rao G, Wang X, Jin H, Xu L, Sui N, Chen Q* (2010) Morphine induces Beclin 1- and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus. Autophagy 6: 386-394 (*通讯作者, IF=6.6643, 他引23)
(14)Zhu Y*, Zhao L, Liu L, Gao P, Tian W, Wang X, Jin H, Xu H, Chen Q (2010) Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein & cell 1: 468-477 (*通讯作者, IF=3.22,他引86)
(15)Zhu Y, Huang K, and Xu H. Mitochondrial Permeabiltiy Transition and Release of Cytochrome c Induced by Selenite. J Inorganic Biochemistry, 2002, 90:43-50
(16)Zhu Y, Xu H, Huang K, Hu W, and Liu M. A study on human urine in a high selenium area of china by 1H-NMR spectroscopy. Biol Trace Elem Res. 2002, 89:1-9.
参加论文
(1)Wang L, Yang X, Li S, Wang Z, Liu Y, Feng J, Zhu Y, Shen Y (2014) Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. The EMBO journal 33:594-604.
(2)Wu H, Xue D, Chen G, Han Z, Huang L, Zhu C, Wang X, Jin H, Wang J, Zhu Y, Liu L, Chen Q (2014) The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy 10:1712-25.
(3)Wang L, Ye X, Zhao Q, Zhou Z, Dan J, Zhu Y, Chen Q, Liu L (2014) Drp1 is dispensable for mitochondria biogenesis in induction to pluripotency but required for differentiation of embryonic stem cells. Stem Cells and Development, 23:2422-34.
(4)Liu Y, Cheng H, Zhou Y, Zhu Y, Bian R, Chen Y, Li C, Ma Q, Zheng Q, Zhang Y, Jin H, Wang X, Chen Q, Zhu D (2013) Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells. Cell Death & Disease 4: e494
(5)Zhang W, Wu H, Liu L, Zhu Y, Chen Q. (2013) Phosphorylation Events in Selective Mitophagy: Possible Biochemical Markers? Current Pathobiology Reports,1(4): 273-282 (Inivited review)
(6)Du L, Rao G, Wang H, Li B, Tian W, Cui J, He L, Laffin B, Tian X, Hao C, Liu H, Sun X, Zhu Y, Tang DG, Mehrpour M, Lu Y, Chen Q (2013) CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer. Cancer Research 73: 2682-2694
(7)Rao G, Wang H, Li B, Huang L, Xue D, Wang X, Jin H, Wang J, Zhu Y, Lu Y, Du L, Chen Q (2013) Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer. Clinical Cancer Research 19: 785-797 
(8)Feng D, Liu L, Zhu Y, Chen Q (2013) Molecular signaling toward mitophagy and its physiological significance. Experimental Cell Research 319: 1697-1705(Inivited review)
(9)Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, Huang L, Xue P, Li B, Wang X, Jin H, Wang J, Yang F, Liu P, Zhu Y, Sui S, Chen Q (2012) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nature Cell Biology 14: 177-185
(10)Gao P, Bauvy C, Souquere S, Tonelli G, Liu L, Zhu Y, Qiao Z, Bakula D, Proikas-Cezanne T, Pierron G, Codogno P, Chen Q, Mehrpour M (2010) The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. The Journal of Biological Chemistry 285: 25570-25581 
(11)Wang H, Song P, Du L, Tian W, Yue W, Liu M, Li D, Wang B, Zhu Y, Cao C, Zhou J, Chen Q (2011) Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. The Journal of Biological Chemistry 286: 11649-11658 
(12)Zhang J, Liu W, Liu J, Xiao W, Liu L, Jiang C, Sun X, Liu P, Zhu Y, Zhang C, Chen Q (2010) G-protein beta2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion. Nature communications 1: 101
(13)Xu H, Huang K, Zhu Y, Gao Q, Wu Q, Tian W, Sheng X, Chen Z and Gao Z. Hypoglycemic Effect of A Novel Insulin Buccal Formulation on Rabbits. Pharmacological Research, 2002, 46(5):459-67.
(14)Xu H, Huang K, Gao Q, Zhu Y, Han X. Prevention of axial elongation in myopia by the trace element zinc. Biol Trace Elem Res, 2001, 79(1): 39-47.

联系方式:
生物站A401;23501201
 zhuys@nankai.edu.cn
::主要学术论文::
::主要科研项目::