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丁丹

性别： 男

部门： 生物材料与组织工程系

电话： 022-23501229

办公地址： 分子所210室

职称： 研究员

招生专业： 生物化学与分子生物学

邮箱： dingd@nankai.edu.cn

通讯地址： 天津市卫津路94号南开大学分子所210室

个人简介

丁丹，男，1982年8月出生。2005年本科毕业于南京大学化学系，2010年毕业于南京大学高分子系并获得理学博士学位。2010 年8 月加入新加坡国立大学化学与生物分子工程系从事博士后研究。2013年3月加入南开大学生命科学学院任教。丁丹课题组的研究方向为新型分子影像探针的设计、制备与生物医学应用。课题组主要发展基于“聚集诱导发光”荧光分子以及半导体共轭高分子等材料的新型分子影像探针，并致力于发展能够应用于肿瘤、组织缺血等重要疾病的诊断与治疗的新材料与新方法。2013年以来，丁丹先后入选了南开大学“百名青年学科带头人”、天津市“青年科技优秀人才”等人才计划，并于2016年获得了国家自然科学基金委“优秀青年”科学基金项目的资助。迄今为止，以通讯作者或第一作者在Nature Communications, JACS, Advanced Materials, ACS Nano等重要国际期刊上发表了SCI论文50余篇，研究成果受到国内外同行专家的广泛关注，H-index为36（截至2018年6月22日）。

教育经历

2005.09 – 2010.07 南京大学，化学化工学院高分子科学与工程系，博士学位 2001.09 – 2005.07 南京大学，化学化工学院化学系，学士学位

工作经历

2017.01 – 今 南开大学生命科学学院，研究员，博导 2013.03 – 2016.12 南开大学生命科学学院，副教授，博导 2010.08 – 2013.03 新加坡国立大学，化学与生物分子工程系，博士后

研究方向

新型分子影像探针与纳米药物的设计、制备与生物医学应用。

科研成果

承担科研项目

1. 国家自然科学基金优秀青年项目“荧光材料与分子探针”。经费：150万；执行年限：2017.01-2019.12；项目批准号：51622305；

2. 国家自然科学基金面上项目“具有“聚集诱导发光”性质的多功能纳米生物探针的制备及其生物医学应用”。经费：29.8万；执行年限：2016.01-2017.12；项目批准号：31571011；

3. 国家自然科学基金青年项目“基于共轭高分子的生物探针的制备及其应用于干细胞示踪的研究”。经费：23万；执行年限：2014.01-2016.12；项目批准号：81301311；

4. 天津市自然科学基金一般项目“纳米结构形成诱导的荧光开启用于生物分子检测的研究”。经费：10万；执行年限：2015.04-2018.03；项目批准号：15JCYBJC29800。


已发表的论文

  1. Xu, H.; Wang, T.; Yang, C.; Li, X.;* Liu, G.; Yang, Z.; Singh, P. K.; Krishnan, S.;* Ding, D.*Supramolecular Nanofibers of Curcumin for Highly Amplified Radiosensitization of Colorectal Cancers to Ionizing Radiation, Adv. Funct. Mater. 2018, 28, 1707140.

  2. Qi, J.; Chen, C.; Zhang, X.; Hu, X.; Ji. S.; Kwok, R. T. K.; Lam, J. W. Y.; Ding, D.;* Tang, B. Z.* Light-Driven Transformable Optical Agent with Adaptive Functions for Boosting Cancer Surgery Outcomes, Nat. Commun. 2018, 9, 1848.

  3. Gu, X.; Zhang, X.; Ma, H.; Jia, S.; Zhang, P.; Zhao, Y.; Liu, Q.; Wang, J.; Zheng, X.; Lam, J. W. Y.; Ding, D.;* Tang, B. Z.* Corannulene-Incorporated AIE Nanodots with Highly Suppressed Nanradiative Decay for Boosted Cancer Phototheranostics in Vivo, Adv. Mater. 2018, 30, 1801065.

  4. Gao, J.; Li, J.; Geng, W. C.; Chen, F. Y.; Duan, X.; Zheng, Z.; Ding, D.;* Guo, D.* Biomarker Displacement Activation: A General Host-Guest Strategy for Targeted Phototheranostics in Vivo, J. Am. Chem. Soc. 2018, 140, 4945.

  5. Ji, S.; Gao, H.; Mu, W.; Ni, X.; Yi, X.; Shen, J.; Liu, Q.;* Bao, P.;* Ding, D.*Enzyme-Instructed Self-Assembly Leads To Activation of Optical Properties for Selective Fluorescence Detection and Photodynamic Ablation of Cancer Cells, J. Mater. Chem. B 2018, DOI: 10.1039/C7TB02685D.

  6. Mao, D.; Liu, J.; Ji, S.; Wang, T.; Hu, Y.; Zheng, D.;* Yang, R.; Kong, D.;*Ding, D.* Amplification of Near-Infrared Fluorescence in Semiconducting Polymer Nanoprobe for Grasping the Behaviors of Systemically Administered Endothelial Cells in Ischemia Treatment, Biomaterials2017, 143, 109-119.

  7. Peng, S.; Pan, Y. C.; Wang, Y.; Xu, Z.; Chen, C.;Ding, D.;*Wang, Y.;* Guo, D. S.* Sequentially Programmable and Cellularly Selective Assembly of Fluorescent Polymerized Vesicles for Monitoring Cell Apoptosis, Adv. Sci.2017, 4, 1700310.

  8. Li, J.; Zhu, Z.; Rong, S.; Li, H.; Guo, Y.; Xue, Q.;*Ding, D.* A Specific Environment-Sensitive Near-Infrared Fluorescence Turn-On Probe for Synergistic Enhancement of Anticancer Activity of a Chemo-Drug, Biomater. Sci.2017, 5, 1622-1628.

  9. Yi, X.; Li, J.; Zhu, Z.; Liu, Q.; Xue, Q.;* Ding, D.* In Vivo Cancer Research Using Aggregation-Induced Emission Organic Nanoparticles, Drug Discover. Today 2017, 22, 1412-1420.

  10. Liu, D.; Ji, S.; Li, H.; Hong, L.; Kong, D.; Qi, X.;* Ding, D.* Cellular Membrane-Anchored Fluorescent Probe with Aggregation-Induced Emission Characteristics for Selective Detection of Cu2+ Ions, Faraday Discuss. 2017, 196, 377-393.

  11. Zhu, H.; Fang, Y.; Miao, Q.; Qi, X.;Ding, D.;* Chen, P.;* Pu, K.* Regulating Near-Infrared Photodynamic Properties of Semiconducting Polymer Nanotheranostics for Optimized Cancer Therapy, ACS Nano2017, 11, 8998-9009.

  12. Qi, J.; Fang, Y.; Kwok, R. T. K.; Zhang, X.; Hu, X.; Lam, J. W. Y.;Ding, D.;* Tang, B. Z.* Highly Stable Organic Small Molecular Nanoparticles as an Advanced and Biocompatible Phototheranostic Agent of Tumor in Living Mice,ACS Nano 2017, 11, 7177-7188.

  13. Song, Z.; Mao, D.; Sung, S. H. P.; Kwok, R. T. K.; Lam, J. W. Y.; Kong, D.; Ding, D.;* Tang, B. Z.* Activatable Fluorescent Nanoprobe with Aggregation-Induced Emission Characteristics for Selective In Vivo Imaging of Elevated Peroxynitrite Generation, Adv. Mater. 2016, 28, 7249-7256.

  14. Yu, C. Y. Y.; Xu, H.; Ji, X.; Kwok, R. T. K.; Lam, J. W. Y.; Li, X.;* Krishnan, S.; Ding, D.;* Tang, B. Z.* Mitochondrion-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics Synergistically Boosts the Radiosensitivity of Cancer Cells to Ionizing Radiation, Adv. Mater. 2017, 29, 1606167.

  15. Liu, J.; Chen, C.; Ji, S.; Liu, Q.;* Ding, D.;* Zhao, D.; Liu, B.* Long Wavelength Excitable Near-Infrared Fluorescent Nanoparticles with Aggregation-Induced Emission Characteristics for Image-Guided Tumor Resection, Chem. Sci. 2017, 8, 2782-2789.

  16. Chen, C.; Song, Z.; Zheng, X.; He, Z.; Liu, B.;* Huang, X.; Kong, D.; Ding, D.;* Tang, B. Z.* AIEgen-based Theranostic System: Targeted Imaging of Cancer Cells and Adjuvant Amplification of Antitumor Efficacy of Paclitaxel, Chem. Sci. 2017, 8, 2191-2198.

  17. Zhu, H.; Lai, Z.; Fang, Y.; Zhen, X.; Tan, C.; Qi, X.; Ding, D.;* Chen, P.;* Pu, K.* Ternary Chalcogenide Nanosheets with Ultrahigh Photothermal Conversion Efficiency for Photoacoustic Theranostics, Small2017, 13, 1604139.

  18. Feng, G.; Fang, Y.; Liu, J.; Geng, J.; Ding, D.;* Liu, B.* Multifunctional Conjugated Polymer Nanoparticles for Image-Guided Photodynamic and Photothermal Therapy, Small2017, 13, 1602807.

  19. Wang, H.; Liu, J.; Han, A.; Xiao, N.; Xue, Z.; Wang, G.; Long, J.; Kong, D.; Liu, B.;* Yang, Z.;* Ding, D.* Self-Assembly-Induced Far-Red/Near-Infrared Fluorescence Light-up for Detecting and Visualizing Specific Protein-Peptide Interactions, ACS Nano 2014, 8, 1475-1484.

  20. Ding, D.; Mao, D.; Li, K.; Wang, X.; Qin, W.; Liu, R.; Chiam, D. S.; Tomczak, N.; Yang, Z.; Tang, B. Z.;* Kong, D.;* Liu, B.* Precise and Long-Term Tracking of Adipose-Derived Stem Cells and Their Regenerative Capacity via Superb Bright and Stable Organic Nanodots, ACS Nano 2014, 8, 12620-12631.

  21. Jin, G.; Mao, D.; Cai, P.; Liu, R.; Tomczak, N.; Liu, J.; Chen, X.; Kong, D.; Ding, D.;* Liu, B.;* Li, K.* Conjugated Polymer Nanodots as Ultrastable Long-Term Trackers to Understand Mesenchymal Stem Cell Therapy in Skin Regeneration. Adv. Funct. Mater. 2015, 25, 4263-4273.

  22. Han, A.; Wang, H.; Kwok, R. T. K.; Ji, S.; Li, J.; Kong, D.; Tang, B. Z.; Liu, B.;* Yang, Z.;* Ding, D.* Peptide-Induced AIEgen Self-Assembly: A New Strategy to Realize Highly Sensitive Fluorescent Light-Up Probes, Anal. Chem. 2016, 88, 3872-3878.

  23. Zhu, H.; Fang, Y.; Zhen, X.; Wei, N.; Gao, Y.; Luo, K. Q.; Xu, C.; Duan, H.; Ding, D.;* Chen, P.;* Pu, K.* Multilayered Semiconducting Polymer Nanoparticles with Enhanced NIR Fluorescence for Molecular Imaging in Cells, Zebrafish and Mice. Chem. Sci. 2016, 7, 5118-5125.

  24. Ding, D.; Kwok, R. T. K.; Yuan, Y.; Feng, G.; Tang, B. Z.;* Liu, B.* A Fluorescent Light-Up Nanoparticle Probe with Aggregation-Induced Emission Characteristics and Tumor-Acidity Responsiveness for Targeted Imaging and Selective Suppression of Cancer Cells, Mater. Horiz. 2015, 2, 100-105.

  25. Yang, C.; Chu, L.; Zhang, Y.; Shi, Y.; Liu, J.; Liu, Q.; Fan, S.; Yang, Z.; Ding, D.;* Kong, D.;* Liu, J.* Dynamic Biostability, Biodistribution, and Toxicity of L/D-Peptide-Based Supramolecular Nanofibers. ACS Appl. Mater. Interfaces 2015, 7, 2735-2744.

  26. Liu, J. F.; Liu, J. J.; Chu, L. P.; Zhang, Y. M.; Xu, H. Y.; Kong, D. L.; Yang, Z. M.; Yang, C. H.;* Ding, D.* Self-Assembling Peptide of D-Amino Acids Boosts Selectivity and Antitumor Efficacy of 10-Hydroxycamptothecin, ACS Appl. Mater. Interfaces2014, 6, 5558-5565.

  27. Chen, G.; Hua, Y.; Ou, C.; Zhang, X.; Mao, D.; Yang, Z.; Ding, D.;* Chen, M.* Nanostructure Formation-Induced Fluorescence Turn-On for Selectively Detecting Protein Thiols in Solutions, Bacteria and Live Cells. Chem. Commun. 2015, 51, 10758-10761.

  28. Zhang, X.; Zhou, H.; Xie, Y.; Ren, C.; Ding, D.;* Long, J.;* Yang Z.* Rational Design of Multifunctional Hetero-Hexameric Proteins for Hydrogel Formation and Controlled Delivery of Bioactive Molecules, Adv. Healthcare Mater. 2014, 3, 1804-1811.

  29. Chen, C.; Hua, Y.; Hu, Y.; Fang, Y.; Ji, S.; Yang, Z.; Ou, C.;* Kong, D.;* Ding, D.* Far-Red/Near-Infrared Fluorescence Light-Up Probes for Specific In Vitro and In Vivo Imaging of a Tumour-Related Protein, Sci. Rep. 2016, 6, 23190.

  30. Xue, Q.; Ren, H.; Xu, C.; Wang, G.; Ren, C.; Hao, J.;* Ding, D.* Nanospheres of Doxorubicin as Cross-Linkers for a Supramolecular Hydrogelation. Sci. Rep. 2015, 5, 8764.

  31. Wang, H.; Mao, D.; Wang, Y.; Wang, K.;* Yi, X.; Kong, D.; Yang, Z.; Liu, Q.;* Ding, D.* Biocompatible Fluorescent Supramolecular Nanofibrous Hydrogel for Long-Term Cell Tracking and Tumor Imaging Application. Sci. Rep. 2015, 5, 16680.

  32. Shi, Y.; Zhou, H.; Zhang, X.; Wang, J.; Long, J.; Yang, Z.;* Ding, D.* Self-Assembling Choline Mimicks with Enhanced Binding Affinities to C-LytA Protein, Sci. Rep.2014, 4: 6621.

  33. Tian, R.; Wang, H.; Niu, R.;* Ding, D.* Drug Delivery with Nanospherical Supramolecular Cell Penetrating Peptide-Taxol Conjugates Containing a High Drug Loading. J. Colloid. Interface Sci. 2015, 453, 15-20.

  34. Wang, W.; Li, G; Zhang, W.; Gao, J.; Zhang, J.; Li, C.;* Ding, D.* Kong, D., Reduction-Triggered Formation of EFK8 Molecular Hydrogel for 3D Cell Culture, RSC Adv. 2014, 4, 30168-30171.

  35. Zhang, J.; Wang, G.; Mao, D.; Han, A.; Xiao, N.; Qi, X.;* Ding, D.;* Kong, D. Targeted In Vivo Imaging of Mouse Hindlimb Ischemia Using Fluorescent Gelatin Nanoparticles. J. Nanomater. 2015, 704817.

  36. Ding, D.; Li, K.; Liu, B.;* Tang, B. Z.* Bioprobes Based on AIE Fluorogens, Accounts Chem. Res. 2013, 46, 2441-2453.

  37. Ding, D.; Goh, C. C.; Feng, G. X.; Zhao, Z. J.; Liu, J.; Liu, R. R.; Tomczak, N.; Geng, J. L.; Tang, B. Z.; Ng, L. G.;* Liu, B.* Ultrabright Organic Dots with Aggregation-Induced Emission Characteristics for Real-Time Two-Photon Intravital Vasculature Imaging, Adv. Mater. 2013, 25, 6083-6088.

  38. Ding, D.; Zhu, Z. S.; Li, R. T.; Li, X. L.; Wu, W.; Jiang, X. Q.;* Liu, B. R. Nanospheres-Incorporated Implantable Hydrogel as a Trans-Tissue Drug Delivery System,ACS Nano2011, 5, 2520-2534.

  39. Qin, W.;†Ding, D.;† Liu, J. Z.; Yuan, W. Z.; Hu, Y.; Liu, B.;* Tang, B. Z.* Biocompatible Nanoparticles with Aggregation-Induced Emission Characteristics as Far-Red/Near-Infrared Fluorescent Bioprobes for In Vitro and In Vivo Imaging Applications, Adv. Funct. Mater. 2012, 22, 771-779. †contributed equally

  40. Ding, D.; Liu, J.; Feng, G. X.; Li, K.; Hu, Y.; Liu, B.*Bright Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for In Vivo Bioimaging, Small2013, 9, 3093-3102.

  41. Ding, D.; Wang, G.; Liu, J. Z.; Li, K.; Pu, K. Y.; Hu, Y.; Ng, J. C. Y.; Tang, B. Z.; Liu, B.* Hyperbranched Conjugated Polyelectrolyte for Dual-Modality Fluorescence and Magnetic Resonance Cancer Imaging,Small2012, 8, 3523-3530.

  42. Ding, D.; Pu, K. Y.; Li, K.; Liu, B.* Conjugated Oligoelectrolyte-Polyhedral Oligomeric Silsesquioxane Loaded pH-Responsive Nanoparticles for Targeted Fluorescence Imaging of Cancer Cell Nucleus, Chem. Commun. 2011, 47, 9837-9839.

  43. Ding, D.; Li, K.; Zhu, Z. S.; Pu, K. Y.; Hu, Y.; Jiang, X. Q.; Liu, B.* Conjugated Polyelectrolyte-Cisplatin Complex Nanoparticles for Simultaneous In Vivo Imaging and Drug Tracking, Nanoscale2011, 3, 1997-2002.

  44. Ding, D.; Li, K.; Qin, W.; Zhan, R. Y.; Hu, Y.; Liu, J. Z.; Tang, B. Z.; Liu, B.* Conjugated Polymer Amplified Far-Red/Near-Infrared Fluorescence from Nanoparticles with Aggregation-Induced Emission Characteristics for Targeted In Vivo Imaging, Adv. HealthcareMater.2012, 2, 500-507.

  45. Ding, D.; Lang, J.; Shi, H.; Kwok, R. T. K.; Gao, M.; Feng, G. X.; Yuan, Y. Y.; Tang, B. Z.,* Liu, B.* Light-Up Bioprobe with Aggregation-Induced Emission Characteristics for Real-Time Apoptosis Imaging in Target Cancer Cells,J. Mater. Chem. B 2013, 2, 231-238.

  46. Ding, D.; Wang, J.; Zhu, Z. S.; Li, R. T.; Wu, W.; Liu, B. R.; Jiang, X. Q.* Tumor Accumulation, Penetration and Antitumor Response of Cisplatin-Loaded Gelatin/Poly(Acrylic Acid) Nanoparticles,ACS Appl. Mater. Interfaces2012, 4, 1838-1846.

  47. Ding, D.; Zhu, Z. S.; Liu, Q.; Wang, J.; Hu, Y.; Jiang, X. Q.;* Liu, B. R. Cisplatin-Loaded Gelatin-Poly(Acrylic Acid) Nanoparticles: Synthesis, Antitumor Efficiency In Vivo and Penetration in Tumors, Eur. J. Pharm. Biopharm.2011, 79, 142-149.

  48. Ding, D.; Wang, J.; Chen, Y.; Wu, W.; Jiang, X. Q.,* Synthesis of Novel Gelatin/Poly(Acrylic Acid) Nanorods via the Self-Assembly of Nanospheres, Sci. China Chem. 2011, 54, 392-396.


社会兼职

1. 天津市生物医学工程学会口腔医学工程专业委员会青年委员，青年工作组组长；

2. Science China Chemistry期刊青年编委。

教学经历

参与讲授研究生课程《高级生化（二）》和《分子生物学前沿讲座》；参与讲授本科生课程《创新与创业实践》

荣誉称号

1. 2014年入选南开大学“百名青年学科带头人计划”
2. 2015年获得天津市“青年科技优秀人才”称号
3. 2016年获得国家自然科学基金委“优秀青年”科学基金项目的资助

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