亚当·米德格利

英国卡迪夫大学医学院博士毕业，在威尔士肾脏研究单位从事博士后研究。2018年加入南开大学，2020年被任命为副教授，2024年入选南开大学的 “百名青年学科带头人”。他的研究方向包括：利用基因-纳米载体及肽/蛋白质释放生物材料实现纤维化疾病（肾脏、心血管、皮肤、肝脏）的靶向防治；利用肾脏类器官模型探索疾病发病机制，并辅助开发基于发育生物学原理的组织再生疗法。在 Sci Signal、J Am Soc Nephrol、Bioactive Mater、Adv Mater、Nano Today、J Biol Chem等SCI杂志发表论文 >85 余篇。其中，第一份或通讯作者SCI杂志发表论文 >25 余篇。作为项目负责人主持国家自然科学基金3项。

(2010.10 – 2013.10) 博士学位分子与实验医学英国威尔士卡迪夫大学生物医学与生命科学学院医学院; (2009.10 - 2010.10) 理学硕士组织工程与再生英国威尔士卡迪夫大学牙科学院; (2006.10 – 2009.06) 理学学士生物医学英国威尔士卡迪夫大学生物科学学院

(2020.06 - 现在) 副教授天津市南开大学生命科学学院，生物活性材料教育部重点实验室; (2019.01 - 现在) 国家自然科学基金委员会研究员天津市南开大学生命科学学院，徐荣祥再生生命科学中心，药物化学生物学国家重点实验室; (2018.03 - 2020.06) 博士后研究助理天津市南开大学生命科学学院，徐荣祥再生生命科学中心，药物化学生物学国家重点实验室; (2013.10 - 2018.01) 博士后研究助理英国威尔士卡迪夫大学生物医学与生命科学学院，感染与免疫学系，威尔士肾脏研究室

• 利用基因-纳米载体及肽/蛋白质释放生物材料实现纤维化疾病（肾脏、心血管、皮肤、肝脏）的靶向防治；

• 利用肾脏类器官模型探索疾病发病机制，并辅助开发基于发育生物学原理的组织再生疗法；

• 伤口愈合生物材料（皮肤再生、抗疤痕疗法）；

• 慢性疾病的分子机制（细胞分化、基质生物学和信号通路）；

• 年龄对组织再生的影响。

代表作品

2025

Li R#; Tai Y#; Zhang X; Liu Z; Si H; Kong D; Zhao L*; Li J*; Midgley AC*. (2025) Tissue‐Microenvironment‐Responsive Self‐Assembling Peptide Nanoshells Boost Pirfenidone Efficacy in the Treatment of Liver Fibrosis. Advanced Healthcare Materials. 14(15):2500101.

Wang L; Li Y; He Y; Fang Y; Mimuro H; Midgley AC*; Yoshida S*. (2025) Macropinocytosis regulates cytokine expression through Erk signaling in LPS-stimulated macrophages. Cell Structure and Function. 25008.

Sun X; Li Y; He Y; Cheng L; Wang L; Wei J; Chen J; Du L; Shen Z; Xie Y*; Midgley AC*; Jiang W*; Yoshida S*. (2025) Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells. Cell Communication and Signaling. 23:75.

Li W*/#; Zhao Y#; Cheng Z#; Niu F; Ding J; Bai Y; Li Z; Midgley AC*; Zhu M*. (2025) Fine-tuning of porous microchannelled silk fibroin scaffolds for optimal tissue ingrowth. Materials & Design. 251:113711.

 

2024

Xing M; Wang F; Chu R; Wang H; Sun Y; Qian M; Jiang H; Midgley AC*; Dai G*; Zhao Q*. (2024) Localized COUP-TFII pDNA delivery modulates stem/progenitor cell differentiation to enhance endothelialization and inhibit calcification of decellularized allografts. Advanced Science. 12(5):2409744.

Wang Y; Li Z; Zhang C; Jin Z; Midgley AC*. (2024) Dermal Fibrosis and the Current Scope of Hydrogel Strategies for Scarless Wound Healing. Fibrosis. 2:10010. [Review]

Tai Y; Liu Z; Wang Y; Zhang X; Li R; Yu J; Chen Y; Zhao L; Li J; Bai X; Kong D; Midgley AC*. (2024) Enhanced glomerular transfection by BMP7 gene nanocarriers inhibits CKD and promotes SOX9-dependent tubuleregeneration. Nano Today. 59:102545.

Jin Z; Midgley AC*. (2024) Natural Biological Solutions for Chronic Pathological Problems. Biomolecules. 14:1248. [Editorial]

Gu XR; Tai Y; Liu Z; Zhang X; Liu K; Zhou LY; Yin WJ; Deng YX; Kong D; Midgley AC*; Zuo XC*. (2024) Layer-by-layer Assembly of Renal-targeted Polymeric Nanoparticles for Robust Arginase-2 Knockdown and Contrast-induced Acute Kidney Injury Prevention. Advanced Healthcare Materials. e2304675. DOI: 10.1002/adhm.202304675.

 

2023

Li L; Cao J; Li S; Cui T; Ni J; Zhang H; Zhu Y; Mao J; Gao X*; Midgley AC*; Zhu M*; Fan G*. (2023) M2 Macrophage-Derived sEV Regulate Pro-Inflammatory CCR2+ Macrophage Subpopulations to Favor Post-AMI Cardiac Repair. Advanced Science. 10(14):2202964.

Yan H#; Cheng Q#; Si J; Wang S; Wan Y; Kong X; Wang T; Zheng W; Rafique M; Li X; He J; Midgley AC*; Zhu Y; Wang K*; Kong D. (2023) Functionalization of in vivo tissue-engineered living biotubes enhance patency and endothelization without the requirement of systemic anticoagulant administration. Bioactive Materials, 26:292-305.

Zhuang J#; Midgley AC#; Wei Y; Liu Q; Kong D*; Huang X*. (2023) Machine Learning‐assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes. Advanced Materials, :2210848. [Review]

 

2022

Wu Z; Midgley AC*; Kong D*; Ding D. (2022) Organic persistent luminescence imaging for biomedical applications. Materials Today Bio, 17:100481. [Review]

Wang H; Xing M; Deng W; Qian M; Wang F; Wang K; Midgley AC*; Zhao Q*. (2022) Anti-Sca-1 antibody-functionalized vascular grafts improve vascular regeneration via selective capture of endogenous vascular stem/progenitor cells. Bioactive Materials, 16:433-450.

Midgley AC*; Zhao Q*. (2022) CD44 receptor diversity and potential in preventative and regenerative therapies. Clinical and Translational Discovery, 2(2):e78. [Commentary]

Gu X; Liu Z; Tai Y; Zhou LY; Liu K; Kong D*; Midgley AC*; Zuo XC*. (2022) Hydrogel and nanoparticle carriers for kidney disease therapy: trends and recent advancements. Progress in Biomedical Engineering, 4(2):022006. [Review]

Qi C; Liu X; Zhi D; Tai Y; Liu Y; Sun Q; Wang K; Wang S*; Midgley AC*; Kong D*. (2022) Exosome-mimicking nanovesicles derived from efficacy-potentiated stem cell membrane and secretome for regeneration of injured tissue, Nano Research, 15(2):1680-1690.

Midgley AC; Bowen T*. (2022) Analysis of Human Hyaluronan Synthase Gene Transcriptional Regulation and Downstream Hyaluronan Cell Surface Receptor Mobility in Myofibroblast Differentiation. Methods Mol Biol, 2303:453-468.

 

2021

Zhang L#; Tai Y#; Liu X; Liu Y; Dong Y; Liu Y; Yang C; Kong D; Qi C*; Wang S*; Midgley AC*. (2021) Natural polymeric and peptide-loaded composite wound dressings for scar prevention. Applied Materials Today, 25:101186.

Sun Q; Shen Z; Liang X; He Y; Kong D; Midgley AC*; Wang K*. (2021) Progress and Current Limitations of Materials for Artificial Bile Duct Engineering. Materials, 14(23):7468. [Review]

Yang S; Zheng X; Qian M; Wang H; Wang F; Wei Y; Midgley AC*; He J; Tian H*; Zhao Q*. (2021) Nitrate-Functionalized poly(ε-Caprolactone) Small-Diameter Vascular Grafts Enhance Vascular Regeneration via Sustained Release of Nitric Oxide. Frontiers in Bioengineering and Biotechnology, 9:770121.

Tai Y#; Woods EL#; Dally J; Kong D; Steadman R; Moseley R*; Midgley AC*.(2021) Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis. Biomolecules, 11(8):1095. [Review]

Zhang L; Yan H; Tai Y; Xue Y; Wei Y; Wang K; Zhao Q; Wang S*; Kong D; Midgley AC*. (2021) Design and Evaluation of a Polypeptide that Mimics the Integrin Binding Site for EDA Fibronectin to Block Profibrotic Cell Activity. International Journal of Molecular Science, 22(4):1575.

2020

Midgley AC*; Wei Y; Zhu D; Gao F; Yan H; Khalique A; Luo W; Jiang H; Liu X; Guo J; Zhang C; Feng G; Wang K; Bai X; Ning W; Yang C; Zhao Q; Kong D.* (2020) Multifunctional natural polymer nanoparticles as antifibrotic gene carriers for chronic kidney disease therapy. Journal of the American Society of Nephrology, 31(10):ASN.2019111160.

Midgley AC#; Woods EL#; Roberts T; Jenkins RH; Hascall V; Steadman R; Phillips AO; Meran S*. (2020) Hyaluronidase-2 Regulates RhoA Signalling, Myofibroblast Contractility and other Key Pro-fibrotic Myofibroblast Functions. American Journal of Pathology,190(6):1236-1255.

2013-2019

Midgley AC#; Wei Y#; Li Z; Kong D; Zhao Q*. (2019) Nitric-Oxide-Releasing Biomaterial Regulation of the Stem Cell Microenvironment in Regenerative Medicine. Advanced Materials, 32(3):1805818. [Review]

Dally J; Khan JS; Voisey A; Charalambous C; John HL; Woods EL; Steadman R; Moseley R; Midgley AC* (2017) Hepatocyte Growth Factor mediates enhanced wound healing responses and resistance to Transforming Growth Factor-beta1-driven myofibroblast differentiation in oral mucosal fibroblasts. International Journal of Molecular Science, 18(9):1843.

Midgley AC, Oltean S; Hascall V; Woods EL; Steadman R; Phillips AO; Meran S*. (2017) Nuclear Hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to dictate pro-fibrotic or anti-fibrotic cell phenotype. Science Signaling, 10(506):eaao1822.

Midgley AC*; Morris G; Phillips AO; Steadman R*. (2016) 17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation. Aging Cell, 15(3):531-41.

Midgley AC; Bowen T*. (2015) Analysis of human hyaluronan synthase gene transcriptional regulation and downstream hyaluronan cell surface receptor mobility in myofibroblast differentiation. Methods Mol Biol, Glycosaminoglycans Part II, 1229:605-618.

Midgley AC; Duggal L; Jenkins R; Hascall V; Steadman R; Phillips AO; Meran S*. (2015) Hyaluronan regulates Bone Morphogenetic Protein-7 dependent prevention and reversal of myofibroblast phenotype. J Biol Chem, 290(18):11218-34.

Midgley AC; Bowen T; Phillips AO; Steadman R*. (2014) MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts. Aging Cell, 13:235-244.

Midgley AC; Rogers M; Hallett MB; Clayton A; Bowen T; Phillips AO; Steadman R*. (2013) TGF-β1-stimulated fibroblast to myofibroblast differentiation is mediated by HA-facilitated EGFR and CD44 colocalisation in lipid rafts. J Biol Chem, 288(21):14824-14838.

 

专利 Patents

1. Application date: 2020/12/24; Authorisation date: ----/--/--; Inventors: 孔德领, 亚当·米德格利; Description:一种小型阻断肽的没计筛选方法及其用于合成纤维化疾病治疗药物的应用 (202011572701.4); Country: China; Status: Closed; Type: 发明专利

2. Application date: 2021/04/09; Authorisation date: 2023/02/28; Inventors: 王淑芳, 亚当·米德格利, 张琳, 孔德领; Description:一种防疤痕皮肤创伤修复用水凝胶及其制备方法 (ZL202110380295.X); Country: China; Status: Authorised; Type: 发明专利

3. Application date: 2023/09/12; Authorisation date: ----/--/--; Inventors: 亚当·米德格利; 孔德领; 台逸凡; 刘震; Description:一种多功能逐层组装复合纳米颗粒基因载体的制备方法 (202311172849.2); Country: China; Status: Applied; Type: 发明专利

4. Application date: 2024/11/01; Authorisation date: ----/--/--; Inventors: 亚当·米德格利; 李瑞芳; 台逸凡; 孔德领; 李嘉; 赵黎莉; 张欣妍; Description: 一种自组装多肽、自组装多肽纳米材料及其制备方法和应用 (202411550865.5); Country: China; Status: Applied; Type: 发明专利

Editoiral Board Roles

BME Horizons 青年编辑委员会成员 (2025-今);

World Journal of Nephrology 编辑委员会成员 (2025-今);

International Journal of Biomaterials 编辑委员会成员 (2025-今);

Fibrosis 编辑委员会成员 (2023-今);

Society Memberships

International Society of Regenerative Medicine and Wound Repair (ISRMWR) 会员 (2025/09-今);

International Society for Applied Cardiovascular Biology (ISACB) 年轻会员 (2024/06-今);

Chinese Society for Biomaterials 会员 (2022/04-今);

European Tissue Repair Society 会员 (2017/03-2021/03); 

Biochemical Society 早期职业会员 (2016/05-2020/05); 

Cardiff Institute of Tissue Engineering and Repair 会员 (2009/10-2018/01)。

专家同行评审员
硕士学位论文
英国研究与创新机构-医学研究委员会（UKRI-MRC）资助申请

Nature Communications, Advanced Materials, Bioactive Materials, Materials Today Bio, Kidney International , 等的同行评审员。

Tutoring/Mentorship
博士生导师, 南开大学 (2024-今);

硕士生导师, 南开大学 (2020-今);

硕士生导师, 英国卡迪夫大学 (2013-2018);

 

Teaching

Lecturer on the [INTL0003-核酸生物技术] 本科选修课程, 南开大学 (2025-今);

Lecturer on the [LIFE0068-高级英文生物化学] 本科选修课程: [核酸生物], 南开大学 (2022-2025);

Lecturer on the [International and Intercultural Dialogue] 本科选修课程, 南开大学 (2022-2023);

Lecturer on the [硕士-Human Tissue Engineering and Regeneration]课程: [Cell Culture] 和 [Bioengineering the Kidney], 英国卡迪夫大学 (2016-2018)

Lecturer on the [学士-Biomedical Sciences]课程: [Bioengineering the Kidney], 英国卡迪夫大学 (2017-2018)

 

Teaching Reform Projects

参加 [2023南开大学本科教育教学改革项目 - 生物学科全英文专业核心课程群建设] (2023-2024);

2024年 入选南开大学的 “百名青年学科带头人”；

2024年 高等教育学院院士（FHEA）；

2023年 国家自然科学基金委员会外国优秀青年学者研究基金项目；

2023年 入选科技部的外国学者研究基金项目；

2023年 入选天津市重点联系专家项目；

2021年 入选科技部的外国青年人才计划。