Chenquan

1. Fan Yu, Lingyu Jiang and Quan Chen

Sweet signaling for ferroptosis   Cell Chemical Biology 2025 (32):1097-1098

2. Jin Gao, Yan Wang, and Quan Chen*  

Lipoproteins: Friend and foe for ferroptosis?  Molecular Cell (preview) 2025 (doi.org/10.1016/j.molcel.2025.07.021)

3. Navdeep S. Chandel, Marni J. Falk, Janine H. Santos, Jonathan R. Brestoff, Ana V. Lechuga-Vieco, Yasemin S. Sancak, Quan Chen, Alvaro A. Elorza & Rubén Quintana-Cabrera   Mitochondrial transfer：Firewood in cold weather or a Trojan horse?   Nature Metabolism (Invited viewpoint) 2025  (doi.org/10.1038/s42255-025-01364-0)

4. Pei Y, Ren D, Yin Y, Shi J, Ai Q, Hao W, Luo X, Zhang C, Zhao Y, Bai C, Zhu L, Wang Q, Li S, Zhang Y, Lu J, Liu L, Zhou L, Wu Y, Weng Y, Jing Y, Lu C, Cui Y, Zheng H, Li Y, Chen G, Hu G, Chen Q*, Liao X* Endothelial FUNDC1 deficiency drives pulmonary hypertension  Circulation Research 2025 136(2):e1-e19 (editorial: Targeting endothelial cell mitochondrial quality control in PAH 2025 136:209-210)  

5. Zhang QP, Sun TT, Yu F, Liu W, Gao J, Chen JY, Zheng H, Liu JM, Tian W, Su MH, Guo YJ, Liu X, Pei YD, Mu CL, Lam SM, Shui GH, Li ZJ, Zhang Y, Chen G, Lu CC, Midgley AC, Li CH, Bian X, Wang Y, Liao XD, Li YJ*, Chen Q* PAFAH2 suppresses PAF-like phospholipid-mediated synchronized ferroptosis to ameliorate acute kidney injury  Nature Chemical Biology  2024  (20):835-846 (highlighted as preview: Chain of Death Nature Chemical Biology 2024 20: 799–800)

6. Zheng H, Liu JM, Cheng Q, Zhang QP, Zhang YY, Jiang LY, Huang Y, Li WL, Zhao YP, Chen G, Yu F, Liu L, Li YJ, Liao XD, Xu L, Xiao Y, Zheng ZB, Li M,  Wang HY, Hu G*, Du L*, Chen Q*  Targeted activation of ferroptosis in colorectal cancer overcomes acquired drug resistance, Nature Cancer 2024 (5):572-589 (highlighted as News & View: Targeting LGR4/Wnt activates ferroptosis and reverses drug resistance in colorectal cancer  Nature Cancer 2024 5: 542–543)

7. Berndt C, et al., Conrad M*  Ferroptosis in health and disease.. Redox Biol. 2024 75:103211

8. Guo YJ, Zhang H, Yan C, Shen BR, Zhang Y, Guo XY, Sun S, Yu F, Yan JY, Liu RH, Zhang QP, Zhang D, Liu HY, Liu Y, Zhang YY, Li WL, Qin JY, Lv H, Wang ZX, Yuan Y, Yang JF, Zhong YT, Gao S, Zhou B, Liu L, Kong DL, Hao XJ^*, Hu JJ^*, Chen Q^*  Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction Nature Chemical Biology 2023 (4):468-477 (Choice of the week in Science)

9. Ta N, Qu C, Wu H, Zhang D, Sun T, Li Y, Wang J, Wang X, Tang T, Chen Q, Liu L* Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy  Proc Natl Acad Sci USA. 2022 119(36):e211 7396119

10. Chen LB, Zhang QP, Mu CL, Fu CY, Feng JY, Zhao T, Du SL, Geng GF, Ma KL, Cheng HC, Liu QQ, Luo Q, Chang R, Wang JL, He LQ, Zhang JJ, Wang JJ, Lin JP, Chen G, Liu L, Lam SM, Shui GH, Zhu YS^*, Chen Q^*  Saturated fatty acids signal FUNDC1 dimerization and stability to regulate mitochondrial quality

EMBO Reports, 2023 24(4):e54731

11. Yu F, Zhang QP, Liu HY, Liu JM, Yang S, Luo XF, Liu W, Zheng H, Liu QQ,  Cui YX, Chen G, Li YJ, Huang XL, Yan XY, Zhou J*, Chen Q* Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis  Cell Discovery, 2022 8(1):40

12. Geng G, Liu J, Xu C, Pei Y, Chen L, Mu C, Wang D, Gao J, Li Y, Liang J, Zhao T, Zhang C, Zhou J, Chen Q*, Zhu Y*, Shi L*  Receptor-mediated mitophagy regulates EPO production and protects against renal anemia. Elife. 2021 10: e64480. doi: 10.7554/eLife.64480.

13. Liu L*, Li Y, Wang J, Zhang D, Wu H, Li W, Wei H, Ta N, Fan Y, Liu Y, Wang X, Wang J, Pan X, Liao X, Zhu Y, Chen Q*. Mitophagy receptor FUNDC1 is regulated by PGC-1α/NRF1 to fine tune mitochondrial homeostasis. EMBO Reports, 22(3) (2021) e50629.

14. Ma KL, Chen G, Li WH, Kepp O, Zhu YS, Chen Q* Mitophagy, Mitochondrial Homeostasis, and Cell Fate. Frontiers in Cell and Development Biology, 8, 467(2020), P1-14 (invited review).

15. Wu H, Wei H, Zhang D, Sehgal SA, Zhang D,Wang X, Qin Y, Liu L, Chen Q*. Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy. Redox Biology, 36 (2020)101661, P1-13.

16. Liu L, Liao X, Wu H, Li Y, Zhu Y, Chen Q*. Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders. Antioxid Redox Signal, 32(12) (2020), P 906-927 (invited review).

17. Li YJ; Liu L; Zhu YS; Chen Q* Mitochondria organize the cellular proteostatic response and promote cellular senescence. Cell stress, 3(4) (2019), P110-114.

18. Wu H, Wang Y, Li WH, Chen H, Du L, Liu D, Wang XH, Xu T, Liu L & Chen Q Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietaryinduced obesity and metabolic syndrome. Autophagy, 15(11) (2019), P1882-1898.

19. Ma B; Cheng HC; Mu CL; Geng GF; Zhao T; Luo Q; Ma KL; Chang R; Liu QQ; Gao RZ; Nie JL; Xie JY; Han JX; Chen LB; Ma G; Zhu YS*; Chen Q* The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression. Nature Communications, 10(1034) (2019), P1-17.

20. Ma KL, Zhang Z, Chang R, Cheng HC, Mu CL, Zhao T, Chen LB, Zhang CM, Luo Q, Lin JL*, Zhu YS*, Chen Q* Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate. Cell death and differentiation, 27(3) (2020), P1036-1051

21. Liu D, Wu H, Wang CG, Li YJ, Tian HB, Siraj S, Sehgal SA, Wang XH, Wang J, Shang YL, Jiang ZF, Liu L*, Chen Q*. STING directly activates autophagy to tune the innate immune response. Cell death and differentiation, 26(9) (2019), P1735-1749.

22. Li YJ, Xue YH, Xu XJ, Wang GP, Liu YQ, Wu H, Li WH, Wang YY, Chen ZH, Zhang WL, Zhu YS, Ji W, Xu T, Liu L*, Chen Q* A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. EMBO Journal, 38(3) (2019), P1-20 (highlighted by Nature Chemical Biology)

23. Ma Q*, Zhang WL, Zhu CZ, Liu JL*, Chen Q. FUNDC2 regulates platelet activation through AKT/GSK-3beta/cGMP axis. Cardiovascular Research,115, (2019), P1672–1679.

24. Li WH, Li YJ, Siraj S, Jin HJ, Fan YY, Yang XR, Huang XW, Wang XH, Wang J, Liu L, Du L, Chen Q* FUN14 Domain-Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice. Hepatology, 69 (2) (2019), P604-621 (Faculty 1000 recommended).

25. Ma Q, Zhu C, Zhang W, Ta N, Zhang R, Liu L, Feng D, Cheng H, Liu J, Chen Q* Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway. Cell Death Differentiation, 26(2) (2019), P321-331.

26. Fu TT, Xu ZS, Liu L, Guo QQ, Wu H, Liang XJ, Zhu DH, Xiao LW, Liu L, Liu Y, Zhu MS, Chen Q*, Gan ZJ* Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity. Cell Report, 23(5) (2018), P1357-1372.

27. Zhang WL, Chen CY, Wang J, Liu L, He YB*, Chen Q* Mitophagy in cardiomyocytes and in platelets: a major mechanism of cardioprotection against ischemia/reperfusion (I/R) injury. Physiology, 33(2) (2018), P86-98 (invited review).

28. Shoshan Barmatz V, Krelin Y, Chen Q. VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Target for Modulating Apoptosis. Current Medicinal Chemistry, 24(2017), P1-12 (invited review).

29. Liu PL, Liu K, Gu HF, Wang WX, Gong JQ, Zhu YJ, Zhao Q, Cao JN, Han CS, Gao F, Chen Q, Li W, Jiao JW, Hu BY, Zhou Q, Zhao TB* High Autophagic Flux Guards ESC Identity Through Coordinating Autophagy Machinery Gene Program by FOXO1. Cell Death and Differentiation, 24 (10) (2017), P1672-1680.

30. Huang XF, Zhou X, Hu XY, Joshic AS, Guo XY, Zhu YS, Chen Q, Prina W., Hu JJ* Sequences Flanking the Transmembrane Segments Facilitate Mitochondrial Localization and Membrane Fusion by Mitofusin. Proceedings of the National Academy of Sciences of the United States of America, 114(46) (2017), E9863-E9872.

31. Yuan WJ, Ding X, Wang Z, Yang BJ, Li XN, Zhang Y, Chen DZ, Li SL, Chen Q, Di YT, Aisa HA, Hao XJ* Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A. Scientific Reports, 7, 14507. (2017), P1-9.

32. Zhang HL, Wang P, Bisetto S, Yoon Y, Chen Q, Sheu SS, Wang W* A Novel Fission-Independent Role of Dynamin-Related Protein 1 in Cardiac Mitochondrial Respiration. Cardiovascular Research, 113(2) (2017), P160–170.

33. Tooze Sharon A, Chen Q* Editorial Overview: Celebrating the Advances in Cell Biology from China. Traffic, 18(6) (2017), P335.

34. Chen LB, Ma KL, Han J, Chen Q*, Zhu YS* Monitoring Mitophagy in Mammalian Cells. Methods in Enzymology, 588 (2017), P187-208.

35. Chen ZH, Siraj S, Liu L, Chen Q* MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy. Autophagy, 13(7) (2017), P1244-1245.

36. Zhang WL, Siraj S, Zhang R, Chen Q* Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury. Autophagy, 13(6) (2017), P1080-1081.

37. Zhou CQ, Ma Kl, Gao RZ, Mu CL, Chen LB, Liu QQ, Luo Q, Feng D, Zhu YS*, Chen Q* Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy. Cell Research, 27(2) (2017), P184-201.

38. Chen ZH, Liu L, Cheng Q, Li YJ, Wu H, Zhang WL, Wang YY, Sehgal SA, Siraj S, Wang XH, Wang J, Zhu YS, Chen Q*. Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy. EMBO Reports, 18(3) (2017), P495-509.

39. Zhang WL, Ren H, Xu CL, Zhu CZ, Wu H, Liu D, Wang J, Liu L, Li W, Ma Q, Du L, Zheng M, Zhang CM, Liu JL*, Chen Q*. Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury. eLife, 5 (2016), e21407.

40. Wu H, Wei HF, Sehgal SA, Liu L; Chen Q*. Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control. Free Radical Biology and Medicine, 100 (2016), P199-209.

41. Liu D, Du L, Chen D, Ye ZD, Duan HX, Xu T, Feng J, Yang YL, Chen Q, Yan XY*. Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling. Oncotarget, 7(26) (2016), P40704-40718,

42. Wang QC, Zheng QX, Tan HY, Zhang B, Li XL, Yang YX, Yu J, Liu Y, Chai H, Wang X, Sun ZS, Wang JQ, Zhu S, Wang FL, Yang MJ, Guo CX, Wang H, Zheng QY, Li Y, Chen Q, Zhou AM* and Tang TS*. TMCO1 Is an ER Ca2+ Load-Activated Ca2+ Channel. Cell, 165 (2016), P1454-1466.

43. Wang YH, Wang JQ, Wang QC, Wang Y, Guo CX, Chen Q, Chai TY*, Tang TS*. Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy. Scientific Reports, 6 (2016), P25153

44. He LW; Han JJ Li BW, Huang L; Ma K, Chen Q, Liu XZ, Bao L, Liu HW*. Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity. European Journal of Medicinal Chemistry, 111 (2016), P183-192.

45. Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, Chen Q, Zhu Y*. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signaling pathways. Nature Communications, 7 (2016), P11123

46. Song PP, Li SS, Wu H, Gao RZ, Rao GH, Wang DM, Chen ZH, Ma B, Wang HX, Sui N, Deng HT, Zhang ZH, Tang TS, Tan Z, Han ZH, Lu TY, Zhu YS*, Chen Q*. Parkin promotes proteasomal degradation of p62：Implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease. Protein & Cell, 7(2) (2016), P114-29.

47. Kuang Y, Ma KL, Zhou CQ, Ding PF, Zhu YS*, Chen Q*, Xia B*. Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy. Autophagy, 12(12) (2016), P 2363-2373.

48. Liu K, Zhao Q, Liu PL, Cao JN, Gong JQ, Wang CQ, Wang WX, Li ZY, Sun HY, Zhang C, Li YF, Jiang MG, Zhu SH, Sun QY, Jiao JW, Hu BY, Zhao XY, Li W, Chen Q, Zhou Q*, Zhao TB*. ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. Autophagy, 12(11) (2016), P2000-2008.

49. Wei ZB, Yuan YF, Jaouen F, Ma MS, Hao CJ; Zhang Z, Chen Q, Yuan ZQ, Yu L, Beurrier C, Li W*. SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation. Autophagy, 12(7) (2016),1168-1179.

50. Liu HH, Zheng KW, He YD, Chen Q, Hao YH, Tan Z*. RNA G-quadruplex formation in defined sequence in living cells detected by bimolecular fluorescence complementation. Chemical Science, 7(7) (2016), P4573-4581.

51. Chen M, Chen ZH, Wang YY, Tan Z, Zhu CZ, Li YJ, Han Z, Chen LB, Gao RZ, Liu L*, Chen Q*. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy, 12(4) (2016), P689-702.

52. Wei H, Liu L, Chen Q*. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Biochimica et Biophysica Acta-Molecular Cell Research, 1853(10) (2015), P2784-2790.

53. Huang L, Han J, Ben-Hail D, He LW, Li B, Chen ZH, Wang YY, Yang YL, Liu L, Zhu YS, Shoshan-Barmatz V*, Liu HW*, Chen Q*. A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells. Journal of Biological Chemistry, 290(39) (2015), P 23563-23578.

54. Li J, Qi W, Chen G, Feng D, Liu J, Ma B, Zhou C, Mu C, Zhang W, Chen Q*, Zhu Y*. Mitochondrial outer-membrane E3 ligase MUL1 ubiqutinates ULK1 and regulates selenite-induced mitophagy. Autophagy, 11(8) (2015), P1216-1229.

55. Wu H, Chen Q*. Hypoxia Activation of Mitophagy and Its Role in Disease Pathogenesis. Antioxidants & Redox Signaling, 22(12) (2015), P1032-1046.

56. Xue DF, Wang QX, Chen ZH, Cai L, Bao L, Qi QY, Liu LH, Wang XH, Jin HJ, Wang J, Wu H*, Liu HW*, Chen Q*. 3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of alpha-synuclein in PC12 cells. Bioorganic & Medicinal Chemistry Letters, 25(7) (2015), P1464-1470.

57. Zhao XX*, Liu Y, Du L, He LY, Ni BY, Hu JB, Zhu DH, Chen Q*. Threonine 32 (Thr32) of FoxO3 is critical for TGF-beta-induced apoptosis via Bim in hepatocarcinoma cells. Protein & Cell, 6(2) (2015), P 127-138.

58. Ma B, Chen Y, Chen L, Cheng HC, Mu C, Li J, Gao R, Zhou C, Cao L, Liu J , Zhu Y*, Chen Q*, Wu S*, Hypoxia regulates Hippo signaling through the SIAH2 ubiquitin E3 ligase. Nature Cell Biology, 17(1) (2015), P95–103.

59. Wang L, Ye XY, Zhao Q, Zhou ZC, Dan JM, Zhu YS, Chen Q, Liu L*. Drp1 Is Dispensable for Mitochondria Biogenesis in Induction to Pluripotency but Required for Differentiation of Embryonic Stem Cells. Stem Cells and Development, 23(20) (2014), P 2422-2434.

60. Wu H, Xue DF, Chen G, Han Z, Huang L, Zhu.CZ, Wang XH, Jin HJ, Wang J, Zhu YS, Liu L, Chen Q*. The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy, 10(10) (2014), P 1712–1725.

61. Liu L, Sakakibara K, Chen Q*, Okamoto K* Receptor-mediated mitophagy in yeast and in mammalian systems. Cell Research. 24(7) (2014), P787-795.

62. Chen G, Han Z., Feng D, Chen YF, Chen LB, Wu H, Huang L, Zhou CQ, Cai XY, Fu CY, Duan LW, Wang XH, Liu L, Liu XQ, Shen YQ, Zhu YS*, Chen Q*. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Molecular Cell, 54(3) (2014), P 362-377.

63. Yan C, Huang L, Liu H, Chen D, Liu H, Li X, Zhang Y, Geng M, Chen Q, Hao X*. Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells. Bioorganic & Medicinal Chemistry Letters, 24(8) (2014), P1884-1888.

64. Yue W, Chen ZH, Liu HY, Yan C, Chen M, Feng D, Yan C, Wu H, Du L, Wang YY, Liu JH, Huang XH, Xia LX, Liu L., Wang XH., Jin HJ, Wang J, Song ZY, Hao XJ*, Chen Q*. A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Research, 24(4) (2014), P482-496.

65. Zhu YS, Liu JH, Lu TY, Chen Q*.  Autophagy, Mitochondrial Quality Control and Aging. Progress in Biochemistry and Biophysics, 41(3) (2014), P 247-256.

66. Zhu Y, Chen G, Chen L, Zhang W, Feng D, Liu L, Chen Q*, Monitoring mitophagy in Mammalian Cells, Methods in Enzymology, 547 (2014), P39-55.

67. Liu JH, Mu CL, Yue W, Li J, Ma B, Zhao LX, Liu L, Chen Q, Yan C, Liu HY, Hao XJ, Zhu YS*. A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis, Free Radical Biology and Medicine, 63 (S1) (2013), P485-494.

68. Feng D, Liu L, Zhu YS, Chen Q *.  Molecular signaling toward mitophagy and its physiological significance, Experimental Cell Research, 319(12) (2013), P1697-1705.

69. Rao GH^#, Liu HM^#, Li BW, Hao JJ, Yang YL, Wang MR, Wang XH, Wang J, Jin HJ, Du L*, Chen Q *. Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs. Acta Pharmacologica Sinica , 34(6) (2013), P 793–804.

70. Rao GH, Du L, Chen Q* Osteopontin, a possible modulator of cancer stem cells and their malignant niche. Oncoimmunology, 2(5) (2016), e24169.

71. Du L, Rao G, Wang H, Li B, Tian W, Cui JT, He L, Laffin B, Tian X, Hao C, Liu H, Sun X, Zhu Y, Tang DG, Mehrpour M, Lu Y*, Chen Q*. CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer, Cancer Research, 73(8) (2013), P 2682-2694 (cover).

72. Zhao HY, Zhao YG, Wang XW, Xu LJ, Miao L, Feng D, Chen Q, Kovács AL, Fan DS, Zhang H*. Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration. Journal of Cell Biology, 200(6) (2013), P731-741.

73. Rao G, Wang H, Li B, Huang L, Xue D, Wang X, Jin H, Wang J, Zhu Y, Lu Y, Du L*, Chen Q*. Reciprocal interactions between tumor-associated macrophages and CD44-Positive cancer cells via Osteopontin/CD44 promote tumorigenicity in colorectal cancer. Clinical Cancer Research, 19(4) (2013), P785-797.

74. Liu Y, Cheng H, Zhou Y, Zhu Y, Bian R, Chen Y, Li C, Ma Q, Zheng Q, Zhang Y, Jin H, Wang X, Chen Q*, Zhu D*. Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells. Cell Death & Disease, (2013) e494.

75. Wang JQ, Chen Q, Wang XH, Wang QC, Wang Y, Cheng HP, Guo CX, Sun QM, Chen Q, Tang TS*.  Dysregulation of mitochondrial calcium signaling and superoxide flashes cause mitochondrial genomic DNA damage in huntington’s disease. Journal of Biological Chemistry, 288(5) (2013), P 3070-3084.

76. Zhang H, Zhang YW, Chen YM, Huang XM, Zhou FF, Wang WW, Xian B, Zhang X, Masliah E, Chen Q, Han, JDJ, Bu, GJ, Reed, JC, Liao FF, Chen YG*, Xu HX*. Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration. Journal of Neuroscience, 32(44) (2012), P15565-15576.

77. Zhang X, Weng C, Li Y, Wang X, Jiang C, Li X, Xu Y, Chen Q, Pan L*, Tang H*. Human Bop is a novel BH3-only member of the Bcl-2 protein family. Protein & Cell, 3(10) (2012), P790-801.

78. Zhao T, Huang XH, Han L, Wang XH, Cheng HQ, Zhao YG, Chen Q, Chen J, Cheng HP, Xiao RP, Zheng M*. Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes. Journal of Biological Chemistry, 287(28) (2012), P23615-23625.

79. Huang YM, Cui JG, Zheng QX, Zeng C, Chen Q, Zhou AM*. 6-Hydroximino-4-aza-A-homo-cholest-3-one and related analogue as a potent inducer of apoptosis in cancer cells. Steroids, 77(8-9) (2012), P829-834.  

80. Wang SQ, Xiao WM, Shan SC, Jiang CS, Chen M, Zhang Y, Lu SQ, Chen J, Zhang CM, Chen Q*, Long M*. Multi-Patterned Dynamics of Mitochondrial Fission and Fusion in a Living Cell. Plos One, 7(5) (2012), e19879.

81. Liu L, Feng D, Chen G, Chen M, Zheng QX, Song PP, Ma Q, Zhu CZ, Wang R, Qi WJ, Huang L, Xue P, Li BW, Wang XH, Jin HJ, Wang J, Yang FQ, Liu PS, Zhu YS, Sui SF and Chen Q*. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nature Cell Biology, 14 (2) (2012), P177-185.

82. Zhao LX, He F, Liu HY, Zhu YS, Tian WL, Gao P, He HP, Yue W, Lei XB, Ni BY, Wang XH, Jin HJ, Hao XJ*, Lin JL*, and Chen Q*. Natural Diterpenoid Compound Elevates Expression of Bim Protein, Which Interacts with Antiapoptotic Protein Bcl-2, Converting It to Proapoptotic Bax-like Molecule. Journal of Biological Chemistry, 287(2) (2012), P 1054-1065. 

83. Zhu YS, Li M, Wang XH, Jin HJ, Liu SS, Xu JX*, Chen Q*. Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release. Cell Research, 22(1) (2012), P127-141. 

84. Ni BY, Ma Q, Li BW, Zhao LX, Liu Y, Zhu YS and Chen Q*. Phenylarsine Oxide Induces Apoptosis in Bax- and Bak-Deficient Cells Through Upregulation of Bim. Clinical Cancer Research, 18(1) (2012), P140-151. 

85. Tang F , Wang B , Li N , Wu YF , Jia JY , Suo TL , Chen Q , Liu YJ ,Tang J* . RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. Plos One, 6 (9) (2011), e24367.

86. Ma Q, Fang HQ, Shang W, Liu L, Xu ZS, Ye T, Wang XH, Zheng M*, Chen Q* and Cheng HP*. Superoxide flashes: early mitochondrial signals for oxidative stress induced apoptosis. Journal of Biological Chemistry, 286(31) (2011), P27573-27581.

87. Wang HX, Song PP, Du L, Tian WL, Yue W, Liu M, Li DW, Wang B, Zhu YS, Zhou J*, Chen Q*. Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson’s disease. Journal of Biological Chemistry, 286(13) (2011), P11649-11658.

88. Mao JH, Sun XY, Liu JX, Zhang QY, Liu P, Huang QH, Li KK, Chen Q, Chen Z*, and Chen SJ*. As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia. Proc Natl Acad Sci U S A. 107(50) (2010), P21683-21688.

89. Mao JH, Sun XY, Liu JX, Zhang QY, Liu P, Huang QH, Li KQ, Zhang XW, Chen Q, Chen Z, Chen SJ*. Arsenic Sulfide Binds c-CBL to Promote BCR-ABL Ubiquitination and Degradation In Chronic Myelogenous Leukemia. Blood, 116(21) (2010), P515-515.

90. Zhang J, Liu WH, Liu JC, Xiao WM, Liu L, Jiang CS, Sun X, Liu PS, Zhu YS, Zhang CM, and Chen Q*. G protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion. Nature Communications, 1(2010), 101-110.

91. Gao P, Bauvy C, Souquere S, Tonelli G, Liu L, Zhu YS, Qiao ZZ, Bakula D, Proikas-Cezanne T, Pierron G, Codogno P, Chen Q*, and Mehrpour M*. The Bcl-2 Homology Domain 3 Mimetic Gossypol Induces Both Beclin 1-dependent and Beclin 1-independent Cytoprotective Autophagy in Cancer Cells. Journal of Biological Chemistry, 285 (33) (2010), P25570-25581.

92. Shao D, Liu Y, Liu XJ, Zhu LL, Cui Y, Cui AF, Qiao AJ, Kong XX, Liu Y, Chen Q, Gupta N, Fang FD, Chang YS*. PGC-1b-regulated mitochondrial biogenesis and function inmyotubes is mediated by NRF-1and ERRa. Mitochondrion, 10 (2010), P516-527.

93. Zhu YS, Zhao LX, Liu L, Gao P, Tian WL, Wang XH, Jin HJ, Xu HD, Chen Q *. Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein & Cell, 1 (5) (2010), P468-477.

94. Zhao LX, Zhu YS* Wang DM, Chen M, Gao P, Xiao WM, Rao GH Wang XH, Jin J, Xu L, Sui N, * and Chen Q*. Morphine induces Beclin 1- and ATG5 dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus. Autophagy, 6(3) (2010), P386-94.

95. Zhang T, Wu M, Chen Q* and Sun ZR*. Investigation into the regulation mechanisms of TRAIL apoptosis pathway by mathematical modelling. Acta Biochim Biophys Sin, 42(2) (2010), P98-108.

96. Shang YL, Liu Y, Du L, Wang YL, Cheng X, Xiao WM, Wang XH, Jin HJ, Yang X, Liu SS and Chen Q*. Targeted expression of uncoupling protein 2 to mouse liver increases the susceptibility to LPS/GalN-induced acute liver injury. Hepatology, 50(4) (2009), P1204-1216.

97. Wang H, Liu B, Zhang C, Peng G, Liu M, Li D, Gu F, Chen Q, Dong JT, Fu L, Zhou J*.  Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule-dependent mechanism. J Pathol, 218(1) (2009), P76-85.

98. Huang F, Nie C; Yang Y, Yue W, Ren Y, Shang YL, Wang X, Jin J, Xu C*, Chen Q*. Selenite induces redox dependent Bax activation and apoptosis in colorectal cancer cells. Free Radical Biology & Medicine, 46(8) (2009), P1186-1196.  

99. Zhang QY, Mao JH, Liu P, Huang QH, Lu J, Xie YY, Weng L, Zhang Y, Chen Q, Chen SJ, Chen Z*. A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 106(9) (2009), P3378-3383.

100. Zhao X, Liu Y, Ma Q, Wang X, Jin H, Mehrpour M, Chen Q*. Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells. Biochem Biophys Res Commun. 378 (1) (2009), P21-26. 

101. Du L, Wang H, He L, Zhang J, Ni B, Wang X, Jin H, Cahuzac N, Mehrpour M, Lu Y*, Chen Q*. CD44 is of functional importance for colorectal cancer stem cell. Clinical Cancer Research, 14(21) (2008), P6751-6760.

102. Mao JH, Zhang QY, Huang QH, Chen Z, Chen Q, Chen SJ*. Identification of protein ubiquitination by IP-2D nano-HPLC-MALDI-TOF-TOF. Progress in Biochemistry and Biophysics, 35(7) (2008), P839-847.

103. Nie C, Tian C, Zhao L, Petit P, Mehrpour M and Chen Q*. Cysteine 62 of Bax is critical for its conformational activation and its pro-apoptotic activity in response to H2O2 -induced apoptosis. Journal of Biological Chemistry, 283(22) (2008), P15359-15369.

104. Tian C, Gao P., Zheng Y, Yue W, Wang X, Jin H and Chen Q*. Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG(2)) to arsenic trioxide-induced cell death. Cell Res, 18(4) (2008), P458-471.

105. Du L, Yu Y, Chen J, Liu Y, Xia Y, Chen Q, Liu X. Arsenic induces caspase- and mitochondria-mediated apoptosis in Saccharomyces cerevisiae. FEMS Yeast Res. 7(6) (2007), P860-865.

106. Zhang K, Shang Y, Liao S, Zhang W, Nian H, Liu Y, Chen Q, Han C*. Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis. Biochem Biophys Res Commun. 360 (2) (2007), P327-332.

107. Lei XB, Chen YY, DuGH, Yu WY, Wang XH, Qu H, Xia B, He HP, Mao JH, Zong WX, Mehrpour M, Hao XJ and Chen Q*. Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. FASEB Journal, 20(12) (2006), P2147-2149.

108. Liao XD, Liu,JM Du L, Tang AH, Wang SQ, Chen LY*, Chen Q*. Nitric Oxide Signaling in Stretch-induced Apoptosis of Neonatal Rat Cardiomyocytes, FASEB Journal, 20(11) (2006), P 1883-1885.

109. Zheng JT, Rix U, Zhao LX, Mattingly C, Adams V, Chen Q, Rohr J, Yang. KQ*. Cytotoxic. Activities of New Jadomycin Derivatives. J. Antibiot. 58(6) (2005), P405-408.

110. Liao XD, Wang XH, Gu Y, Chen Q*, Chen LY*. Involvement of death receptor signaling in mechanical stretch-induced cardiomyocyte apoptosis, Life Sciences 77 (2005), P160–174.

111. Sun YX, Zhou J, Liao XD, Yaxin Lu YX, Deng CX, Huang PT, Chen Q, Xiao Yang* Disruption of Smad5 gene induces mitochondria-dependent apoptosis in cardiomyocytes.  Experimental Cell Research, 306(1) (2005) P85-93.

112. Zheng YH, Tian CH, Wang HG, Chen Q *. Arsenic trioxide induces apoptosis through activation of Bax in hematopoietic cells. Oncogene, 24(20) (2005), P3339-3347.

113. Wang ZX, Jiang CS; Liu L, Wang XH, Jin HJ, Wu Q, Chen Q*. The role of akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation. Cell Research,15（5）(2005), P379-386.

114. Zheng YH, Shi R, Jiang CH, Tang H, Chen Q*. Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. Oncogene 23(6) (2004), P1239-1247. 

115. Liao XD, Wang XH, Jin HJ, Chen LY, Chen Q*. Mechanical stretch induces mitochondria-dependent apoptosis in neonatal rat cardiomyocytes and G(2)/M accumulation in cardiac fibroblasts. Cell Research, 14(1) (2004), P16-26.  

116. Liao XD, Tang AH, Chen Q, Jin HJ, Wu CH, Chen LY, Wang SQ*. Role of Ca²⁺signaling in initiation of stretch-induced apoptosis in neonatal heart cells. Biochem Biophys Res Commun., 310 (2003), P405-411.

117. Chen Q, Ray S, Hussein M, Srkalovic G, Almasan A*. Role of Apo2L/TRAIL and Bcl-2 family proteins in apoptosis in Multiple Myeloma. Leukemia and Lymphoma 44（7）(2002), P1209-1214 .

118. Shi Y, Chen JJ，Weng CJ, Chen R, Zheng YH, Chen Q and Tang H*. Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins. Biochem Biophys Res Commun., 305(2003), P989-996.

119. Shi Y, Jiang CS, Chen Q, Tang H*. One step on column affinity purification and functional analysis of recombinant human VDAC1. Biochem Biophys Res Commun., 303 (2003), P475-482.

120. Chen Q, Chai Y-Ch, Mazumder S, Jiang C, Macklis RM, Chisolm GM, Almasan A*. The late increase of intracellular free radical species during apoptosis is associated with cytochrome c release, Caspase activation and mitochondrial dysfunction. Cell Death and Differentiation, 10(3) (2003), P323-334.

121. Zhou JJ, Jin Y, Hu GX, Huang YM, Chen Q, Wu CH, Feng MF*. Genomic-scale analysis of gene expression in tumor necrosis factor-alpha induced human umbilical vein endothelial cells. Inflammation Research, 51(7) (2002), P332-341.

122. Xia T, Jiang CS, Li LJ, Zhang Y, Wu CH, Liu SS, Chen Q*. Bid BH3 peptide, but its mutant form G94E, induces permeability transition pore opening and cytochrome c release in vitro. Chinese Science Bulletin, 47(7) (2002), P553-557.

123. Mazumder S, Gong B, Chen Q, Drazba J., Buchsbaum JC, Almasan A*. Proteolytic cleavage of cyclin E kinase activity and amplification leads to inactivation of associated of apoptosis in hematopoietic cells. Molecular and Cellular Biology, 22 (7) (2002), P2398-2409.

124. Xia T, Jiang CS, Li L., Wu CH, Liu SS, Chen Q*. A study on permeability transition pore opening and cytochrome c release from mitochondria induced by Caspase -3 in vitro. FEBS Letters, 510 (1-2) (2002), P62-66.

125. Chen Q., Gong B, Zhou A, Hussein M, and Almasan A*. Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced in multiple myeloma. Blood, 98(7) (2001), P2183-2192.

126. Chen Q, Gong B, Almasan A*. Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis. Cell Death and Differentiation, 7(2) (2000), P227-233.

127. Gong B, Chen Q, Endlich B., Mazumder S, Almasan A*. Ionizing radiation-induced, Bax -mediated cell death is dependent on activation of cysteine and serine proteases. Cell Growth and Differentiation, 10 (1999), P491-502.

128. Chen Q, Takeyama N, Brady G, Watson A & Dive C*. Blood cells with reduced mitochondria membrane potential and cytosolic cytochrome can survive and maintain clonogenicity given appropriate signals to suppress apoptosis. Blood, 92(12) (1998), P 4545-4553.

129. Gong B, Chen Q, Almasan A*. Ionizing radiation stimulates mitochondrial gene expression and activity. Radiation Research, 150 (1998), P505-512.

130. Chen Q, Turner J, Watson A, Dive C*. V-Abelson protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with up-regulation of Bcl-x/L. Oncogene, 15 (1997), P2249-2254.

131. Chen Q, Benson R., Brant S, Donowitz M, Dive C, Watson A*. The role of acid/base homeostasis in the suppression of apoptosis in IL-3 dependent haemopoietic cells by Abelson protein tyrosine kinase. Journal of Cell Science, 110 (1997), P379-387.