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Dingdan

Gender: male

Department: 生物材料与组织工程系

Tel: 022-23501229

Office Location: Institute of Molecular Biology #210

Career: Professor

Major: Biochemistry and Molecular Biology

Email: dingd@nankai.edu.cn

Address: Institute of Molecular Biology #210, Nankai University, 94 Weijin Road, Tianjin 300071, China

Resume

DING Dan obtained his Bsc. in Chemistry (2005) and DPhil. (2010) in Polymer Chemistry and Physics from Nanjing University. After a postdoctoral training with Professor Bin Liu in the Department of Chemical & Biomolecular Engineering in National University of Singapore, he joined Nankai University in March 2013, where he is currently a professor in the College of Life Sciences.In 2014, he was selected in the 100 Young Academic Leaders Plan in Nankai University. In 2016, he was obtained the China National Science Fund for Excellent Young Scientists. His current research interest focuses on the design and preparation of nanomedicines and new molecular imaging probes as well as exploration of their biomedical applications. To date, he has published around 50 papers as the corresponding/first author in the journals such as Nat. Commun., JACS, Adv. Mater. and ACS Nano.

Education

September 2005-July 2010 Ph. D. of Science, Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University September 2001-July 2005 Bachelor of Science, Department of Chemistry, College of Chemistry and Chemical Engineering, Nanjing University

WorkExperience

January 2017-Present Professor, College of Life Sciences, Nankai University March 2013-December 2016 Associate Professor, College of Life Sciences, Nankai University September 2010-March 2013 Research Fellow, Department of Chemical and Biomolecular Engineering, National University of Singapore

Research Fields

Design, preparation and biomedical applications of new nanomedicine and molecular imaging probes.

Achievement

Grants

(1) National Natural Science Foundation of China (NSFC): National Science Fund for Excellent Young Scientists; Fluorescent materials and molecular probe; Jan 2017-Dec 2019, 1.5 million RMB.

(2) NSFC: General Project;Synthesis and biomedical application of multifunctional nanoprobes with aggregation-induced emission characteristics; Jan 2016-Dec 2017, 298,000RMB.

(3) NSFC: Youth Project; Synthesis of conjugated polymer-based bioprobes for stem cell tracing; Jan 2014-Dec 2016, 230,000RMB.

(4) The Science & Technology Project of Tianjin of China: General Project; Nanostructure formation-induced fluorescence turn-on for detection of bioactive molecules; April 2015-March 2018, 100,000RMB.


Publications


  1. Xu, H.; Wang, T.; Yang, C.; Li, X.;* Liu, G.; Yang, Z.; Singh, P. K.; Krishnan, S.;* Ding, D.*Supramolecular Nanofibers of Curcumin for Highly Amplified Radiosensitization of Colorectal Cancers to Ionizing Radiation, Adv. Funct. Mater.2018, 28, 1707140.

  2. Qi, J.; Chen, C.; Zhang, X.; Hu, X.; Ji. S.; Kwok, R. T. K.; Lam, J. W. Y.; Ding, D.;* Tang, B. Z.* Light-Driven Transformable Optical Agent with Adaptive Functions for Boosting Cancer Surgery Outcomes, Nat. Commun.2018, 9, 1848.

  3. Gu, X.; Zhang, X.; Ma, H.; Jia, S.; Zhang, P.; Zhao, Y.; Liu, Q.; Wang, J.; Zheng, X.; Lam, J. W. Y.; Ding, D.;* Tang, B. Z.* Corannulene-Incorporated AIE Nanodots with Highly Suppressed Nanradiative Decay for Boosted Cancer Phototheranostics in Vivo, Adv. Mater.2018, 30, 1801065.

  4. Gao, J.; Li, J.; Geng, W. C.; Chen, F. Y.; Duan, X.; Zheng, Z.; Ding, D.;* Guo, D.* Biomarker Displacement Activation: A General Host-Guest Strategy for Targeted Phototheranostics in Vivo, J. Am. Chem. Soc.2018, 140, 4945.

  5. Ji, S.; Gao, H.; Mu, W.; Ni, X.; Yi, X.; Shen, J.; Liu, Q.;* Bao, P.;* Ding, D.*Enzyme-Instructed Self-Assembly Leads To Activation of Optical Properties for Selective Fluorescence Detection and Photodynamic Ablation of Cancer Cells, J. Mater. Chem. B 2018, DOI: 10.1039/C7TB02685D.

  6. Mao, D.; Liu, J.; Ji, S.; Wang, T.; Hu, Y.; Zheng, D.;* Yang, R.; Kong, D.;*Ding, D.* Amplification of Near-Infrared Fluorescence in Semiconducting Polymer Nanoprobe for Grasping the Behaviors of Systemically Administered Endothelial Cells in Ischemia Treatment, Biomaterials2017, 143, 109-119.

  7. Peng, S.; Pan, Y. C.; Wang, Y.; Xu, Z.; Chen, C.;Ding, D.;*Wang, Y.;* Guo, D. S.* Sequentially Programmable and Cellularly Selective Assembly of Fluorescent Polymerized Vesicles for Monitoring Cell Apoptosis, Adv. Sci.2017, 4, 1700310.

  8. Li, J.; Zhu, Z.; Rong, S.; Li, H.; Guo, Y.; Xue, Q.;*Ding, D.* A Specific Environment-Sensitive Near-Infrared Fluorescence Turn-On Probe for Synergistic Enhancement of Anticancer Activity of a Chemo-Drug, Biomater. Sci.2017, 5, 1622-1628.

  9. Yi, X.; Li, J.; Zhu, Z.; Liu, Q.; Xue, Q.;* Ding, D.* In Vivo Cancer Research Using Aggregation-Induced Emission Organic Nanoparticles, Drug Discover. Today 2017, 22, 1412-1420.

  10. Liu, D.; Ji, S.; Li, H.; Hong, L.; Kong, D.; Qi, X.;* Ding, D.* Cellular Membrane-Anchored Fluorescent Probe with Aggregation-Induced Emission Characteristics for Selective Detection of Cu2+ Ions, Faraday Discuss. 2017, 196, 377-393.

  11. Zhu, H.; Fang, Y.; Miao, Q.; Qi, X.;Ding, D.;* Chen, P.;* Pu, K.* Regulating Near-Infrared Photodynamic Properties of Semiconducting Polymer Nanotheranostics for Optimized Cancer Therapy, ACS Nano2017, 11, 8998-9009.

  12. Qi, J.; Fang, Y.; Kwok, R. T. K.; Zhang, X.; Hu, X.; Lam, J. W. Y.;Ding, D.;* Tang, B. Z.* Highly Stable Organic Small Molecular Nanoparticles as an Advanced and Biocompatible Phototheranostic Agent of Tumor in Living Mice,ACS Nano 2017, 11, 7177-7188.

  13. Song, Z.; Mao, D.; Sung, S. H. P.; Kwok, R. T. K.; Lam, J. W. Y.; Kong, D.; Ding, D.;* Tang, B. Z.* Activatable Fluorescent Nanoprobe with Aggregation-Induced Emission Characteristics for Selective In Vivo Imaging of Elevated Peroxynitrite Generation, Adv. Mater. 2016, 28, 7249-7256.

  14. Yu, C. Y. Y.; Xu, H.; Ji, X.; Kwok, R. T. K.; Lam, J. W. Y.; Li, X.;* Krishnan, S.; Ding, D.;* Tang, B. Z.* Mitochondrion-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics Synergistically Boosts the Radiosensitivity of Cancer Cells to Ionizing Radiation, Adv. Mater. 2017, 29, 1606167.

  15. Liu, J.; Chen, C.; Ji, S.; Liu, Q.;* Ding, D.;* Zhao, D.; Liu, B.* Long Wavelength Excitable Near-Infrared Fluorescent Nanoparticles with Aggregation-Induced Emission Characteristics for Image-Guided Tumor Resection, Chem. Sci. 2017, 8, 2782-2789.

  16. Chen, C.; Song, Z.; Zheng, X.; He, Z.; Liu, B.;* Huang, X.; Kong, D.; Ding, D.;* Tang, B. Z.* AIEgen-based Theranostic System: Targeted Imaging of Cancer Cells and Adjuvant Amplification of Antitumor Efficacy of Paclitaxel, Chem. Sci. 2017, 8, 2191-2198.

  17. Zhu, H.; Lai, Z.; Fang, Y.; Zhen, X.; Tan, C.; Qi, X.; Ding, D.;* Chen, P.;* Pu, K.* Ternary Chalcogenide Nanosheets with Ultrahigh Photothermal Conversion Efficiency for Photoacoustic Theranostics, Small2017, 13, 1604139.

  18. Feng, G.; Fang, Y.; Liu, J.; Geng, J.; Ding, D.;* Liu, B.* Multifunctional Conjugated Polymer Nanoparticles for Image-Guided Photodynamic and Photothermal Therapy, Small2017, 13, 1602807.

  19. Wang, H.; Liu, J.; Han, A.; Xiao, N.; Xue, Z.; Wang, G.; Long, J.; Kong, D.; Liu, B.;* Yang, Z.;* Ding, D.* Self-Assembly-Induced Far-Red/Near-Infrared Fluorescence Light-up for Detecting and Visualizing Specific Protein-Peptide Interactions, ACS Nano 2014, 8, 1475-1484.

  20. Ding, D.; Mao, D.; Li, K.; Wang, X.; Qin, W.; Liu, R.; Chiam, D. S.; Tomczak, N.; Yang, Z.; Tang, B. Z.;* Kong, D.;* Liu, B.* Precise and Long-Term Tracking of Adipose-Derived Stem Cells and Their Regenerative Capacity via Superb Bright and Stable Organic Nanodots, ACS Nano 2014, 8, 12620-12631.

  21. Jin, G.; Mao, D.; Cai, P.; Liu, R.; Tomczak, N.; Liu, J.; Chen, X.; Kong, D.; Ding, D.;* Liu, B.;* Li, K.* Conjugated Polymer Nanodots as Ultrastable Long-Term Trackers to Understand Mesenchymal Stem Cell Therapy in Skin Regeneration. Adv. Funct. Mater. 2015, 25, 4263-4273.

  22. Han, A.; Wang, H.; Kwok, R. T. K.; Ji, S.; Li, J.; Kong, D.; Tang, B. Z.; Liu, B.;* Yang, Z.;* Ding, D.* Peptide-Induced AIEgen Self-Assembly: A New Strategy to Realize Highly Sensitive Fluorescent Light-Up Probes, Anal. Chem. 2016, 88, 3872-3878.

  23. Zhu, H.; Fang, Y.; Zhen, X.; Wei, N.; Gao, Y.; Luo, K. Q.; Xu, C.; Duan, H.; Ding, D.;* Chen, P.;* Pu, K.* Multilayered Semiconducting Polymer Nanoparticles with Enhanced NIR Fluorescence for Molecular Imaging in Cells, Zebrafish and Mice. Chem. Sci. 2016, 7, 5118-5125.

  24. Ding, D.; Kwok, R. T. K.; Yuan, Y.; Feng, G.; Tang, B. Z.;* Liu, B.* A Fluorescent Light-Up Nanoparticle Probe with Aggregation-Induced Emission Characteristics and Tumor-Acidity Responsiveness for Targeted Imaging and Selective Suppression of Cancer Cells, Mater. Horiz. 2015, 2, 100-105.

  25. Yang, C.; Chu, L.; Zhang, Y.; Shi, Y.; Liu, J.; Liu, Q.; Fan, S.; Yang, Z.; Ding, D.;* Kong, D.;* Liu, J.* Dynamic Biostability, Biodistribution, and Toxicity of L/D-Peptide-Based Supramolecular Nanofibers. ACS Appl. Mater. Interfaces 2015, 7, 2735-2744.

  26. Liu, J. F.; Liu, J. J.; Chu, L. P.; Zhang, Y. M.; Xu, H. Y.; Kong, D. L.; Yang, Z. M.; Yang, C. H.;* Ding, D.* Self-Assembling Peptide of D-Amino Acids Boosts Selectivity and Antitumor Efficacy of 10-Hydroxycamptothecin, ACS Appl. Mater. Interfaces2014, 6, 5558-5565.

  27. Chen, G.; Hua, Y.; Ou, C.; Zhang, X.; Mao, D.; Yang, Z.; Ding, D.;* Chen, M.* Nanostructure Formation-Induced Fluorescence Turn-On for Selectively Detecting Protein Thiols in Solutions, Bacteria and Live Cells. Chem. Commun. 2015, 51, 10758-10761.

  28. Zhang, X.; Zhou, H.; Xie, Y.; Ren, C.; Ding, D.;* Long, J.;* Yang Z.* Rational Design of Multifunctional Hetero-Hexameric Proteins for Hydrogel Formation and Controlled Delivery of Bioactive Molecules, Adv. Healthcare Mater. 2014, 3, 1804-1811.

  29. Chen, C.; Hua, Y.; Hu, Y.; Fang, Y.; Ji, S.; Yang, Z.; Ou, C.;* Kong, D.;* Ding, D.* Far-Red/Near-Infrared Fluorescence Light-Up Probes for Specific In Vitro and In Vivo Imaging of a Tumour-Related Protein, Sci. Rep. 2016, 6, 23190.

  30. Xue, Q.; Ren, H.; Xu, C.; Wang, G.; Ren, C.; Hao, J.;* Ding, D.* Nanospheres of Doxorubicin as Cross-Linkers for a Supramolecular Hydrogelation. Sci. Rep. 2015, 5, 8764.

  31. Wang, H.; Mao, D.; Wang, Y.; Wang, K.;* Yi, X.; Kong, D.; Yang, Z.; Liu, Q.;* Ding, D.* Biocompatible Fluorescent Supramolecular Nanofibrous Hydrogel for Long-Term Cell Tracking and Tumor Imaging Application. Sci. Rep. 2015, 5, 16680.

  32. Shi, Y.; Zhou, H.; Zhang, X.; Wang, J.; Long, J.; Yang, Z.;* Ding, D.* Self-Assembling Choline Mimicks with Enhanced Binding Affinities to C-LytA Protein, Sci. Rep.2014, 4: 6621.

  33. Tian, R.; Wang, H.; Niu, R.;* Ding, D.* Drug Delivery with Nanospherical Supramolecular Cell Penetrating Peptide-Taxol Conjugates Containing a High Drug Loading. J. Colloid. Interface Sci. 2015, 453, 15-20.

  34. Wang, W.; Li, G; Zhang, W.; Gao, J.; Zhang, J.; Li, C.;* Ding, D.* Kong, D., Reduction-Triggered Formation of EFK8 Molecular Hydrogel for 3D Cell Culture, RSC Adv. 2014, 4, 30168-30171.

  35. Zhang, J.; Wang, G.; Mao, D.; Han, A.; Xiao, N.; Qi, X.;* Ding, D.;* Kong, D. Targeted In Vivo Imaging of Mouse Hindlimb Ischemia Using Fluorescent Gelatin Nanoparticles. J. Nanomater. 2015, 704817.

  36. Ding, D.; Li, K.; Liu, B.;* Tang, B. Z.* Bioprobes Based on AIE Fluorogens, Accounts Chem. Res. 2013, 46, 2441-2453.

  37. Ding, D.; Goh, C. C.; Feng, G. X.; Zhao, Z. J.; Liu, J.; Liu, R. R.; Tomczak, N.; Geng, J. L.; Tang, B. Z.; Ng, L. G.;* Liu, B.* Ultrabright Organic Dots with Aggregation-Induced Emission Characteristics for Real-Time Two-Photon Intravital Vasculature Imaging, Adv. Mater. 2013, 25, 6083-6088.

  38. Ding, D.; Zhu, Z. S.; Li, R. T.; Li, X. L.; Wu, W.; Jiang, X. Q.;* Liu, B. R. Nanospheres-Incorporated Implantable Hydrogel as a Trans-Tissue Drug Delivery System,ACS Nano2011, 5, 2520-2534.

  39. Qin, W.;†Ding, D.;† Liu, J. Z.; Yuan, W. Z.; Hu, Y.; Liu, B.;* Tang, B. Z.* Biocompatible Nanoparticles with Aggregation-Induced Emission Characteristics as Far-Red/Near-Infrared Fluorescent Bioprobes for In Vitro and In Vivo Imaging Applications, Adv. Funct. Mater. 2012, 22, 771-779. †contributed equally

  40. Ding, D.; Liu, J.; Feng, G. X.; Li, K.; Hu, Y.; Liu, B.*Bright Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for In Vivo Bioimaging, Small2013, 9, 3093-3102.

  41. Ding, D.; Wang, G.; Liu, J. Z.; Li, K.; Pu, K. Y.; Hu, Y.; Ng, J. C. Y.; Tang, B. Z.; Liu, B.* Hyperbranched Conjugated Polyelectrolyte for Dual-Modality Fluorescence and Magnetic Resonance Cancer Imaging,Small2012, 8, 3523-3530.

  42. Ding, D.; Pu, K. Y.; Li, K.; Liu, B.* Conjugated Oligoelectrolyte-Polyhedral Oligomeric Silsesquioxane Loaded pH-Responsive Nanoparticles for Targeted Fluorescence Imaging of Cancer Cell Nucleus, Chem. Commun.2011, 47, 9837-9839.

  43. Ding, D.; Li, K.; Zhu, Z. S.; Pu, K. Y.; Hu, Y.; Jiang, X. Q.; Liu, B.* Conjugated Polyelectrolyte-Cisplatin Complex Nanoparticles for Simultaneous In Vivo Imaging and Drug Tracking, Nanoscale2011, 3, 1997-2002.

  44. Ding, D.; Li, K.; Qin, W.; Zhan, R. Y.; Hu, Y.; Liu, J. Z.; Tang, B. Z.; Liu, B.* Conjugated Polymer Amplified Far-Red/Near-Infrared Fluorescence from Nanoparticles with Aggregation-Induced Emission Characteristics for Targeted In Vivo Imaging, Adv. HealthcareMater.2012, 2, 500-507.

  45. Ding, D.; Lang, J.; Shi, H.; Kwok, R. T. K.; Gao, M.; Feng, G. X.; Yuan, Y. Y.; Tang, B. Z.,* Liu, B.* Light-Up Bioprobe with Aggregation-Induced Emission Characteristics for Real-Time Apoptosis Imaging in Target Cancer Cells,J. Mater. Chem. B 2013, 2, 231-238.

  46. Ding, D.; Wang, J.; Zhu, Z. S.; Li, R. T.; Wu, W.; Liu, B. R.; Jiang, X. Q.* Tumor Accumulation, Penetration and Antitumor Response of Cisplatin-Loaded Gelatin/Poly(Acrylic Acid) Nanoparticles,ACS Appl. Mater. Interfaces2012, 4, 1838-1846.

  47. Ding, D.; Zhu, Z. S.; Liu, Q.; Wang, J.; Hu, Y.; Jiang, X. Q.;* Liu, B. R. Cisplatin-Loaded Gelatin-Poly(Acrylic Acid) Nanoparticles: Synthesis, Antitumor Efficiency In Vivo and Penetration in Tumors, Eur. J. Pharm. Biopharm.2011, 79, 142-149.

  48. Ding, D.; Wang, J.; Chen, Y.; Wu, W.; Jiang, X. Q.,* Synthesis of Novel Gelatin/Poly(Acrylic Acid) Nanorods via the Self-Assembly of Nanospheres, Sci. China Chem. 2011, 54, 392-396.




Social Appointments

1. Tianjin Biomedical Engineering Society Dental Engineering Committee, Youth Committee, youth working group leader;

2. Editorial board youth member of the journal of Science China Chemistry.

Teaching Experience

Participate in the teaching of postgraduate courses: Advanced Biochemistry (II) and Frontier Lectures in Molecular Biology; participate in the teaching of undergraduate course: Innovation and Entrepreneurship Practice.

Honor Title

 

1. In 2014, selected in the 100 Young Academic Leaders Plan in Nankai University;

2. In 2015, obtained the Tianjin Young Talents of Science and Technology;

3. In 2016, obtained the China National Science Fund for Excellent Young Scientists.

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