程志晖

本人分别于1999年和2002年获得南开大学本科学位和理学硕士学位，之后进入美国俄亥俄州立大学，跟随美国科学院院士Yasuko Rikihisa教授学习深造，于2008年取得博士学位。毕业后在Yasuko Rikihisa教授的挽留下，继续在美国俄亥俄州立大学从事博士后研究。现受聘于南开大学微生物学系，主要研究方向是病原菌的致病机理及宿主免疫，新型抗菌药物的研发。本人作为第一作者和通讯作者发表SCI论文多篇，其中包括PNAS，Nature Communications，Cell reports，mBio等。

学士，1995.9-1999.6，南开大学，微生物学 硕士，1999.9-2002.6，南开大学，微生物学 博士，2002.9-2008.12，美国俄亥俄州立大学，兽医生物学

博士后研究员，2009.1-2014.11，美国俄亥俄州立大学，兽医生物学系 副教授，2014.12-2022.12，南开大学，微生物学系 研究员，2023.01-至今，南开大学，微生物学系

病原微生物感染致病机理以及宿主免疫

1. Nan Yang, Meifang Li, Shanhua Qin, Nan Duan, Xiaoxiao Li, Yuhong Zhou, Mengyao Wang, Yongxin Jin, Weihui Wu, Zhihui Cheng* (2024) Ehrlichia chaffeensis Etf-3 induces host RAB15 upregulation for bacterial intracellular growth. International Journal of Molecular Sciences 25: 2551.

2. Wen Yang, Yingxing Feng, Jun Yan, Chenbo Kang, Ting Yao, Hongmin Sun, Zhihui Cheng* (2023) Phosphate (Pi) transporter PIT1 induces Pi starvation in Salmonella-containing vacuole in HeLa cells. (2023) International Journal of Molecular Sciences 24: 17216.

3. Zhihui Cheng, Yangyang Zheng, Wen Yang, Hongmin Sun, Fangyu Zhou, Chuangjie Huang, Shuwen Zhang, Yingying Song, Qi’an Liang, Nan Yang, Meifang Li, Bin Liu, Lu Feng, Lei Wang*(2023) Pathogenic bacteria exploit transferrin receptor transcytosis to penetrate the blood-brain barrier. Proceedings of the National Academy of Sciences 120(39): e2307899120.

4. Ronghao Chen, Yu Cao, Yajing Liu, Dongdong Zhao, Ju Li, Zhihui Cheng*, Changhao Bi*, Xueli Zhang* (2023) Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65. Nature Communications 14(1):257.

5. Qi'an Liang, Jiaqi Yan, Shuwen Zhang, Nan Yang, Meifang Li, Yongxin Jin, Fang Bai, Weihui Wu, Zhihui Cheng* (2022) CtrA activates the expression of glutathione S-transferase conferring oxidative stress resistance to Ehrlichia chaffeensis. Frontiers in Cellular and Infection Microbiology 12:1081614.

6. Jiaqi Yan, Qi'an Liang, Zhouyi Chai, Nan Duan, Xiaoxiao Li, Yajing Liu, Nan Yang, Meifang Li, Yongxin Jin, Fang Bai, Weihui Wu, Zhihui Cheng* (2022) Glutathione synthesis regulated by CtrA protects Ehrlichia chaffeensis from host cell oxidative stress. Frontiers in Microbiology 13: 846488.

7. Yu Pang, Zhihui Cheng, Si Zhang, Shujie Li, Xueping Li, Xiaodan Li, Xiao Zhang, Xiaoxiao Li, Yingxing Feng, Heting Cui, Zhen Chen, Le Liu, Qing Li, Jianxiao Huang, Mingqing Zhang, Siwei Zhu, Lei Wang, Lu Feng (2022) (Co-first author) Bladder epithelial cell phosphate transporter inhibition protects mice against uropathogenic Escherichia coli infection. Cell Reports 39(3):110698.

8. Nan Duan, Xiaohui Ma, Heting Cui, Zhexuan Wang, Zhouyi Chai, Jiaqi Yan, Xiaoxiao Li, Yingxing Feng, Yu Cao, Yongxin Jin, Fang Bai, Weihui Wu, Yasuko Rikihisa and Zhihui Cheng* (2021) Insights into the mechanism regulating the differential expression of the P28-OMP outer membrane proteins in obligatory intracellular pathogen Ehrlichia chaffeensis. Emerging Microbes & Infections 10(1): 461-471.

9. Yuqing Long, Weixin Fu, Su Wang, Xuan Deng, Yongxin Jin, Fang Bai, Zhihui Cheng*, Weihui Wu* (2020) Fis contributes to resistance of Pseudomonas aeruginosa to ciprofloxacin by regulating pyocin synthesis. Journal of Bacteriology 202(11): e00064-20.

10. Chang Liu, Xiaolei Pan, Bin Xia, Fei Chen, Yongxin Jin, Fang Bai, Gregory Priebe, Zhihui Cheng*, Shouguang Jin*, Weihui Wu* (2018) Construction of a protective vaccine against lipopolysaccharide-heterologous Pseudomonas aeruginosa strains based on expression profiling of outer membrane proteins during infection. Frontiers in Immunology 9: 1737.

11. Ruiping Zheng, Xuemei Feng, Xueying Wei, Xiaolei Pan, Chang Liu, Ruopu Song, Yongxin Jin, Fang Bai, Shouguang Jin, Weihui Wu，Zhihui Cheng*（2018）PutA is required for virulence and regulated by PruR in Pseudomonas aeruginosa. Frontiers in Microbiology 9: 548

12. Xuan Deng, Mei Li, Xiaolei Pan, Ruiping Zheng, Chang Liu, Fei Chen, Xue Liu, Zhihui Cheng*, Shouguang Jin*, Weihui Wu* (2017) Fis regulates type III secretion system by influencing the transcription of exsA in Pseudomonas aeruginosa strain PA14. Frontiers in Microbiology 8: 669.

13. Xiaolei Pan, Yangyang Dong, Zheng Fan, Chang Liu, Bin Xia, Jing Shi, Fang Bai, Yongxin Jin, Zhihui Cheng*, Shouguang Jin*, Weihui Wu* (2017) in vivo host environment alters Pseudomonas aeruginosa susceptibility to aminoglycoside antibiotics. Frontiers in Cellular and Infection Microbiology 7: 83.

14. Mei Li, Yuqing Long, Ying Liu, Yang Liu, Ronghao Chen, Jing Shi, Lu Zhang, Yongxin Jin, Liang Yang, Fang Bai, Shouguang Jin*, Zhihui Cheng*and Weihui Wu* (2016) HigB of Pseudomonas aeruginosa enhances killing of phagocytes by up-regulating the type III secretion system in ciprofloxacin induced persister cells. Frontiers in Cellular and Infection Microbiology 6:125.

15. Gukui Chen, Qiang Zhao, Feng Zhu, Ronghao Chen ,Yongxin Jin, Chang Liu, Xiaolei Pan, Shouguang Jin，Weihui Wu and Zhihui Cheng* (2016) Oligoribonuclease is required for the type III secretion system and pathogenesis of Pseudomonas aeruginosa. Microbiological Research 188-189:90-6.

16. Ronghao Chen, Yuding Weng, Feng Zhu, Yongxin Jin, Chang Liu, Xiaolei Pan, Bin Xia, Zhihui Cheng*, Shouguang Jin*, Weihui Wu* (2016) Polynucleotide phosphorylase regulates multiple virulence factors and the stabilities of small RNAs RsmY/Z in Pseudomonas aeruginosa. Frontiers in Microbiology 7: 247.

天津市微生物学会理事，秘书长

承担《免疫学》《普通生物学》《生物技术综合实验》《微生物基础研讨》《生物学科职业生涯发展与规划》等课教学任务

第八届南开大学“良师益友”