Lingyi Chen

Professor Lingyi Chen, recipient of the National Science Fund for Excellent Young Scholars，has published more than 50 papers in high impact journals, including Cell, Nature, PNAS, Cell Research. The goal of his research is to understand the regulatory mechanisms underlying pluripotency maintenance and establishment, in embryonic stem cells and during early embryogenesis. How do embryonic stem cells maintain their differentiation potential while proliferate unlimited? How does a zygote differentiate into various types of cells? Particularly, how are the cell fates of the inner cell mass and the trophectoderm determined during the development of the blastocyst?

1999 B.S. Peking University2004 Ph.D. Northwestern University, USA

2005--2008 Harvard Medical School, Postdoctoral Fellow2008-- Nankai University, Professor

（1）Molecular mechanism of pluripotency maintenance in embryonic stem cells.

（2）Molecular basis underlying mouse preimplantation development.

（3）Oncogenes and their functions in tumors.

1.   Duan X, Zhang Q, Gao L, Ling B, Du X, and Chen L*, ERK phosphorylates ESRRB to regulate the self-renewal and differentiation of mouse embryonic stem cells. Stem Cell Reports, 2025. 20:102397. 

2.   Yu J, Zhao N, Wang Y, Ding N, Guo Z, He Z, Zhang Q, Zhang J, Yang X, Zhang M, Du X, Zhang K, and Chen L*, DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells. Cell Rep, 2024. 43(12):115058.

3.   Nai S, Wang M, Yang J, Ling B, Dong Q, Yang X, Du X, Lu M, Liu L, Yu Z, and Chen L*, Novel role for Ddx39 in differentiation and telomere length regulation of embryonic stem cells. Cell Death Differ, 2024. 31(11):1534-1544.

4.   Dong Q, Yang X, Wang L, Zhang Q, Zhao N, Nai S, Du X, and Chen L*, Lactylation of Hdac1 regulated by Ldh prevents the pluripotent-to-2C state conversion. Stem Cell Res Ther, 2024.15(1):415.

5.   Yang X, He Z, Dong Q, Nai S, Duan X, Yu J, Zhao N, Du X, and Chen L*, Btbd8 deficiency reduces susceptibility to colitis by enhancing intestinal barrier function and suppressing inflammation. Front Immunol, 2024. 15:1382661.

6.   Dong Q, Zhang Q, Yang X, Nai S, Du X, and Chen L*, Glycolysis-Stimulated Esrrb Lactylation Promotes the Self-Renewal and Extraembryonic Endoderm Stem Cell Differentiation of Embryonic Stem Cells. Int J Mol Sci, 2024. 25(5):2692.

7.   Qin Y, Ni P, Zhang Q, Wang X, Du X, Yin Z, Wang L, Ye L*, and Chen L*, Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1. Development, 2022. 149(12):dev200527.

8.   Chen H, Li P, Du X, Zhao Y, Wang L, Tian Y, Song X, Shuai L*, Bai X*, and Chen L*, Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads to Male Infertility and Fertilization Failure. Front Cell Dev Biol, 2022. 10:850052.

9.   Ha N, Ding N, Hong R, Liu R, Roca X, Luo Y, Duan X, Wang X, Ni P, Wu H, Zhang LF*, and Chen L*, The lupus autoantigen La/Ssb is an Xist-binding protein involved in Xist folding and cloud formation. Nucleic Acids Res, 2021. 49(20):11596-11613.

10.   Li P, Gao L, Cui T, Zhang W, Zhao Z, and Chen L*, Cops5 safeguards genomic stability of embryonic stem cells through regulating cellular metabolism and DNA repair. Proc Natl Acad Sci U S A, 2020. 117(5):2519-2525.

11.   Zhao T, Cai M, Liu M, Su G, An D, Moon B, Lyu G, Si Y, Chen L*, and Lu W*, lncRNA 5430416N02Rik Promotes the Proliferation of Mouse Embryonic Stem Cells by Activating Mid1 Expression through 3D Chromatin Architecture. Stem Cell Reports, 2020. 14:493-505.

12.   Ruan X, Shi X, Dong Q, Yu Y, Hou X, Song X, Wei X, Chen L*, and Gao M*, Antitumor effects of anlotinib in thyroid cancer. Endocr Relat Cancer, 2019. 26(1):153-164.

13. Li P, Ding N, Zhang W, and Chen L*, COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells. Stem Cell Reports, 2018. 11(2):317-324.

14. Shi X, Yin Z, Ling B, Wang L, Liu C, Ruan X, Zhang W, and Chen L*, Rho differentially regulates the Hippo pathway by modulating the interaction between Amot and Nf2 in the blastocyst. Development, 2017. 144:3957-3967.

15. Chen H, Guo R, Zhang Q, Guo H, Yang M, Wu Z, Gao S, Liu L*, and Chen L*, Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A, 2015. 112(44):E5936-5943.

16. Chen L and Widom J, Mechanism of transcriptional silencing in yeast. Cell, 2005. 120(1):37-48.

Undergraduate Course： Cell Biology                                               2010 - till now

Graduate Course：          Stem Cell and Developmental Biology      2013 - till now

Recipient of the National Science Fund for Excellent Young Scholars

Program for New Century Excellent Talents in University