冯喜增

目前实验室的研究方向包括：

1. 鼠卵母细胞成熟方向，目前的研究内容为环境激素及内分泌干扰物对鼠发育及卵母细胞成熟影响的分子机制及表观遗传学等，研究其对延缓细胞周期、微管组装及相关蛋白磷酸化甲基化水平的影响，并分析其是否会引起早期凋亡和自噬效应。

2. 帕金森药物研究方向：构建PD鼠模型在行为学与分子水平上研究药物对帕金森的改善效果及其治疗机制，另外找寻活性物质与左旋多巴协同来降低左旋多巴过量所导致的副作用。

3. 斑马鱼研究方向，主要研究斑马鱼行为学与神经科学，进行药物筛选，研究内分泌干扰物、纳米粒子、环境污染物、除草剂、杀虫剂等物质对斑马鱼形态发育的毒性，及对斑马鱼行为学及神经发育的影响。通过构建斑马鱼疾病模型，研究药物对焦虑、癫痫、抑郁等精神疾病的研究，并结合组织化学和分子手段研究疾病的作用机理和对机体行为学方面的影响。借助学科交叉，利用搭建的视频追踪检测平台和方法，研究药物作用对斑马鱼行为学方面的影响。

近两年发表的论文

1. Du Shuangli #, Wang Hongyu #, Yang Yueyue, Feng Xizeng*, Shao Xueguang, Chipot Christophe, and Cai Wensheng *. Curvature of Buckybowl Corannulene Enhances Its Binding to Proteins. THE JOURNAL OF PHYSICAL CHEMISTRY C, 2018, 123.1: 922-930.

2. Li Meng, Liu Xing-Yu, Feng Xi-Zeng*, Cardiovascular toxicity and anxiety-like behavior induced by deltamethrin in zebrafish (Danio rerio) larvae, CHEMOSPHERE, 2019, 219: 155-164

3. Mi Ping #, Zhang Qiu Ping #, Li Shi Bao, LiuXing-Yu, Zhang Shu-Hui, Li Meng, Chen Dong-Yan*, Zhao Xin*, Feng Dao-Fu*, Feng Xi-Zeng*, Melatonin protects embryonic development and maintains sleep/wake behaviors from the deleterious effects of fluorene‐9‐bisphenol in zebrafish (Danio rerio), JOURNAL OF PINEAL RESEARCH, 2018: e12530

4.Liu Xing-Yu #, Zhang Qiu-Ping #, Li Shi-Bao #, Mi Ping, Chen Dong-Yan*, Zhao Xin*, Feng Xi-Zeng*, Developmental toxicity and neurotoxicity of synthetic organic insecticides in zebrafish (Danio rerio): A comparative study of deltamethrin, acephate, and thiamethoxam, CHEMOSPHERE, 2018, 199: 16-25

5.Jia Zhenzhen #, Feng Zeyang #, Wang Lining, Li Hao, Wang Hongyu, Xu Ding qi, Zhao Xin*, Feng Daofu*, Feng Xizeng*, Resveratrol reverses the adverse effects of diet-induced obese murine model on oocyte quality and zona pellucida softening, FOOD & FUNCTION, 2018, 9 (5): 2623-2633

2017年发表论文

1. Li, XY (Li, Xinyu); Sun, DD (Sun, Dandan); Li X (Li, Xu); Zhang, DX (Dashuai); Jao, JJ (Jiao, Jiajia); Wang, K (Wang, Kai); Kong, DL (Kong, Deling); Zhao, X (Zhao, Xin); Xu, L* (Xu, Lin); Zhao, Q* (Zhao, Qing); Chen, DY* (Chen, Dongyan); Feng, XZ* (Feng, Xizeng). PEGylation corannulene enhances response of stress through promoting neurogenesis. BIOMATERIALS SCIENCE, 2017, 5(4): 849-859.

2. Li, XY (Li, Xinyu); Wang, HY (Wang, Hongyu); Kuang, XH (Kuang, Xiangyu); Ma, JR (Ma, Jingrui);Feng, XZ* (Feng, Xizeng). Exploring the effects and mechanisms of carbon nanomaterial diversity on the morphology of lysozyme crystals. CRYSTENGCOMM, 2017, 19(39): 5873-5881.

3. Zhang, SH (Zhang, Shuhui); Xu, J (Xu, Jia);Kuang, XH (Kuang, Xiangyu);Li, SB (Li, Shibao); Li, X (Li, Xiang); Zhao, X* (Zhao, Xin); Chen, DY* (Chen, Dongyan); Feng, XZ* (Feng, Xizeng). Biological impacts of glyphosate on morphology, embryo biomechanics and larval behavior in zebrafish (Danio rerio). CHEMOSPHERE, 2017, 181: 270-280.

4. Li, X(Li, Xiang);Guo, JYGuo, JY (Guo, Jia-Yu);Li, X (Li, Xu); Zhou, HJ (Zhou Hai-Jun); Zhang,SH (Zhang Shu-Hui); Liu XD (Liu, Xiao-Dong); Chen, DY* (Chen, Dong-yan); Fang, YC*(Fang Yong-Chun); Feng, XZ* (Feng, Xi-Zeng). Behavioural effect of low-dose BPA on male zebrafish: Tuning of male mating competition and female mating preference during courtship process. CHEMOSPHERE, 2017, 169, 40-52.

5. Li, X (Li, Xiang); Zhang, Y (Zhang, Yuan); Li, X (Li, Xu); Feng, DF (Feng, Dao-Fu);Zhang,SH (Zhang Shu-Hui); Zhao, X (Zhao, Xin); Chen, DY* (Chen, Dong-Yan); Zhang, ZX* (Zhang, Zhi-Xiang); Feng, XZ* (Feng, Xi-Zeng). Comparative analysis of biological effect of corannulene and graphene on developmental and sleep/wake profile ofzebrafish larvae. ACTA BIOMATERIALIA, 2017, 55, 271-282.

6. Jia, ZZ (Jia, Zhenzhen); Yang, C (Yang, Cui); Jiao, JJ (Jiao,Jiajia); Li, XY (Li, Xinyu); Zhu, DS (Zhu, Da-shuai); Yang, YC (Yang, Yongchao); Yang, JY (Yang, Jingyi); Che, YZ (Che, Yongzhe); Lu, Y* (Lu, Yun); Feng, XZ* (Feng, Xizeng). Rhein and PDMS functionalized C/C composites as prostheticimplants for bone repair application. BIOMEDICAL MATERIALS, 2017, 12, 045004.

7. Jia, ZZ (Jia, Zhenzhen); Yang, C (Yang, Cui);Jiao, JJ (Jiao,Jiajia);Li, XY (Li, Xinyu); Yang, YC (Yang, Yongchao); Yang, JY (Yang, Jingyi); Geng, XJ (Geng, Xingjie); Lu, Y* (Lu, Yun); Feng, XZ* (Feng, Xizeng). In vitro and in vivo investigation of the effects of polydimethylsiloxane and paeonol modification on the biocompatibility of carbon/carbon composites. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 2017, 4(1), 015010.

2016年发表论文：

1. Jiao, JJ (Jiao,Jia-Jia); Sun,LL (Sun,Li-Li); Guo, ZY (Guo,Zai-Yu); Hou, S (Hou, Sen);Robert Holyst*; Lu, Y*(Lu, Yun) ; Feng, XZ* (Feng, Xi-Zeng).Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2- hydroxyacetophenone).SCIENTIFIC REPORTS. 2016. 6:38973.

2. Han, GM (Han, Gui-Mei); Jia, ZZ (Jia, Zhen-Zhen); Zhu, YJ (Zhu, Yan-Jun); Jiao,JJ (Jiao, Jia-Jia); Kong, DM* (Kong, De-Ming); Feng, XZ* (Feng, Xi-Zeng).Biostable L-DNA-Templated Aptamer-Silver Nanoclusters for Cell-Type-Specific Imaging at Physiological Temperature. ANALYTICAL CHEMISTRY.2016. 88(22),10800-10804.

3. Li, X (Li, Xiang);Li, X (Li, Xu); Chen, D (Chen, Di);Guo, JL (Guo, Jia-Liang); Feng, DF (Feng, Dao-Fu); Sun, MZ (Sun, Ming-Zhu); Lu, Y*(Lu, Yun); Chen, DY* (Chen, Dong-Yan); Zhao, X* (Zhao, Xin); Feng, XZ* (Feng, Xi-Zeng).Evaluating the biological impact of polyhydroxyalkanoates (PHAs) on developmental and exploratory profile of zebrafish larvae. RSC ADVANCES. 2016. 6, 37018–37030.

4. Li, X (Li, Xu);Gao AA (Gao, Ai-Ai); Wang, YN (Wang, Ya-Nan); Chen, M (Chen, Man); Peng, J (Peng, Jun); Yan, HY (Yan, Hua-Ying); Zhao, X (Zhao, Xin); Feng, XZ* (Feng, Xi-Zeng); Chen, DY* (Chen, Dong-Yan).Alcohol exposure leads to unrecoverable cardiovascular defects along with edema and motor function changes in developing zebrafish larvae. BIOLOGY OPEN. 2016. 5(8),1128-1133.

①本科生教学---结构生物学

②研究生教学---纳米生物技术研究进展